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Items: 1 to 50 of 174

1.

The anti-staphylococcal lipolanthines are ribosomally synthesized lipopeptides.

Wiebach V, Mainz A, Siegert MJ, Jungmann NA, Lesquame G, Tirat S, Dreux-Zigha A, Aszodi J, Le Beller D, Süssmuth RD.

Nat Chem Biol. 2018 Jul;14(7):652-654. doi: 10.1038/s41589-018-0068-6. Epub 2018 Jun 18.

PMID:
29915235
2.

Correction to: Aspergillus niger is a superior expression host for the production of bioactive fungal cyclodepsipeptides.

Boecker S, Grätz S, Kerwat D, Adam L, Schirmer D, Richter L, Schütze T, Petras D, Süssmuth RD, Meyer V.

Fungal Biol Biotechnol. 2018 Mar 27;5:7. doi: 10.1186/s40694-018-0051-8. eCollection 2018.

3.

Aspergillus niger is a superior expression host for the production of bioactive fungal cyclodepsipeptides.

Boecker S, Grätz S, Kerwat D, Adam L, Schirmer D, Richter L, Schütze T, Petras D, Süssmuth RD, Meyer V.

Fungal Biol Biotechnol. 2018 Mar 2;5:4. doi: 10.1186/s40694-018-0048-3. eCollection 2018. Erratum in: Fungal Biol Biotechnol. 2018 Mar 27;5:7.

4.

Streptomyces AcH 505 triggers production of a salicylic acid analogue in the fungal pathogen Heterobasidion abietinum that enhances infection of Norway spruce seedlings.

Keilhofer N, Nachtigall J, Kulik A, Ecke M, Hampp R, Süssmuth RD, Fiedler HP, Schrey SD.

Antonie Van Leeuwenhoek. 2018 May;111(5):691-704. doi: 10.1007/s10482-018-1017-9. Epub 2018 Jan 19.

PMID:
29350358
5.

Comparative Venomics of the Vipera ammodytes transcaucasiana and Vipera ammodytes montandoni from Turkey Provides Insights into Kinship.

Hempel BF, Damm M, Göçmen B, Karis M, Oguz MA, Nalbantsoy A, Süssmuth RD.

Toxins (Basel). 2018 Jan 1;10(1). pii: E23. doi: 10.3390/toxins10010023.

6.

Quantitative Expression of Hepatobiliary Transporters and Functional Uptake of Substrates in Hepatic Two-Dimensional Sandwich Cultures: A Comparative Evaluation of Upcyte and Primary Human Hepatocytes.

Schaefer M, Morinaga G, Matsui A, Schänzle G, Bischoff D, Süssmuth RD.

Drug Metab Dispos. 2018 Feb;46(2):166-177. doi: 10.1124/dmd.117.078238. Epub 2017 Dec 6.

PMID:
29212823
7.

Harnessing fungal nonribosomal cyclodepsipeptide synthetases for mechanistic insights and tailored engineering.

Steiniger C, Hoffmann S, Mainz A, Kaiser M, Voigt K, Meyer V, Süssmuth RD.

Chem Sci. 2017 Nov 1;8(11):7834-7843. doi: 10.1039/c7sc03093b. Epub 2017 Sep 25.

8.

Prerequisites of Isopeptide Bond Formation in Microcystin Biosynthesis.

Meyer S, Mainz A, Kehr JC, Süssmuth RD, Dittmann E.

Chembiochem. 2017 Dec 14;18(24):2376-2379. doi: 10.1002/cbic.201700389. Epub 2017 Oct 27.

PMID:
29024253
9.

Halogenation of glycopeptide antibiotics occurs at the amino acid level during non-ribosomal peptide synthesis.

Kittilä T, Kittel C, Tailhades J, Butz D, Schoppet M, Büttner A, Goode RJA, Schittenhelm RB, van Pee KH, Süssmuth RD, Wohlleben W, Cryle MJ, Stegmann E.

Chem Sci. 2017 Sep 1;8(9):5992-6004. doi: 10.1039/c7sc00460e. Epub 2017 Jul 13.

10.

Total Synthesis and Biological Assessment of Novel Albicidins Discovered by Mass Spectrometric Networking.

von Eckardstein L, Petras D, Dang T, Cociancich S, Sabri S, Grätz S, Kerwat D, Seidel M, Pesic A, Dorrestein PC, Royer M, Weston JB, Süssmuth RD.

Chemistry. 2017 Nov 2;23(61):15316-15321. doi: 10.1002/chem.201704074. Epub 2017 Oct 12.

PMID:
28876492
11.

The medical threat of mamba envenoming in sub-Saharan Africa revealed by genus-wide analysis of venom composition, toxicity and antivenomics profiling of available antivenoms.

Ainsworth S, Petras D, Engmark M, Süssmuth RD, Whiteley G, Albulescu LO, Kazandjian TD, Wagstaff SC, Rowley P, Wüster W, Dorrestein PC, Arias AS, Gutiérrez JM, Harrison RA, Casewell NR, Calvete JJ.

J Proteomics. 2018 Feb 10;172:173-189. doi: 10.1016/j.jprot.2017.08.016. Epub 2017 Aug 24.

PMID:
28843532
12.

The Natural Fungal Metabolite Beauvericin Exerts Anticancer Activity In Vivo: A Pre-Clinical Pilot Study.

Heilos D, Rodríguez-Carrasco Y, Englinger B, Timelthaler G, van Schoonhoven S, Sulyok M, Boecker S, Süssmuth RD, Heffeter P, Lemmens-Gruber R, Dornetshuber-Fleiss R, Berger W.

Toxins (Basel). 2017 Aug 24;9(9). pii: E258. doi: 10.3390/toxins9090258.

13.

A Self-Sacrificing N-Methyltransferase Is the Precursor of the Fungal Natural Product Omphalotin.

Ramm S, Krawczyk B, Mühlenweg A, Poch A, Mösker E, Süssmuth RD.

Angew Chem Int Ed Engl. 2017 Aug 7;56(33):9994-9997. doi: 10.1002/anie.201703488. Epub 2017 Jul 17.

PMID:
28715095
14.

Bioactive Peptide Natural Products as Lead Structures for Medicinal Use.

Dang T, Süssmuth RD.

Acc Chem Res. 2017 Jul 18;50(7):1566-1576. doi: 10.1021/acs.accounts.7b00159. Epub 2017 Jun 26.

PMID:
28650175
15.

Combined venom profiling and cytotoxicity screening of the Radde's mountain viper (Montivipera raddei) and Mount Bulgar Viper (Montivipera bulgardaghica) with potent cytotoxicity against human A549 lung carcinoma cells.

Nalbantsoy A, Hempel BF, Petras D, Heiss P, Göçmen B, Iğci N, Yildiz MZ, Süssmuth RD.

Toxicon. 2017 Sep 1;135:71-83. doi: 10.1016/j.toxicon.2017.06.008. Epub 2017 Jun 16.

PMID:
28625888
16.

Phylogenomic Analysis of the Microviridin Biosynthetic Pathway Coupled with Targeted Chemo-Enzymatic Synthesis Yields Potent Protease Inhibitors.

Ahmed MN, Reyna-González E, Schmid B, Wiebach V, Süssmuth RD, Dittmann E, Fewer DP.

ACS Chem Biol. 2017 Jun 16;12(6):1538-1546. doi: 10.1021/acschembio.7b00124. Epub 2017 Apr 26.

PMID:
28406289
17.

Nonribosomal Peptide Synthesis-Principles and Prospects.

Süssmuth RD, Mainz A.

Angew Chem Int Ed Engl. 2017 Mar 27;56(14):3770-3821. doi: 10.1002/anie.201609079. Epub 2017 Mar 21. Review.

PMID:
28323366
18.

Making the mute speak again.

Boecker S, Süssmuth RD.

Environ Microbiol. 2017 Feb;19(2):423-425. doi: 10.1111/1462-2920.13675. No abstract available.

PMID:
28109046
19.

Biological Role of Paenilarvins, Iturin-Like Lipopeptide Secondary Metabolites Produced by the Honey Bee Pathogen Paenibacillus larvae.

Hertlein G, Seiffert M, Gensel S, Garcia-Gonzalez E, Ebeling J, Skobalj R, Kuthning A, Süssmuth RD, Genersch E.

PLoS One. 2016 Oct 19;11(10):e0164656. doi: 10.1371/journal.pone.0164656. eCollection 2016.

20.
21.

Synthesis of Albicidin Derivatives: Assessing the Role of N-terminal Acylation on the Antibacterial Activity.

Kerwat D, Grätz S, Kretz J, Seidel M, Kunert M, Weston JB, Süssmuth RD.

ChemMedChem. 2016 Sep 6;11(17):1899-903. doi: 10.1002/cmdc.201600231. Epub 2016 Jul 21.

PMID:
27439374
22.

Leader Peptide-Free In Vitro Reconstitution of Microviridin Biosynthesis Enables Design of Synthetic Protease-Targeted Libraries.

Reyna-González E, Schmid B, Petras D, Süssmuth RD, Dittmann E.

Angew Chem Int Ed Engl. 2016 Aug 1;55(32):9398-401. doi: 10.1002/anie.201604345. Epub 2016 Jun 23.

PMID:
27336908
23.

Top-down venomics of the East African green mamba, Dendroaspis angusticeps, and the black mamba, Dendroaspis polylepis, highlight the complexity of their toxin arsenals.

Petras D, Heiss P, Harrison RA, Süssmuth RD, Calvete JJ.

J Proteomics. 2016 Sep 2;146:148-64. doi: 10.1016/j.jprot.2016.06.018. Epub 2016 Jun 16.

PMID:
27318176
24.

Understanding the crucial interactions between Cytochrome P450s and non-ribosomal peptide synthetases during glycopeptide antibiotic biosynthesis.

Peschke M, Gonsior M, Süssmuth RD, Cryle MJ.

Curr Opin Struct Biol. 2016 Dec;41:46-53. doi: 10.1016/j.sbi.2016.05.018. Epub 2016 Jun 9. Review.

25.

Synthesis and Antimicrobial Activity of Albicidin Derivatives with Variations of the Central Cyanoalanine Building Block.

Grätz S, Kerwat D, Kretz J, von Eckardstein L, Semsary S, Seidel M, Kunert M, Weston JB, Süssmuth RD.

ChemMedChem. 2016 Jul 19;11(14):1499-502. doi: 10.1002/cmdc.201600163. Epub 2016 Jun 1.

PMID:
27245621
26.

Deuterium-Labeled Precursor Feeding Reveals a New pABA-Containing Meroterpenoid from the Mango Pathogen Xanthomonas citri pv. mangiferaeindicae.

Saleh H, Petras D, Mainz A, Kerwat D, Nalbantsoy A, Erzurumlu Y, Süssmuth RD.

J Nat Prod. 2016 Jun 24;79(6):1532-7. doi: 10.1021/acs.jnatprod.5b01049. Epub 2016 May 27.

PMID:
27232656
27.

Biochemical Dissection of the Natural Diversification of Microcystin Provides Lessons for Synthetic Biology of NRPS.

Meyer S, Kehr JC, Mainz A, Dehm D, Petras D, Süssmuth RD, Dittmann E.

Cell Chem Biol. 2016 Apr 21;23(4):462-71. doi: 10.1016/j.chembiol.2016.03.011.

28.

Laxitextines A and B, Cyathane Xylosides from the Tropical Fungus Laxitextum incrustatum.

Mudalungu CM, Richter C, Wittstein K, Abdalla MA, Matasyoh JC, Stadler M, Süssmuth RD.

J Nat Prod. 2016 Apr 22;79(4):894-8. doi: 10.1021/acs.jnatprod.5b00950. Epub 2016 Apr 4.

PMID:
27043217
29.

Mouse tissue distribution and persistence of the food-born fusariotoxins Enniatin B and Beauvericin.

Rodríguez-Carrasco Y, Heilos D, Richter L, Süssmuth RD, Heffeter P, Sulyok M, Kenner L, Berger W, Dornetshuber-Fleiss R.

Toxicol Lett. 2016 Apr 15;247:35-44. doi: 10.1016/j.toxlet.2016.02.008. Epub 2016 Feb 15.

30.

The O-Carbamoyl-Transferase Alb15 Is Responsible for the Modification of Albicidin.

Petras D, Kerwat D, Pesic A, Hempel BF, von Eckardstein L, Semsary S, Arasté J, Marguerettaz M, Royer M, Cociancich S, Süssmuth RD.

ACS Chem Biol. 2016 May 20;11(5):1198-204. doi: 10.1021/acschembio.5b01001. Epub 2016 Feb 23.

PMID:
26886160
31.

Rational biosynthetic approaches for the production of new-to-nature compounds in fungi.

Boecker S, Zobel S, Meyer V, Süssmuth RD.

Fungal Genet Biol. 2016 Apr;89:89-101. doi: 10.1016/j.fgb.2016.02.003. Epub 2016 Feb 9. Review.

PMID:
26872866
32.

Upcyte Human Hepatocytes: a Potent In Vitro Tool for the Prediction of Hepatic Clearance of Metabolically Stable Compounds.

Schaefer M, Schänzle G, Bischoff D, Süssmuth RD.

Drug Metab Dispos. 2016 Mar;44(3):435-44. doi: 10.1124/dmd.115.067348. Epub 2015 Dec 28.

33.

Reprogramming the Biosynthesis of Cyclodepsipeptide Synthetases to Obtain New Enniatins and Beauvericins.

Zobel S, Boecker S, Kulke D, Heimbach D, Meyer V, Süssmuth RD.

Chembiochem. 2016 Feb 15;17(4):283-7. doi: 10.1002/cbic.201500649. Epub 2016 Jan 5.

PMID:
26663099
34.

Biosynthesis of the Peptide Antibiotic Feglymycin by a Linear Nonribosomal Peptide Synthetase Mechanism.

Gonsior M, Mühlenweg A, Tietzmann M, Rausch S, Poch A, Süssmuth RD.

Chembiochem. 2015 Dec;16(18):2610-4. doi: 10.1002/cbic.201500432. Epub 2015 Oct 30.

PMID:
26515424
35.

The Supersized Class III Lanthipeptide Stackepeptin Displays Motif Multiplication in the Core Peptide.

Jungmann NA, van Herwerden EF, Hügelland M, Süssmuth RD.

ACS Chem Biol. 2016 Jan 15;11(1):69-76. doi: 10.1021/acschembio.5b00651. Epub 2015 Oct 29.

PMID:
26488920
36.

Streptocollin, a Type IV Lanthipeptide Produced by Streptomyces collinus Tü 365.

Iftime D, Jasyk M, Kulik A, Imhoff JF, Stegmann E, Wohlleben W, Süssmuth RD, Weber T.

Chembiochem. 2015 Dec;16(18):2615-23. doi: 10.1002/cbic.201500377. Epub 2015 Nov 6.

PMID:
26437689
37.

Sources for Leads: Natural Products and Libraries.

van Herwerden EF, Süssmuth RD.

Handb Exp Pharmacol. 2016;232:91-123. doi: 10.1007/164_2015_19. Review.

PMID:
26408018
38.

Mass spectrometry guided venom profiling and bioactivity screening of the Anatolian Meadow Viper, Vipera anatolica.

Göçmen B, Heiss P, Petras D, Nalbantsoy A, Süssmuth RD.

Toxicon. 2015 Dec 1;107(Pt B):163-74. doi: 10.1016/j.toxicon.2015.09.013. Epub 2015 Sep 16.

PMID:
26385313
39.

Minimum Information about a Biosynthetic Gene cluster.

Medema MH, Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K, de Bruijn I, Chooi YH, Claesen J, Coates RC, Cruz-Morales P, Duddela S, Düsterhus S, Edwards DJ, Fewer DP, Garg N, Geiger C, Gomez-Escribano JP, Greule A, Hadjithomas M, Haines AS, Helfrich EJ, Hillwig ML, Ishida K, Jones AC, Jones CS, Jungmann K, Kegler C, Kim HU, Kötter P, Krug D, Masschelein J, Melnik AV, Mantovani SM, Monroe EA, Moore M, Moss N, Nützmann HW, Pan G, Pati A, Petras D, Reen FJ, Rosconi F, Rui Z, Tian Z, Tobias NJ, Tsunematsu Y, Wiemann P, Wyckoff E, Yan X, Yim G, Yu F, Xie Y, Aigle B, Apel AK, Balibar CJ, Balskus EP, Barona-Gómez F, Bechthold A, Bode HB, Borriss R, Brady SF, Brakhage AA, Caffrey P, Cheng YQ, Clardy J, Cox RJ, De Mot R, Donadio S, Donia MS, van der Donk WA, Dorrestein PC, Doyle S, Driessen AJ, Ehling-Schulz M, Entian KD, Fischbach MA, Gerwick L, Gerwick WH, Gross H, Gust B, Hertweck C, Höfte M, Jensen SE, Ju J, Katz L, Kaysser L, Klassen JL, Keller NP, Kormanec J, Kuipers OP, Kuzuyama T, Kyrpides NC, Kwon HJ, Lautru S, Lavigne R, Lee CY, Linquan B, Liu X, Liu W, Luzhetskyy A, Mahmud T, Mast Y, Méndez C, Metsä-Ketelä M, Micklefield J, Mitchell DA, Moore BS, Moreira LM, Müller R, Neilan BA, Nett M, Nielsen J, O'Gara F, Oikawa H, Osbourn A, Osburne MS, Ostash B, Payne SM, Pernodet JL, Petricek M, Piel J, Ploux O, Raaijmakers JM, Salas JA, Schmitt EK, Scott B, Seipke RF, Shen B, Sherman DH, Sivonen K, Smanski MJ, Sosio M, Stegmann E, Süssmuth RD, Tahlan K, Thomas CM, Tang Y, Truman AW, Viaud M, Walton JD, Walsh CT, Weber T, van Wezel GP, Wilkinson B, Willey JM, Wohlleben W, Wright GD, Ziemert N, Zhang C, Zotchev SB, Breitling R, Takano E, Glöckner FO.

Nat Chem Biol. 2015 Sep;11(9):625-31. doi: 10.1038/nchembio.1890. No abstract available.

40.

Lipocarbazole, an efficient lipid peroxidation inhibitor anchored in the membrane.

Fabre G, Hänchen A, Calliste CA, Berka K, Banala S, Otyepka M, Süssmuth RD, Trouillas P.

Bioorg Med Chem. 2015 Aug 1;23(15):4866-70. doi: 10.1016/j.bmc.2015.05.031. Epub 2015 May 27.

PMID:
26068016
41.

Scale-up bioprocess development for production of the antibiotic valinomycin in Escherichia coli based on consistent fed-batch cultivations.

Li J, Jaitzig J, Lu P, Süssmuth RD, Neubauer P.

Microb Cell Fact. 2015 Jun 12;14:83. doi: 10.1186/s12934-015-0272-y.

42.

The Albicidin Resistance Factor AlbD Is a Serine Endopeptidase That Hydrolyzes Unusual Oligoaromatic-Type Peptides.

Vieweg L, Kretz J, Pesic A, Kerwat D, Grätz S, Royer M, Cociancich S, Mainz A, Süssmuth RD.

J Am Chem Soc. 2015 Jun 24;137(24):7608-11. doi: 10.1021/jacs.5b04099. Epub 2015 Jun 15.

PMID:
26057615
43.

Multiple attack on bacteria by the new antibiotic teixobactin.

von Nussbaum F, Süssmuth RD.

Angew Chem Int Ed Engl. 2015 Jun 1;54(23):6684-6. doi: 10.1002/anie.201501440. Epub 2015 May 12. No abstract available.

PMID:
25968231
44.

What makes Xanthomonas albilineans unique amongst xanthomonads?

Pieretti I, Pesic A, Petras D, Royer M, Süssmuth RD, Cociancich S.

Front Plant Sci. 2015 Apr 24;6:289. doi: 10.3389/fpls.2015.00289. eCollection 2015. Review.

45.

Structural aspects of phenylglycines, their biosynthesis and occurrence in peptide natural products.

Al Toma RS, Brieke C, Cryle MJ, Süssmuth RD.

Nat Prod Rep. 2015 Aug;32(8):1207-35. doi: 10.1039/c5np00025d. Review.

PMID:
25940955
46.

Involvement of secondary metabolites in the pathogenesis of the American foulbrood of honey bees caused by Paenibacillus larvae.

Müller S, Garcia-Gonzalez E, Genersch E, Süssmuth RD.

Nat Prod Rep. 2015 Jun;32(6):765-78. doi: 10.1039/c4np00158c. Epub 2015 Apr 23. Review.

PMID:
25904391
47.

Venom Proteomics of Indonesian King Cobra, Ophiophagus hannah: Integrating Top-Down and Bottom-Up Approaches.

Petras D, Heiss P, Süssmuth RD, Calvete JJ.

J Proteome Res. 2015 Jun 5;14(6):2539-56. doi: 10.1021/acs.jproteome.5b00305. Epub 2015 Apr 27.

PMID:
25896403
48.

Engineering the heterologous expression of lanthipeptides in Escherichia coli by multigene assembly.

Kuthning A, Mösker E, Süssmuth RD.

Appl Microbiol Biotechnol. 2015 Aug;99(15):6351-61. doi: 10.1007/s00253-015-6557-6. Epub 2015 Apr 7.

PMID:
25846334
49.

The gyrase inhibitor albicidin consists of p-aminobenzoic acids and cyanoalanine.

Cociancich S, Pesic A, Petras D, Uhlmann S, Kretz J, Schubert V, Vieweg L, Duplan S, Marguerettaz M, Noëll J, Pieretti I, Hügelland M, Kemper S, Mainz A, Rott P, Royer M, Süssmuth RD.

Nat Chem Biol. 2015 Mar;11(3):195-7. doi: 10.1038/nchembio.1734. Epub 2015 Jan 19.

PMID:
25599532
50.

The naturally born fusariotoxin enniatin B and sorafenib exert synergistic activity against cervical cancer in vitro and in vivo.

Dornetshuber-Fleiss R, Heilos D, Mohr T, Richter L, Süssmuth RD, Zlesak M, Novicky A, Heffeter P, Lemmens-Gruber R, Berger W.

Biochem Pharmacol. 2015 Feb 1;93(3):318-331. doi: 10.1016/j.bcp.2014.12.013. Epub 2014 Dec 31.

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