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Items: 9

1.

Optimization of a Novel Series of Ataxia-Telangiectasia Mutated Kinase Inhibitors as Potential Radiosensitizing Agents.

Min J, Guo K, Suryadevara PK, Zhu F, Holbrook G, Chen Y, Feau C, Young BM, Lemoff A, Connelly MC, Kastan MB, Guy RK.

J Med Chem. 2016 Jan 28;59(2):559-77. doi: 10.1021/acs.jmedchem.5b01092. Epub 2016 Jan 12.

PMID:
26632965
2.

Potent Plasmodium falciparum gametocytocidal activity of diaminonaphthoquinones, lead antimalarial chemotypes identified in an antimalarial compound screen.

Tanaka TQ, Guiguemde WA, Barnett DS, Maron MI, Min J, Connelly MC, Suryadevara PK, Guy RK, Williamson KC.

Antimicrob Agents Chemother. 2015 Mar;59(3):1389-97. doi: 10.1128/AAC.01930-13. Epub 2014 Dec 15.

3.

Pharmacokinetics and efficacy of the spleen tyrosine kinase inhibitor r406 after ocular delivery for retinoblastoma.

Pritchard EM, Stewart E, Zhu F, Bradley C, Griffiths L, Yang L, Suryadevara PK, Zhang J, Freeman BB 3rd, Guy RK, Dyer MA.

Pharm Res. 2014 Nov;31(11):3060-72. doi: 10.1007/s11095-014-1399-y. Epub 2014 Jun 7.

4.

Dialkylimidazole inhibitors of Trypanosoma cruzi sterol 14α-demethylase as anti-Chagas disease agents.

Suryadevara PK, Racherla KK, Olepu S, Norcross NR, Tatipaka HB, Arif JA, Planer JD, Lepesheva GI, Verlinde CL, Buckner FS, Gelb MH.

Bioorg Med Chem Lett. 2013 Dec 1;23(23):6492-9. doi: 10.1016/j.bmcl.2013.08.015. Epub 2013 Aug 12.

5.

Pharmacological characterization, structural studies, and in vivo activities of anti-Chagas disease lead compounds derived from tipifarnib.

Buckner FS, Bahia MT, Suryadevara PK, White KL, Shackleford DM, Chennamaneni NK, Hulverson MA, Laydbak JU, Chatelain E, Scandale I, Verlinde CL, Charman SA, Lepesheva GI, Gelb MH.

Antimicrob Agents Chemother. 2012 Sep;56(9):4914-21. doi: 10.1128/AAC.06244-11. Epub 2012 Jul 9.

6.

Novel C-9, 9'-O-acyl esters of (-)-carinol as free-radical scavengers and xanthine oxidase enzyme inhibitors: synthesis and biological evaluation.

Suryadevara PK, Tatipaka HB, Vidadala RS, Tiwari AK, Rao JM, Babu KS.

Med Chem. 2013 Feb;9(1):100-3.

PMID:
22762167
7.

Structurally simple inhibitors of lanosterol 14alpha-demethylase are efficacious in a rodent model of acute Chagas disease.

Suryadevara PK, Olepu S, Lockman JW, Ohkanda J, Karimi M, Verlinde CL, Kraus JM, Schoepe J, Van Voorhis WC, Hamilton AD, Buckner FS, Gelb MH.

J Med Chem. 2009 Jun 25;52(12):3703-15. doi: 10.1021/jm900030h.

8.

2-Oxo-tetrahydro-1,8-naphthyridines as selective inhibitors of malarial protein farnesyltransferase and as anti-malarials.

Olepu S, Suryadevara PK, Rivas K, Yokoyama K, Verlinde CL, Chakrabarti D, Van Voorhis WC, Gelb MH.

Bioorg Med Chem Lett. 2008 Jan 15;18(2):494-7. Epub 2007 Dec 3.

9.

Second generation tetrahydroquinoline-based protein farnesyltransferase inhibitors as antimalarials.

Bendale P, Olepu S, Suryadevara PK, Bulbule V, Rivas K, Nallan L, Smart B, Yokoyama K, Ankala S, Pendyala PR, Floyd D, Lombardo LJ, Williams DK, Buckner FS, Chakrabarti D, Verlinde CL, Van Voorhis WC, Gelb MH.

J Med Chem. 2007 Sep 20;50(19):4585-605. Epub 2007 Aug 28.

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