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Cell surface polysaccharides of Bifidobacterium bifidum induce the generation of Foxp3+ regulatory T cells.

Verma R, Lee C, Jeun EJ, Yi J, Kim KS, Ghosh A, Byun S, Lee CG, Kang HJ, Kim GC, Jun CD, Jan G, Suh CH, Jung JY, Sprent J, Rudra D, De Castro C, Molinaro A, Surh CD, Im SH.

Sci Immunol. 2018 Oct 19;3(28). pii: eaat6975. doi: 10.1126/sciimmunol.aat6975.


Spontaneous Proliferation of CD4+ T Cells in RAG-Deficient Hosts Promotes Antigen-Independent but IL-2-Dependent Strong Proliferative Response of Naïve CD8+ T Cells.

Kim J, Lee JY, Cho K, Hong SW, Kim KS, Sprent J, Im SH, Surh CD, Cho JH.

Front Immunol. 2018 Aug 23;9:1907. doi: 10.3389/fimmu.2018.01907. eCollection 2018.


Phenotypic and Functional Changes of Peripheral Ly6C+ T Regulatory Cells Driven by Conventional Effector T Cells.

Lee JY, Kim J, Yi J, Kim D, Kim HO, Han D, Sprent J, Lee YJ, Surh CD, Cho JH.

Front Immunol. 2018 Mar 16;9:437. doi: 10.3389/fimmu.2018.00437. eCollection 2018.


Self-Recognition Sensitizes Mouse and Human Regulatory T Cells to Low-Dose CD28 Superagonist Stimulation.

Langenhorst D, Tabares P, Gulde T, Becklund BR, Berr S, Surh CD, Beyersdorf N, Hünig T.

Front Immunol. 2018 Jan 30;8:1985. doi: 10.3389/fimmu.2017.01985. eCollection 2017.


Writer's block: preventing m6A mRNA methylation promotes T cell naivety.

Sprent J, Surh CD.

Immunol Cell Biol. 2017 Nov;95(10):855-856. doi: 10.1038/icb.2017.67. Epub 2017 Sep 18. No abstract available.


Interleukin-7 Availability Is Maintained by a Hematopoietic Cytokine Sink Comprising Innate Lymphoid Cells and T Cells.

Martin CE, Spasova DS, Frimpong-Boateng K, Kim HO, Lee M, Kim KS, Surh CD.

Immunity. 2017 Jul 18;47(1):171-182.e4. doi: 10.1016/j.immuni.2017.07.005.


Functional and Homeostatic Impact of Age-Related Changes in Lymph Node Stroma.

Thompson HL, Smithey MJ, Surh CD, Nikolich-Žugich J.

Front Immunol. 2017 Jun 14;8:706. doi: 10.3389/fimmu.2017.00706. eCollection 2017. Review.


Dendritic cell expression of the signaling molecule TRAF6 is required for immune tolerance in the lung.

Han D, Walsh MC, Kim KS, Hong SW, Lee J, Yi J, Rivas G, Choi Y, Surh CD.

Int Immunol. 2017 Feb 1;29(2):71-78. doi: 10.1093/intimm/dxx011.


Beyond Hygiene: Commensal Microbiota and Allergic Diseases.

Hong SW, Kim KS, Surh CD.

Immune Netw. 2017 Feb;17(1):48-59. doi: 10.4110/in.2017.17.1.48. Epub 2017 Feb 23. Review.


Gut-Specific Delivery of T-Helper 17 Cells Reduces Obesity and Insulin Resistance in Mice.

Hong CP, Park A, Yang BG, Yun CH, Kwak MJ, Lee GW, Kim JH, Jang MS, Lee EJ, Jeun EJ, You G, Kim KS, Choi Y, Park JH, Hwang D, Im SH, Kim JF, Kim YK, Seoh JY, Surh CD, Kim YM, Jang MH.

Gastroenterology. 2017 Jun;152(8):1998-2010. doi: 10.1053/j.gastro.2017.02.016. Epub 2017 Feb 27.


CD45-mediated control of TCR tuning in naïve and memory CD8+ T cells.

Cho JH, Kim HO, Ju YJ, Kye YC, Lee GW, Lee SW, Yun CH, Bottini N, Webster K, Goodnow CC, Surh CD, King C, Sprent J.

Nat Commun. 2016 Nov 14;7:13373. doi: 10.1038/ncomms13373.


The aged lymphoid tissue environment fails to support naïve T cell homeostasis.

Becklund BR, Purton JF, Ramsey C, Favre S, Vogt TK, Martin CE, Spasova DS, Sarkisyan G, LeRoy E, Tan JT, Wahlus H, Bondi-Boyd B, Luther SA, Surh CD.

Sci Rep. 2016 Aug 2;6:30842. doi: 10.1038/srep30842.


Affinity for self antigen selects Treg cells with distinct functional properties.

Wyss L, Stadinski BD, King CG, Schallenberg S, McCarthy NI, Lee JY, Kretschmer K, Terracciano LM, Anderson G, Surh CD, Huseby ES, Palmer E.

Nat Immunol. 2016 Sep;17(9):1093-101. doi: 10.1038/ni.3522. Epub 2016 Aug 1.


Harnessing the IL-7/IL-7Rα axis to improve tumor immunotherapy.

Johnson CB, Wrangle J, Mehrotra S, Li Z, Paulos CM, Cole DJ, Surh CD, Rubinstein MP.

Oncoimmunology. 2016 Jan 19;5(5):e1122865. doi: 10.1080/2162402X.2015.1122865. eCollection 2016 May.


Human antibody reactivity against xenogeneic N-glycolylneuraminic acid and galactose-α-1,3-galactose antigen.

Hurh S, Kang B, Choi I, Cho B, Lee EM, Kim H, Kim YJ, Chung YS, Jeong JC, Hwang JI, Kim JY, Lee BC, Surh CD, Yang J, Ahn C.

Xenotransplantation. 2016 Jul;23(4):279-92. doi: 10.1111/xen.12239. Epub 2016 Jul 4.


Small intestinal eosinophils regulate Th17 cells by producing IL-1 receptor antagonist.

Sugawara R, Lee EJ, Jang MS, Jeun EJ, Hong CP, Kim JH, Park A, Yun CH, Hong SW, Kim YM, Seoh JY, Jung Y, Surh CD, Miyasaka M, Yang BG, Jang MH.

J Exp Med. 2016 Apr 4;213(4):555-67. doi: 10.1084/jem.20141388. Epub 2016 Mar 7.


Dietary antigens limit mucosal immunity by inducing regulatory T cells in the small intestine.

Kim KS, Hong SW, Han D, Yi J, Jung J, Yang BG, Lee JY, Lee M, Surh CD.

Science. 2016 Feb 19;351(6275):858-63. doi: 10.1126/science.aac5560. Epub 2016 Jan 28.


Transcription factor NFAT1 controls allergic contact hypersensitivity through regulation of activation induced cell death program.

Kwon HK, Kim GC, Hwang JS, Kim Y, Chae CS, Nam JH, Jun CD, Rudra D, Surh CD, Im SH.

Sci Rep. 2016 Jan 18;6:19453. doi: 10.1038/srep19453.


Intranasal Introduction of Fc-Fused Interleukin-7 Provides Long-Lasting Prophylaxis against Lethal Influenza Virus Infection.

Kang MC, Choi DH, Choi YW, Park SJ, Namkoong H, Park KS, Ahn SS, Surh CD, Yoon SW, Kim DJ, Choi JA, Park Y, Sung YC, Lee SW.

J Virol. 2015 Dec 9;90(5):2273-84. doi: 10.1128/JVI.02768-15.


Pep19 drives epitope spreading in periodontitis and periodontitis-associated autoimmune diseases.

Kwon EY, Cha GS, Jeong E, Lee JY, Kim SJ, Surh CD, Choi J.

J Periodontal Res. 2016 Jun;51(3):381-94. doi: 10.1111/jre.12318. Epub 2015 Sep 12.


Induction of Immune Tolerance to Dietary Antigens.

Kim KS, Surh CD.

Adv Exp Med Biol. 2015;850:93-118. doi: 10.1007/978-3-319-15774-0_8. Review.


Microbiota-Independent Ameliorative Effects of Antibiotics on Spontaneous Th2-Associated Pathology of the Small Intestine.

Han D, Walsh MC, Kim KS, Hong SW, Lee J, Yi J, Rivas G, Surh CD, Choi Y.

PLoS One. 2015 Feb 17;10(2):e0118795. doi: 10.1371/journal.pone.0118795. eCollection 2015. Erratum in: PLoS One. 2015;10(7):e0133787.


miR-155 augments CD8+ T-cell antitumor activity in lymphoreplete hosts by enhancing responsiveness to homeostatic γc cytokines.

Ji Y, Wrzesinski C, Yu Z, Hu J, Gautam S, Hawk NV, Telford WG, Palmer DC, Franco Z, Sukumar M, Roychoudhuri R, Clever D, Klebanoff CA, Surh CD, Waldmann TA, Restifo NP, Gattinoni L.

Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):476-81. doi: 10.1073/pnas.1422916112. Epub 2014 Dec 29.


Clearance of persistent HPV infection and cervical lesion by therapeutic DNA vaccine in CIN3 patients.

Kim TJ, Jin HT, Hur SY, Yang HG, Seo YB, Hong SR, Lee CW, Kim S, Woo JW, Park KS, Hwang YY, Park J, Lee IH, Lim KT, Lee KH, Jeong MS, Surh CD, Suh YS, Park JS, Sung YC.

Nat Commun. 2014 Oct 30;5:5317. doi: 10.1038/ncomms6317.


Blowing on embers: commensal microbiota and our immune system.

Spasova DS, Surh CD.

Front Immunol. 2014 Jul 28;5:318. doi: 10.3389/fimmu.2014.00318. eCollection 2014. Review.


Crucial roles of interleukin-7 in the development of T follicular helper cells and in the induction of humoral immunity.

Seo YB, Im SJ, Namkoong H, Kim SW, Choi YW, Kang MC, Lim HS, Jin HT, Yang SH, Cho ML, Kim YM, Lee SW, Choi YK, Surh CD, Sung YC.

J Virol. 2014 Aug;88(16):8998-9009. doi: 10.1128/JVI.00534-14. Epub 2014 Jun 4.


Self-gratification yields not-so-naive T cells.

Martin CE, Surh CD.

Nat Immunol. 2014 Mar;15(3):217-9. doi: 10.1038/ni.2832. No abstract available.


Unique features of naive CD8+ T cell activation by IL-2.

Cho JH, Kim HO, Kim KS, Yang DH, Surh CD, Sprent J.

J Immunol. 2013 Dec 1;191(11):5559-73. doi: 10.4049/jimmunol.1302293. Epub 2013 Oct 28.


IL-2/anti-IL-2 complex attenuates renal ischemia-reperfusion injury through expansion of regulatory T cells.

Kim MG, Koo TY, Yan JJ, Lee E, Han KH, Jeong JC, Ro H, Kim BS, Jo SK, Oh KH, Surh CD, Ahn C, Yang J.

J Am Soc Nephrol. 2013 Oct;24(10):1529-36. doi: 10.1681/ASN.2012080784. Epub 2013 Jul 5.


CD70-CD27 ligation between neural stem cells and CD4+ T cells induces Fas-FasL-mediated T-cell death.

Lee EM, Hurh S, Cho B, Oh KH, Kim SU, Surh CD, Sprent J, Yang J, Kim JY, Ahn C.

Stem Cell Res Ther. 2013 May 21;4(3):56. doi: 10.1186/scrt206.


IL-7/anti-IL-7 mAb complexes augment cytokine potency in mice through association with IgG-Fc and by competition with IL-7R.

Martin CE, van Leeuwen EM, Im SJ, Roopenian DC, Sung YC, Surh CD.

Blood. 2013 May 30;121(22):4484-92. doi: 10.1182/blood-2012-08-449215. Epub 2013 Apr 22.


Homeostatic proliferation of mature T cells.

Martin CE, Frimpong-Boateng K, Spasova DS, Stone JC, Surh CD.

Methods Mol Biol. 2013;979:81-106. doi: 10.1007/978-1-62703-290-2_9.


Systemic human T cell developmental processes in humanized mice cotransplanted with human fetal thymus/liver tissue and hematopoietic stem cells.

Joo SY, Chung YS, Choi B, Kim M, Kim JH, Jun TG, Chang J, Sprent J, Surh CD, Joh JW, Kim SJ.

Transplantation. 2012 Dec 15;94(11):1095-102. doi: 10.1097/TP.0b013e318270f392.


Interleukin-2/anti-interleukin-2 monoclonal antibody immune complex suppresses collagen-induced arthritis in mice by fortifying interleukin-2/STAT5 signalling pathways.

Lee SY, Cho ML, Oh HJ, Ryu JG, Park MJ, Jhun JY, Park MK, Stone JC, Ju JH, Hwang SY, Park SH, Surh CD, Kim HY.

Immunology. 2012 Dec;137(4):305-16. doi: 10.1111/imm.12008.


Generation and characterization of human heme oxygenase-1 transgenic pigs.

Yeom HJ, Koo OJ, Yang J, Cho B, Hwang JI, Park SJ, Hurh S, Kim H, Lee EM, Ro H, Kang JT, Kim SJ, Won JK, O'Connell PJ, Kim H, Surh CD, Lee BC, Ahn C.

PLoS One. 2012;7(10):e46646. doi: 10.1371/journal.pone.0046646. Epub 2012 Oct 5.


TGF-β puts the brakes on homeostatic proliferation.

Surh CD, Sprent J.

Nat Immunol. 2012 Jun 19;13(7):628-30. doi: 10.1038/ni.2345. No abstract available.


Selectively expanding subsets of T cells in mice by injection of interleukin-2/antibody complexes: implications for transplantation tolerance.

Boyman O, Krieg C, Letourneau S, Webster K, Surh CD, Sprent J.

Transplant Proc. 2012 May;44(4):1032-4. doi: 10.1016/j.transproceed.2012.01.093. Review.


Interleukin 7, maestro of the immune system.

Sprent J, Surh CD.

Semin Immunol. 2012 Jun;24(3):149-50. doi: 10.1016/j.smim.2012.04.011. Epub 2012 May 1. No abstract available.


IL-7 signaling and CD127 receptor regulation in the control of T cell homeostasis.

Carrette F, Surh CD.

Semin Immunol. 2012 Jun;24(3):209-17. doi: 10.1016/j.smim.2012.04.010. Epub 2012 May 1. Review.


In vivo accumulation of T cells in response to IL-2/anti-IL-2 mAb complexes is dependent in part on the TNF family ligand 4-1BBL.

Lin GH, Stone JC, Surh CD, Watts TH.

Immunol Cell Biol. 2012 Aug;90(7):743-7. doi: 10.1038/icb.2011.83. Epub 2011 Sep 27.


Dissecting the requirements for maintenance of the CMV-specific memory T-cell pool.

Loewendorf AI, Arens R, Purton JF, Surh CD, Benedict CA.

Viral Immunol. 2011 Aug;24(4):351-5. doi: 10.1089/vim.2010.0140. Epub 2011 Jul 1.


Generation of soluble human tumor necrosis factor-α receptor 1-Fc transgenic pig.

Cho B, Koo OJ, Hwang JI, Kim H, Lee EM, Hurh S, Park SJ, Ro H, Yang J, Surh CD, D'Apice AJ, Lee BC, Ahn C.

Transplantation. 2011 Jul 27;92(2):139-47. doi: 10.1097/TP.0b013e3182215e7e.


Is IL-7 from dendritic cells essential for the homeostasis of CD4+ T cells?

Martin CE, Kim DM, Sprent J, Surh CD.

Nat Immunol. 2010 Jul;11(7):547-8; author reply 548. doi: 10.1038/ni0710-547. No abstract available.


T cell receptor-dependent regulation of lipid rafts controls naive CD8+ T cell homeostasis.

Cho JH, Kim HO, Surh CD, Sprent J.

Immunity. 2010 Feb 26;32(2):214-26. doi: 10.1016/j.immuni.2009.11.014. Epub 2010 Feb 4.


IL-2/anti-IL-2 antibody complexes show strong biological activity by avoiding interaction with IL-2 receptor alpha subunit CD25.

Létourneau S, van Leeuwen EM, Krieg C, Martin C, Pantaleo G, Sprent J, Surh CD, Boyman O.

Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2171-6. doi: 10.1073/pnas.0909384107. Epub 2010 Jan 19.


Glimpsing the real CD4+ T cell response.

Surh CD, Sprent J.

Nat Immunol. 2010 Jan;11(1):47-9. doi: 10.1038/ni0110-47. No abstract available.


Characterization in vitro and engraftment potential in vivo of human progenitor T cells generated from hematopoietic stem cells.

Awong G, Herer E, Surh CD, Dick JE, La Motte-Mohs RN, Zúñiga-Pflücker JC.

Blood. 2009 Jul 30;114(5):972-82. doi: 10.1182/blood-2008-10-187013. Epub 2009 Jun 2.


In vivo expansion of T reg cells with IL-2-mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression.

Webster KE, Walters S, Kohler RE, Mrkvan T, Boyman O, Surh CD, Grey ST, Sprent J.

J Exp Med. 2009 Apr 13;206(4):751-60. doi: 10.1084/jem.20082824. Epub 2009 Mar 30.

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