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Items: 1 to 50 of 180

1.

Pim1 Maintains Telomere Length in Mouse Cardiomyocytes by Inhibiting TGFβ Signaling.

Ebeid DE, Khalafalla FG, Broughton KM, Monsanto MM, Esquer CY, Sacchi V, Hariharan N, Korski KI, Moshref M, Emathinger J, Cottage CT, Quijada PJ, Nguyen JH, Alvarez R, Völkers M, Konstandin MH, Wang BJ, Firouzi F, Navarrete JM, Gude NA, Goumans MJ, Sussman MA.

Cardiovasc Res. 2020 Mar 16. pii: cvaa066. doi: 10.1093/cvr/cvaa066. [Epub ahead of print]

PMID:
32176281
2.

Human CardioChimeras: Creation of a Novel "Next-Generation" Cardiac Cell.

Firouzi F, Sinha Choudhury S, Broughton K, Salazar A, Bailey B, Sussman MA.

J Am Heart Assoc. 2020 Jan 7;9(1):e013452. doi: 10.1161/JAHA.119.013452. Epub 2020 Jan 4.

3.

Adaptation within embryonic and neonatal heart environment reveals alternative fates for adult c-kit+ cardiac interstitial cells.

Wang BJ, Alvarez R Jr, Muliono A, Sengphanith S, Monsanto MM, Weeks J, Sacripanti R, Sussman MA.

Stem Cells Transl Med. 2019 Dec 31. doi: 10.1002/sctm.19-0277. [Epub ahead of print]

4.

Cardiac tissue engineering therapeutic products to enhance myocardial contractility.

Broughton KM, Sussman MA.

J Muscle Res Cell Motil. 2019 Dec 20. doi: 10.1007/s10974-019-09570-6. [Epub ahead of print]

PMID:
31863324
5.

Adult human cardiac stem cell supplementation effectively increases contractile function and maturation in human engineered cardiac tissues.

Murphy JF, Mayourian J, Stillitano F, Munawar S, Broughton KM, Agullo-Pascual E, Sussman MA, Hajjar RJ, Costa KD, Turnbull IC.

Stem Cell Res Ther. 2019 Dec 4;10(1):373. doi: 10.1186/s13287-019-1486-4.

6.

Cardiac regenerative therapy: Many paths to repair.

Gude NA, Sussman MA.

Trends Cardiovasc Med. 2019 Sep 2. pii: S1050-1738(19)30127-6. doi: 10.1016/j.tcm.2019.08.009. [Epub ahead of print] Review.

PMID:
31515053
7.

Transcribing the heart: faithfully interpreting cardiac transcriptional insights.

Echeagaray O, Sussman MA.

Regen Med. 2019 Sep;14(9):805-810. doi: 10.2217/rme-2019-0063. Epub 2019 Aug 29.

8.

Adult Cardiomyocyte Cell Cycle Detour: Off-ramp to Quiescent Destinations.

Broughton KM, Sussman MA.

Trends Endocrinol Metab. 2019 Aug;30(8):557-567. doi: 10.1016/j.tem.2019.05.006. Epub 2019 Jun 28. Review.

PMID:
31262545
9.

Safety profiling of genetically engineered Pim-1 kinase overexpression for oncogenicity risk in human c-kit+ cardiac interstitial cells.

Broughton K, Korski K, Echeagaray O, Adamson R, Dembitsky W, Lu Z, Schaefer E, Sussman MA.

Gene Ther. 2019 Aug;26(7-8):324-337. doi: 10.1038/s41434-019-0084-5. Epub 2019 Jun 25.

PMID:
31239537
10.

Cardiac interstitial tetraploid cells can escape replicative senescence in rodents but not large mammals.

Broughton KM, Khieu T, Nguyen N, Rosa M, Mohsin S, Quijada P, Wang BJ, Echeagaray OH, Kubli DA, Kim T, Firouzi F, Monsanto MM, Gude NA, Adamson RM, Dembitsky WP, Davis ME, Sussman MA.

Commun Biol. 2019 Jun 13;2:205. doi: 10.1038/s42003-019-0453-z. eCollection 2019.

11.

Cardiac nonmyocyte subpopulations: a secular congregation.

Sussman MA.

Regen Med. 2019 Jun;14(6):489-494. doi: 10.2217/rme-2019-0053. Epub 2019 May 22. Review. No abstract available.

12.

BNIP3L/NIX and FUNDC1-mediated mitophagy is required for mitochondrial network remodeling during cardiac progenitor cell differentiation.

Lampert MA, Orogo AM, Najor RH, Hammerling BC, Leon LJ, Wang BJ, Kim T, Sussman MA, Gustafsson ÅB.

Autophagy. 2019 Jul;15(7):1182-1198. doi: 10.1080/15548627.2019.1580095. Epub 2019 Feb 22.

13.

Hypoxia Prevents Mitochondrial Dysfunction and Senescence in Human c-Kit+ Cardiac Progenitor Cells.

Korski KI, Kubli DA, Wang BJ, Khalafalla FG, Monsanto MM, Firouzi F, Echeagaray OH, Kim T, Adamson RM, Dembitsky WP, Gustafsson ÅB, Sussman MA.

Stem Cells. 2019 Apr;37(4):555-567. doi: 10.1002/stem.2970. Epub 2019 Jan 30.

14.

Cardiomyocyte cell cycle dynamics and proliferation revealed through cardiac-specific transgenesis of fluorescent ubiquitinated cell cycle indicator (FUCCI).

Alvarez R Jr, Wang BJ, Quijada PJ, Avitabile D, Ho T, Shaitrit M, Chavarria M, Firouzi F, Ebeid D, Monsanto MM, Navarrete N, Moshref M, Siddiqi S, Broughton KM, Bailey BA, Gude NA, Sussman MA.

J Mol Cell Cardiol. 2019 Feb;127:154-164. doi: 10.1016/j.yjmcc.2018.12.007. Epub 2018 Dec 18.

15.

In situ transcriptome characteristics are lost following culture adaptation of adult cardiac stem cells.

Kim T, Echeagaray OH, Wang BJ, Casillas A, Broughton KM, Kim BH, Sussman MA.

Sci Rep. 2018 Aug 13;8(1):12060. doi: 10.1038/s41598-018-30551-1.

16.

Cardiac ageing: extrinsic and intrinsic factors in cellular renewal and senescence.

Gude NA, Broughton KM, Firouzi F, Sussman MA.

Nat Rev Cardiol. 2018 Sep;15(9):523-542. doi: 10.1038/s41569-018-0061-5. Review.

PMID:
30054574
17.

Enhancement Strategies for Cardiac Regenerative Cell Therapy: Focus on Adult Stem Cells.

Broughton KM, Sussman MA.

Circ Res. 2018 Jul 6;123(2):177-187. doi: 10.1161/CIRCRESAHA.118.311207. Review.

18.

Cardiac progenitor cell ion currents: revealing a little more on the lesser known.

Khalafalla FG, Sussman MA.

J Physiol. 2018 Jun;596(12):2271-2272. doi: 10.1113/JP276132. Epub 2018 May 20. No abstract available.

19.

Mechanisms of Cardiac Repair and Regeneration.

Broughton KM, Wang BJ, Firouzi F, Khalafalla F, Dimmeler S, Fernandez-Aviles F, Sussman MA.

Circ Res. 2018 Apr 13;122(8):1151-1163. doi: 10.1161/CIRCRESAHA.117.312586. Review.

20.

Cardiac c-Kit Biology Revealed by Inducible Transgenesis.

Gude NA, Firouzi F, Broughton KM, Ilves K, Nguyen KP, Payne CR, Sacchi V, Monsanto MM, Casillas AR, Khalafalla FG, Wang BJ, Ebeid DE, Alvarez R, Dembitsky WP, Bailey BA, van Berlo J, Sussman MA.

Circ Res. 2018 Jun 22;123(1):57-72. doi: 10.1161/CIRCRESAHA.117.311828. Epub 2018 Apr 10.

21.

Short Telomeres Induce p53 and Autophagy and Modulate Age-Associated Changes in Cardiac Progenitor Cell Fate.

Matsumoto C, Jiang Y, Emathinger J, Quijada P, Nguyen N, De La Torre A, Moshref M, Nguyen J, Levinson AB, Shin M, Sussman MA, Hariharan N.

Stem Cells. 2018 Jun;36(6):868-880. doi: 10.1002/stem.2793. Epub 2018 Feb 25.

22.

Editorial commentary: Mitochondrial autophagy in cardiac aging is all fluxed up.

Kubli DA, Sussman MA.

Trends Cardiovasc Med. 2018 May;28(4):261-262. doi: 10.1016/j.tcm.2017.12.008. Epub 2017 Dec 19. No abstract available.

23.

Peptidyl-Prolyl Isomerase 1 Regulates Ca2+ Handling by Modulating Sarco(Endo)Plasmic Reticulum Calcium ATPase and Na2+/Ca2+ Exchanger 1 Protein Levels and Function.

Sacchi V, Wang BJ, Kubli D, Martinez AS, Jin JK, Alvarez R Jr, Hariharan N, Glembotski C, Uchida T, Malter JS, Yang Y, Gross P, Zhang C, Houser S, Rota M, Sussman MA.

J Am Heart Assoc. 2017 Oct 10;6(10). pii: e006837. doi: 10.1161/JAHA.117.006837.

24.

Empowering human cardiac progenitor cells by P2Y14 nucleotide receptor overexpression.

Khalafalla FG, Kayani W, Kassab A, Ilves K, Monsanto MM, Alvarez R Jr, Chavarria M, Norman B, Dembitsky WP, Sussman MA.

J Physiol. 2017 Dec 1;595(23):7135-7148. doi: 10.1113/JP274980. Epub 2017 Nov 9.

25.

P2Y2 Nucleotide Receptor Prompts Human Cardiac Progenitor Cell Activation by Modulating Hippo Signaling.

Khalafalla FG, Greene S, Khan H, Ilves K, Monsanto MM, Alvarez R Jr, Chavarria M, Nguyen J, Norman B, Dembitsky WP, Sussman MA.

Circ Res. 2017 Nov 10;121(11):1224-1236. doi: 10.1161/CIRCRESAHA.117.310812. Epub 2017 Sep 18.

26.

Cardiac Stem Cells: Working Independently Together.

Sussman MA.

J Am Coll Cardiol. 2017 Aug 8;70(6):742-744. doi: 10.1016/j.jacc.2017.06.044. No abstract available.

27.

Accumulation of mitochondrial DNA mutations disrupts cardiac progenitor cell function and reduces survival.

Orogo AM, Gonzalez ER, Kubli DA, Baptista IL, Ong SB, Prolla TA, Sussman MA, Murphy AN, Gustafsson ÅB.

J Biol Chem. 2017 Jul 7;292(27):11348. doi: 10.1074/jbc.A115.649657. No abstract available.

28.

Cardiomyocyte Regeneration: A Consensus Statement.

Eschenhagen T, Bolli R, Braun T, Field LJ, Fleischmann BK, Frisén J, Giacca M, Hare JM, Houser S, Lee RT, Marbán E, Martin JF, Molkentin JD, Murry CE, Riley PR, Ruiz-Lozano P, Sadek HA, Sussman MA, Hill JA.

Circulation. 2017 Aug 15;136(7):680-686. doi: 10.1161/CIRCULATIONAHA.117.029343. Epub 2017 Jul 6. Review. No abstract available.

29.

Chasing c-Kit through the heart: Taking a broader view.

Gude NA, Sussman MA.

Pharmacol Res. 2018 Jan;127:110-115. doi: 10.1016/j.phrs.2017.06.007. Epub 2017 Jun 13. Review.

30.

Synthetic MSC? Nothing Beats the Real Thing.

Monsanto MM, Wang BJ, Sussman MA.

Circ Res. 2017 May 26;120(11):1694-1695. doi: 10.1161/CIRCRESAHA.117.310986. No abstract available.

31.

Concurrent Isolation of 3 Distinct Cardiac Stem Cell Populations From a Single Human Heart Biopsy.

Monsanto MM, White KS, Kim T, Wang BJ, Fisher K, Ilves K, Khalafalla FG, Casillas A, Broughton K, Mohsin S, Dembitsky WP, Sussman MA.

Circ Res. 2017 Jul 7;121(2):113-124. doi: 10.1161/CIRCRESAHA.116.310494. Epub 2017 Apr 26.

32.

Eat, breathe, ROS: controlling stem cell fate through metabolism.

Kubli DA, Sussman MA.

Expert Rev Cardiovasc Ther. 2017 May;15(5):345-356. doi: 10.1080/14779072.2017.1319278. Epub 2017 Apr 21. Review.

33.

PIM1-minicircle as a therapeutic treatment for myocardial infarction.

Liu N, Wang BJ, Broughton KM, Alvarez R, Siddiqi S, Loaiza R, Nguyen N, Quijada P, Gude N, Sussman MA.

PLoS One. 2017 Mar 21;12(3):e0173963. doi: 10.1371/journal.pone.0173963. eCollection 2017.

34.

A Matter of Opinion.

Sussman MA.

Circ Res. 2017 Jan 6;120(1):36-38. doi: 10.1161/CIRCRESAHA.116.310131. Review. No abstract available.

35.

Myocardial Regeneration for Humans - Modifying Biology and Manipulating Evolution.

Broughton KM, Sussman MA.

Circ J. 2017 Jan 25;81(2):142-148. doi: 10.1253/circj.CJ-16-1228. Epub 2016 Dec 27. Review.

36.

Pim1 Kinase Overexpression Enhances ckit+ Cardiac Stem Cell Cardiac Repair Following Myocardial Infarction in Swine.

Kulandavelu S, Karantalis V, Fritsch J, Hatzistergos KE, Loescher VY, McCall F, Wang B, Bagno L, Golpanian S, Wolf A, Grenet J, Williams A, Kupin A, Rosenfeld A, Mohsin S, Sussman MA, Morales A, Balkan W, Hare JM.

J Am Coll Cardiol. 2016 Dec 6;68(22):2454-2464. doi: 10.1016/j.jacc.2016.09.925.

37.

S100A4 protects the myocardium against ischemic stress.

Doroudgar S, Quijada P, Konstandin M, Ilves K, Broughton K, Khalafalla FG, Casillas A, Nguyen K, Gude N, Toko H, Ornelas L, Thuerauf DJ, Glembotski CC, Sussman MA, Völkers M.

J Mol Cell Cardiol. 2016 Nov;100:54-63. doi: 10.1016/j.yjmcc.2016.10.001. Epub 2016 Oct 6.

38.

Inject Me Once and Inject Me Twice. Then Inject Me Once Again.

Sussman MA.

Circ Res. 2016 Aug 19;119(5):580-1. doi: 10.1161/CIRCRESAHA.116.309445. No abstract available.

PMID:
27539968
39.

Correction: The Impact of Juvenile Coxsackievirus Infection on Cardiac Progenitor Cells and Postnatal Heart Development.

Sin J, Puccini JM, Huang C, Konstandin MH, Gilbert PE, Sussman MA, Gottlieb RA, Feuer R.

PLoS Pathog. 2016 May 24;12(5):e1005673. doi: 10.1371/journal.ppat.1005673. eCollection 2016 May.

40.

Sphingosine 1-phosphate elicits RhoA-dependent proliferation and MRTF-A mediated gene induction in CPCs.

Castaldi A, Chesini GP, Taylor AE, Sussman MA, Brown JH, Purcell NH.

Cell Signal. 2016 Aug;28(8):871-9. doi: 10.1016/j.cellsig.2016.04.006. Epub 2016 Apr 14.

41.

Empowering Adult Stem Cells for Myocardial Regeneration V2.0: Success in Small Steps.

Broughton KM, Sussman MA.

Circ Res. 2016 Mar 4;118(5):867-80. doi: 10.1161/CIRCRESAHA.115.305227. Review. Erratum in: Circ Res. 2016 Apr 15;118(8):e34.

42.

Personalizing cardiac regenerative therapy: At the heart of Pim1 kinase.

Samse K, Hariharan N, Sussman MA.

Pharmacol Res. 2016 Jan;103:13-6. doi: 10.1016/j.phrs.2015.11.001. Epub 2015 Nov 10. Review.

43.

Nuclear Calcium/Calmodulin-dependent Protein Kinase II Signaling Enhances Cardiac Progenitor Cell Survival and Cardiac Lineage Commitment.

Quijada P, Hariharan N, Cubillo JD, Bala KM, Emathinger JM, Wang BJ, Ormachea L, Bers DM, Sussman MA, Poizat C.

J Biol Chem. 2015 Oct 16;290(42):25411-26. doi: 10.1074/jbc.M115.657775. Epub 2015 Aug 31.

44.

Cardiac Stem Cell Hybrids Enhance Myocardial Repair.

Quijada P, Salunga HT, Hariharan N, Cubillo JD, El-Sayed FG, Moshref M, Bala KM, Emathinger JM, De La Torre A, Ormachea L, Alvarez R Jr, Gude NA, Sussman MA.

Circ Res. 2015 Sep 25;117(8):695-706. doi: 10.1161/CIRCRESAHA.115.306838. Epub 2015 Jul 30.

45.

Accumulation of Mitochondrial DNA Mutations Disrupts Cardiac Progenitor Cell Function and Reduces Survival.

Orogo AM, Gonzalez ER, Kubli DA, Baptista IL, Ong SB, Prolla TA, Sussman MA, Murphy AN, Gustafsson ÅB.

J Biol Chem. 2015 Sep 4;290(36):22061-75. doi: 10.1074/jbc.M115.649657. Epub 2015 Jul 16. Erratum in: J Biol Chem. 2017 Jul 7;292(27):11348.

46.

Hrd1 and ER-Associated Protein Degradation, ERAD, are Critical Elements of the Adaptive ER Stress Response in Cardiac Myocytes.

Doroudgar S, Völkers M, Thuerauf DJ, Khan M, Mohsin S, Respress JL, Wang W, Gude N, Müller OJ, Wehrens XH, Sussman MA, Glembotski CC.

Circ Res. 2015 Aug 28;117(6):536-46. doi: 10.1161/CIRCRESAHA.115.306993. Epub 2015 Jul 2.

47.

Myocardial Infarct Scar: Hunting Down the Responsible Cells, But Then What?

Monsanto M, Sussman MA.

J Am Coll Cardiol. 2015 May 19;65(19):2067-9. doi: 10.1016/j.jacc.2015.03.519. No abstract available.

48.

Notch activation enhances lineage commitment and protective signaling in cardiac progenitor cells.

Gude N, Joyo E, Toko H, Quijada P, Villanueva M, Hariharan N, Sacchi V, Truffa S, Joyo A, Voelkers M, Alvarez R, Sussman MA.

Basic Res Cardiol. 2015 May;110(3):29. doi: 10.1007/s00395-015-0488-3. Epub 2015 Apr 19.

49.

Cardiac aging - Getting to the stem of the problem.

Hariharan N, Sussman MA.

J Mol Cell Cardiol. 2015 Jun;83:32-6. doi: 10.1016/j.yjmcc.2015.04.008. Epub 2015 Apr 14. Review.

50.

Functional Effect of Pim1 Depends upon Intracellular Localization in Human Cardiac Progenitor Cells.

Samse K, Emathinger J, Hariharan N, Quijada P, Ilves K, Völkers M, Ormachea L, De La Torre A, Orogo AM, Alvarez R, Din S, Mohsin S, Monsanto M, Fischer KM, Dembitsky WP, Gustafsson ÅB, Sussman MA.

J Biol Chem. 2015 May 29;290(22):13935-47. doi: 10.1074/jbc.M114.617431. Epub 2015 Apr 16.

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