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Items: 1 to 50 of 83

1.

The Long Noncoding RNA Paupar Modulates PAX6 Regulatory Activities to Promote Alpha Cell Development and Function.

Singer RA, Arnes L, Cui Y, Wang J, Gao Y, Guney MA, Burnum-Johnson KE, Rabadan R, Ansong C, Orr G, Sussel L.

Cell Metab. 2019 Oct 9. pii: S1550-4131(19)30516-9. doi: 10.1016/j.cmet.2019.09.013. [Epub ahead of print]

PMID:
31607563
2.

Murine Perinatal Beta Cell Proliferation and the Differentiation of Human Stem Cell Derived Insulin Expressing Cells Require NEUROD1.

Romer AI, Singer RA, Sui L, Egli D, Sussel L.

Diabetes. 2019 Sep 13. pii: db190117. doi: 10.2337/db19-0117. [Epub ahead of print]

PMID:
31519700
3.

β Cell dysfunction during progression of metabolic syndrome to type 2 diabetes.

Hudish LI, Reusch JE, Sussel L.

J Clin Invest. 2019 Oct 1;129(10):4001-4008. doi: 10.1172/JCI129188. Review.

4.

FISHing for β Cells.

Hudish LI, Lorberbaum DS, Sussel L.

Dev Cell. 2019 Jan 7;48(1):7-8. doi: 10.1016/j.devcel.2018.12.007.

PMID:
30620904
5.

Long Non-coding RNAs as Local Regulators of Pancreatic Islet Transcription Factor Genes.

Font-Cunill B, Arnes L, Ferrer J, Sussel L, Beucher A.

Front Genet. 2018 Nov 6;9:524. doi: 10.3389/fgene.2018.00524. eCollection 2018. Review.

6.

Notch signaling dynamically regulates adult β cell proliferation and maturity.

Bartolome A, Zhu C, Sussel L, Pajvani UB.

J Clin Invest. 2019 Jan 2;129(1):268-280. doi: 10.1172/JCI98098. Epub 2018 Dec 3.

7.

Islet Long Noncoding RNAs: A Playbook for Discovery and Characterization.

Singer RA, Sussel L.

Diabetes. 2018 Aug;67(8):1461-1470. doi: 10.2337/dbi18-0001. Epub 2018 Jun 24. Review.

8.

High Spatial Resolution Imaging of Mouse Pancreatic Islets Using Nanospray Desorption Electrospray Ionization Mass Spectrometry.

Yin R, Kyle J, Burnum-Johnson K, Bloodsworth KJ, Sussel L, Ansong C, Laskin J.

Anal Chem. 2018 Jun 5;90(11):6548-6555. doi: 10.1021/acs.analchem.8b00161. Epub 2018 May 9.

9.

Comprehensive characterisation of compartment-specific long non-coding RNAs associated with pancreatic ductal adenocarcinoma.

Arnes L, Liu Z, Wang J, Maurer C, Sagalovskiy I, Sanchez-Martin M, Bommakanti N, Garofalo DC, Balderes DA, Sussel L, Olive KP, Rabadan R.

Gut. 2018 Feb 10. pii: gutjnl-2017-314353. doi: 10.1136/gutjnl-2017-314353. [Epub ahead of print] Erratum in: Gut. 2019 May;68(5):952.

10.

Fluctuation localization imaging-based fluorescence in situ hybridization (fliFISH) for accurate detection and counting of RNA copies in single cells.

Cui Y, Hu D, Markillie LM, Chrisler WB, Gaffrey MJ, Ansong C, Sussel L, Orr G.

Nucleic Acids Res. 2018 Jan 25;46(2):e7. doi: 10.1093/nar/gkx874.

11.

Gotta Have GATA for Human Pancreas Development.

Lorberbaum DS, Sussel L.

Cell Stem Cell. 2017 May 4;20(5):577-579. doi: 10.1016/j.stem.2017.04.004.

12.

Heterogeneity of the Pancreatic Beta Cell.

Gutierrez GD, Gromada J, Sussel L.

Front Genet. 2017 Mar 6;8:22. doi: 10.3389/fgene.2017.00022. eCollection 2017. Review.

13.

Genetic evidence that Nkx2.2 acts primarily downstream of Neurog3 in pancreatic endocrine lineage development.

Churchill AJ, Gutiérrez GD, Singer RA, Lorberbaum DS, Fischer KA, Sussel L.

Elife. 2017 Jan 10;6. pii: e20010. doi: 10.7554/eLife.20010.

14.

Pancreatic β cell identity requires continual repression of non-β cell programs.

Gutiérrez GD, Bender AS, Cirulli V, Mastracci TL, Kelly SM, Tsirigos A, Kaestner KH, Sussel L.

J Clin Invest. 2017 Jan 3;127(1):244-259. doi: 10.1172/JCI88017. Epub 2016 Dec 12.

15.

LIM domain-binding 1 maintains the terminally differentiated state of pancreatic β cells.

Ediger BN, Lim HW, Juliana C, Groff DN, Williams LT, Dominguez G, Liu JH, Taylor BL, Walp ER, Kameswaran V, Yang J, Liu C, Hunter CS, Kaestner KH, Naji A, Li C, Sander M, Stein R, Sussel L, Won KJ, May CL, Stoffers DA.

J Clin Invest. 2017 Jan 3;127(1):215-229. doi: 10.1172/JCI88016. Epub 2016 Dec 12.

16.

The novel enterochromaffin marker Lmx1a regulates serotonin biosynthesis in enteroendocrine cell lineages downstream of Nkx2.2.

Gross S, Garofalo DC, Balderes DA, Mastracci TL, Dias JM, Perlmann T, Ericson J, Sussel L.

Development. 2016 Jul 15;143(14):2616-28. doi: 10.1242/dev.130682. Epub 2016 Jun 10.

17.

βlinc1 encodes a long noncoding RNA that regulates islet β-cell formation and function.

Arnes L, Akerman I, Balderes DA, Ferrer J, Sussel L.

Genes Dev. 2016 Mar 1;30(5):502-7. doi: 10.1101/gad.273821.115.

18.

GATA4 and GATA6 regulate pancreatic endoderm identity through inhibition of hedgehog signaling.

Xuan S, Sussel L.

Development. 2016 Mar 1;143(5):780-6. doi: 10.1242/dev.127217.

19.

Unique functions of Gata4 in mouse liver induction and heart development.

Borok MJ, Papaioannou VE, Sussel L.

Dev Biol. 2016 Feb 15;410(2):213-222. doi: 10.1016/j.ydbio.2015.12.007. Epub 2015 Dec 11.

20.

Nkx2.2 is expressed in a subset of enteroendocrine cells with expanded lineage potential.

Gross S, Balderes D, Liu J, Asfaha S, Gu G, Wang TC, Sussel L.

Am J Physiol Gastrointest Liver Physiol. 2015 Dec 15;309(12):G975-87. doi: 10.1152/ajpgi.00244.2015. Epub 2015 Oct 22.

21.

Pancreatic islet cell development and regeneration.

Romer AI, Sussel L.

Curr Opin Endocrinol Diabetes Obes. 2015 Aug;22(4):255-64. doi: 10.1097/MED.0000000000000174. Review.

22.

Ghrelin.

Müller TD, Nogueiras R, Andermann ML, Andrews ZB, Anker SD, Argente J, Batterham RL, Benoit SC, Bowers CY, Broglio F, Casanueva FF, D'Alessio D, Depoortere I, Geliebter A, Ghigo E, Cole PA, Cowley M, Cummings DE, Dagher A, Diano S, Dickson SL, Diéguez C, Granata R, Grill HJ, Grove K, Habegger KM, Heppner K, Heiman ML, Holsen L, Holst B, Inui A, Jansson JO, Kirchner H, Korbonits M, Laferrère B, LeRoux CW, Lopez M, Morin S, Nakazato M, Nass R, Perez-Tilve D, Pfluger PT, Schwartz TW, Seeley RJ, Sleeman M, Sun Y, Sussel L, Tong J, Thorner MO, van der Lely AJ, van der Ploeg LH, Zigman JM, Kojima M, Kangawa K, Smith RG, Horvath T, Tschöp MH.

Mol Metab. 2015 Mar 21;4(6):437-60. doi: 10.1016/j.molmet.2015.03.005. eCollection 2015 Jun. Review.

23.

The Origin, Development and Molecular Diversity of Rodent Olfactory Bulb Glutamatergic Neurons Distinguished by Expression of Transcription Factor NeuroD1.

Roybon L, Mastracci TL, Li J, Stott SR, Leiter AB, Sussel L, Brundin P, Li JY.

PLoS One. 2015 Jun 1;10(6):e0128035. doi: 10.1371/journal.pone.0128035. eCollection 2015.

24.

Epigenetic modifications and long noncoding RNAs influence pancreas development and function.

Arnes L, Sussel L.

Trends Genet. 2015 Jun;31(6):290-9. doi: 10.1016/j.tig.2015.02.008. Epub 2015 Mar 23. Review.

25.

Noncoding RNAs in β cell biology.

Singer RA, Arnes L, Sussel L.

Curr Opin Endocrinol Diabetes Obes. 2015 Apr;22(2):77-85. doi: 10.1097/MED.0000000000000141. Review.

26.

Editorial overview: developmental mechanisms, patterning and evolution.

Sussel L, Niswander L.

Curr Opin Genet Dev. 2014 Aug;27:v-vii. doi: 10.1016/j.gde.2014.06.007. Epub 2014 Jul 2. No abstract available.

PMID:
24998023
27.

Mammalian Nkx2.2+ perineurial glia are essential for motor nerve development.

Clark JK, O'keefe A, Mastracci TL, Sussel L, Matise MP, Kucenas S.

Dev Dyn. 2014 Sep;243(9):1116-29. doi: 10.1002/dvdy.24158. Epub 2014 Jul 9.

28.

β-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment.

Halban PA, Polonsky KS, Bowden DW, Hawkins MA, Ling C, Mather KJ, Powers AC, Rhodes CJ, Sussel L, Weir GC.

Diabetes Care. 2014 Jun;37(6):1751-8. doi: 10.2337/dc14-0396. Epub 2014 May 8. Review.

29.

β-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment.

Halban PA, Polonsky KS, Bowden DW, Hawkins MA, Ling C, Mather KJ, Powers AC, Rhodes CJ, Sussel L, Weir GC.

J Clin Endocrinol Metab. 2014 Jun;99(6):1983-92. doi: 10.1210/jc.2014-1425. Epub 2014 Apr 8.

30.

Time to look back and to look forward.

Nair KS, Abel ED, Adler SG, Dyck PJ, Gardner TW, Haskins KM, Hotamisligil G, Jensen MD, Krook A, Mandarino LJ, Mitchell BD, Pessin JE, Sowers JR, Sussel L, Wareham N, Vella A.

Diabetes. 2014 Apr;63(4):1169-70. doi: 10.2337/db14-0067. No abstract available.

31.

Genetic evidence that Nkx2.2 and Pdgfra are major determinants of the timing of oligodendrocyte differentiation in the developing CNS.

Zhu Q, Zhao X, Zheng K, Li H, Huang H, Zhang Z, Mastracci T, Wegner M, Chen Y, Sussel L, Qiu M.

Development. 2014 Feb;141(3):548-55. doi: 10.1242/dev.095323.

32.

Nkx2.2:Cre knock-in mouse line: a novel tool for pancreas- and CNS-specific gene deletion.

Balderes DA, Magnuson MA, Sussel L.

Genesis. 2013 Dec;51(12):844-51. doi: 10.1002/dvg.22715. Epub 2013 Oct 1.

33.

Gastrin: a distinct fate of neurogenin3 positive progenitor cells in the embryonic pancreas.

Suissa Y, Magenheim J, Stolovich-Rain M, Hija A, Collombat P, Mansouri A, Sussel L, Sosa-Pineda B, McCracken K, Wells JM, Heller RS, Dor Y, Glaser B.

PLoS One. 2013 Aug 5;8(8):e70397. doi: 10.1371/journal.pone.0070397. Print 2013.

34.

The endocrine pancreas: insights into development, differentiation, and diabetes.

Mastracci TL, Sussel L.

Wiley Interdiscip Rev Dev Biol. 2012 Sep-Oct;1(5):609-28. doi: 10.1002/wdev.44. Epub 2012 Mar 14. Review.

PMID:
23799564
35.

Generation of mice encoding a conditional allele of Nkx2.2.

Mastracci TL, Lin CS, Sussel L.

Transgenic Res. 2013 Oct;22(5):965-72. doi: 10.1007/s11248-013-9700-0. Epub 2013 Mar 15.

36.

A retrotransposon insertion in the 5' regulatory domain of Ptf1a results in ectopic gene expression and multiple congenital defects in Danforth's short tail mouse.

Lugani F, Arora R, Papeta N, Patel A, Zheng Z, Sterken R, Singer RA, Caridi G, Mendelsohn C, Sussel L, Papaioannou VE, Gharavi AG.

PLoS Genet. 2013;9(2):e1003206. doi: 10.1371/journal.pgen.1003206. Epub 2013 Feb 21.

37.

Regulation of Neurod1 contributes to the lineage potential of Neurogenin3+ endocrine precursor cells in the pancreas.

Mastracci TL, Anderson KR, Papizan JB, Sussel L.

PLoS Genet. 2013;9(2):e1003278. doi: 10.1371/journal.pgen.1003278. Epub 2013 Feb 7.

38.

Ghrelin expression in the mouse pancreas defines a unique multipotent progenitor population.

Arnes L, Hill JT, Gross S, Magnuson MA, Sussel L.

PLoS One. 2012;7(12):e52026. doi: 10.1371/journal.pone.0052026. Epub 2012 Dec 12.

39.

ALDH1B1 is a potential stem/progenitor marker for multiple pancreas progenitor pools.

Ioannou M, Serafimidis I, Arnes L, Sussel L, Singh S, Vasiliou V, Gavalas A.

Dev Biol. 2013 Feb 1;374(1):153-63. doi: 10.1016/j.ydbio.2012.10.030. Epub 2012 Nov 6.

40.

Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes.

Morán I, Akerman I, van de Bunt M, Xie R, Benazra M, Nammo T, Arnes L, Nakić N, García-Hurtado J, Rodríguez-Seguí S, Pasquali L, Sauty-Colace C, Beucher A, Scharfmann R, van Arensbergen J, Johnson PR, Berry A, Lee C, Harkins T, Gmyr V, Pattou F, Kerr-Conte J, Piemonti L, Berney T, Hanley N, Gloyn AL, Sussel L, Langman L, Brayman KL, Sander M, McCarthy MI, Ravassard P, Ferrer J.

Cell Metab. 2012 Oct 3;16(4):435-48. doi: 10.1016/j.cmet.2012.08.010.

41.

Pancreas-specific deletion of mouse Gata4 and Gata6 causes pancreatic agenesis.

Xuan S, Borok MJ, Decker KJ, Battle MA, Duncan SA, Hale MA, Macdonald RJ, Sussel L.

J Clin Invest. 2012 Oct;122(10):3516-28. doi: 10.1172/JCI63352. Epub 2012 Sep 24.

42.

Pancreatic β cell dedifferentiation as a mechanism of diabetic β cell failure.

Talchai C, Xuan S, Lin HV, Sussel L, Accili D.

Cell. 2012 Sep 14;150(6):1223-34. doi: 10.1016/j.cell.2012.07.029.

43.

The Endocrine Pancreas: insights into development, differentiation and diabetes.

Mastracci TL, Sussel L.

Wiley Interdiscip Rev Membr Transp Signal. 2012 Sep;1(5):609-628. Epub 2012 Mar 14.

44.

Advances in pancreas development: generation informs regeneration.

Sussel L.

Semin Cell Dev Biol. 2012 Aug;23(6):655. doi: 10.1016/j.semcdb.2012.06.007. Epub 2012 Jun 23. No abstract available.

45.

Generation of Nkx2.2:lacZ mice using recombination-mediated cassette exchange technology.

Arnes L, Leclerc K, Friel JM, Hipkens SB, Magnuson MA, Sussel L.

Genesis. 2012 Aug;50(8):612-24. doi: 10.1002/dvg.22037. Epub 2012 May 19.

46.

Nkx2.2 repressor complex regulates islet β-cell specification and prevents β-to-α-cell reprogramming.

Papizan JB, Singer RA, Tschen SI, Dhawan S, Friel JM, Hipkens SB, Magnuson MA, Bhushan A, Sussel L.

Genes Dev. 2011 Nov 1;25(21):2291-305. doi: 10.1101/gad.173039.111.

47.

Nkx2.2 and Arx genetically interact to regulate pancreatic endocrine cell development and endocrine hormone expression.

Mastracci TL, Wilcox CL, Arnes L, Panea C, Golden JA, May CL, Sussel L.

Dev Biol. 2011 Nov 1;359(1):1-11. doi: 10.1016/j.ydbio.2011.08.001. Epub 2011 Aug 11.

48.

The L6 domain tetraspanin Tm4sf4 regulates endocrine pancreas differentiation and directed cell migration.

Anderson KR, Singer RA, Balderes DA, Hernandez-Lagunas L, Johnson CW, Artinger KB, Sussel L.

Development. 2011 Aug;138(15):3213-24. doi: 10.1242/dev.058693.

49.

Novel computational analysis of protein binding array data identifies direct targets of Nkx2.2 in the pancreas.

Hill JT, Anderson KR, Mastracci TL, Kaestner KH, Sussel L.

BMC Bioinformatics. 2011 Feb 25;12:62. doi: 10.1186/1471-2105-12-62.

50.

Spatial and temporal requirements for sonic hedgehog in the regulation of thalamic interneuron identity.

Jeong Y, Dolson DK, Waclaw RR, Matise MP, Sussel L, Campbell K, Kaestner KH, Epstein DJ.

Development. 2011 Feb;138(3):531-41. doi: 10.1242/dev.058917.

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