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Items: 19


High-throughput screening for phosphatidylserine decarboxylase inhibitors using a distyrylbenzene-bis-aldehyde (DSB-3)-based fluorescence assay.

Hendricson A, Umlauf S, Choi JY, Thekkiniath J, Surovtseva YV, Fuller KK, Reynolds TB, Voelker DR, Ben Mamoun C.

J Biol Chem. 2019 Aug 9;294(32):12146-12156. doi: 10.1074/jbc.RA119.007766. Epub 2019 Jun 21.


Model Colibactins Exhibit Human Cell Genotoxicity in the Absence of Host Bacteria.

Shine EE, Xue M, Patel JR, Healy AR, Surovtseva YV, Herzon SB, Crawford JM.

ACS Chem Biol. 2018 Dec 21;13(12):3286-3293. doi: 10.1021/acschembio.8b00714. Epub 2018 Nov 20.


PKCε contributes to lipid-induced insulin resistance through cross talk with p70S6K and through previously unknown regulators of insulin signaling.

Gassaway BM, Petersen MC, Surovtseva YV, Barber KW, Sheetz JB, Aerni HR, Merkel JS, Samuel VT, Shulman GI, Rinehart J.

Proc Natl Acad Sci U S A. 2018 Sep 18;115(38):E8996-E9005. doi: 10.1073/pnas.1804379115. Epub 2018 Sep 4.


Diverse Regulators of Human Ribosome Biogenesis Discovered by Changes in Nucleolar Number.

Farley-Barnes KI, McCann KL, Ogawa LM, Merkel J, Surovtseva YV, Baserga SJ.

Cell Rep. 2018 Feb 13;22(7):1923-1934. doi: 10.1016/j.celrep.2018.01.056.


A novel fluorescence assay for measuring phosphatidylserine decarboxylase catalysis.

Choi JY, Surovtseva YV, Van Sickle SM, Kumpf J, Bunz UHF, Ben Mamoun C, Voelker DR.

J Biol Chem. 2018 Feb 2;293(5):1493-1503. doi: 10.1074/jbc.RA117.000525. Epub 2017 Dec 15.


Combined HMG-COA reductase and prenylation inhibition in treatment of CCM.

Nishimura S, Mishra-Gorur K, Park J, Surovtseva YV, Sebti SM, Levchenko A, Louvi A, Gunel M.

Proc Natl Acad Sci U S A. 2017 May 23;114(21):5503-5508. doi: 10.1073/pnas.1702942114. Epub 2017 May 12.


2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity.

Sulkowski PL, Corso CD, Robinson ND, Scanlon SE, Purshouse KR, Bai H, Liu Y, Sundaram RK, Hegan DC, Fons NR, Breuer GA, Song Y, Mishra-Gorur K, De Feyter HM, de Graaf RA, Surovtseva YV, Kachman M, Halene S, Günel M, Glazer PM, Bindra RS.

Sci Transl Med. 2017 Feb 1;9(375). pii: eaal2463. doi: 10.1126/scitranslmed.aal2463.


Characterization of Cardiac Glycoside Natural Products as Potent Inhibitors of DNA Double-Strand Break Repair by a Whole-Cell Double Immunofluorescence Assay.

Surovtseva YV, Jairam V, Salem AF, Sundaram RK, Bindra RS, Herzon SB.

J Am Chem Soc. 2016 Mar 23;138(11):3844-55. doi: 10.1021/jacs.6b00162. Epub 2016 Mar 9.


Mitochondrial Ribosomal Protein L12 Is Required for POLRMT Stability and Exists as Two Forms Generated by Alternative Proteolysis during Import.

Nouws J, Goswami AV, Bestwick M, McCann BJ, Surovtseva YV, Shadel GS.

J Biol Chem. 2016 Jan 8;291(2):989-97. doi: 10.1074/jbc.M115.689299. Epub 2015 Nov 19.


Complement membrane attack complexes activate noncanonical NF-κB by forming an Akt+ NIK+ signalosome on Rab5+ endosomes.

Jane-wit D, Surovtseva YV, Qin L, Li G, Liu R, Clark P, Manes TD, Wang C, Kashgarian M, Kirkiles-Smith NC, Tellides G, Pober JS.

Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):9686-91. doi: 10.1073/pnas.1503535112. Epub 2015 Jul 20.


Transcription-independent role for human mitochondrial RNA polymerase in mitochondrial ribosome biogenesis.

Surovtseva YV, Shadel GS.

Nucleic Acids Res. 2013 Feb 1;41(4):2479-88. doi: 10.1093/nar/gks1447. Epub 2013 Jan 8.


Mitochondrial ribosomal protein L12 selectively associates with human mitochondrial RNA polymerase to activate transcription.

Surovtseva YV, Shutt TE, Cotney J, Cimen H, Chen SY, Koc EC, Shadel GS.

Proc Natl Acad Sci U S A. 2011 Nov 1;108(44):17921-6. doi: 10.1073/pnas.1108852108. Epub 2011 Oct 14.


LRP130 protein remodels mitochondria and stimulates fatty acid oxidation.

Liu L, Sanosaka M, Lei S, Bestwick ML, Frey JH Jr, Surovtseva YV, Shadel GS, Cooper MP.

J Biol Chem. 2011 Dec 2;286(48):41253-64. doi: 10.1074/jbc.M111.276121. Epub 2011 Oct 4.


Conserved telomere maintenance component 1 interacts with STN1 and maintains chromosome ends in higher eukaryotes.

Surovtseva YV, Churikov D, Boltz KA, Song X, Lamb JC, Warrington R, Leehy K, Heacock M, Price CM, Shippen DE.

Mol Cell. 2009 Oct 23;36(2):207-18. doi: 10.1016/j.molcel.2009.09.017.


STN1 protects chromosome ends in Arabidopsis thaliana.

Song X, Leehy K, Warrington RT, Lamb JC, Surovtseva YV, Shippen DE.

Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19815-20. doi: 10.1073/pnas.0807867105. Epub 2008 Dec 8.


Arabidopsis POT1 associates with the telomerase RNP and is required for telomere maintenance.

Surovtseva YV, Shakirov EV, Vespa L, Osbun N, Song X, Shippen DE.

EMBO J. 2007 Aug 8;26(15):3653-61. Epub 2007 Jul 12.


The Arabidopsis Pot1 and Pot2 proteins function in telomere length homeostasis and chromosome end protection.

Shakirov EV, Surovtseva YV, Osbun N, Shippen DE.

Mol Cell Biol. 2005 Sep;25(17):7725-33.


A C-terminal Myb extension domain defines a novel family of double-strand telomeric DNA-binding proteins in Arabidopsis.

Karamysheva ZN, Surovtseva YV, Vespa L, Shakirov EV, Shippen DE.

J Biol Chem. 2004 Nov 12;279(46):47799-807. Epub 2004 Sep 10.


A new enrichment approach identifies genes that alter cell cycle progression in Saccharomyces cerevisiae.

Bogomolnaya LM, Pathak R, Cham R, Guo J, Surovtseva YV, Jaeckel L, Polymenis M.

Curr Genet. 2004 Jun;45(6):350-9. Epub 2004 Mar 12.


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