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Items: 1 to 50 of 227

1.

Allele-selective transcriptional repression of mutant HTT for the treatment of Huntington's disease.

Zeitler B, Froelich S, Marlen K, Shivak DA, Yu Q, Li D, Pearl JR, Miller JC, Zhang L, Paschon DE, Hinkley SJ, Ankoudinova I, Lam S, Guschin D, Kopan L, Cherone JM, Nguyen HB, Qiao G, Ataei Y, Mendel MC, Amora R, Surosky R, Laganiere J, Vu BJ, Narayanan A, Sedaghat Y, Tillack K, Thiede C, Gärtner A, Kwak S, Bard J, Mrzljak L, Park L, Heikkinen T, Lehtimäki KK, Svedberg MM, Häggkvist J, Tari L, Tóth M, Varrone A, Halldin C, Kudwa AE, Ramboz S, Day M, Kondapalli J, Surmeier DJ, Urnov FD, Gregory PD, Rebar EJ, Muñoz-Sanjuán I, Zhang HS.

Nat Med. 2019 Jul;25(7):1131-1142. doi: 10.1038/s41591-019-0478-3. Epub 2019 Jul 1.

PMID:
31263285
2.

Increased Lysosomal Exocytosis Induced by Lysosomal Ca2+ Channel Agonists Protects Human Dopaminergic Neurons from α-Synuclein Toxicity.

Tsunemi T, Perez-Rosello T, Ishiguro Y, Yoroisaka A, Jeon S, Hamada K, Rammonhan M, Wong YC, Xie Z, Akamatsu W, Mazzulli JR, Surmeier DJ, Hattori N, Krainc D.

J Neurosci. 2019 Jul 17;39(29):5760-5772. doi: 10.1523/JNEUROSCI.3085-18.2019. Epub 2019 May 16.

PMID:
31097622
3.

Mutant huntingtin enhances activation of dendritic Kv4 K+ channels in striatal spiny projection neurons.

Carrillo-Reid L, Day M, Xie Z, Melendez AE, Kondapalli J, Plotkin JL, Wokosin DL, Chen Y, Kress GJ, Kaplitt M, Ilijic E, Guzman JN, Chan CS, Surmeier DJ.

Elife. 2019 Apr 24;8. pii: e40818. doi: 10.7554/eLife.40818.

4.

Dopaminergic modulation of striatal function and Parkinson's disease.

Zhai S, Shen W, Graves SM, Surmeier DJ.

J Neural Transm (Vienna). 2019 Apr;126(4):411-422. doi: 10.1007/s00702-019-01997-y. Epub 2019 Apr 1. Review.

PMID:
30937538
5.

Delayed Spine Pruning of Direct Pathway Spiny Projection Neurons in a Mouse Model of Parkinson's Disease.

Graves SM, Surmeier DJ.

Front Cell Neurosci. 2019 Feb 12;13:32. doi: 10.3389/fncel.2019.00032. eCollection 2019.

6.

Enhanced striatopallidal gamma-aminobutyric acid (GABA)A receptor transmission in mouse models of huntington's disease.

Perez-Rosello T, Gelman S, Tombaugh G, Cachope R, Beaumont V, Surmeier DJ.

Mov Disord. 2019 May;34(5):684-696. doi: 10.1002/mds.27622. Epub 2019 Feb 6.

PMID:
30726572
7.

Cholinergic Interneurons Amplify Thalamostriatal Excitation of Striatal Indirect Pathway Neurons in Parkinson's Disease Models.

Tanimura A, Du Y, Kondapalli J, Wokosin DL, Surmeier DJ.

Neuron. 2019 Feb 6;101(3):444-458.e6. doi: 10.1016/j.neuron.2018.12.004. Epub 2019 Jan 15.

PMID:
30658860
8.

Targeting the pedunculopontine nucleus in Parkinson's disease: Time to go back to the drawing board.

Albin RL, Surmeier DJ, Tubert C, Sarter M, Müller MLTM, Bohnen NI, Dauer WT.

Mov Disord. 2018 Dec;33(12):1871-1875. doi: 10.1002/mds.27540. Epub 2018 Nov 6. No abstract available.

9.

The pedunclopontine nucleus and Parkinson's disease.

Tubert C, Galtieri D, Surmeier DJ.

Neurobiol Dis. 2019 Aug;128. pii: S0969-9961(18)30493-5. doi: 10.1016/j.nbd.2018.08.017. Epub 2018 Aug 29. Review.

PMID:
30171892
10.

Determinants of dopaminergic neuron loss in Parkinson's disease.

Surmeier DJ.

FEBS J. 2018 Oct;285(19):3657-3668. doi: 10.1111/febs.14607. Epub 2018 Aug 14. Review.

PMID:
30028088
11.

Systemic isradipine treatment diminishes calcium-dependent mitochondrial oxidant stress.

Guzman JN, Ilijic E, Yang B, Sanchez-Padilla J, Wokosin D, Galtieri D, Kondapalli J, Schumacker PT, Surmeier DJ.

J Clin Invest. 2018 Jun 1;128(6):2266-2280. doi: 10.1172/JCI95898. Epub 2018 Apr 30.

12.

CNTNAP2 stabilizes interneuron dendritic arbors through CASK.

Gao R, Piguel NH, Melendez-Zaidi AE, Martin-de-Saavedra MD, Yoon S, Forrest MP, Myczek K, Zhang G, Russell TA, Csernansky JG, Surmeier DJ, Penzes P.

Mol Psychiatry. 2018 Sep;23(9):1832-1850. doi: 10.1038/s41380-018-0027-3. Epub 2018 Apr 9.

13.

α-Synuclein-Dependent Calcium Entry Underlies Differential Sensitivity of Cultured SN and VTA Dopaminergic Neurons to a Parkinsonian Neurotoxin.

Lieberman OJ, Choi SJ, Kanter E, Saverchenko A, Frier MD, Fiore GM, Wu M, Kondapalli J, Zampese E, Surmeier DJ, Sulzer D, Mosharov EV.

eNeuro. 2017 Nov 21;4(6). pii: ENEURO.0167-17.2017. doi: 10.1523/ENEURO.0167-17.2017. eCollection 2017 Nov-Dec.

14.

Parkinson's Disease Is Not Simply a Prion Disorder.

Surmeier DJ, Obeso JA, Halliday GM.

J Neurosci. 2017 Oct 11;37(41):9799-9807. doi: 10.1523/JNEUROSCI.1787-16.2017. Review.

15.

Pedunculopontine glutamatergic neurons control spike patterning in substantia nigra dopaminergic neurons.

Galtieri DJ, Estep CM, Wokosin DL, Traynelis S, Surmeier DJ.

Elife. 2017 Oct 5;6. pii: e30352. doi: 10.7554/eLife.30352.

16.

Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Shaking Palsy.

Obeso JA, Stamelou M, Goetz CG, Poewe W, Lang AE, Weintraub D, Burn D, Halliday GM, Bezard E, Przedborski S, Lehericy S, Brooks DJ, Rothwell JC, Hallett M, DeLong MR, Marras C, Tanner CM, Ross GW, Langston JW, Klein C, Bonifati V, Jankovic J, Lozano AM, Deuschl G, Bergman H, Tolosa E, Rodriguez-Violante M, Fahn S, Postuma RB, Berg D, Marek K, Standaert DG, Surmeier DJ, Olanow CW, Kordower JH, Calabresi P, Schapira AHV, Stoessl AJ.

Mov Disord. 2017 Sep;32(9):1264-1310. doi: 10.1002/mds.27115. Review.

17.

Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson's disease.

Burbulla LF, Song P, Mazzulli JR, Zampese E, Wong YC, Jeon S, Santos DP, Blanz J, Obermaier CD, Strojny C, Savas JN, Kiskinis E, Zhuang X, Krüger R, Surmeier DJ, Krainc D.

Science. 2017 Sep 22;357(6357):1255-1261. doi: 10.1126/science.aam9080. Epub 2017 Sep 7.

18.

Striatal synapses, circuits, and Parkinson's disease.

Zhai S, Tanimura A, Graves SM, Shen W, Surmeier DJ.

Curr Opin Neurobiol. 2018 Feb;48:9-16. doi: 10.1016/j.conb.2017.08.004. Epub 2017 Aug 24. Review.

19.

Calcium, mitochondrial dysfunction and slowing the progression of Parkinson's disease.

Surmeier DJ, Halliday GM, Simuni T.

Exp Neurol. 2017 Dec;298(Pt B):202-209. doi: 10.1016/j.expneurol.2017.08.001. Epub 2017 Aug 2. Review.

20.

Intracellular Uncaging of cGMP with Blue Light.

Agarwal HK, Zhai S, Surmeier DJ, Ellis-Davies GCR.

ACS Chem Neurosci. 2017 Oct 18;8(10):2139-2144. doi: 10.1021/acschemneuro.7b00237. Epub 2017 Aug 1.

21.

Striatal cholinergic interneurons and Parkinson's disease.

Tanimura A, Pancani T, Lim SAO, Tubert C, Melendez AE, Shen W, Surmeier DJ.

Eur J Neurosci. 2018 May;47(10):1148-1158. doi: 10.1111/ejn.13638. Epub 2017 Jul 20. Review.

22.

Cryopreservation Maintains Functionality of Human iPSC Dopamine Neurons and Rescues Parkinsonian Phenotypes In Vivo.

Wakeman DR, Hiller BM, Marmion DJ, McMahon CW, Corbett GT, Mangan KP, Ma J, Little LE, Xie Z, Perez-Rosello T, Guzman JN, Surmeier DJ, Kordower JH.

Stem Cell Reports. 2017 Jul 11;9(1):149-161. doi: 10.1016/j.stemcr.2017.04.033. Epub 2017 Jun 1.

23.

Sirt3 protects dopaminergic neurons from mitochondrial oxidative stress.

Shi H, Deng HX, Gius D, Schumacker PT, Surmeier DJ, Ma YC.

Hum Mol Genet. 2017 May 15;26(10):1915-1926. doi: 10.1093/hmg/ddx100.

24.

WAVE1 in neurons expressing the D1 dopamine receptor regulates cellular and behavioral actions of cocaine.

Ceglia I, Lee KW, Cahill ME, Graves SM, Dietz D, Surmeier DJ, Nestler EJ, Nairn AC, Greengard P, Kim Y.

Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):1395-1400. doi: 10.1073/pnas.1621185114. Epub 2017 Jan 23.

25.

Selective neuronal vulnerability in Parkinson disease.

Surmeier DJ, Obeso JA, Halliday GM.

Nat Rev Neurosci. 2017 Jan 20;18(2):101-113. doi: 10.1038/nrn.2016.178. Review.

26.

Transient Activation of GABAB Receptors Suppresses SK Channel Currents in Substantia Nigra Pars Compacta Dopaminergic Neurons.

Estep CM, Galtieri DJ, Zampese E, Goldberg JA, Brichta L, Greengard P, Surmeier DJ.

PLoS One. 2016 Dec 30;11(12):e0169044. doi: 10.1371/journal.pone.0169044. eCollection 2016.

27.

Cholinergic Interneurons Amplify Corticostriatal Synaptic Responses in the Q175 Model of Huntington's Disease.

Tanimura A, Lim SA, Aceves Buendia JJ, Goldberg JA, Surmeier DJ.

Front Syst Neurosci. 2016 Dec 16;10:102. doi: 10.3389/fnsys.2016.00102. eCollection 2016.

28.

Early dysfunction and progressive degeneration of the subthalamic nucleus in mouse models of Huntington's disease.

Atherton JF, McIver EL, Mullen MR, Wokosin DL, Surmeier DJ, Bevan MD.

Elife. 2016 Dec 20;5. pii: e21616. doi: 10.7554/eLife.21616.

29.

Calcium and Parkinson's disease.

Surmeier DJ, Schumacker PT, Guzman JD, Ilijic E, Yang B, Zampese E.

Biochem Biophys Res Commun. 2017 Feb 19;483(4):1013-1019. doi: 10.1016/j.bbrc.2016.08.168. Epub 2016 Aug 30. Review.

30.

Haloperidol Selectively Remodels Striatal Indirect Pathway Circuits.

Sebel LE, Graves SM, Chan CS, Surmeier DJ.

Neuropsychopharmacology. 2017 Mar;42(4):963-973. doi: 10.1038/npp.2016.173. Epub 2016 Aug 31.

31.

M4 Muscarinic Receptor Signaling Ameliorates Striatal Plasticity Deficits in Models of L-DOPA-Induced Dyskinesia.

Shen W, Plotkin JL, Francardo V, Ko WK, Xie Z, Li Q, Fieblinger T, Wess J, Neubig RR, Lindsley CW, Conn PJ, Greengard P, Bezard E, Cenci MA, Surmeier DJ.

Neuron. 2016 Jun 1;90(5):1139. doi: 10.1016/j.neuron.2016.05.017. No abstract available.

32.

The indirect pathway of the nucleus accumbens shell amplifies neuropathic pain.

Ren W, Centeno MV, Berger S, Wu Y, Na X, Liu X, Kondapalli J, Apkarian AV, Martina M, Surmeier DJ.

Nat Neurosci. 2016 Feb;19(2):220-2. doi: 10.1038/nn.4199. Epub 2015 Dec 21.

33.

M4 Muscarinic Receptor Signaling Ameliorates Striatal Plasticity Deficits in Models of L-DOPA-Induced Dyskinesia.

Shen W, Plotkin JL, Francardo V, Ko WK, Xie Z, Li Q, Fieblinger T, Wess J, Neubig RR, Lindsley CW, Conn PJ, Greengard P, Bezard E, Cenci MA, Surmeier DJ.

Neuron. 2015 Nov 18;88(4):762-73. doi: 10.1016/j.neuron.2015.10.039. Erratum in: Neuron. 2016 Jun 1;90(5):1139.

34.

Interneuronal Nitric Oxide Signaling Mediates Post-synaptic Long-Term Depression of Striatal Glutamatergic Synapses.

Rafalovich IV, Melendez AE, Plotkin JL, Tanimura A, Zhai S, Surmeier DJ.

Cell Rep. 2015 Nov 17;13(7):1336-1342. doi: 10.1016/j.celrep.2015.10.015. Epub 2015 Nov 5.

35.

Sodium channel Nax is a regulator in epithelial sodium homeostasis.

Xu W, Hong SJ, Zhong A, Xie P, Jia S, Xie Z, Zeitchek M, Niknam-Bienia S, Zhao J, Porterfield DM, Surmeier DJ, Leung KP, Galiano RD, Mustoe TA.

Sci Transl Med. 2015 Nov 4;7(312):312ra177. doi: 10.1126/scitranslmed.aad0286.

PMID:
26537257
36.

Functional segregation of voltage-activated calcium channels in motoneurons of the dorsal motor nucleus of the vagus.

Cooper G, Lasser-Katz E, Simchovitz A, Sharon R, Soreq H, Surmeier DJ, Goldberg JA.

J Neurophysiol. 2015 Sep;114(3):1513-20. doi: 10.1152/jn.00432.2014. Epub 2015 Jul 8.

37.

Genetic dissection of horizontal cell inhibitory signaling in mice in complete darkness in vivo.

Berkowitz BA, Murphy GG, Craft CM, Surmeier DJ, Roberts R.

Invest Ophthalmol Vis Sci. 2015 May;56(5):3132-9. doi: 10.1167/iovs.15-16581.

38.

Corrigendum: Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1.

Guzman JN, Sanchez-Padilla J, Wokosin D, Kondapalli J, Ilijic E, Schumacker PT, Surmeier DJ.

Nature. 2015 May 21;521(7552):380. doi: 10.1038/nature14487. No abstract available.

PMID:
25993967
39.

Corticostriatal synaptic adaptations in Huntington's disease.

Plotkin JL, Surmeier DJ.

Curr Opin Neurobiol. 2015 Aug;33:53-62. doi: 10.1016/j.conb.2015.01.020. Epub 2015 Feb 18. Review.

40.

Heterosynaptic regulation of external globus pallidus inputs to the subthalamic nucleus by the motor cortex.

Chu HY, Atherton JF, Wokosin D, Surmeier DJ, Bevan MD.

Neuron. 2015 Jan 21;85(2):364-76. doi: 10.1016/j.neuron.2014.12.022. Epub 2015 Jan 8.

41.

Nitric oxide regulates synaptic transmission between spiny projection neurons.

Sagi Y, Heiman M, Peterson JD, Musatov S, Scarduzio M, Logan SM, Kaplitt MG, Surmeier DJ, Heintz N, Greengard P.

Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):17636-41. doi: 10.1073/pnas.1420162111. Epub 2014 Nov 20. Erratum in: Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):E1811.

42.

Hydration status regulates sodium flux and inflammatory pathways through epithelial sodium channel (ENaC) in the skin.

Xu W, Hong SJ, Zeitchek M, Cooper G, Jia S, Xie P, Qureshi HA, Zhong A, Porterfield MD, Galiano RD, Surmeier DJ, Mustoe TA.

J Invest Dermatol. 2015 Mar;135(3):796-806. doi: 10.1038/jid.2014.477. Epub 2014 Nov 5.

43.

Cell type-specific plasticity of striatal projection neurons in parkinsonism and L-DOPA-induced dyskinesia.

Fieblinger T, Graves SM, Sebel LE, Alcacer C, Plotkin JL, Gertler TS, Chan CS, Heiman M, Greengard P, Cenci MA, Surmeier DJ.

Nat Commun. 2014 Oct 31;5:5316. doi: 10.1038/ncomms6316.

44.

Dopaminergic modulation of striatal networks in health and Parkinson's disease.

Surmeier DJ, Graves SM, Shen W.

Curr Opin Neurobiol. 2014 Dec;29:109-17. doi: 10.1016/j.conb.2014.07.008. Epub 2014 Jul 22. Review.

45.

Multiphoton imaging approaches for studying striatal dendritic excitability.

Plotkin JL, Surmeier DJ.

Methods Mol Biol. 2014;1183:171-82. doi: 10.1007/978-1-4939-1096-0_10.

PMID:
25023308
46.

Impaired TrkB receptor signaling underlies corticostriatal dysfunction in Huntington's disease.

Plotkin JL, Day M, Peterson JD, Xie Z, Kress GJ, Rafalovich I, Kondapalli J, Gertler TS, Flajolet M, Greengard P, Stavarache M, Kaplitt MG, Rosinski J, Chan CS, Surmeier DJ.

Neuron. 2014 Jul 2;83(1):178-88. doi: 10.1016/j.neuron.2014.05.032.

47.

Astrocytes go awry in Huntington's disease.

Chan CS, Surmeier DJ.

Nat Neurosci. 2014 May;17(5):641-2. No abstract available.

PMID:
24883452
48.

Mitochondrial oxidant stress in locus coeruleus is regulated by activity and nitric oxide synthase.

Sanchez-Padilla J, Guzman JN, Ilijic E, Kondapalli J, Galtieri DJ, Yang B, Schieber S, Oertel W, Wokosin D, Schumacker PT, Surmeier DJ.

Nat Neurosci. 2014 Jun;17(6):832-40. doi: 10.1038/nn.3717. Epub 2014 May 11.

49.

Molecular adaptations of striatal spiny projection neurons during levodopa-induced dyskinesia.

Heiman M, Heilbut A, Francardo V, Kulicke R, Fenster RJ, Kolaczyk ED, Mesirov JP, Surmeier DJ, Cenci MA, Greengard P.

Proc Natl Acad Sci U S A. 2014 Mar 25;111(12):4578-83. doi: 10.1073/pnas.1401819111. Epub 2014 Mar 5.

50.

Impaired striatal function in Huntington's disease is due to aberrant p75NTR signaling.

Plotkin JL, Surmeier DJ.

Rare Dis. 2014 Nov 3;2(1):e968482. doi: 10.4161/2167549X.2014.968482. eCollection 2014.

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