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Items: 26


Inhaled Steroids and Active Smoking Drive Chronic Obstructive Pulmonary Disease Symptoms and Biomarkers to a Greater Degree Than Airflow Limitation.

Silkoff PE, Singh D, FitzGerald JM, Eich A, Ludwig-Sengpiel A, Chupp GC, Backer V, Porsbjerg C, Girodet PO, Dransfield MT, Baribaud F, Susulic VS, Loza MJ.

Biomark Insights. 2017 Sep 7;12:1177271917730306. doi: 10.1177/1177271917730306. eCollection 2017.


Discovery of 7-(3-(piperazin-1-yl)phenyl)pyrrolo[2,1-f][1,2,4]triazin-4-amine derivatives as highly potent and selective PI3Kδ inhibitors.

Qin LY, Ruan Z, Cherney RJ, Dhar TGM, Neels J, Weigelt CA, Sack JS, Srivastava AS, Cornelius LAM, Tino JA, Stefanski K, Gu X, Xie J, Susulic V, Yang X, Yarde-Chinn M, Skala S, Bosnius R, Goldstein C, Davies P, Ruepp S, Salter-Cid L, Bhide RS, Poss MA.

Bioorg Med Chem Lett. 2017 Feb 15;27(4):855-861. doi: 10.1016/j.bmcl.2017.01.016. Epub 2017 Jan 10.


Identification of airway mucosal type 2 inflammation by using clinical biomarkers in asthmatic patients.

Silkoff PE, Laviolette M, Singh D, FitzGerald JM, Kelsen S, Backer V, Porsbjerg CM, Girodet PO, Berger P, Kline JN, Chupp G, Susulic VS, Barnathan ES, Baribaud F, Loza MJ; Airways Disease Endotyping for Personalized Therapeutics (ADEPT) study investigators.

J Allergy Clin Immunol. 2017 Sep;140(3):710-719. doi: 10.1016/j.jaci.2016.11.038. Epub 2017 Jan 13.


Validated and longitudinally stable asthma phenotypes based on cluster analysis of the ADEPT study.

Loza MJ, Djukanovic R, Chung KF, Horowitz D, Ma K, Branigan P, Barnathan ES, Susulic VS, Silkoff PE, Sterk PJ, Baribaud F; ADEPT (Airways Disease Endotyping for Personalized Therapeutics) and U-BIOPRED (Unbiased Biomarkers for the Prediction of Respiratory Disease Outcome Consortium) investigators.

Respir Res. 2016 Dec 15;17(1):165.


Longitudinal stability of asthma characteristics and biomarkers from the Airways Disease Endotyping for Personalized Therapeutics (ADEPT) study.

Silkoff PE, Laviolette M, Singh D, FitzGerald JM, Kelsen S, Backer V, Porsbjerg C, Girodet PO, Berger P, Kline JN, Khatri S, Chanez P, Susulic VS, Barnathan ES, Baribaud F, Loza MJ; ADEPT Investigators.

Respir Res. 2016 Apr 23;17:43. doi: 10.1186/s12931-016-0360-5.


Longitudinally Stable, Clinically Defined Clusters of Patients with Asthma Independently Identified in the ADEPT and U-BIOPRED Asthma Studies.

Loza MJ, Adcock I, Auffray C, Chung KF, Djukanovic R, Sterk PJ, Susulic VS, Barnathan ES, Baribaud F, Silkoff PE; ADEPT and U-BIOPRED Investigators.

Ann Am Thorac Soc. 2016 Mar;13 Suppl 1:S102-3. doi: 10.1513/AnnalsATS.201508-519MG.


Asthma characteristics and biomarkers from the Airways Disease Endotyping for Personalized Therapeutics (ADEPT) longitudinal profiling study.

Silkoff PE, Strambu I, Laviolette M, Singh D, FitzGerald JM, Lam S, Kelsen S, Eich A, Ludwig-Sengpiel A, Hupp GC, Backer V, Porsbjerg C, Girodet PO, Berger P, Leigh R, Kline JN, Dransfield M, Calhoun W, Hussaini A, Khatri S, Chanez P, Susulic VS, Barnathan ES, Curran M, Das AM, Brodmerkel C, Baribaud F, Loza MJ.

Respir Res. 2015 Nov 17;16:142. doi: 10.1186/s12931-015-0299-y.


Engineering of a novel anti-CD40L domain antibody for treatment of autoimmune diseases.

Xie JH, Yamniuk AP, Borowski V, Kuhn R, Susulic V, Rex-Rabe S, Yang X, Zhou X, Zhang Y, Gillooly K, Brosius R, Ravishankar R, Waggie K, Mink K, Price L, Rehfuss R, Tamura J, An Y, Cheng L, Abramczyk B, Ignatovich O, Drew P, Grant S, Bryson JW, Suchard S, Salter-Cid L, Nadler S, Suri A.

J Immunol. 2014 May 1;192(9):4083-92. doi: 10.4049/jimmunol.1303239. Epub 2014 Mar 26.


Secreted frizzled-related protein 5 suppresses adipocyte mitochondrial metabolism through WNT inhibition.

Mori H, Prestwich TC, Reid MA, Longo KA, Gerin I, Cawthorn WP, Susulic VS, Krishnan V, Greenfield A, Macdougald OA.

J Clin Invest. 2012 Jul;122(7):2405-16. doi: 10.1172/JCI63604. Epub 2012 Jun 25.


Loss of toll-like receptor 3 function improves glucose tolerance and reduces liver steatosis in obese mice.

Wu LH, Huang CC, Adhikarakunnathu S, San Mateo LR, Duffy KE, Rafferty P, Bugelski P, Raymond H, Deutsch H, Picha K, Ward CK, Alexoupolou L, Flavell RA, Mbow ML, Susulic VS.

Metabolism. 2012 Nov;61(11):1633-45. doi: 10.1016/j.metabol.2012.04.015. Epub 2012 May 17.


An LFA-1 (alphaLbeta2) small-molecule antagonist reduces inflammation and joint destruction in murine models of arthritis.

Suchard SJ, Stetsko DK, Davis PM, Skala S, Potin D, Launay M, Dhar TG, Barrish JC, Susulic V, Shuster DJ, McIntyre KW, McKinnon M, Salter-Cid L.

J Immunol. 2010 Apr 1;184(7):3917-26. doi: 10.4049/jimmunol.0901095. Epub 2010 Feb 26.


Periodic, partial inhibition of IkappaB Kinase beta-mediated signaling yields therapeutic benefit in preclinical models of rheumatoid arthritis.

Gillooly KM, Pattoli MA, Taylor TL, Chen L, Cheng L, Gregor KR, Whitney GS, Susulic V, Watterson SH, Kempson J, Pitts WJ, Booth-Lute H, Yang G, Davies P, Kukral DW, Strnad J, McIntyre KW, Darienzo CJ, Salter-Cid L, Yang Z, Wang-Iverson DB, Burke JR.

J Pharmacol Exp Ther. 2009 Nov;331(2):349-60. doi: 10.1124/jpet.109.156018. Epub 2009 Aug 3.


Dasatinib, a small-molecule protein tyrosine kinase inhibitor, inhibits T-cell activation and proliferation.

Schade AE, Schieven GL, Townsend R, Jankowska AM, Susulic V, Zhang R, Szpurka H, Maciejewski JP.

Blood. 2008 Feb 1;111(3):1366-77. Epub 2007 Oct 25.


Wnt10b inhibits obesity in ob/ob and agouti mice.

Wright WS, Longo KA, Dolinsky VW, Gerin I, Kang S, Bennett CN, Chiang SH, Prestwich TC, Gress C, Burant CF, Susulic VS, MacDougald OA.

Diabetes. 2007 Feb;56(2):295-303.


Identification of a PTH regulated gene selectively induced in vivo during PTH-mediated bone formation.

Robinson JA, Susulic V, Liu YB, Taylor C, Hardenburg J, Gironda V, Zhao W, Kharode Y, McLarney S, Bai Y, Malone DP, Murrills R, Bex F.

J Cell Biochem. 2006 Aug 1;98(5):1203-20.


A highly selective inhibitor of IkappaB kinase, BMS-345541, augments graft survival mediated by suboptimal immunosuppression in a murine model of cardiac graft rejection.

Townsend RM, Postelnek J, Susulic V, McIntyre KW, Shuster DJ, Qiu Y, Zusi FC, Burke JR.

Transplantation. 2004 Apr 15;77(7):1090-4.


Expression of the human beta(3)-adrenergic receptor gene in SK-N-MC cells is under the control of a distal enhancer.

Susulic VS, LaVallette L, Duzic E, Chen L, Shuey D, Karathanasis SK, Steiner KE.

Endocrinology. 2001 May;142(5):1935-49.


Beta-3 adrenergic receptor agonists cause an increase in gastrointestinal transit time in wild-type mice, but not in mice lacking the beta-3 adrenergic receptor.

Fletcher DS, Candelore MR, Grujic D, Lowell BB, Luell S, Susulic VS, Macintyre DE.

J Pharmacol Exp Ther. 1998 Nov;287(2):720-4.


Mice expressing human but not murine beta3-adrenergic receptors under the control of human gene regulatory elements.

Ito M, Grujic D, Abel ED, Vidal-Puig A, Susulic VS, Lawitts J, Harper ME, Himms-Hagen J, Strosberg AD, Lowell BB.

Diabetes. 1998 Sep;47(9):1464-71.


Functional antagonism between CCAAT/Enhancer binding protein-alpha and peroxisome proliferator-activated receptor-gamma on the leptin promoter.

Hollenberg AN, Susulic VS, Madura JP, Zhang B, Moller DE, Tontonoz P, Sarraf P, Spiegelman BM, Lowell BB.

J Biol Chem. 1997 Feb 21;272(8):5283-90.


Activation of beta(3) adrenergic receptors suppresses leptin expression and mediates a leptin-independent inhibition of food intake in mice.

Mantzoros CS, Qu D, Frederich RC, Susulic VS, Lowell BB, Maratos-Flier E, Flier JS.

Diabetes. 1996 Jul;45(7):909-14.


Cocaine-induced microvascular vasoconstriction but differential systemic haemodynamic responses in Yucatan versus Yorkshire varieties of swine.

Miao L, Núñez BD, Susulic V, Wheeler S, Carrozza JP, Ross JN, Morgan JP.

Br J Pharmacol. 1996 Feb;117(3):559-565.


Targeted disruption of the beta 3-adrenergic receptor gene.

Susulic VS, Frederich RC, Lawitts J, Tozzo E, Kahn BB, Harper ME, Himms-Hagen J, Flier JS, Lowell BB.

J Biol Chem. 1995 Dec 8;270(49):29483-92.


Characterization of insulin resistance and NIDDM in transgenic mice with reduced brown fat.

Hamann A, Benecke H, Le Marchand-Brustel Y, Susulic VS, Lowell BB, Flier JS.

Diabetes. 1995 Nov;44(11):1266-73.


Cocaine-induced microvascular spasm in Yucatan miniature swine. In vivo and in vitro evidence of spasm.

Núñez BD, Miao L, Wang Y, Núñez MM, Klein MA, Sellke FW, Ross JN, Susulic V, Paik GY, Carrozza JP, et al.

Circ Res. 1994 Feb;74(2):281-90. Erratum in: Circ Res 1994 Sep;75(3):601.


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