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Single Nucleotide Polymorphisms in MIR143 Contribute to Protection Against Non-Hodgkin Lymphoma (NHL) in Caucasian Populations.

Bradshaw G, Haupt LM, Aquino EM, Lea RA, Sutherland HG, Griffiths LR.

Genes (Basel). 2019 Feb 27;10(3). pii: E185. doi: 10.3390/genes10030185.


3,5-Dialkoxypyridine analogues of bedaquiline are potent antituberculosis agents with minimal inhibition of the hERG channel.

Sutherland HS, Tong AST, Choi PJ, Blaser A, Conole D, Franzblau SG, Lotlikar MU, Cooper CB, Upton AM, Denny WA, Palmer BD.

Bioorg Med Chem. 2019 Apr 1;27(7):1292-1307. doi: 10.1016/j.bmc.2019.02.026. Epub 2019 Feb 15.


Structure-activity relationships for unit C pyridyl analogues of the tuberculosis drug bedaquiline.

Blaser A, Sutherland HS, Tong AST, Choi PJ, Conole D, Franzblau SG, Cooper CB, Upton AM, Lotlikar M, Denny WA, Palmer BD.

Bioorg Med Chem. 2019 Apr 1;27(7):1283-1291. doi: 10.1016/j.bmc.2019.02.025. Epub 2019 Feb 15.


A Comprehensive LC-QTOF-MS Metabolic Phenotyping Strategy: Application to Alkaptonuria.

Norman BP, Davison AS, Ross GA, Milan AM, Hughes AT, Sutherland H, Jarvis JC, Roberts NB, Gallagher JA, Ranganath LR.

Clin Chem. 2019 Apr;65(4):530-539. doi: 10.1373/clinchem.2018.295345. Epub 2019 Feb 19.


SpillOver stimulation: A novel hypertrophy model using co-contraction of the plantar-flexors to load the tibial anterior muscle in rats.

Schmoll M, Unger E, Sutherland H, Haller M, Bijak M, Lanmüller H, Jarvis JC.

PLoS One. 2018 Nov 20;13(11):e0207886. doi: 10.1371/journal.pone.0207886. eCollection 2018.


Targeting B-cell maturation antigen with GSK2857916 antibody-drug conjugate in relapsed or refractory multiple myeloma (BMA117159): a dose escalation and expansion phase 1 trial.

Trudel S, Lendvai N, Popat R, Voorhees PM, Reeves B, Libby EN, Richardson PG, Anderson LD Jr, Sutherland HJ, Yong K, Hoos A, Gorczyca MM, Lahiri S, He Z, Austin DJ, Opalinska JB, Cohen AD.

Lancet Oncol. 2018 Dec;19(12):1641-1653. doi: 10.1016/S1470-2045(18)30576-X. Epub 2018 Nov 12.


Selinexor plus low-dose bortezomib and dexamethasone for patients with relapsed or refractory multiple myeloma.

Bahlis NJ, Sutherland H, White D, Sebag M, Lentzsch S, Kotb R, Venner CP, Gasparetto C, Del Col A, Neri P, Reece D, Kauffman M, Shacham S, Unger TJ, Jeha J, Saint-Martin JR, Shah J, Chen C.

Blood. 2018 Dec 13;132(24):2546-2554. doi: 10.1182/blood-2018-06-858852. Epub 2018 Oct 23.


Whole-Exome Sequencing Implicates SCN2A in Episodic Ataxia, but Multiple Ion Channel Variants May Contribute to Phenotypic Complexity.

Maksemous N, Smith RA, Sutherland HG, Sampaio H, Griffiths LR.

Int J Mol Sci. 2018 Oct 11;19(10). pii: E3113. doi: 10.3390/ijms19103113.


Organochlorine Levels in Plasma and Risk of Multiple Myeloma.

Weber L, Song K, Boyle T, Gaudreau É, Lai A, Sutherland HJ, LeBlanc A, Spinelli JJ.

J Occup Environ Med. 2018 Oct;60(10):911-916. doi: 10.1097/JOM.0000000000001387.


Daratumumab plus lenalidomide and dexamethasone versus lenalidomide and dexamethasone in relapsed or refractory multiple myeloma: updated analysis of POLLUX.

Dimopoulos MA, San-Miguel J, Belch A, White D, Benboubker L, Cook G, Leiba M, Morton J, Ho PJ, Kim K, Takezako N, Moreau P, Kaufman JL, Sutherland HJ, Lalancette M, Magen H, Iida S, Kim JS, Prince HM, Cochrane T, Oriol A, Bahlis NJ, Chari A, O'Rourke L, Wu K, Schecter JM, Casneuf T, Chiu C, Soong D, Sasser AK, Khokhar NZ, Avet-Loiseau H, Usmani SZ.

Haematologica. 2018 Dec;103(12):2088-2096. doi: 10.3324/haematol.2018.194282. Epub 2018 Sep 20.


High-dose Benda-EAM versus BEAM in patients with relapsed/refractory classical Hodgkin lymphoma undergoing autologous stem cell transplantation.

Tsang ES, Villa D, Loscocco F, Visani G, Power M, Guiducci B, Clissa C, Song K, Toze C, Abou Mourad Y, Sutherland H, Sanford D, Nantel SH, Sehn LH, Scott DW, Savage KJ, Connors JM, Gerrie AS, Isidori A.

Bone Marrow Transplant. 2019 Mar;54(3):481-484. doi: 10.1038/s41409-018-0328-9. Epub 2018 Aug 31. No abstract available.


Investigation of the CADM2 polymorphism rs17518584 in memory and executive functions measures in a cohort of young healthy individuals.

Ibrahim O, Sutherland HG, Avgan N, Spriggens LK, Lea RA, Haupt LM, Shum DHK, Griffiths LR.

Neurobiol Learn Mem. 2018 Nov;155:330-336. doi: 10.1016/j.nlm.2018.08.001. Epub 2018 Aug 17.


Outcomes of Intermediate Risk Karyotype Acute Myeloid Leukemia in First Remission Undergoing Autologous Stem Cell Transplantation Compared With Allogeneic Stem Cell Transplantation and Chemotherapy Consolidation: A Retrospective, Propensity-score Adjusted Analysis.

Limvorapitak W, Barnett MJ, Hogge DE, Forrest DL, Nevill TJ, Narayanan S, Power MM, Nantel SH, Broady R, Song KW, Toze CL, Mourad YA, Sutherland HJ, Gerrie AS, White J, Sanford DS.

Clin Lymphoma Myeloma Leuk. 2018 Nov;18(11):e481-e491. doi: 10.1016/j.clml.2018.07.290. Epub 2018 Jul 17.


Organochlorine Levels in Plasma and Risk of Multiple Myeloma: Organochlorines and risk of multiple myeloma.

Weber L, Song K, Boyle T, Gaudreau É, Lai A, Sutherland HJ, Leblanc A, Spinelli JJ.

J Occup Environ Med. 2018 Jun 21. doi: 10.1097/JOM.0000000000001387. [Epub ahead of print]


Excellent real-world outcomes of adults with Burkitt lymphoma treated with CODOX-M/IVAC plus or minus rituximab.

Zhu KY, Song KW, Connors JM, Leitch H, Barnett MJ, Ramadan K, Slack GW, Abou Mourad Y, Forrest DL, Hogge DE, Nantel SH, Narayanan S, Nevill TJ, Power MM, Sanford DS, Sutherland HJ, Tucker T, Toze CL, Sehn LH, Broady R, Gerrie AS.

Br J Haematol. 2018 Jun;181(6):782-790. doi: 10.1111/bjh.15262. Epub 2018 May 9.


The NRP1 migraine risk variant shows evidence of association with menstrual migraine.

Pollock CE, Sutherland HG, Maher BH, Lea RA, Haupt LM, Frith A, Anne MacGregor E, Griffiths LR.

J Headache Pain. 2018 Apr 18;19(1):31. doi: 10.1186/s10194-018-0857-z.


Prolonged granulocyte colony stimulating factor use in glycogen storage disease type 1b associated with acute myeloid leukemia and with shortened telomere length.

Li AM, Thyagu S, Maze D, Schreiber R, Sirrs S, Stockler-Ipsiroglu S, Sutherland H, Vercauteren S, Schultz KR.

Pediatr Hematol Oncol. 2018 Feb;35(1):45-51. doi: 10.1080/08880018.2018.1440675. Epub 2018 Apr 13.


Exome Sequencing Diagnoses X-Linked Moesin-Associated Immunodeficiency in a Primary Immunodeficiency Case.

Bradshaw G, Lualhati RR, Albury CL, Maksemous N, Roos-Araujo D, Smith RA, Benton MC, Eccles DA, Lea RA, Sutherland HG, Haupt LM, Griffiths LR.

Front Immunol. 2018 Mar 5;9:420. doi: 10.3389/fimmu.2018.00420. eCollection 2018.


Structure-activity relationships for analogs of the tuberculosis drug bedaquiline with the naphthalene unit replaced by bicyclic heterocycles.

Sutherland HS, Tong AST, Choi PJ, Conole D, Blaser A, Franzblau SG, Cooper CB, Upton AM, Lotlikar MU, Denny WA, Palmer BD.

Bioorg Med Chem. 2018 May 1;26(8):1797-1809. doi: 10.1016/j.bmc.2018.02.026. Epub 2018 Feb 20.


Improving Revised International Prognostic Scoring System Pre-Allogeneic Stem Cell Transplantation Does Not Translate Into Better Post-Transplantation Outcomes for Patients with Myelodysplastic Syndromes: A Single-Center Experience.

Alzahrani M, Power M, Abou Mourad Y, Barnett M, Broady R, Forrest D, Gerrie A, Hogge D, Nantel S, Sanford D, Song K, Sutherland H, Toze C, Nevill T, Narayanan S.

Biol Blood Marrow Transplant. 2018 Jun;24(6):1209-1215. doi: 10.1016/j.bbmt.2018.02.007. Epub 2018 Feb 20.


Next Generation Sequencing Methods for Diagnosis of Epilepsy Syndromes.

Dunn P, Albury CL, Maksemous N, Benton MC, Sutherland HG, Smith RA, Haupt LM, Griffiths LR.

Front Genet. 2018 Feb 7;9:20. doi: 10.3389/fgene.2018.00020. eCollection 2018. Review.


An emerging role for epigenetic factors in relation to executive function.

Ibrahim O, Sutherland HG, Haupt LM, Griffiths LR.

Brief Funct Genomics. 2018 May 1;17(3):170-180. doi: 10.1093/bfgp/elx032.


Synthesis and evaluation of analogues of the tuberculosis drug bedaquiline containing heterocyclic B-ring units.

Choi PJ, Sutherland HS, Tong AST, Blaser A, Franzblau SG, Cooper CB, Lotlikar MU, Upton AM, Guillemont J, Motte M, Queguiner L, Andries K, Van den Broeck W, Denny WA, Palmer BD.

Bioorg Med Chem Lett. 2017 Dec 1;27(23):5190-5196. doi: 10.1016/j.bmcl.2017.10.042. Epub 2017 Oct 20.


6-Cyano Analogues of Bedaquiline as Less Lipophilic and Potentially Safer Diarylquinolines for Tuberculosis.

Tong AST, Choi PJ, Blaser A, Sutherland HS, Tsang SKY, Guillemont J, Motte M, Cooper CB, Andries K, Van den Broeck W, Franzblau SG, Upton AM, Denny WA, Palmer BD, Conole D.

ACS Med Chem Lett. 2017 Sep 22;8(10):1019-1024. doi: 10.1021/acsmedchemlett.7b00196. eCollection 2017 Oct 12.


A CREB1 Gene Polymorphism (rs2253206) Is Associated with Prospective Memory in a Healthy Cohort.

Avgan N, Sutherland HG, Lea RA, Spriggens LK, Haupt LM, Shum DHK, Griffiths LR.

Front Behav Neurosci. 2017 May 16;11:86. doi: 10.3389/fnbeh.2017.00086. eCollection 2017.


In-situ measurements of tensile forces in the tibialis anterior tendon of the rat in concentric, isometric, and resisted co-contractions.

Schmoll M, Unger E, Sutherland H, Haller M, Bijak M, Lanmüller H, Jarvis JC.

Physiol Rep. 2017 Apr;5(8). pii: e13245. doi: 10.14814/phy2.13245.


Gene-centric analysis implicates nuclear encoded mitochondrial protein gene variants in migraine susceptibility.

Stuart S, Benton MC, Eccles DA, Sutherland HG, Haupt LM, Lea RA, Griffiths LR.

Mol Genet Genomic Med. 2017 Jan 17;5(2):157-163. doi: 10.1002/mgg3.270. eCollection 2017 Mar.


BDNF Variants May Modulate Long-Term Visual Memory Performance in a Healthy Cohort.

Avgan N, Sutherland HG, Spriggens LK, Yu C, Ibrahim O, Bellis C, Haupt LM, Shum DH, Griffiths LR.

Int J Mol Sci. 2017 Mar 17;18(3). pii: E655. doi: 10.3390/ijms18030655.


Genetics of Migraine: Insights into the Molecular Basis of Migraine Disorders.

Sutherland HG, Griffiths LR.

Headache. 2017 Apr;57(4):537-569. doi: 10.1111/head.13053. Epub 2017 Mar 8. Review.


Methylome-wide association study of whole blood DNA in the Norfolk Island isolate identifies robust loci associated with age.

Benton MC, Sutherland HG, Macartney-Coxson D, Haupt LM, Lea RA, Griffiths LR.

Aging (Albany NY). 2017 Feb 28;9(3):753-768. doi: 10.18632/aging.101187.


On the Rate of Synthesis of Individual Proteins within and between Different Striated Muscles of the Rat.

Hesketh S, Srisawat K, Sutherland H, Jarvis J, Burniston J.

Proteomes. 2016 Mar 15;4(1). pii: E12. doi: 10.3390/proteomes4010012.


Signal conditioning for compensating nonlinearity and nonrepeatability of an optical frequency scanning laser implemented in a C-OFDR system.

Martínez Manuel R, Sutherland HE.

Appl Opt. 2017 Jan 20;56(3):457-461. doi: 10.1364/AO.56.000457.


Investigation of polymorphisms in genes involved in estrogen metabolism in menstrual migraine.

Sutherland HG, Champion M, Plays A, Stuart S, Haupt LM, Frith A, MacGregor EA, Griffiths LR.

Gene. 2017 Apr 5;607:36-40. doi: 10.1016/j.gene.2017.01.008. Epub 2017 Jan 13.


Dysregulated MicroRNA Expression Profiles and Potential Cellular, Circulating and Polymorphic Biomarkers in Non-Hodgkin Lymphoma.

Bradshaw G, Sutherland HG, Haupt LM, Griffiths LR.

Genes (Basel). 2016 Dec 17;7(12). pii: E130. doi: 10.3390/genes7120130. Review.


Comparison of a pediatric-inspired treatment protocol versus standard-intensity chemotherapy for young adults with standard-risk BCR-ABL negative acute lymphoblastic leukemia.

Kliman D, Barnett M, Broady R, Forrest D, Gerrie A, Hogge D, Nantel S, Narayanan S, Nevill T, Power M, Sanford D, Song K, Sutherland H, Toze C, Abou Mourad Y.

Leuk Lymphoma. 2017 Apr;58(4):909-915. doi: 10.1080/10428194.2016.1222376. Epub 2016 Aug 26.


Final overall survival results of a randomized trial comparing bortezomib plus pegylated liposomal doxorubicin with bortezomib alone in patients with relapsed or refractory multiple myeloma.

Orlowski RZ, Nagler A, Sonneveld P, Bladé J, Hajek R, Spencer A, Robak T, Dmoszynska A, Horvath N, Spicka I, Sutherland HJ, Suvorov AN, Xiu L, Cakana A, Parekh T, San-Miguel JF.

Cancer. 2016 Jul 1;122(13):2050-6. doi: 10.1002/cncr.30026. Epub 2016 May 18.


Daratumumab monotherapy in patients with treatment-refractory multiple myeloma (SIRIUS): an open-label, randomised, phase 2 trial.

Lonial S, Weiss BM, Usmani SZ, Singhal S, Chari A, Bahlis NJ, Belch A, Krishnan A, Vescio RA, Mateos MV, Mazumder A, Orlowski RZ, Sutherland HJ, Bladé J, Scott EC, Oriol A, Berdeja J, Gharibo M, Stevens DA, LeBlanc R, Sebag M, Callander N, Jakubowiak A, White D, de la Rubia J, Richardson PG, Lisby S, Feng H, Uhlar CM, Khan I, Ahmadi T, Voorhees PM.

Lancet. 2016 Apr 9;387(10027):1551-60. doi: 10.1016/S0140-6736(15)01120-4. Epub 2016 Jan 7.


A quinazoline-based HDAC inhibitor affects gene expression pathways involved in cholesterol biosynthesis and mevalonate in prostate cancer cells.

Lin Z, Bishop KS, Sutherland H, Marlow G, Murray P, Denny WA, Ferguson LR.

Mol Biosyst. 2016 Mar;12(3):839-49. doi: 10.1039/c5mb00554j.


Genetic and epigenetic variants in the MTHFR gene are not associated with non-Hodgkin lymphoma.

Bradshaw G, Sutherland HG, Camilleri ET, Lea RA, Haupt LM, Griffiths LR.

Meta Gene. 2015 Oct 22;6:91-5. doi: 10.1016/j.mgene.2015.09.004. eCollection 2015 Dec.


Methylenetetrahydrofolate Reductase CpG Islands: Epigenotyping.

Wei LK, Sutherland H, Au A, Camilleri E, Haupt LM, Gan SH, Griffiths LR.

J Clin Lab Anal. 2016 Jul;30(4):335-44. doi: 10.1002/jcla.21860. Epub 2015 Jun 25.


Nitisinone Arrests but Does Not Reverse Ochronosis in Alkaptonuric Mice.

Keenan CM, Preston AJ, Sutherland H, Wilson PJ, Psarelli EE, Cox TF, Ranganath LR, Jarvis JC, Gallagher JA.

JIMD Rep. 2015;24:45-50. doi: 10.1007/8904_2015_437. Epub 2015 May 5.


Case-control study of ADARB1 and ADARB2 gene variants in migraine.

Gasparini CF, Sutherland HG, Maher B, Rodriguez-Acevedo AJ, Khlifi E, Haupt LM, Griffiths LR.

J Headache Pain. 2015;16:511. doi: 10.1186/s10194-015-0511-y. Epub 2015 Apr 3.


Allogeneic Hematopoietic Stem Cell Transplantation Is an Effective Salvage Therapy for Patients with Chronic Myeloid Leukemia Presenting with Advanced Disease or Failing Treatment with Tyrosine Kinase Inhibitors.

Nair AP, Barnett MJ, Broady RC, Hogge DE, Song KW, Toze CL, Nantel SH, Power MM, Sutherland HJ, Nevill TJ, Abou Mourad Y, Narayanan S, Gerrie AS, Forrest DL.

Biol Blood Marrow Transplant. 2015 Aug;21(8):1437-44. doi: 10.1016/j.bbmt.2015.04.005. Epub 2015 Apr 10.


Synthesis and structure-activity relationships for extended side chain analogues of the antitubercular drug (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824).

Palmer BD, Sutherland HS, Blaser A, Kmentova I, Franzblau SG, Wan B, Wang Y, Ma Z, Denny WA, Thompson AM.

J Med Chem. 2015 Apr 9;58(7):3036-59. doi: 10.1021/jm501608q. Epub 2015 Mar 27.


A potential epigenetic marker mediating serum folate and vitamin B12 levels contributes to the risk of ischemic stroke.

Wei LK, Sutherland H, Au A, Camilleri E, Haupt LM, Gan SH, Griffiths LR.

Biomed Res Int. 2015;2015:167976. doi: 10.1155/2015/167976. Epub 2015 Feb 1.


Outcome of Patients With Non-Hodgkin Lymphomas With Concurrent MYC and BCL2 Rearrangements Treated With CODOX-M/IVAC With Rituximab Followed by Hematopoietic Stem Cell Transplantation.

Sun H, Savage KJ, Karsan A, Slack GW, Gascoyne RD, Toze CL, Sehn LH, Abou Mourad Y, Barnett MJ, Broady RC, Connors JM, Forrest DL, Gerrie AS, Hogge DE, Narayanan S, Nevill TJ, Nantel SH, Power MM, Sutherland HJ, Villa D, Shepherd JD, Song KW.

Clin Lymphoma Myeloma Leuk. 2015 Jun;15(6):341-8. doi: 10.1016/j.clml.2014.12.015. Epub 2015 Jan 3.


Access to primary care affects the health of Deaf people.

Emond A, Ridd M, Sutherland H, Allsop L, Alexander A, Kyle J.

Br J Gen Pract. 2015 Feb;65(631):95-6. doi: 10.3399/bjgp15X683629. Review. No abstract available.


The current health of the signing Deaf community in the UK compared with the general population: a cross-sectional study.

Emond A, Ridd M, Sutherland H, Allsop L, Alexander A, Kyle J.

BMJ Open. 2015 Jan 25;5(1):e006668. doi: 10.1136/bmjopen-2014-006668.


Genetic association and gene expression studies suggest that genetic variants in the SYNE1 and TNF genes are related to menstrual migraine.

Rodriguez-Acevedo AJ, Smith RA, Roy B, Sutherland H, Lea RA, Frith A, MacGregor EA, Griffiths LR.

J Headache Pain. 2014 Oct 14;15:62. doi: 10.1186/1129-2377-15-62.


A phase 2, randomized, double-blind, placebo-controlled study of siltuximab (anti-IL-6 mAb) and bortezomib versus bortezomib alone in patients with relapsed or refractory multiple myeloma.

Orlowski RZ, Gercheva L, Williams C, Sutherland H, Robak T, Masszi T, Goranova-Marinova V, Dimopoulos MA, Cavenagh JD, Špička I, Maiolino A, Suvorov A, Bladé J, Samoylova O, Puchalski TA, Reddy M, Bandekar R, van de Velde H, Xie H, Rossi JF.

Am J Hematol. 2015 Jan;90(1):42-9. doi: 10.1002/ajh.23868.

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