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Items: 1 to 50 of 115

1.

Genetic characterization of B-cell prolymphocytic leukemia: a prognostic model involving MYC and TP53.

Chapiro E, Pramil E, Diop M, Roos-Weil D, Dillard C, Gabillaud C, Maloum K, Settegrana C, Baseggio L, Lesesve JF, Yon M, Jondreville L, Lesty C, Davi FB, Le Garff-Tavernier M, Droin NM, Dessen P, Algrin C, Leblond V, Gabarre J, Bouzy S, Eclache V, Gaillard B, Callet-Bauchu E, Muller M, Lefebvre C, Nadal N, Ittel A, Struski S, Collonge-Rame MA, Quilichini B, Fert-Ferrer S, Auger N, Radford-Weiss I, Wagner L, Scheinost S, Zenz T, Susin SA, Bernard OA, Nguyen-Khac F.

Blood. 2019 Sep 16. pii: blood.2019001187. doi: 10.1182/blood.2019001187. [Epub ahead of print]

PMID:
31527074
2.

Homotrimerization Approach in the Design of Thrombospondin-1 Mimetic Peptides with Improved Potency in Triggering Regulated Cell Death of Cancer Cells.

Denèfle T, Pramil E, Gómez-Morales L, Levasseur MD, Lardé E, Newton C, Herry K, Herbi L, Lamotte Y, Odile E, Ancellin N, Grondin P, Martinez-Torres AC, Viviani F, Merle-Beral H, Lequin O, Susin SA, Karoyan P.

J Med Chem. 2019 Sep 12;62(17):7656-7668. doi: 10.1021/acs.jmedchem.9b00024. Epub 2019 Aug 26.

PMID:
31403795
3.

Gain of the short arm of chromosome 2 (2p gain) has a significant role in drug-resistant chronic lymphocytic leukemia.

Kostopoulou F, Gabillaud C, Chapiro E, Grange B, Tran J, Bouzy S, Degaud M, Ghamlouch H, Le Garff-Tavernier M, Maloum K, Choquet S, Leblond V, Gabarre J, Lavaud A, Morel V, Roos-Weil D, Uzunov M, Guieze R, Bernard OA, Susin SA, Tournilhac O, Nguyen-Khac F; French Innovative Leukemia Organization (FILO) group.

Cancer Med. 2019 Jun;8(6):3131-3141. doi: 10.1002/cam4.2123. Epub 2019 May 7.

4.

CD47 agonist peptide PKHB1 induces immunogenic cell death in T-cell acute lymphoblastic leukemia cells.

Uscanga-Palomeque AC, Calvillo-Rodríguez KM, Gómez-Morales L, Lardé E, Denèfle T, Caballero-Hernández D, Merle-Béral H, Susin SA, Karoyan P, Martínez-Torres AC, Rodríguez-Padilla C.

Cancer Sci. 2019 Jan;110(1):256-268. doi: 10.1111/cas.13885. Epub 2018 Dec 14.

5.

Revisiting Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Cancer: Saint or Sinner?

Bauvois B, Susin SA.

Cancers (Basel). 2018 Sep 18;10(9). pii: E336. doi: 10.3390/cancers10090336. Review.

6.

Mitochondrial OXPHOS influences immune cell fate: lessons from hematopoietic AIF-deficient and NDUFS4-deficient mouse models.

Bertaux A, Cabon L, Brunelle-Navas MN, Bouchet S, Nemazanyy I, Susin SA.

Cell Death Dis. 2018 May 22;9(6):581. doi: 10.1038/s41419-018-0583-0. No abstract available.

7.

AIF loss deregulates hematopoiesis and reveals different adaptive metabolic responses in bone marrow cells and thymocytes.

Cabon L, Bertaux A, Brunelle-Navas MN, Nemazanyy I, Scourzic L, Delavallée L, Vela L, Baritaud M, Bouchet S, Lopez C, Quang Van V, Garbin K, Chateau D, Gilard F, Sarfati M, Mercher T, Bernard OA, Susin SA.

Cell Death Differ. 2018 May;25(5):983-1001. doi: 10.1038/s41418-017-0035-x. Epub 2018 Jan 11.

8.

"Double-hit" chronic lymphocytic leukemia: An aggressive subgroup with 17p deletion and 8q24 gain.

Chapiro E, Lesty C, Gabillaud C, Durot E, Bouzy S, Armand M, Le Garff-Tavernier M, Bougacha N, Struski S, Bidet A, Laharanne E, Barin C, Veronese L, Prié N, Eclache V, Gaillard B, Michaux L, Lefebvre C, Gaillard JB, Terré C, Penther D, Bastard C, Nadal N, Fert-Ferrer S, Auger N, Godon C, Sutton L, Tournilhac O, Susin SA, Nguyen-Khac F; GroupeFrancophone de Cytogénétique Hématologique(GFCH) and the French Innovative Leukemia Organization (FILO) group.

Am J Hematol. 2018 Mar;93(3):375-382. doi: 10.1002/ajh.24990. Epub 2017 Dec 18.

9.

Gain in the short arm of chromosome 2 (2p+) induces gene overexpression and drug resistance in chronic lymphocytic leukemia: analysis of the central role of XPO1.

Cosson A, Chapiro E, Bougacha N, Lambert J, Herbi L, Cung HA, Algrin C, Keren B, Damm F, Gabillaud C, Brunelle-Navas MN, Davi F, Merle-Béral H, Le Garff-Tavernier M, Roos-Weil D, Choquet S, Uzunov M, Morel V, Leblond V, Maloum K, Lepretre S, Feugier P, Lesty C, Lejeune J, Sutton L, Landesman Y, Susin SA, Nguyen-Khac F.

Leukemia. 2017 Jul;31(7):1625-1629. doi: 10.1038/leu.2017.100. Epub 2017 Mar 27. No abstract available.

PMID:
28344316
10.

Thrombospondin-1 Mimetic Agonist Peptides Induce Selective Death in Tumor Cells: Design, Synthesis, and Structure-Activity Relationship Studies.

Denèfle T, Boullet H, Herbi L, Newton C, Martinez-Torres AC, Guez A, Pramil E, Quiney C, Pourcelot M, Levasseur MD, Lardé E, Moumné R, Ogi FX, Grondin P, Merle-Beral H, Lequin O, Susin SA, Karoyan P.

J Med Chem. 2016 Sep 22;59(18):8412-21. doi: 10.1021/acs.jmedchem.6b00781. Epub 2016 Sep 2.

PMID:
27526615
11.

Key Residues Regulating the Reductase Activity of the Human Mitochondrial Apoptosis Inducing Factor.

Villanueva R, Ferreira P, Marcuello C, Usón A, Miramar MD, Peleato ML, Lostao A, Susin SA, Medina M.

Biochemistry. 2015 Aug 25;54(33):5175-84. doi: 10.1021/acs.biochem.5b00696. Epub 2015 Aug 13.

PMID:
26237213
12.

CD47 agonist peptides induce programmed cell death in refractory chronic lymphocytic leukemia B cells via PLCγ1 activation: evidence from mice and humans.

Martinez-Torres AC, Quiney C, Attout T, Boullet H, Herbi L, Vela L, Barbier S, Chateau D, Chapiro E, Nguyen-Khac F, Davi F, Le Garff-Tavernier M, Moumné R, Sarfati M, Karoyan P, Merle-Béral H, Launay P, Susin SA.

PLoS Med. 2015 Mar 3;12(3):e1001796. doi: 10.1371/journal.pmed.1001796. eCollection 2015 Mar.

13.

Structural insights into the coenzyme mediated monomer-dimer transition of the pro-apoptotic apoptosis inducing factor.

Ferreira P, Villanueva R, Martínez-Júlvez M, Herguedas B, Marcuello C, Fernandez-Silva P, Cabon L, Hermoso JA, Lostao A, Susin SA, Medina M.

Biochemistry. 2014 Jul 1;53(25):4204-15. doi: 10.1021/bi500343r. Epub 2014 Jun 20.

PMID:
24914854
14.

[Programmed cell death comes in many flavors].

Cabon L, Martinez-Torres AC, Susin SA.

Med Sci (Paris). 2013 Dec;29(12):1117-24. doi: 10.1051/medsci/20132912015. Epub 2013 Dec 20. Review. French.

15.

The oxido-reductase activity of the apoptosis inducing factor: a promising pharmacological tool?

Ferreira P, Villanueva R, Cabon L, Susín SA, Medina M.

Curr Pharm Des. 2013;19(14):2628-36. Review.

PMID:
23116400
16.

AIF-mediated caspase-independent necroptosis requires ATM and DNA-PK-induced histone H2AX Ser139 phosphorylation.

Baritaud M, Cabon L, Delavallée L, Galán-Malo P, Gilles ME, Brunelle-Navas MN, Susin SA.

Cell Death Dis. 2012 Sep 13;3:e390. doi: 10.1038/cddis.2012.120.

17.

CD47(high) expression on CD4 effectors identifies functional long-lived memory T cell progenitors.

Van VQ, Raymond M, Baba N, Rubio M, Wakahara K, Susin SA, Sarfati M.

J Immunol. 2012 May 1;188(9):4249-55. doi: 10.4049/jimmunol.1102702. Epub 2012 Mar 28.

18.

BID regulates AIF-mediated caspase-independent necroptosis by promoting BAX activation.

Cabon L, Galán-Malo P, Bouharrour A, Delavallée L, Brunelle-Navas MN, Lorenzo HK, Gross A, Susin SA.

Cell Death Differ. 2012 Feb;19(2):245-56. doi: 10.1038/cdd.2011.91. Epub 2011 Jul 8.

19.

AIF-mediated caspase-independent necroptosis: a new chance for targeted therapeutics.

Delavallée L, Cabon L, Galán-Malo P, Lorenzo HK, Susin SA.

IUBMB Life. 2011 Apr;63(4):221-32. doi: 10.1002/iub.432. Epub 2011 Mar 24. Review.

20.

Functional assessment of p53 in chronic lymphocytic leukemia.

Le Garff-Tavernier M, Blons H, Nguyen-Khac F, Pannetier M, Brissard M, Gueguen S, Jacob F, Ysebaert L, Susin SA, Merle-Béral H.

Blood Cancer J. 2011 Feb;1(2):e5. doi: 10.1038/bcj.2011.3. Epub 2011 Feb 25. No abstract available.

21.

Histone H2AX: The missing link in AIF-mediated caspase-independent programmed necrosis.

Baritaud M, Boujrad H, Lorenzo HK, Krantic S, Susin SA.

Cell Cycle. 2010 Aug 15;9(16):3166-73. Epub 2010 Aug 28. Review.

PMID:
20697198
22.

AIF promotes chromatinolysis and caspase-independent programmed necrosis by interacting with histone H2AX.

Artus C, Boujrad H, Bouharrour A, Brunelle MN, Hoos S, Yuste VJ, Lenormand P, Rousselle JC, Namane A, England P, Lorenzo HK, Susin SA.

EMBO J. 2010 May 5;29(9):1585-99. doi: 10.1038/emboj.2010.43. Epub 2010 Apr 1.

23.

Different contribution of BH3-only proteins and caspases to doxorubicin-induced apoptosis in p53-deficient leukemia cells.

López-Royuela N, Pérez-Galán P, Galán-Malo P, Yuste VJ, Anel A, Susín SA, Naval J, Marzo I.

Biochem Pharmacol. 2010 Jun 15;79(12):1746-58. doi: 10.1016/j.bcp.2010.02.010. Epub 2010 Feb 24.

PMID:
20188077
24.

Caspase-independent type III programmed cell death in chronic lymphocytic leukemia: the key role of the F-actin cytoskeleton.

Barbier S, Chatre L, Bras M, Sancho P, Roué G, Virely C, Yuste VJ, Baudet S, Rubio M, Esquerda JE, Sarfati M, Merle-Béral H, Susin SA.

Haematologica. 2009 Apr;94(4):507-17. doi: 10.3324/haematol.13690. Epub 2009 Mar 10.

25.

Caspase-independent type III PCD: a new means to modulate cell death in chronic lymphocytic leukemia.

Merle-Béral H, Barbier S, Roué G, Bras M, Sarfati M, Susin SA.

Leukemia. 2009 May;23(5):974-7. doi: 10.1038/leu.2008.321. Epub 2008 Nov 13. No abstract available.

PMID:
19005478
26.

Highly cytotoxic and neurotoxic acetogenins of the Annonaceae: new putative biological targets of squamocin detected by activity-based protein profiling.

Derbré S, Gil S, Taverna M, Boursier C, Nicolas V, Demey-Thomas E, Vinh J, Susin SA, Hocquemiller R, Poupon E.

Bioorg Med Chem Lett. 2008 Nov 1;18(21):5741-4. doi: 10.1016/j.bmcl.2008.09.091. Epub 2008 Sep 30.

PMID:
18851912
27.

Therapeutic potential of AIF-mediated caspase-independent programmed cell death.

Lorenzo HK, Susin SA.

Drug Resist Updat. 2007 Dec;10(6):235-55. doi: 10.1016/j.drup.2007.11.001. Epub 2008 Jan 3. Review.

PMID:
18180198
28.

AIF-mediated programmed necrosis: a highly regulated way to die.

Boujrad H, Gubkina O, Robert N, Krantic S, Susin SA.

Cell Cycle. 2007 Nov 1;6(21):2612-9. Epub 2007 Aug 1. Review.

PMID:
17912035
29.

Drp1 mediates caspase-independent type III cell death in normal and leukemic cells.

Bras M, Yuste VJ, Roué G, Barbier S, Sancho P, Virely C, Rubio M, Baudet S, Esquerda JE, Merle-Béral H, Sarfati M, Susin SA.

Mol Cell Biol. 2007 Oct;27(20):7073-88. Epub 2007 Aug 6.

30.

Sequential activation of poly(ADP-ribose) polymerase 1, calpains, and Bax is essential in apoptosis-inducing factor-mediated programmed necrosis.

Moubarak RS, Yuste VJ, Artus C, Bouharrour A, Greer PA, Menissier-de Murcia J, Susin SA.

Mol Cell Biol. 2007 Jul;27(13):4844-62. Epub 2007 Apr 30.

31.

Semisynthesis and screening of a small library of pro-apoptotic squamocin analogues: selection and study of a benzoquinone hybrid with an improved biological profile.

Derbré S, Duval R, Roué G, Garofano A, Poupon E, Brandt U, Susin SA, Hocquemiller R.

ChemMedChem. 2006 Jan;1(1):118-29.

PMID:
16892343
32.

Identification and characterization of AIFsh2, a mitochondrial apoptosis-inducing factor (AIF) isoform with NADH oxidase activity.

Delettre C, Yuste VJ, Moubarak RS, Bras M, Robert N, Susin SA.

J Biol Chem. 2006 Jul 7;281(27):18507-18. Epub 2006 Apr 27.

33.

CD44 ligation induces caspase-independent cell death via a novel calpain/AIF pathway in human erythroleukemia cells.

Artus C, Maquarre E, Moubarak RS, Delettre C, Jasmin C, Susin SA, Robert-Lézénès J.

Oncogene. 2006 Sep 21;25(42):5741-51. Epub 2006 Apr 24.

PMID:
16636662
34.

Regulation of apoptosis/necrosis execution in cadmium-treated human promonocytic cells under different forms of oxidative stress.

Sancho P, Fernández C, Yuste VJ, Amrán D, Ramos AM, de Blas E, Susin SA, Aller P.

Apoptosis. 2006 May;11(5):673-86.

PMID:
16532269
35.

Expression of cortical and hippocampal apoptosis-inducing factor (AIF) in aging and Alzheimer's disease.

Reix S, Mechawar N, Susin SA, Quirion R, Krantic S.

Neurobiol Aging. 2007 Mar;28(3):351-6. Epub 2006 Feb 28.

PMID:
16504343
36.

Use of penetrating peptides interacting with PP1/PP2A proteins as a general approach for a drug phosphatase technology.

Guergnon J, Dessauge F, Dominguez V, Viallet J, Bonnefoy S, Yuste VJ, Mercereau-Puijalon O, Cayla X, Rebollo A, Susin SA, Bost PE, Garcia A.

Mol Pharmacol. 2006 Apr;69(4):1115-24. Epub 2005 Dec 30.

PMID:
16387795
37.

AIFsh, a novel apoptosis-inducing factor (AIF) pro-apoptotic isoform with potential pathological relevance in human cancer.

Delettre C, Yuste VJ, Moubarak RS, Bras M, Lesbordes-Brion JC, Petres S, Bellalou J, Susin SA.

J Biol Chem. 2006 Mar 10;281(10):6413-27. Epub 2005 Dec 19.

38.

The contribution of apoptosis-inducing factor, caspase-activated DNase, and inhibitor of caspase-activated DNase to the nuclear phenotype and DNA degradation during apoptosis.

Yuste VJ, Sánchez-López I, Solé C, Moubarak RS, Bayascas JR, Dolcet X, Encinas M, Susin SA, Comella JX.

J Biol Chem. 2005 Oct 21;280(42):35670-83. Epub 2005 Jul 27.

39.

Cysteine protease inhibition prevents mitochondrial apoptosis-inducing factor (AIF) release.

Yuste VJ, Moubarak RS, Delettre C, Bras M, Sancho P, Robert N, d'Alayer J, Susin SA.

Cell Death Differ. 2005 Nov;12(11):1445-8. No abstract available.

40.
41.

Programmed cell death via mitochondria: different modes of dying.

Bras M, Queenan B, Susin SA.

Biochemistry (Mosc). 2005 Feb;70(2):231-9. Review.

42.

A dual role of IFN-alpha in the balance between proliferation and death of human CD4+ T lymphocytes during primary response.

Dondi E, Roué G, Yuste VJ, Susin SA, Pellegrini S.

J Immunol. 2004 Sep 15;173(6):3740-7.

43.

Apoptosis inversely correlates with rabies virus neurotropism.

Thoulouze MI, Lafage M, Yuste VJ, Kroemer G, Susin SA, Israel N, Lafon M.

Ann N Y Acad Sci. 2003 Dec;1010:598-603.

PMID:
15033799
44.

Mitochondrial effectors in caspase-independent cell death.

Lorenzo HK, Susin SA.

FEBS Lett. 2004 Jan 16;557(1-3):14-20. Review.

45.

Palmitate induces apoptosis via a direct effect on mitochondria.

de Pablo MA, Susin SA, Jacotot E, Larochette N, Costantini P, Ravagnan L, Zamzami N, Kroemer G.

Apoptosis. 1999 Apr;4(2):81-7.

PMID:
14634285
46.

Expression of dengue ApoptoM sequence results in disruption of mitochondrial potential and caspase activation.

Catteau A, Roué G, Yuste VJ, Susin SA, Desprès P.

Biochimie. 2003 Aug;85(8):789-93.

PMID:
14585546
47.

Mitochondrial dysfunction in CD47-mediated caspase-independent cell death: ROS production in the absence of cytochrome c and AIF release.

Roué G, Bitton N, Yuste VJ, Montange T, Rubio M, Dessauge F, Delettre C, Merle-Béral H, Sarfati M, Susin SA.

Biochimie. 2003 Aug;85(8):741-6.

PMID:
14585540
48.

High level of Bcl-2 counteracts apoptosis mediated by a live rabies virus vaccine strain and induces long-term infection.

Thoulouze MI, Lafage M, Yuste VJ, Baloul L, Edelman L, Kroemer G, Israel N, Susin SA, Lafon M.

Virology. 2003 Sep 30;314(2):549-61.

49.

Clearance of apoptotic photoreceptors: elimination of apoptotic debris into the subretinal space and macrophage-mediated phagocytosis via phosphatidylserine receptor and integrin alphavbeta3.

Hisatomi T, Sakamoto T, Sonoda KH, Tsutsumi C, Qiao H, Enaida H, Yamanaka I, Kubota T, Ishibashi T, Kura S, Susin SA, Kroemer G.

Am J Pathol. 2003 Jun;162(6):1869-79.

50.

Critical role of photoreceptor apoptosis in functional damage after retinal detachment.

Hisatomi T, Sakamoto T, Goto Y, Yamanaka I, Oshima Y, Hata Y, Ishibashi T, Inomata H, Susin SA, Kroemer G.

Curr Eye Res. 2002 Mar;24(3):161-72.

PMID:
12221523

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