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Items: 1 to 50 of 154

1.

The origin of RNA precursors on exoplanets.

Rimmer PB, Xu J, Thompson SJ, Gillen E, Sutherland JD, Queloz D.

Sci Adv. 2018 Aug 1;4(8):eaar3302. doi: 10.1126/sciadv.aar3302. eCollection 2018 Aug.

2.

A Light-Releasable Potentially Prebiotic Nucleotide Activating Agent.

Mariani A, Russell DA, Javelle T, Sutherland JD.

J Am Chem Soc. 2018 Jul 18;140(28):8657-8661. doi: 10.1021/jacs.8b05189. Epub 2018 Jul 3.

PMID:
29965757
3.

Photochemical reductive homologation of hydrogen cyanide using sulfite and ferrocyanide.

Xu J, Ritson DJ, Ranjan S, Todd ZR, Sasselov DD, Sutherland JD.

Chem Commun (Camb). 2018 May 29;54(44):5566-5569. doi: 10.1039/c8cc01499j.

4.

Mimicking the surface and prebiotic chemistry of early Earth using flow chemistry.

Ritson DJ, Battilocchio C, Ley SV, Sutherland JD.

Nat Commun. 2018 May 8;9(1):1821. doi: 10.1038/s41467-018-04147-2.

5.

Sulfidic Anion Concentrations on Early Earth for Surficial Origins-of-Life Chemistry.

Ranjan S, Todd ZR, Sutherland JD, Sasselov DD.

Astrobiology. 2018 Aug;18(8):1023-1040. doi: 10.1089/ast.2017.1770. Epub 2018 Apr 8.

PMID:
29627997
6.

Truncated SALL1 Impedes Primary Cilia Function in Townes-Brocks Syndrome.

Bozal-Basterra L, Martín-Ruíz I, Pirone L, Liang Y, Sigurðsson JO, Gonzalez-Santamarta M, Giordano I, Gabicagogeascoa E, de Luca A, Rodríguez JA, Wilkie AOM, Kohlhase J, Eastwood D, Yale C, Olsen JV, Rauchman M, Anderson KV, Sutherland JD, Barrio R.

Am J Hum Genet. 2018 Feb 1;102(2):249-265. doi: 10.1016/j.ajhg.2017.12.017.

7.

Corrigendum: mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer.

Zabala-Letona A, Arruabarrena-Aristorena A, Martín-Martín N, Fernandez-Ruiz S, Sutherland JD, Clasquin M, Tomas-Cortazar J, Jimenez J, Torres I, Quang P, Ximenez-Embun P, Bago R, Ugalde-Olano A, Loizaga-Iriarte A, Lacasa-Viscasillas I, Unda M, Torrano V, Cabrera D, van Liempd SM, Cendon Y, Castro E, Murray S, Revandkar A, Alimonti A, Zhang Y, Barnett A, Lein G, Pirman D, Cortazar AR, Arreal L, Prudkin L, Astobiza I, Valcarcel-Jimenez L, Zuñiga-García P, Fernandez-Dominguez I, Piva M, Caro-Maldonado A, Sánchez-Mosquera P, Castillo-Martín M, Serra V, Beraza N, Gentilella A, Thomas G, Azkargorta M, Elortza F, Farràs R, Olmos D, Efeyan A, Anguita J, Muñoz J, Falcón-Pérez JM, Barrio R, Macarulla T, Mato JM, Martinez-Chantar ML, Cordon-Cardo C, Aransay AM, Marks K, Baselga J, Tabernero J, Nuciforo P, Manning BD, Marjon K, Carracedo A.

Nature. 2018 Feb 22;554(7693):554. doi: 10.1038/nature25470. Epub 2018 Jan 17.

PMID:
29342137
8.

PPARδ Elicits Ligand-Independent Repression of Trefoil Factor Family to Limit Prostate Cancer Growth.

Martín-Martín N, Zabala-Letona A, Fernández-Ruiz S, Arreal L, Camacho L, Castillo-Martin M, Cortazar AR, Torrano V, Astobiza I, Zúñiga-García P, Ugalde-Olano A, Loizaga-Iriarte A, Unda M, Valcárcel-Jiménez L, Arruabarrena-Aristorena A, Piva M, Sánchez-Mosquera P, Aransay AM, Gomez-Muñoz A, Barrio R, Sutherland JD, Carracedo A.

Cancer Res. 2018 Jan 15;78(2):399-409. doi: 10.1158/0008-5472.CAN-17-0908. Epub 2017 Nov 29.

PMID:
29187400
9.

UV-light-driven prebiotic synthesis of iron-sulfur clusters.

Bonfio C, Valer L, Scintilla S, Shah S, Evans DJ, Jin L, Szostak JW, Sasselov DD, Sutherland JD, Mansy SS.

Nat Chem. 2017 Dec;9(12):1229-1234. doi: 10.1038/nchem.2817. Epub 2017 Jul 10.

10.

Cyanamide as a prebiotic phosphate activating agent - catalysis by simple 2-oxoacid salts.

Tsanakopoulou M, Sutherland JD.

Chem Commun (Camb). 2017 Oct 31;53(87):11893-11896. doi: 10.1039/c7cc07517k.

11.

The immunosuppressive effect of the tick protein, Salp15, is long-lasting and persists in a murine model of hematopoietic transplant.

Tomás-Cortázar J, Martín-Ruiz I, Barriales D, Pascual-Itoiz MÁ, de Juan VG, Caro-Maldonado A, Merino N, Marina A, Blanco FJ, Flores JM, Sutherland JD, Barrio R, Rojas A, Martínez-Chantar ML, Carracedo A, Simó C, García-Cañas V, Abecia L, Lavín JL, Aransay AM, Rodríguez H, Anguita J.

Sci Rep. 2017 Sep 6;7(1):10740. doi: 10.1038/s41598-017-11354-2.

12.

Erratum: The metabolic co-regulator PGC1α suppresses prostate cancer metastasis.

Torrano V, Valcarcel-Jimenez L, Cortazar AR, Liu X, Urosevic J, Castillo-Martin M, Fernández-Ruiz S, Morciano G, Caro-Maldonado A, Guiu M, Zúñiga-García P, Graupera M, Bellmunt A, Pandya P, Lorente M, Martín-Martín N, Sutherland JD, Sanchez-Mosquera P, Bozal-Basterra L, Zabala-Letona A, Arruabarrena-Aristorena A, Berenguer A, Embade N, Ugalde-Olano A, Lacasa-Viscasillas I, Loizaga-Iriarte A, Unda-Urzaiz M, Schultz N, Aransay AM, Sanz-Moreno V, Barrio R, Velasco G, Pinton P, Cordon-Cardo C, Locasale JW, Gomis RR, Carracedo A.

Nat Cell Biol. 2017 Jun 29;19(7):873. doi: 10.1038/ncb3558.

PMID:
28659639
13.

mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer.

Zabala-Letona A, Arruabarrena-Aristorena A, Martín-Martín N, Fernandez-Ruiz S, Sutherland JD, Clasquin M, Tomas-Cortazar J, Jimenez J, Torres I, Quang P, Ximenez-Embun P, Bago R, Ugalde-Olano A, Loizaga-Iriarte A, Lacasa-Viscasillas I, Unda M, Torrano V, Cabrera D, van Liempd SM, Cendon Y, Castro E, Murray S, Revandkar A, Alimonti A, Zhang Y, Barnett A, Lein G, Pirman D, Cortazar AR, Arreal L, Prudkin L, Astobiza I, Valcarcel-Jimenez L, Zuñiga-García P, Fernandez-Dominguez I, Piva M, Caro-Maldonado A, Sánchez-Mosquera P, Castillo-Martín M, Serra V, Beraza N, Gentilella A, Thomas G, Azkargorta M, Elortza F, Farràs R, Olmos D, Efeyan A, Anguita J, Muñoz J, Falcón-Pérez JM, Barrio R, Macarulla T, Mato JM, Martinez-Chantar ML, Cordon-Cardo C, Aransay AM, Marks K, Baselga J, Tabernero J, Nuciforo P, Manning BD, Marjon K, Carracedo A.

Nature. 2017 Jul 6;547(7661):109-113. doi: 10.1038/nature22964. Epub 2017 Jun 28. Erratum in: Nature. 2018 Jan 17;:.

14.

Is coronary calcium scoring too late? Total body arterial calcium burden in patients without known CAD and normal MPI.

Allam AHA, Thompson RC, Eskander MA, Mandour Ali MA, Sadek A, Rowan CJ, Sutherland ML, Sutherland JD, Frohlich B, Michalik DE; HORUS research team, Finch CE, Narula J, Thomas GS, Samuel Wann L.

J Nucl Cardiol. 2017 May 25. doi: 10.1007/s12350-017-0925-9. [Epub ahead of print]

PMID:
28547671
15.

Non-Enzymatic RNA Backbone Proofreading through Energy-Dissipative Recycling.

Mariani A, Sutherland JD.

Angew Chem Int Ed Engl. 2017 Jun 1;56(23):6563-6566. doi: 10.1002/anie.201703169. Epub 2017 May 3.

16.

Quantitative proteomic analysis of Parkin substrates in Drosophila neurons.

Martinez A, Lectez B, Ramirez J, Popp O, Sutherland JD, Urbé S, Dittmar G, Clague MJ, Mayor U.

Mol Neurodegener. 2017 Apr 11;12(1):29. doi: 10.1186/s13024-017-0170-3.

17.

A prebiotically plausible synthesis of pyrimidine β-ribonucleosides and their phosphate derivatives involving photoanomerization.

Xu J, Tsanakopoulou M, Magnani CJ, Szabla R, Šponer JE, Šponer J, Góra RW, Sutherland JD.

Nat Chem. 2017 Apr;9(4):303-309. doi: 10.1038/nchem.2664. Epub 2016 Nov 21.

18.

Coronary atherosclerosis in indigenous South American Tsimane: a cross-sectional cohort study.

Kaplan H, Thompson RC, Trumble BC, Wann LS, Allam AH, Beheim B, Frohlich B, Sutherland ML, Sutherland JD, Stieglitz J, Rodriguez DE, Michalik DE, Rowan CJ, Lombardi GP, Bedi R, Garcia AR, Min JK, Narula J, Finch CE, Gurven M, Thomas GS.

Lancet. 2017 Apr 29;389(10080):1730-1739. doi: 10.1016/S0140-6736(17)30752-3. Epub 2017 Mar 17.

19.

A new and potentially prebiotic α-cytidine derivative.

Tsanakopoulou M, Xu J, Bond AD, Sutherland JD.

Chem Commun (Camb). 2017 Mar 16;53(23):3327-3329. doi: 10.1039/c7cc00693d.

20.

A comprehensive platform for the analysis of ubiquitin-like protein modifications using in vivo biotinylation.

Pirone L, Xolalpa W, Sigurðsson JO, Ramirez J, Pérez C, González M, de Sabando AR, Elortza F, Rodriguez MS, Mayor U, Olsen JV, Barrio R, Sutherland JD.

Sci Rep. 2017 Jan 18;7:40756. doi: 10.1038/srep40756.

21.

Analysis of SUMOylated Proteins in Cells and In Vivo Using the bioSUMO Strategy.

Pirone L, Xolalpa W, Mayor U, Barrio R, Sutherland JD.

Methods Mol Biol. 2016;1475:161-9. doi: 10.1007/978-1-4939-6358-4_12.

PMID:
27631805
22.

Using Biotinylated SUMO-Traps to Analyze SUMOylated Proteins.

Lang V, Da Silva-Ferrada E, Barrio R, Sutherland JD, Rodriguez MS.

Methods Mol Biol. 2016;1475:109-21. doi: 10.1007/978-1-4939-6358-4_8.

PMID:
27631801
23.

Stratification and therapeutic potential of PML in metastatic breast cancer.

Martín-Martín N, Piva M, Urosevic J, Aldaz P, Sutherland JD, Fernández-Ruiz S, Arreal L, Torrano V, Cortazar AR, Planet E, Guiu M, Radosevic-Robin N, Garcia S, Macías I, Salvador F, Domenici G, Rueda OM, Zabala-Letona A, Arruabarrena-Aristorena A, Zúñiga-García P, Caro-Maldonado A, Valcárcel-Jiménez L, Sánchez-Mosquera P, Varela-Rey M, Martínez-Chantar ML, Anguita J, Ibrahim YH, Scaltriti M, Lawrie CH, Aransay AM, Iovanna JL, Baselga J, Caldas C, Barrio R, Serra V, Vivanco Md, Matheu A, Gomis RR, Carracedo A.

Nat Commun. 2016 Aug 24;7:12595. doi: 10.1038/ncomms12595.

24.

Mixed Anhydride Intermediates in the Reaction of 5(4H)-Oxazolones with Phosphate Esters and Nucleotides.

Liu Z, Rigger L, Rossi JC, Sutherland JD, Pascal R.

Chemistry. 2016 Oct 10;22(42):14940-14949. doi: 10.1002/chem.201602697. Epub 2016 Aug 18.

25.

The metabolic co-regulator PGC1α suppresses prostate cancer metastasis.

Torrano V, Valcarcel-Jimenez L, Cortazar AR, Liu X, Urosevic J, Castillo-Martin M, Fernández-Ruiz S, Morciano G, Caro-Maldonado A, Guiu M, Zúñiga-García P, Graupera M, Bellmunt A, Pandya P, Lorente M, Martín-Martín N, Sutherland JD, Sanchez-Mosquera P, Bozal-Basterra L, Zabala-Letona A, Arruabarrena-Aristorena A, Berenguer A, Embade N, Ugalde-Olano A, Lacasa-Viscasillas I, Loizaga-Iriarte A, Unda-Urzaiz M, Schultz N, Aransay AM, Sanz-Moreno V, Barrio R, Velasco G, Pinton P, Cordon-Cardo C, Locasale JW, Gomis RR, Carracedo A.

Nat Cell Biol. 2016 Jun;18(6):645-656. doi: 10.1038/ncb3357. Epub 2016 May 23. Erratum in: Nat Cell Biol. 2017 Jun 29;19(7):873.

26.

Transcriptomic profiling of urine extracellular vesicles reveals alterations of CDH3 in prostate cancer.

Royo F, Zuñiga-Garcia P, Torrano V, Loizaga A, Sanchez-Mosquera P, Ugalde-Olano A, González E, Cortazar AR, Palomo L, Fernández-Ruiz S, Lacasa-Viscasillas I, Berdasco M, Sutherland JD, Barrio R, Zabala-Letona A, Martín-Martín N, Arruabarrena-Aristorena A, Valcarcel-Jimenez L, Caro-Maldonado A, Gonzalez-Tampan J, Cachi-Fuentes G, Esteller M, Aransay AM, Unda M, Falcón-Pérez JM, Carracedo A.

Oncotarget. 2016 Feb 9;7(6):6835-46. doi: 10.18632/oncotarget.6899.

27.

Evolution of SUMO Function and Chain Formation in Insects.

Ureña E, Pirone L, Chafino S, Pérez C, Sutherland JD, Lang V, Rodriguez MS, Lopitz-Otsoa F, Blanco FJ, Barrio R, Martín D.

Mol Biol Evol. 2016 Feb;33(2):568-84. doi: 10.1093/molbev/msv242. Epub 2015 Nov 4.

28.

The Origin of Life--Out of the Blue.

Sutherland JD.

Angew Chem Int Ed Engl. 2016 Jan 4;55(1):104-21. doi: 10.1002/anie.201506585. Epub 2015 Oct 29. Review.

PMID:
26510485
29.

Ikaros mediates the DNA methylation-independent silencing of MCJ/DNAJC15 gene expression in macrophages.

Navasa N, Martin-Ruiz I, Atondo E, Sutherland JD, Angel Pascual-Itoiz M, Carreras-González A, Izadi H, Tomás-Cortázar J, Ayaz F, Martin-Martin N, Torres IM, Barrio R, Carracedo A, Olivera ER, Rincón M, Anguita J.

Sci Rep. 2015 Sep 30;5:14692. doi: 10.1038/srep14692.

30.

PTEN mediates Notch-dependent stalk cell arrest in angiogenesis.

Serra H, Chivite I, Angulo-Urarte A, Soler A, Sutherland JD, Arruabarrena-Aristorena A, Ragab A, Lim R, Malumbres M, Fruttiger M, Potente M, Serrano M, Fabra À, Viñals F, Casanovas O, Pandolfi PP, Bigas A, Carracedo A, Gerhardt H, Graupera M.

Nat Commun. 2015 Jul 31;6:7935. doi: 10.1038/ncomms8935.

31.

Ecdysone promotes growth of imaginal discs through the regulation of Thor in D. melanogaster.

Herboso L, Oliveira MM, Talamillo A, Pérez C, González M, Martín D, Sutherland JD, Shingleton AW, Mirth CK, Barrio R.

Sci Rep. 2015 Jul 22;5:12383. doi: 10.1038/srep12383.

32.

The orthopedic diseases of ancient Egypt.

Fritsch KO, Hamoud H, Allam AH, Grossmann A, Nur El-Din AH, Abdel-Maksoud G, Soliman MA, Badr I, Sutherland JD, Sutherland ML, Akl M, Finch CE, Thomas GS, Wann LS, Thompson RC.

Anat Rec (Hoboken). 2015 Jun;298(6):1036-46. doi: 10.1002/ar.23136.

33.

Common origins of RNA, protein and lipid precursors in a cyanosulfidic protometabolism.

Patel BH, Percivalle C, Ritson DJ, Duffy CD, Sutherland JD.

Nat Chem. 2015 Apr;7(4):301-7. doi: 10.1038/nchem.2202. Epub 2015 Mar 16.

34.

Atherosclerosis: a longue durée approach.

Wann LS, Thompson RC, Allam AH, Finch CE, Zink A, Frohlich B, Kaplan H, Lombardi GP, Sutherland ML, Sutherland JD, Watson L, Cox SL, Miyamoto MI, Stewart AF, Narula J, Thomas GS.

Glob Heart. 2014 Jun;9(2):239-44. doi: 10.1016/j.gheart.2014.02.002. No abstract available.

35.

Why did ancient people have atherosclerosis?: from autopsies to computed tomography to potential causes.

Thomas GS, Wann LS, Allam AH, Thompson RC, Michalik DE, Sutherland ML, Sutherland JD, Lombardi GP, Watson L, Cox SL, Valladolid CM, Abd El-Maksoud G, Al-Tohamy Soliman M, Badr I, el-Halim Nur el-Din A, Clarke EM, Thomas IG, Miyamoto MI, Kaplan HS, Frohlich B, Narula J, Stewart AF, Zink A, Finch CE.

Glob Heart. 2014 Jun;9(2):229-37. doi: 10.1016/j.gheart.2014.04.002. Review.

36.

Funerary artifacts, social status, and atherosclerosis in ancient peruvian mummy bundles.

Sutherland ML, Cox SL, Lombardi GP, Watson L, Valladolid CM, Finch CE, Zink A, Frohlich B, Kaplan HS, Michalik DE, Miyamoto MI, Allam AH, Thompson RC, Wann LS, Narula J, Thomas GS, Sutherland JD.

Glob Heart. 2014 Jun;9(2):219-28. doi: 10.1016/j.gheart.2014.04.004. Review.

37.

Genomic correlates of atherosclerosis in ancient humans.

Zink A, Wann LS, Thompson RC, Keller A, Maixner F, Allam AH, Finch CE, Frohlich B, Kaplan H, Lombardi GP, Sutherland ML, Sutherland JD, Watson L, Cox SL, Miyamoto MI, Narula J, Stewart AF, Thomas GS, Krause J.

Glob Heart. 2014 Jun;9(2):203-9. doi: 10.1016/j.gheart.2014.03.2453. Review.

38.

Atherosclerosis in ancient and modern Egyptians: the Horus study.

Allam AH, Mandour Ali MA, Wann LS, Thompson RC, Sutherland ML, Sutherland JD, Frohlich B, Michalik DE, Zink A, Lombardi GP, Watson L, Cox SL, Finch CE, Miyamoto MI, Sallam SL, Narula J, Thomas GS.

Glob Heart. 2014 Jun;9(2):197-202. doi: 10.1016/j.gheart.2014.03.2454.

39.

Computed tomographic evidence of atherosclerosis in the mummified remains of humans from around the world.

Thompson RC, Allam AH, Zink A, Wann LS, Lombardi GP, Cox SL, Frohlich B, Sutherland ML, Sutherland JD, Frohlich TC, King SI, Miyamoto MI, Monge JM, Valladolid CM, El-Halim Nur El-Din A, Narula J, Thompson AM, Finch CE, Thomas GS.

Glob Heart. 2014 Jun;9(2):187-96. doi: 10.1016/j.gheart.2014.03.2455. Review.

40.

Excited-state hydrogen atom abstraction initiates the photochemistry of β-2'-deoxycytidine.

Szabla R, Campos J, Šponer JE, Šponer J, Góra RW, Sutherland JD.

Chem Sci. 2015 Jan 7;6:2035-2043.

41.

Exosomes as Hedgehog carriers in cytoneme-mediated transport and secretion.

Gradilla AC, González E, Seijo I, Andrés G, Bischoff M, González-Mendez L, Sánchez V, Callejo A, Ibáñez C, Guerra M, Ortigão-Farias JR, Sutherland JD, González M, Barrio R, Falcón-Pérez JM, Guerrero I.

Nat Commun. 2014 Dec 4;5:5649. doi: 10.1038/ncomms6649.

PMID:
25472772
42.

The RING ubiquitin E3 RNF114 interacts with A20 and modulates NF-κB activity and T-cell activation.

Rodriguez MS, Egaña I, Lopitz-Otsoa F, Aillet F, Lopez-Mato MP, Dorronsoro A, Lobato-Gil S, Sutherland JD, Barrio R, Trigueros C, Lang V.

Cell Death Dis. 2014 Aug 28;5:e1399. doi: 10.1038/cddis.2014.366. Erratum in: Cell Death Dis. 2014;5:e1520. Dorronroso, A [corrected to Dorronsoro, A].

43.

Self-assembly of phosphate amphiphiles in mixtures of prebiotically plausible surfactants.

Albertsen AN, Duffy CD, Sutherland JD, Monnard PA.

Astrobiology. 2014 Jun;14(6):462-72. doi: 10.1089/ast.2013.1111. Epub 2014 Jun 2.

44.

Conversion of biosynthetic precursors of RNA to those of DNA by photoredox chemistry.

Ritson DJ, Sutherland JD.

J Mol Evol. 2014 May;78(5):245-50. doi: 10.1007/s00239-014-9617-0. Epub 2014 Apr 16.

45.

Ubiquitin profiling in liver using a transgenic mouse with biotinylated ubiquitin.

Lectez B, Migotti R, Lee SY, Ramirez J, Beraza N, Mansfield B, Sutherland JD, Martinez-Chantar ML, Dittmar G, Mayor U.

J Proteome Res. 2014 Jun 6;13(6):3016-26. doi: 10.1021/pr5001913. Epub 2014 Apr 30.

PMID:
24730562
46.

Solid-phase synthesis and hybrization behavior of partially 2'/3'-O-acetylated RNA oligonucleotides.

Xu J, Duffy CD, Chan CK, Sutherland JD.

J Org Chem. 2014 Apr 18;79(8):3311-26. doi: 10.1021/jo5002824. Epub 2014 Mar 31.

47.

Is atherosclerosis fundamental to human aging? Lessons from ancient mummies.

Clarke EM, Thompson RC, Allam AH, Wann LS, Lombardi GP, Sutherland ML, Sutherland JD, Cox SL, Soliman MA, Abd el-Maksoud G, Badr I, Miyamoto MI, Frohlich B, Nur el-din AH, Stewart AF, Narula J, Zink AR, Finch CE, Michalik DE, Thomas GS.

J Cardiol. 2014 May;63(5):329-34. doi: 10.1016/j.jjcc.2013.12.012. Epub 2014 Feb 28. Review.

48.

An automated synthesis-purification-sample-management platform for the accelerated generation of pharmaceutical candidates.

Sutherland JD, Tu NP, Nemcek TA, Searle PA, Hochlowski JE, Djuric SW, Pan JY.

J Lab Autom. 2014 Apr;19(2):176-82. doi: 10.1177/2211068213516325. Epub 2013 Dec 18.

PMID:
24352687
49.

Towards an evolutionary theory of the origin of life based on kinetics and thermodynamics.

Pascal R, Pross A, Sutherland JD.

Open Biol. 2013 Nov 6;3(11):130156. doi: 10.1098/rsob.130156. Review.

50.

PML: Not all about Tumor Suppression.

Martin-Martin N, Sutherland JD, Carracedo A.

Front Oncol. 2013 Aug 5;3:200. doi: 10.3389/fonc.2013.00200. eCollection 2013. No abstract available.

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