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Items: 29


Activation of Rho Family GTPases by Small Molecules.

Palsuledesai CC, Surviladze Z, Waller A, Miscioscia TF, Guo Y, Wu Y, Strouse J, Romero E, Salas VM, Curpan R, Young S, Carter M, Foutz T, Galochkina Z, Ames H, Haynes MK, Edwards BS, Nicolotti O, Luo L, Ursu O, Bologa CG, Oprea TI, Wandinger-Ness A, Sklar LA.

ACS Chem Biol. 2018 Jun 15;13(6):1514-1524. doi: 10.1021/acschembio.8b00038. Epub 2018 May 24.


Novel Activities of Select NSAID R-Enantiomers against Rac1 and Cdc42 GTPases.

Oprea TI, Sklar LA, Agola JO, Guo Y, Silberberg M, Roxby J, Vestling A, Romero E, Surviladze Z, Murray-Krezan C, Waller A, Ursu O, Hudson LG, Wandinger-Ness A.

PLoS One. 2015 Nov 11;10(11):e0142182. doi: 10.1371/journal.pone.0142182. eCollection 2015.


A small molecule pan-inhibitor of Ras-superfamily GTPases with high efficacy towards Rab7.

Hong L, Simons P, Waller A, Strouse J, Surviladze Z, Ursu O, Bologa C, Gouveia K, Agola JO, BasuRay S, Wandinger-Ness A, Sklar L, Simpson DS, Schroeder CE, Golden JE, Aubé J.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2011 Dec 16 [updated 2013 Mar 7].


Cellular entry of human papillomavirus type 16 involves activation of the phosphatidylinositol 3-kinase/Akt/mTOR pathway and inhibition of autophagy.

Surviladze Z, Sterk RT, DeHaro SA, Ozbun MA.

J Virol. 2013 Mar;87(5):2508-17. doi: 10.1128/JVI.02319-12. Epub 2012 Dec 19.


Mast cell synapses and exosomes: membrane contacts for information exchange.

Carroll-Portillo A, Surviladze Z, Cambi A, Lidke DS, Wilson BS.

Front Immunol. 2012 Mar 15;3:46. doi: 10.3389/fimmu.2012.00046. eCollection 2012.


A competitive nucleotide binding inhibitor: in vitro characterization of Rab7 GTPase inhibition.

Agola JO, Hong L, Surviladze Z, Ursu O, Waller A, Strouse JJ, Simpson DS, Schroeder CE, Oprea TI, Golden JE, Aubé J, Buranda T, Sklar LA, Wandinger-Ness A.

ACS Chem Biol. 2012 Jun 15;7(6):1095-108. doi: 10.1021/cb3001099. Epub 2012 Apr 23.


Drug Repurposing from an Academic Perspective.

Oprea TI, Bauman JE, Bologa CG, Buranda T, Chigaev A, Edwards BS, Jarvik JW, Gresham HD, Haynes MK, Hjelle B, Hromas R, Hudson L, Mackenzie DA, Muller CY, Reed JC, Simons PC, Smagley Y, Strouse J, Surviladze Z, Thompson T, Ursu O, Waller A, Wandinger-Ness A, Winter SS, Wu Y, Young SM, Larson RS, Willman C, Sklar LA.

Drug Discov Today Ther Strateg. 2011 Winter;8(3-4):61-69.


Essential roles for soluble virion-associated heparan sulfonated proteoglycans and growth factors in human papillomavirus infections.

Surviladze Z, Dziduszko A, Ozbun MA.

PLoS Pathog. 2012 Feb;8(2):e1002519. doi: 10.1371/journal.ppat.1002519. Epub 2012 Feb 9.


High-throughput flow cytometry bead-based multiplex assay for identification of Rho GTPase inhibitors.

Surviladze Z, Young SM, Sklar LA.

Methods Mol Biol. 2012;827:253-70. doi: 10.1007/978-1-61779-442-1_17.


A Potent and Selective Inhibitor of Cdc42 GTPase.

Surviladze Z, Waller A, Strouse JJ, Bologa C, Ursu O, Salas V, Parkinson JF, Phillips GK, Romero E, Wandinger-Ness A, Sklar LA, Schroeder C, Simpson D, Nöth J, Wang J, Golden J, Aubé J.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2010 Feb 27 [updated 2010 Dec 16].


Three small molecule pan activator families of Ras-related GTPases.

Surviladze Z, Ursu O, Miscioscia F, Curpan R, Halip L, Bologa C, Oprea T, Waller A, Strouse J, Salas V, Wu Y, Edwards B, Wandinger-Ness A, Sklar L.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2009 May 18 [updated 2010 Sep 2].


Continuous expression of HIF-1α in neural stem/progenitor cells.

Roitbak T, Surviladze Z, Cunningham LA.

Cell Mol Neurobiol. 2011 Jan;31(1):119-33. doi: 10.1007/s10571-010-9561-5. Epub 2010 Sep 16.


Identification of a small GTPase inhibitor using a high-throughput flow cytometry bead-based multiplex assay.

Surviladze Z, Waller A, Wu Y, Romero E, Edwards BS, Wandinger-Ness A, Sklar LA.

J Biomol Screen. 2010 Jan;15(1):10-20. doi: 10.1177/1087057109352240. Epub 2009 Dec 11.


Flow cytometry for real-time measurement of guanine nucleotide binding and exchange by Ras-like GTPases.

Schwartz SL, Tessema M, Buranda T, Pylypenko O, Rak A, Simons PC, Surviladze Z, Sklar LA, Wandinger-Ness A.

Anal Biochem. 2008 Oct 15;381(2):258-66. doi: 10.1016/j.ab.2008.06.039. Epub 2008 Jul 8.


FcepsilonRI and Thy-1 domains have unique protein and lipid compositions.

Surviladze Z, Harrison KA, Murphy RC, Wilson BS.

J Lipid Res. 2007 Jun;48(6):1325-35. Epub 2007 Mar 26.


Plasma membrane-associated proteins are clustered into islands attached to the cytoskeleton.

Lillemeier BF, Pfeiffer JR, Surviladze Z, Wilson BS, Davis MM.

Proc Natl Acad Sci U S A. 2006 Dec 12;103(50):18992-7. Epub 2006 Dec 4.


Revealing the topography of cellular membrane domains by combined atomic force microscopy/fluorescence imaging.

Frankel DJ, Pfeiffer JR, Surviladze Z, Johnson AE, Oliver JM, Wilson BS, Burns AR.

Biophys J. 2006 Apr 1;90(7):2404-13. Epub 2006 Jan 13.


A polycystin multiprotein complex constitutes a cholesterol-containing signalling microdomain in human kidney epithelia.

Roitbak T, Surviladze Z, Tikkanen R, Wandinger-Ness A.

Biochem J. 2005 Nov 15;392(Pt 1):29-38.


Membrane receptor mapping: the membrane topography of Fc(epsilon)RI signaling.

Oliver JM, Pfeiffer JR, Surviladze Z, Steinberg SL, Leiderman K, Sanders ML, Wofsy C, Zhang J, Fan H, Andrews N, Bunge S, Boyle TJ, Kotula P, Wilson BS.

Subcell Biochem. 2004;37:3-34. Review.


Dysregulated FcepsilonRI signaling and altered Fyn and SHIP activities in Lyn-deficient mast cells.

Hernandez-Hansen V, Smith AJ, Surviladze Z, Chigaev A, Mazel T, Kalesnikoff J, Lowell CA, Krystal G, Sklar LA, Wilson BS, Oliver JM.

J Immunol. 2004 Jul 1;173(1):100-12.


Markers for detergent-resistant lipid rafts occupy distinct and dynamic domains in native membranes.

Wilson BS, Steinberg SL, Liederman K, Pfeiffer JR, Surviladze Z, Zhang J, Samelson LE, Yang LH, Kotula PG, Oliver JM.

Mol Biol Cell. 2004 Jun;15(6):2580-92. Epub 2004 Mar 19.


Overcoming the signaling defect of Lyn-sequestering, signal-curtailing FcepsilonRI dimers: aggregated dimers can dissociate from Lyn and form signaling complexes with Syk.

Lara M, Ortega E, Pecht I, Pfeiffer JR, Martinez AM, Lee RJ, Surviladze Z, Wilson BS, Oliver JM.

J Immunol. 2001 Oct 15;167(8):4329-37.


High resolution mapping of mast cell membranes reveals primary and secondary domains of Fc(epsilon)RI and LAT.

Wilson BS, Pfeiffer JR, Surviladze Z, Gaudet EA, Oliver JM.

J Cell Biol. 2001 Aug 6;154(3):645-58.


p110beta and p110delta phosphatidylinositol 3-kinases up-regulate Fc(epsilon)RI-activated Ca2+ influx by enhancing inositol 1,4,5-trisphosphate production.

Smith AJ, Surviladze Z, Gaudet EA, Backer JM, Mitchell CA, Wilson BS.

J Biol Chem. 2001 May 18;276(20):17213-20. Epub 2001 Feb 15.


Differential sensitivity to acute cholesterol lowering of activation mediated via the high-affinity IgE receptor and Thy-1 glycoprotein.

Surviladze Z, Dráberová L, Kovárová M, Boubelík M, Dráber P.

Eur J Immunol. 2001 Jan;31(1):1-10.


Protein tyrosine kinase p53/p56(lyn) forms complexes with gamma-tubulin in rat basophilic leukemia cells.

Dráberová L, Dráberová E, Surviladze Z, Dráber P, Dráber P.

Int Immunol. 1999 Nov;11(11):1829-39.


Functional heterogeneity of Thy-1 membrane microdomains in rat basophilic leukemia cells.

Surviladze Z, Dráberová L, Kubínová L, Dráber P.

Eur J Immunol. 1998 Jun;28(6):1847-58.


[Steady state kinetics of DNA degradation with pancreatic deoxyribonuclease A in the presence of Mg2+].

Surviladze ZG, Dudkin SM.

Mol Biol (Mosk). 1979 Jan-Feb;13(1):205-15. Russian.


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