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Items: 34


Tissue-specific regulation of p53 by PKM2 is redox dependent and provides a therapeutic target for anthracycline-induced cardiotoxicity.

Saleme B, Gurtu V, Zhang Y, Kinnaird A, Boukouris AE, Gopal K, Ussher JR, Sutendra G.

Sci Transl Med. 2019 Feb 6;11(478). pii: eaau8866. doi: 10.1126/scitranslmed.aau8866.


The antianginal ranolazine mitigates obesity-induced nonalcoholic fatty liver disease and increases hepatic pyruvate dehydrogenase activity.

Al Batran R, Gopal K, Aburasayn H, Eshreif A, Almutairi M, Greenwell AA, Campbell SA, Saleme B, Court EA, Eaton F, Light PE, Sutendra G, Ussher JR.

JCI Insight. 2019 Jan 10;4(1). pii: 124643. doi: 10.1172/jci.insight.124643. [Epub ahead of print]


A Similar Metabolic Profile Between the Failing Myocardium and Tumor Could Provide Alternative Therapeutic Targets in Chemotherapy-Induced Cardiotoxicity.

Saleme B, Sutendra G.

Front Cardiovasc Med. 2018 Jun 11;5:61. doi: 10.3389/fcvm.2018.00061. eCollection 2018. No abstract available.


Mitochondrial HSP90 Accumulation Promotes Vascular Remodeling in Pulmonary Arterial Hypertension.

Boucherat O, Peterlini T, Bourgeois A, Nadeau V, Breuils-Bonnet S, Boilet-Molez S, Potus F, Meloche J, Chabot S, Lambert C, Tremblay E, Chae YC, Altieri DC, Sutendra G, Michelakis ED, Paulin R, Provencher S, Bonnet S.

Am J Respir Crit Care Med. 2018 Jul 1;198(1):90-103. doi: 10.1164/rccm.201708-1751OC.


Cell autonomous role of iASPP deficiency in causing cardiocutaneous disorders.

Dedeić Z, Sutendra G, Hu Y, Chung K, Slee EA, White MJ, Zhou FY, Goldin RD, Ferguson DJP, McAndrew D, Schneider JE, Lu X.

Cell Death Differ. 2018 Jul;25(7):1289-1303. doi: 10.1038/s41418-017-0039-6. Epub 2018 Jan 19.


Oxygen Sensing in the Pulmonary Circulation: A Fluid State of Affairs.

Sutendra G, Michelakis ED.

Circ Res. 2017 Aug 4;121(4):323-325. doi: 10.1161/CIRCRESAHA.117.311518. No abstract available.


FoxO1 regulates myocardial glucose oxidation rates via transcriptional control of pyruvate dehydrogenase kinase 4 expression.

Gopal K, Saleme B, Al Batran R, Aburasayn H, Eshreif A, Ho KL, Ma WK, Almutairi M, Eaton F, Gandhi M, Park EA, Sutendra G, Ussher JR.

Am J Physiol Heart Circ Physiol. 2017 Sep 1;313(3):H479-H490. doi: 10.1152/ajpheart.00191.2017. Epub 2017 Jul 7.


Caspase cleavage of iASPP potentiates its ability to inhibit p53 and NF-κB.

Hu Y, Ge W, Wang X, Sutendra G, Zhao K, Dedeić Z, Slee EA, Baer C, Lu X.

Oncotarget. 2015 Dec 15;6(40):42478-90. doi: 10.18632/oncotarget.6478.


Metabolic Modulation of Clear-cell Renal Cell Carcinoma with Dichloroacetate, an Inhibitor of Pyruvate Dehydrogenase Kinase.

Kinnaird A, Dromparis P, Saleme B, Gurtu V, Watson K, Paulin R, Zervopoulos S, Stenson T, Sutendra G, Pink DB, Carmine-Simmen K, Moore R, Lewis JD, Michelakis ED.

Eur Urol. 2016 Apr;69(4):734-744. doi: 10.1016/j.eururo.2015.09.014. Epub 2016 Feb 18.


The iron paradigm of pulmonary arterial hypertension: Popeye knows best.

Sutendra G, Bonnet S.

Circ Res. 2015 May 8;116(10):1636-8. doi: 10.1161/CIRCRESAHA.115.306440. No abstract available.


iASPP, a previously unidentified regulator of desmosomes, prevents arrhythmogenic right ventricular cardiomyopathy (ARVC)-induced sudden death.

Notari M, Hu Y, Sutendra G, Dedeić Z, Lu M, Dupays L, Yavari A, Carr CA, Zhong S, Opel A, Tinker A, Clarke K, Watkins H, Ferguson DJ, Kelsell DP, de Noronha S, Sheppard MN, Hollinshead M, Mohun TJ, Lu X.

Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):E973-81. doi: 10.1073/pnas.1408111112. Epub 2015 Feb 17.


A miR-208-Mef2 axis drives the decompensation of right ventricular function in pulmonary hypertension.

Paulin R, Sutendra G, Gurtu V, Dromparis P, Haromy A, Provencher S, Bonnet S, Michelakis ED.

Circ Res. 2015 Jan 2;116(1):56-69. doi: 10.1161/CIRCRESAHA.115.303910. Epub 2014 Oct 6.


Sirtuin 3 deficiency is associated with inhibited mitochondrial function and pulmonary arterial hypertension in rodents and humans.

Paulin R, Dromparis P, Sutendra G, Gurtu V, Zervopoulos S, Bowers L, Haromy A, Webster L, Provencher S, Bonnet S, Michelakis ED.

Cell Metab. 2014 Nov 4;20(5):827-839. doi: 10.1016/j.cmet.2014.08.011. Epub 2014 Oct 2.


A nuclear pyruvate dehydrogenase complex is important for the generation of acetyl-CoA and histone acetylation.

Sutendra G, Kinnaird A, Dromparis P, Paulin R, Stenson TH, Haromy A, Hashimoto K, Zhang N, Flaim E, Michelakis ED.

Cell. 2014 Jul 3;158(1):84-97. doi: 10.1016/j.cell.2014.04.046.


The metabolic basis of pulmonary arterial hypertension.

Sutendra G, Michelakis ED.

Cell Metab. 2014 Apr 1;19(4):558-73. doi: 10.1016/j.cmet.2014.01.004. Epub 2014 Feb 6. Review.


Pioglitazone inhibits HIF-1α-dependent angiogenesis in rats by paracrine and direct effects on endothelial cells.

Dromparis P, Sutendra G, Paulin R, Proctor S, Michelakis ED, McMurtry MS.

J Mol Med (Berl). 2014 May;92(5):497-507. doi: 10.1007/s00109-013-1115-0. Epub 2014 Jan 10.


Pulmonary arterial hypertension: challenges in translational research and a vision for change.

Sutendra G, Michelakis ED.

Sci Transl Med. 2013 Oct 23;5(208):208sr5. doi: 10.1126/scitranslmed.3005428. Review.


A metabolic remodeling in right ventricular hypertrophy is associated with decreased angiogenesis and a transition from a compensated to a decompensated state in pulmonary hypertension.

Sutendra G, Dromparis P, Paulin R, Zervopoulos S, Haromy A, Nagendran J, Michelakis ED.

J Mol Med (Berl). 2013 Nov;91(11):1315-27. doi: 10.1007/s00109-013-1059-4. Epub 2013 Jul 12.


Uncoupling protein 2 deficiency mimics the effects of hypoxia and endoplasmic reticulum stress on mitochondria and triggers pseudohypoxic pulmonary vascular remodeling and pulmonary hypertension.

Dromparis P, Paulin R, Sutendra G, Qi AC, Bonnet S, Michelakis ED.

Circ Res. 2013 Jul 5;113(2):126-36. doi: 10.1161/CIRCRESAHA.112.300699. Epub 2013 May 7.


Pyruvate dehydrogenase kinase as a novel therapeutic target in oncology.

Sutendra G, Michelakis ED.

Front Oncol. 2013 Mar 7;3:38. doi: 10.3389/fonc.2013.00038. eCollection 2013.


Endothelin axis is upregulated in human and rat right ventricular hypertrophy.

Nagendran J, Sutendra G, Paterson I, Champion HC, Webster L, Chiu B, Haromy A, Rebeyka IM, Ross DB, Michelakis ED.

Circ Res. 2013 Jan 18;112(2):347-54. doi: 10.1161/CIRCRESAHA.111.300448. Epub 2012 Dec 10. Erratum in: Circ Res. 2014 Mar 14;114(6):e32.


The impact of current and novel anti-diabetic therapies on cardiovascular risk.

Ussher JR, Sutendra G, Jaswal JS.

Future Cardiol. 2012 Nov;8(6):895-912. doi: 10.2217/fca.12.68. Review.


Attenuating endoplasmic reticulum stress as a novel therapeutic strategy in pulmonary hypertension.

Dromparis P, Paulin R, Stenson TH, Haromy A, Sutendra G, Michelakis ED.

Circulation. 2013 Jan 1;127(1):115-25. doi: 10.1161/CIRCULATIONAHA.112.133413. Epub 2012 Nov 13.


Mitochondrial activation by inhibition of PDKII suppresses HIF1a signaling and angiogenesis in cancer.

Sutendra G, Dromparis P, Kinnaird A, Stenson TH, Haromy A, Parker JM, McMurtry MS, Michelakis ED.

Oncogene. 2013 Mar 28;32(13):1638-50. doi: 10.1038/onc.2012.198. Epub 2012 May 21.


Ser-796 of β-galactosidase (Escherichia coli) plays a key role in maintaining a balance between the opened and closed conformations of the catalytically important active site loop.

Jancewicz LJ, Wheatley RW, Sutendra G, Lee M, Fraser ME, Huber RE.

Arch Biochem Biophys. 2012 Jan 15;517(2):111-22. doi: 10.1016/ Epub 2011 Dec 1.


Pyruvate dehydrogenase inhibition by the inflammatory cytokine TNFα contributes to the pathogenesis of pulmonary arterial hypertension.

Sutendra G, Dromparis P, Bonnet S, Haromy A, McMurtry MS, Bleackley RC, Michelakis ED.

J Mol Med (Berl). 2011 Aug;89(8):771-83. doi: 10.1007/s00109-011-0762-2. Epub 2011 Aug 2.


The role of Nogo and the mitochondria-endoplasmic reticulum unit in pulmonary hypertension.

Sutendra G, Dromparis P, Wright P, Bonnet S, Haromy A, Hao Z, McMurtry MS, Michalak M, Vance JE, Sessa WC, Michelakis ED.

Sci Transl Med. 2011 Jun 22;3(88):88ra55. doi: 10.1126/scitranslmed.3002194.


The role of mitochondria in pulmonary vascular remodeling.

Dromparis P, Sutendra G, Michelakis ED.

J Mol Med (Berl). 2010 Oct;88(10):1003-10. doi: 10.1007/s00109-010-0670-x. Epub 2010 Aug 24. Review.


Fatty acid oxidation and malonyl-CoA decarboxylase in the vascular remodeling of pulmonary hypertension.

Sutendra G, Bonnet S, Rochefort G, Haromy A, Folmes KD, Lopaschuk GD, Dyck JR, Michelakis ED.

Sci Transl Med. 2010 Aug 11;2(44):44ra58. doi: 10.1126/scitranslmed.3001327.


Metabolic modulation of glioblastoma with dichloroacetate.

Michelakis ED, Sutendra G, Dromparis P, Webster L, Haromy A, Niven E, Maguire C, Gammer TL, Mackey JR, Fulton D, Abdulkarim B, McMurtry MS, Petruk KC.

Sci Transl Med. 2010 May 12;2(31):31ra34. doi: 10.1126/scitranslmed.3000677.


Dehydroepiandrosterone reverses systemic vascular remodeling through the inhibition of the Akt/GSK3-{beta}/NFAT axis.

Bonnet S, Paulin R, Sutendra G, Dromparis P, Roy M, Watson KO, Nagendran J, Haromy A, Dyck JR, Michelakis ED.

Circulation. 2009 Sep 29;120(13):1231-40. doi: 10.1161/CIRCULATIONAHA.109.848911. Epub 2009 Sep 14.


The nuclear factor of activated T cells in pulmonary arterial hypertension can be therapeutically targeted.

Bonnet S, Rochefort G, Sutendra G, Archer SL, Haromy A, Webster L, Hashimoto K, Bonnet SN, Michelakis ED.

Proc Natl Acad Sci U S A. 2007 Jul 3;104(27):11418-23. Epub 2007 Jun 27.


Beta-galactosidase (Escherichia coli) has a second catalytically important Mg2+ site.

Sutendra G, Wong S, Fraser ME, Huber RE.

Biochem Biophys Res Commun. 2007 Jan 12;352(2):566-70. Epub 2006 Nov 20.


The chicken embryo as a model for ductus arteriosus developmental biology: cracking into new territory.

Sutendra G, Michelakis ED.

Am J Physiol Regul Integr Comp Physiol. 2007 Jan;292(1):R481-4. Epub 2006 Sep 21. No abstract available.

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