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Items: 41

1.

Route of immunization defines multiple mechanisms of vaccine-mediated protection against SIV.

Ackerman ME, Das J, Pittala S, Broge T, Linde C, Suscovich TJ, Brown EP, Bradley T, Natarajan H, Lin S, Sassic JK, O'Keefe S, Mehta N, Goodman D, Sips M, Weiner JA, Tomaras GD, Haynes BF, Lauffenburger DA, Bailey-Kellogg C, Roederer M, Alter G.

Nat Med. 2018 Sep 3. doi: 10.1038/s41591-018-0161-0. [Epub ahead of print]

PMID:
30177821
2.

Antigen-specific antibody Fc glycosylation enhances humoral immunity via the recruitment of complement.

Lofano G, Gorman MJ, Yousif AS, Yu WH, Fox JM, Dugast AS, Ackerman ME, Suscovich TJ, Weiner J, Barouch D, Streeck H, Little S, Smith D, Richman D, Lauffenburger D, Walker BD, Diamond MS, Alter G.

Sci Immunol. 2018 Aug 17;3(26). pii: eaat7796. doi: 10.1126/sciimmunol.aat7796.

PMID:
30120121
3.

A Role for Fc Function in Therapeutic Monoclonal Antibody-Mediated Protection against Ebola Virus.

Gunn BM, Yu WH, Karim MM, Brannan JM, Herbert AS, Wec AZ, Halfmann PJ, Fusco ML, Schendel SL, Gangavarapu K, Krause T, Qiu X, He S, Das J, Suscovich TJ, Lai J, Chandran K, Zeitlin L, Crowe JE Jr, Lauffenburger D, Kawaoka Y, Kobinger GP, Andersen KG, Dye JM, Saphire EO, Alter G.

Cell Host Microbe. 2018 Aug 8;24(2):221-233.e5. doi: 10.1016/j.chom.2018.07.009.

PMID:
30092199
4.

Exploiting glycan topography for computational design of Env glycoprotein antigenicity.

Yu WH, Zhao P, Draghi M, Arevalo C, Karsten CB, Suscovich TJ, Gunn B, Streeck H, Brass AL, Tiemeyer M, Seaman M, Mascola JR, Wells L, Lauffenburger DA, Alter G.

PLoS Comput Biol. 2018 Apr 20;14(4):e1006093. doi: 10.1371/journal.pcbi.1006093. eCollection 2018 Apr.

5.

High-resolution definition of humoral immune response correlates of effective immunity against HIV.

Alter G, Dowell KG, Brown EP, Suscovich TJ, Mikhailova A, Mahan AE, Walker BD, Nimmerjahn F, Bailey-Kellogg C, Ackerman ME.

Mol Syst Biol. 2018 Mar 26;14(3):e7881. doi: 10.15252/msb.20177881.

6.

Temporal variation in HIV-specific IgG subclass antibodies during acute infection differentiates spontaneous controllers from chronic progressors.

Sadanand S, Das J, Chung AW, Schoen MK, Lane S, Suscovich TJ, Streeck H, Smith DM, Little SJ, Lauffenburger DA, Richman DD, Alter G.

AIDS. 2018 Feb 20;32(4):443-450. doi: 10.1097/QAD.0000000000001716.

PMID:
29239894
7.

Beyond binding: antibody effector functions in infectious diseases.

Lu LL, Suscovich TJ, Fortune SM, Alter G.

Nat Rev Immunol. 2018 Jan;18(1):46-61. doi: 10.1038/nri.2017.106. Epub 2017 Oct 24. Review.

PMID:
29063907
8.

Pentavalent HIV-1 vaccine protects against simian-human immunodeficiency virus challenge.

Bradley T, Pollara J, Santra S, Vandergrift N, Pittala S, Bailey-Kellogg C, Shen X, Parks R, Goodman D, Eaton A, Balachandran H, Mach LV, Saunders KO, Weiner JA, Scearce R, Sutherland LL, Phogat S, Tartaglia J, Reed SG, Hu SL, Theis JF, Pinter A, Montefiori DC, Kepler TB, Peachman KK, Rao M, Michael NL, Suscovich TJ, Alter G, Ackerman ME, Moody MA, Liao HX, Tomaras G, Ferrari G, Korber BT, Haynes BF.

Nat Commun. 2017 Jun 8;8:15711. doi: 10.1038/ncomms15711.

9.

Virus-driven Inflammation Is Associated With the Development of bNAbs in Spontaneous Controllers of HIV.

Dugast AS, Arnold K, Lofano G, Moore S, Hoffner M, Simek M, Poignard P, Seaman M, Suscovich TJ, Pereyra F, Walker BD, Lauffenburger D, Kwon DS, Keele BF, Alter G.

Clin Infect Dis. 2017 Apr 15;64(8):1098-1104. doi: 10.1093/cid/cix057.

10.

A Functional Role for Antibodies in Tuberculosis.

Lu LL, Chung AW, Rosebrock TR, Ghebremichael M, Yu WH, Grace PS, Schoen MK, Tafesse F, Martin C, Leung V, Mahan AE, Sips M, Kumar MP, Tedesco J, Robinson H, Tkachenko E, Draghi M, Freedberg KJ, Streeck H, Suscovich TJ, Lauffenburger DA, Restrepo BI, Day C, Fortune SM, Alter G.

Cell. 2016 Oct 6;167(2):433-443.e14. doi: 10.1016/j.cell.2016.08.072. Epub 2016 Sep 22.

11.

HLA-C levels impact natural killer cell subset distribution and function.

Sips M, Liu Q, Draghi M, Ghebremichael M, Berger CT, Suscovich TJ, Sun Y, Walker BD, Carrington M, Altfeld M, Brouckaert P, De Jager PL, Alter G.

Hum Immunol. 2016 Dec;77(12):1147-1153. doi: 10.1016/j.humimm.2016.08.004. Epub 2016 Aug 10.

PMID:
27521484
12.

Fc receptor-mediated phagocytosis in tissues as a potent mechanism for preventive and therapeutic HIV vaccine strategies.

Sips M, Krykbaeva M, Diefenbach TJ, Ghebremichael M, Bowman BA, Dugast AS, Boesch AW, Streeck H, Kwon DS, Ackerman ME, Suscovich TJ, Brouckaert P, Schacker TW, Alter G.

Mucosal Immunol. 2016 Nov;9(6):1584-1595. doi: 10.1038/mi.2016.12. Epub 2016 Feb 17.

13.

Polyfunctional HIV-Specific Antibody Responses Are Associated with Spontaneous HIV Control.

Ackerman ME, Mikhailova A, Brown EP, Dowell KG, Walker BD, Bailey-Kellogg C, Suscovich TJ, Alter G.

PLoS Pathog. 2016 Jan 8;12(1):e1005315. doi: 10.1371/journal.ppat.1005315. eCollection 2016 Jan.

14.

Broadly Neutralizing Antibodies Against HIV: New Insights to Inform Vaccine Design.

Sadanand S, Suscovich TJ, Alter G.

Annu Rev Med. 2016;67:185-200. doi: 10.1146/annurev-med-091014-090749. Epub 2015 Nov 9. Review.

PMID:
26565674
15.

Dissecting Polyclonal Vaccine-Induced Humoral Immunity against HIV Using Systems Serology.

Chung AW, Kumar MP, Arnold KB, Yu WH, Schoen MK, Dunphy LJ, Suscovich TJ, Frahm N, Linde C, Mahan AE, Hoffner M, Streeck H, Ackerman ME, McElrath MJ, Schuitemaker H, Pau MG, Baden LR, Kim JH, Michael NL, Barouch DH, Lauffenburger DA, Alter G.

Cell. 2015 Nov 5;163(4):988-98. doi: 10.1016/j.cell.2015.10.027.

16.

Machine learning methods enable predictive modeling of antibody feature:function relationships in RV144 vaccinees.

Choi I, Chung AW, Suscovich TJ, Rerks-Ngarm S, Pitisuttithum P, Nitayaphan S, Kaewkungwal J, O'Connell RJ, Francis D, Robb ML, Michael NL, Kim JH, Alter G, Ackerman ME, Bailey-Kellogg C.

PLoS Comput Biol. 2015 Apr 13;11(4):e1004185. doi: 10.1371/journal.pcbi.1004185. eCollection 2015 Apr.

17.

In situ production of therapeutic monoclonal antibodies.

Suscovich TJ, Alter G.

Expert Rev Vaccines. 2015 Feb;14(2):205-19. doi: 10.1586/14760584.2015.1001375. Epub 2015 Jan 12. Review.

PMID:
25578347
18.

Independent evolution of Fc- and Fab-mediated HIV-1-specific antiviral antibody activity following acute infection.

Dugast AS, Stamatatos L, Tonelli A, Suscovich TJ, Licht AF, Mikell I, Ackerman ME, Streeck H, Klasse PJ, Moore JP, Alter G.

Eur J Immunol. 2014 Oct;44(10):2925-37. doi: 10.1002/eji.201344305. Epub 2014 Aug 11.

19.

Lack of protection following passive transfer of polyclonal highly functional low-dose non-neutralizing antibodies.

Dugast AS, Chan Y, Hoffner M, Licht A, Nkolola J, Li H, Streeck H, Suscovich TJ, Ghebremichael M, Ackerman ME, Barouch DH, Alter G.

PLoS One. 2014 May 12;9(5):e97229. doi: 10.1371/journal.pone.0097229. eCollection 2014.

20.

Sequence variations in HIV-1 p24 Gag-derived epitopes can alter binding of KIR2DL2 to HLA-C*03:04 and modulate primary natural killer cell function.

van Teijlingen NH, Hölzemer A, Körner C, García-Beltrán WF, Schafer JL, Fadda L, Suscovich TJ, Brander C, Carrington M, Evans DT, van Baarle D, Altfeld M.

AIDS. 2014 Jun 19;28(10):1399-408. doi: 10.1097/QAD.0000000000000284.

21.

Polyfunctional Fc-effector profiles mediated by IgG subclass selection distinguish RV144 and VAX003 vaccines.

Chung AW, Ghebremichael M, Robinson H, Brown E, Choi I, Lane S, Dugast AS, Schoen MK, Rolland M, Suscovich TJ, Mahan AE, Liao L, Streeck H, Andrews C, Rerks-Ngarm S, Nitayaphan S, de Souza MS, Kaewkungwal J, Pitisuttithum P, Francis D, Michael NL, Kim JH, Bailey-Kellogg C, Ackerman ME, Alter G.

Sci Transl Med. 2014 Mar 19;6(228):228ra38. doi: 10.1126/scitranslmed.3007736.

22.

Decoupling activation and exhaustion of B cells in spontaneous controllers of HIV infection.

Sciaranghella G, Tong N, Mahan AE, Suscovich TJ, Alter G.

AIDS. 2013 Jan 14;27(2):175-80. doi: 10.1097/QAD.0b013e32835bd1f0.

23.

Type-1 immunity drives early lethality in scurfy mice.

Suscovich TJ, Perdue NR, Campbell DJ.

Eur J Immunol. 2012 Sep;42(9):2305-10. doi: 10.1002/eji.201242391. Epub 2012 Jul 25.

24.

Receptor-ligand requirements for increased NK cell polyfunctional potential in slow progressors infected with HIV-1 coexpressing KIR3DL1*h/*y and HLA-B*57.

Kamya P, Boulet S, Tsoukas CM, Routy JP, Thomas R, Côté P, Boulassel MR, Baril JG, Kovacs C, Migueles SA, Connors M, Suscovich TJ, Brander C, Tremblay CL, Bernard N; Canadian Cohort of HIV Infected Slow Progressors.

J Virol. 2011 Jun;85(12):5949-60. doi: 10.1128/JVI.02652-10. Epub 2011 Apr 6.

25.

Design, expression, and processing of epitomized hepatitis C virus-encoded CTL epitopes.

Yerly D, Heckerman D, Allen T, Suscovich TJ, Jojic N, Kadie C, Pichler WJ, Cerny A, Brander C.

J Immunol. 2008 Nov 1;181(9):6361-70.

26.

Structural and functional constraints limit options for cytotoxic T-lymphocyte escape in the immunodominant HLA-B27-restricted epitope in human immunodeficiency virus type 1 capsid.

Schneidewind A, Brockman MA, Sidney J, Wang YE, Chen H, Suscovich TJ, Li B, Adam RI, Allgaier RL, Mothé BR, Kuntzen T, Oniangue-Ndza C, Trocha A, Yu XG, Brander C, Sette A, Walker BD, Allen TM.

J Virol. 2008 Jun;82(11):5594-605. doi: 10.1128/JVI.02356-07. Epub 2008 Apr 2.

27.

Upregulation of PD-L1 on monocytes and dendritic cells by HIV-1 derived TLR ligands.

Meier A, Bagchi A, Sidhu HK, Alter G, Suscovich TJ, Kavanagh DG, Streeck H, Brockman MA, LeGall S, Hellman J, Altfeld M.

AIDS. 2008 Mar 12;22(5):655-8. doi: 10.1097/QAD.0b013e3282f4de23.

28.

Differential natural killer cell-mediated inhibition of HIV-1 replication based on distinct KIR/HLA subtypes.

Alter G, Martin MP, Teigen N, Carr WH, Suscovich TJ, Schneidewind A, Streeck H, Waring M, Meier A, Brander C, Lifson JD, Allen TM, Carrington M, Altfeld M.

J Exp Med. 2007 Nov 26;204(12):3027-36. Epub 2007 Nov 19.

29.

Extensive HLA class I allele promiscuity among viral CTL epitopes.

Frahm N, Yusim K, Suscovich TJ, Adams S, Sidney J, Hraber P, Hewitt HS, Linde CH, Kavanagh DG, Woodberry T, Henry LM, Faircloth K, Listgarten J, Kadie C, Jojic N, Sango K, Brown NV, Pae E, Zaman MT, Bihl F, Khatri A, John M, Mallal S, Marincola FM, Walker BD, Sette A, Heckerman D, Korber BT, Brander C.

Eur J Immunol. 2007 Sep;37(9):2419-33.

30.

Single-stranded RNA derived from HIV-1 serves as a potent activator of NK cells.

Alter G, Suscovich TJ, Teigen N, Meier A, Streeck H, Brander C, Altfeld M.

J Immunol. 2007 Jun 15;178(12):7658-66.

31.

Lytic and latent antigens of the human gammaherpesviruses Kaposi's sarcoma-associated herpesvirus and Epstein-Barr virus induce T-cell responses with similar functional properties and memory phenotypes.

Bihl F, Narayan M, Chisholm JV 3rd, Henry LM, Suscovich TJ, Brown EE, Welzel TM, Kaufmann DE, Zaman TM, Dollard S, Martin JN, Wang F, Scadden DT, Kaye KM, Brander C.

J Virol. 2007 May;81(9):4904-8. Epub 2007 Feb 28.

32.

Low perforin and elevated SHIP-1 expression is associated with functional anergy of natural killer cells in chronic HIV-1 infection.

Alter G, Suscovich TJ, Kleyman M, Teigen N, Streeck H, Zaman MT, Meier A, Altfeld M.

AIDS. 2006 Jul 13;20(11):1549-51.

PMID:
16847410
33.

Differential targeting and shifts in the immunodominance of Epstein-Barr virus--specific CD8 and CD4 T cell responses during acute and persistent infection.

Woodberry T, Suscovich TJ, Henry LM, Davis JK, Frahm N, Walker BD, Scadden DT, Wang F, Brander C.

J Infect Dis. 2005 Nov 1;192(9):1513-24. Epub 2005 Sep 26.

PMID:
16206065
34.

Alpha E beta 7 (CD103) expression identifies a highly active, tonsil-resident effector-memory CTL population.

Woodberry T, Suscovich TJ, Henry LM, August M, Waring MT, Kaur A, Hess C, Kutok JL, Aster JC, Wang F, Scadden DT, Brander C.

J Immunol. 2005 Oct 1;175(7):4355-62.

35.

Impact of Kaposi sarcoma-associated herpesvirus (KSHV) burden and HIV coinfection on the detection of T cell responses to KSHV ORF73 and ORF65 proteins.

Woodberry T, Suscovich TJ, Henry LM, Martin JN, Dollard S, O'Connor PG, Davis JK, Osmond D, Lee TH, Kedes DH, Khatri A, Lee J, Walker BD, Scadden DT, Brander C.

J Infect Dis. 2005 Aug 15;192(4):622-9. Epub 2005 Jul 15.

PMID:
16028131
36.

Sequential deregulation of NK cell subset distribution and function starting in acute HIV-1 infection.

Alter G, Teigen N, Davis BT, Addo MM, Suscovich TJ, Waring MT, Streeck H, Johnston MN, Staller KD, Zaman MT, Yu XG, Lichterfeld M, Basgoz N, Rosenberg ES, Altfeld M.

Blood. 2005 Nov 15;106(10):3366-9. Epub 2005 Jul 7.

37.

Simultaneous assessment of cytotoxic T lymphocyte responses against multiple viral infections by combined usage of optimal epitope matrices, anti- CD3 mAb T-cell expansion and "RecycleSpot"

Bihl FK, Loggi E, Chisholm JV 3rd, Hewitt HS, Henry LM, Linde C, Suscovich TJ, Wong JT, Frahm N, Andreone P, Brander C.

J Transl Med. 2005 May 11;3(1):20.

38.

Defective immune function of primary effusion lymphoma cells is associated with distinct KSHV gene expression profiles.

Suscovich TJ, Paulose-Murphy M, Harlow JD, Chen Y, Thomas SY, Mellott TJ, Walker BD, Scadden DT, Zeichner S, Brander C.

Leuk Lymphoma. 2004 Jun;45(6):1223-38.

PMID:
15360006
39.

Heat shock protein-mediated cross-presentation of exogenous HIV antigen on HLA class I and class II.

SenGupta D, Norris PJ, Suscovich TJ, Hassan-Zahraee M, Moffett HF, Trocha A, Draenert R, Goulder PJ, Binder RJ, Levey DL, Walker BD, Srivastava PK, Brander C.

J Immunol. 2004 Aug 1;173(3):1987-93.

40.

Tissue distribution of liposome-mediated epidermal growth factor receptor antisense gene therapy.

Thomas SM, Zeng Q, Dyer KF, Suscovich TJ, Kanter PM, Whalen JD, Watkins SF, Grandis JR.

Cancer Gene Ther. 2003 Jul;10(7):518-28.

PMID:
12833132
41.

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