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Items: 1 to 50 of 287

1.

Tracing the transitions from pluripotency to germ cell fate with CRISPR screening.

Hackett JA, Huang Y, Günesdogan U, Gretarsson KA, Kobayashi T, Surani MA.

Nat Commun. 2018 Oct 16;9(1):4292. doi: 10.1038/s41467-018-06230-0.

PMID:
30327475
2.

Metabolic regulation of pluripotency and germ cell fate through α-ketoglutarate.

Tischler J, Gruhn WH, Reid J, Allgeyer E, Buettner F, Marr C, Theis F, Simons BD, Wernisch L, Surani MA.

EMBO J. 2018 Sep 26. pii: e99518. doi: 10.15252/embj.201899518. [Epub ahead of print]

3.

Staged profiling of sperm development in sync.

Ramakrishna NB, Surani MA.

Cell Res. 2018 Oct;28(10):965-966. doi: 10.1038/s41422-018-0088-5. No abstract available.

PMID:
30218061
4.

Targeted DamID reveals differential binding of mammalian pluripotency factors.

Cheetham SW, Gruhn WH, van den Ameele J, Krautz R, Southall TD, Kobayashi T, Surani MA, Brand AH.

Development. 2018 Oct 17;145(20). pii: dev170209. doi: 10.1242/dev.170209.

PMID:
30185410
5.

On the origin of the human germline.

Kobayashi T, Surani MA.

Development. 2018 Jul 23;145(16). pii: dev150433. doi: 10.1242/dev.150433. Review.

PMID:
30037844
6.

SRSF3 maintains transcriptome integrity in oocytes by regulation of alternative splicing and transposable elements.

Do DV, Strauss B, Cukuroglu E, Macaulay I, Wee KB, Hu TX, Igor RLM, Lee C, Harrison A, Butler R, Dietmann S, Jernej U, Marioni J, Smith CWJ, Göke J, Surani MA.

Cell Discov. 2018 Jun 19;4:33. doi: 10.1038/s41421-018-0032-3. eCollection 2018.

7.

What Can Stem Cell Models Tell Us About Human Germ Cell Biology?

Irie N, Sybirna A, Surani MA.

Curr Top Dev Biol. 2018;129:25-65. doi: 10.1016/bs.ctdb.2018.02.010. Epub 2018 Apr 16.

PMID:
29801530
8.

G9a regulates temporal preimplantation developmental program and lineage segregation in blastocyst.

Zylicz JJ, Borensztein M, Wong FC, Huang Y, Lee C, Dietmann S, Surani MA.

Elife. 2018 May 10;7. pii: e33361. doi: 10.7554/eLife.33361.

9.

A PAX5-OCT4-PRDM1 developmental switch specifies human primordial germ cells.

Fang F, Angulo B, Xia N, Sukhwani M, Wang Z, Carey CC, Mazurie A, Cui J, Wilkinson R, Wiedenheft B, Irie N, Surani MA, Orwig KE, Reijo Pera RA.

Nat Cell Biol. 2018 Jun;20(6):655-665. doi: 10.1038/s41556-018-0094-3. Epub 2018 Apr 30.

PMID:
29713018
10.

Author Correction: Segregation of mitochondrial DNA heteroplasmy through a developmental genetic bottleneck in human embryos.

Floros VI, Pyle A, Dietmann S, Wei W, Tang WWC, Irie N, Payne B, Capalbo A, Noli L, Coxhead J, Hudson G, Crosier M, Strahl H, Khalaf Y, Saitou M, Ilic D, Surani MA, Chinnery PF.

Nat Cell Biol. 2018 Aug;20(8):991. doi: 10.1038/s41556-018-0064-9.

PMID:
29674682
11.

Segregation of mitochondrial DNA heteroplasmy through a developmental genetic bottleneck in human embryos.

Floros VI, Pyle A, Dietmann S, Wei W, Tang WCW, Irie N, Payne B, Capalbo A, Noli L, Coxhead J, Hudson G, Crosier M, Strahl H, Khalaf Y, Saitou M, Ilic D, Surani MA, Chinnery PF.

Nat Cell Biol. 2018 Feb;20(2):144-151. doi: 10.1038/s41556-017-0017-8. Epub 2018 Jan 15. Erratum in: Nat Cell Biol. 2018 Apr 19;:.

PMID:
29335530
12.

Esrrb Complementation Rescues Development of Nanog-Null Germ Cells.

Zhang M, Leitch HG, Tang WWC, Festuccia N, Hall-Ponsele E, Nichols J, Surani MA, Smith A, Chambers I.

Cell Rep. 2018 Jan 9;22(2):332-339. doi: 10.1016/j.celrep.2017.12.060.

13.

Germline competency of human embryonic stem cells depends on eomesodermin.

Chen D, Liu W, Lukianchikov A, Hancock GV, Zimmerman J, Lowe MG, Kim R, Galic Z, Irie N, Surani MA, Jacobsen SE, Clark AT.

Biol Reprod. 2017 Jan 1;97(6):850-861. doi: 10.1093/biolre/iox138.

PMID:
29091993
14.

Derivation of hypermethylated pluripotent embryonic stem cells with high potency.

Bao S, Tang WW, Wu B, Kim S, Li J, Li L, Kobayashi T, Lee C, Chen Y, Wei M, Li S, Dietmann S, Tang F, Li X, Surani MA.

Cell Res. 2018 Jan;28(1):22-34. doi: 10.1038/cr.2017.134. Epub 2017 Oct 27.

15.

Principles of early human development and germ cell program from conserved model systems.

Kobayashi T, Zhang H, Tang WWC, Irie N, Withey S, Klisch D, Sybirna A, Dietmann S, Contreras DA, Webb R, Allegrucci C, Alberio R, Surani MA.

Nature. 2017 Jun 15;546(7658):416-420. doi: 10.1038/nature22812. Epub 2017 Jun 7.

16.

Activation of Lineage Regulators and Transposable Elements across a Pluripotent Spectrum.

Hackett JA, Kobayashi T, Dietmann S, Surani MA.

Stem Cell Reports. 2017 Jun 6;8(6):1645-1658. doi: 10.1016/j.stemcr.2017.05.014.

17.

Stella modulates transcriptional and endogenous retrovirus programs during maternal-to-zygotic transition.

Huang Y, Kim JK, Do DV, Lee C, Penfold CA, Zylicz JJ, Marioni JC, Hackett JA, Surani MA.

Elife. 2017 Mar 21;6. pii: e22345. doi: 10.7554/eLife.22345.

18.
19.

Specification and epigenetic programming of the human germ line.

Tang WW, Kobayashi T, Irie N, Dietmann S, Surani MA.

Nat Rev Genet. 2016 Oct;17(10):585-600. doi: 10.1038/nrg.2016.88. Epub 2016 Aug 30. Review.

PMID:
27573372
20.

DNA (De)Methylation: The Passive Route to Naïvety?

Leitch HG, Surani MA, Hajkova P.

Trends Genet. 2016 Oct;32(10):592-595. doi: 10.1016/j.tig.2016.08.005. Epub 2016 Aug 17.

21.

In retrospect: Thirty-five years of endless cell potential.

Surani MA.

Nature. 2016 Jul 28;535(7613):502-3. doi: 10.1038/535502a. No abstract available.

PMID:
27466122
22.

Developmental Competence for Primordial Germ Cell Fate.

Günesdogan U, Surani MA.

Curr Top Dev Biol. 2016;117:471-96. doi: 10.1016/bs.ctdb.2015.11.007. Epub 2016 Feb 18. Review.

PMID:
26969996
23.

Breaking the germ line-soma barrier.

Surani MA.

Nat Rev Mol Cell Biol. 2016 Mar;17(3):136. doi: 10.1038/nrm.2016.12. Epub 2016 Feb 10. No abstract available.

PMID:
26860363
24.

Trim28 Haploinsufficiency Triggers Bi-stable Epigenetic Obesity.

Dalgaard K, Landgraf K, Heyne S, Lempradl A, Longinotto J, Gossens K, Ruf M, Orthofer M, Strogantsev R, Selvaraj M, Lu TT, Casas E, Teperino R, Surani MA, Zvetkova I, Rimmington D, Tung YC, Lam B, Larder R, Yeo GS, O'Rahilly S, Vavouri T, Whitelaw E, Penninger JM, Jenuwein T, Cheung CL, Ferguson-Smith AC, Coll AP, Körner A, Pospisilik JA.

Cell. 2016 Jan 28;164(3):353-64. doi: 10.1016/j.cell.2015.12.025.

25.

Providing Care Beyond the Hospital: Perspective of a Tertiary Care Hospital from a Developing Country.

Khan SA, Waqas M, Ujjan BU, Salim A, Javed G, Ahmed SI, Surani M, Khan M.

World Neurosurg. 2016 Apr;88:370-3. doi: 10.1016/j.wneu.2015.12.086. Epub 2016 Jan 2.

PMID:
26752090
26.

NANOG alone induces germ cells in primed epiblast in vitro by activation of enhancers.

Murakami K, Günesdogan U, Zylicz JJ, Tang WWC, Sengupta R, Kobayashi T, Kim S, Butler R, Dietmann S, Surani MA.

Nature. 2016 Jan 21;529(7586):403-407. doi: 10.1038/nature16480. Epub 2016 Jan 11.

27.

Chromatin dynamics and the role of G9a in gene regulation and enhancer silencing during early mouse development.

Zylicz JJ, Dietmann S, Günesdogan U, Hackett JA, Cougot D, Lee C, Surani MA.

Elife. 2015 Nov 9;4. pii: e09571. doi: 10.7554/eLife.09571.

28.

Germline and Pluripotent Stem Cells.

Reik W, Surani MA.

Cold Spring Harb Perspect Biol. 2015 Nov 2;7(11). pii: a019422. doi: 10.1101/cshperspect.a019422. Review.

29.

Simultaneous deletion of the methylcytosine oxidases Tet1 and Tet3 increases transcriptome variability in early embryogenesis.

Kang J, Lienhard M, Pastor WA, Chawla A, Novotny M, Tsagaratou A, Lasken RS, Thompson EC, Surani MA, Koralov SB, Kalantry S, Chavez L, Rao A.

Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):E4236-45. doi: 10.1073/pnas.1510510112. Epub 2015 Jul 21.

30.

Mest but Not MiR-335 Affects Skeletal Muscle Growth and Regeneration.

Hiramuki Y, Sato T, Furuta Y, Surani MA, Sehara-Fujisawa A.

PLoS One. 2015 Jun 22;10(6):e0130436. doi: 10.1371/journal.pone.0130436. eCollection 2015.

31.

A Unique Gene Regulatory Network Resets the Human Germline Epigenome for Development.

Tang WW, Dietmann S, Irie N, Leitch HG, Floros VI, Bradshaw CR, Hackett JA, Chinnery PF, Surani MA.

Cell. 2015 Jun 4;161(6):1453-67. doi: 10.1016/j.cell.2015.04.053.

32.

Human Germline: A New Research Frontier.

Surani MA.

Stem Cell Reports. 2015 Jun 9;4(6):955-60. doi: 10.1016/j.stemcr.2015.04.014. Epub 2015 May 28. Review.

33.

SOX17 is a critical specifier of human primordial germ cell fate.

Irie N, Weinberger L, Tang WW, Kobayashi T, Viukov S, Manor YS, Dietmann S, Hanna JH, Surani MA.

Cell. 2015 Jan 15;160(1-2):253-68. doi: 10.1016/j.cell.2014.12.013. Epub 2014 Dec 24.

34.

PRMT5 protects genomic integrity during global DNA demethylation in primordial germ cells and preimplantation embryos.

Kim S, Günesdogan U, Zylicz JJ, Hackett JA, Cougot D, Bao S, Lee C, Dietmann S, Allen GE, Sengupta R, Surani MA.

Mol Cell. 2014 Nov 20;56(4):564-79. doi: 10.1016/j.molcel.2014.10.003. Epub 2014 Nov 6.

35.

Primordial germ cell specification: a context-dependent cellular differentiation event [corrected].

Günesdogan U, Magnúsdóttir E, Surani MA.

Philos Trans R Soc Lond B Biol Sci. 2014 Dec 5;369(1657). pii: 20130543. doi: 10.1098/rstb.2013.0543. Review. Erratum in: Philos Trans R Soc Lond B Biol Sci. 2014 Dec 19;369(1658):20140314.

36.

Regulatory principles of pluripotency: from the ground state up.

Hackett JA, Surani MA.

Cell Stem Cell. 2014 Oct 2;15(4):416-430. doi: 10.1016/j.stem.2014.09.015. Review.

37.

Dynamic heterogeneity and DNA methylation in embryonic stem cells.

Singer ZS, Yong J, Tischler J, Hackett JA, Altinok A, Surani MA, Cai L, Elowitz MB.

Mol Cell. 2014 Jul 17;55(2):319-31. doi: 10.1016/j.molcel.2014.06.029.

38.

How to make a primordial germ cell.

Magnúsdóttir E, Surani MA.

Development. 2014 Jan;141(2):245-52. doi: 10.1242/dev.098269. Review.

39.

Synergistic mechanisms of DNA demethylation during transition to ground-state pluripotency.

Hackett JA, Dietmann S, Murakami K, Down TA, Leitch HG, Surani MA.

Stem Cell Reports. 2013 Dec 17;1(6):518-31. doi: 10.1016/j.stemcr.2013.11.010. eCollection 2013.

40.

Rebuilding pluripotency from primordial germ cells.

Leitch HG, Nichols J, Humphreys P, Mulas C, Martello G, Lee C, Jones K, Surani MA, Smith A.

Stem Cell Reports. 2013 Jun 4;1(1):66-78. doi: 10.1016/j.stemcr.2013.03.004. eCollection 2013.

41.

Reversion of mouse postimplantation epiblast stem cells to a naïve pluripotent state by modulation of signalling pathways.

Gillich A, Bao S, Surani MA.

Methods Mol Biol. 2013;1074:15-29. doi: 10.1007/978-1-62703-628-3_2.

PMID:
23975802
42.

Perceiving signals, building networks, reprogramming germ cell fate.

Barrios F, Irie N, Surani MA.

Int J Dev Biol. 2013;57(2-4):123-32. doi: 10.1387/ijdb.130132fb. Review.

43.

Prdm14 promotes germline fate and naive pluripotency by repressing FGF signalling and DNA methylation.

Grabole N, Tischler J, Hackett JA, Kim S, Tang F, Leitch HG, Magnúsdóttir E, Surani MA.

EMBO Rep. 2013 Jul;14(7):629-37. doi: 10.1038/embor.2013.67. Epub 2013 May 14.

44.

Beyond DNA: programming and inheritance of parental methylomes.

Hackett JA, Surani MA.

Cell. 2013 May 9;153(4):737-9. doi: 10.1016/j.cell.2013.04.044.

45.

Primordial germ-cell development and epigenetic reprogramming in mammals.

Leitch HG, Tang WW, Surani MA.

Curr Top Dev Biol. 2013;104:149-87. doi: 10.1016/B978-0-12-416027-9.00005-X. Review.

PMID:
23587241
46.

Naive pluripotency is associated with global DNA hypomethylation.

Leitch HG, McEwen KR, Turp A, Encheva V, Carroll T, Grabole N, Mansfield W, Nashun B, Knezovich JG, Smith A, Surani MA, Hajkova P.

Nat Struct Mol Biol. 2013 Mar;20(3):311-6. doi: 10.1038/nsmb.2510. Epub 2013 Feb 17.

47.

Astroglial IFITM3 mediates neuronal impairments following neonatal immune challenge in mice.

Ibi D, Nagai T, Nakajima A, Mizoguchi H, Kawase T, Tsuboi D, Kano S, Sato Y, Hayakawa M, Lange UC, Adams DJ, Surani MA, Satoh T, Sawa A, Kaibuchi K, Nabeshima T, Yamada K.

Glia. 2013 May;61(5):679-93. doi: 10.1002/glia.22461. Epub 2013 Feb 4.

PMID:
23382131
48.

Germline DNA demethylation dynamics and imprint erasure through 5-hydroxymethylcytosine.

Hackett JA, Sengupta R, Zylicz JJ, Murakami K, Lee C, Down TA, Surani MA.

Science. 2013 Jan 25;339(6118):448-52. doi: 10.1126/science.1229277. Epub 2012 Dec 6.

49.

Cellular reprogramming in pursuit of immortality.

Surani MA.

Cell Stem Cell. 2012 Dec 7;11(6):748-50. doi: 10.1016/j.stem.2012.11.014.

50.

DNA methylation dynamics during the mammalian life cycle.

Hackett JA, Surani MA.

Philos Trans R Soc Lond B Biol Sci. 2013 Jan 5;368(1609):20110328. doi: 10.1098/rstb.2011.0328. Review.

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