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Items: 1 to 50 of 1320

1.

Synthesis, X-ray structure, in silico calculation, and carbonic anhydrase inhibitory properties of benzylimidazole metal complexes.

Bouchouit M, Bouacida S, Zouchoune B, Merazig H, Bua S, Bouaziz Z, Le Borgne M, Supuran CT, Bouraiou A.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):1150-1159. doi: 10.1080/14756366.2018.1481404.

PMID:
30001665
2.

Selective inhibition of carbonic anhydrase-IX by sulphonamide derivatives induces pH and reactive oxygen species-mediated apoptosis in cervical cancer HeLa cells.

Koyuncu I, Gonel A, Kocyigit A, Temiz E, Durgun M, Supuran CT.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):1137-1149. doi: 10.1080/14756366.2018.1481403.

PMID:
30001631
3.

Synthesis of novel benzenesulfamide derivatives with inhibitory activity against human cytosolic carbonic anhydrase I and II and Vibrio cholerae α- and β-class enzymes.

Bua S, Berrino E, Del Prete S, Murthy VS, Vijayakumar V, Tamboli Y, Capasso C, Cerbai E, Mugelli A, Carta F, Supuran CT.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):1125-1136. doi: 10.1080/14756366.2018.1467901.

PMID:
29987956
4.

Intermolecular amination of allylic and benzylic alcohols leads to effective inhibitions of acetylcholinesterase enzyme and carbonic anhydrase I and II isoenzymes.

Atmaca U, Yıldırım A, Taslimi P, Çelik ST, Gülçin İ, Supuran CT, Çelik M.

J Biochem Mol Toxicol. 2018 Jul 5:e22173. doi: 10.1002/jbt.22173. [Epub ahead of print]

PMID:
29975450
5.

Biomedical applications of prokaryotic carbonic anhydrases.

Supuran CT, Capasso C.

Expert Opin Ther Pat. 2018 Jul 4. doi: 10.1080/13543776.2018.1497161. [Epub ahead of print]

PMID:
29973089
6.

Treatment of sleep apnea with a combination of a Carbonic Anhydrase inhibitor and an Aldosterone Antagonist: A patent evaluation of CA2958110 and IN6616DEN2012.

Angeli A, Supuran CT.

Expert Opin Ther Pat. 2018 Jul 4. doi: 10.1080/13543776.2018.1497160. [Epub ahead of print]

PMID:
29972645
7.

The zinc - but not cadmium - containing ζ-carbonic from the diatom Thalassiosira weissflogii is potently activated by amines and amino acids.

Angeli A, Buonanno M, Donald WA, Monti SM, Supuran CT.

Bioorg Chem. 2018 May 26;80:261-265. doi: 10.1016/j.bioorg.2018.05.027. [Epub ahead of print]

PMID:
29966872
8.

Discovery of 4-Hydroxy-3-(3-(phenylureido)benzenesulfonamides As SLC-0111 Analogues For the Treatment of Hypoxic Tumors Overexpressing Carbonic Anhydrase IX.

Bozdag M, Carta F, Ceruso M, Ferraroni M, McDonald PC, Dedhar S, Supuran CT.

J Med Chem. 2018 Jul 2. doi: 10.1021/acs.jmedchem.8b00770. [Epub ahead of print]

PMID:
29962205
9.

Development of a Fingerprint-Based Scoring Function for the Prediction of the Binding Mode of Carbonic Anhydrase II Inhibitors.

Poli G, Jha V, Martinelli A, Supuran CT, Tuccinardi T.

Int J Mol Sci. 2018 Jun 23;19(7). pii: E1851. doi: 10.3390/ijms19071851.

10.

State of the Art on Carbonic Anhydrase Modulators for Biomedical Purposes.

Bozdag M, Altamimi ASA, Vullo D, Supuran CT, Carta F.

Curr Med Chem. 2018 Jun 22. doi: 10.2174/0929867325666180622120625. [Epub ahead of print]

PMID:
29932025
11.

4-Substituted Benzenesulfonamides Incorporating Bi/Tricyclic Moieties Act as Potent and Isoform-Selective Carbonic Anhydrase II/IX Inhibitors.

Salerno S, Barresi E, Amendola G, Berrino E, Milite C, Marini AM, Da Settimo F, Novellino E, Supuran CT, Cosconati S, Taliani S.

J Med Chem. 2018 Jul 12;61(13):5765-5770. doi: 10.1021/acs.jmedchem.8b00670. Epub 2018 Jun 27.

PMID:
29912561
12.

Nitroimidazole-based inhibitors DTP338 and DTP348 are safe for zebrafish embryos and efficiently inhibit the activity of human CA IX in Xenopus oocytes.

Aspatwar A, Becker HM, Parvathaneni NK, Hammaren M, Svorjova A, Barker H, Supuran CT, Dubois L, Lambin P, Parikka M, Parkkila S, Winum JY.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):1064-1073. doi: 10.1080/14756366.2018.1482285.

13.

Design and synthesis of novel benzenesulfonamide containing 1,2,3-triazoles as potent human carbonic anhydrase isoforms I, II, IV and IX inhibitors.

Kumar R, Vats L, Bua S, Supuran CT, Sharma PK.

Eur J Med Chem. 2018 Jun 8;155:545-551. doi: 10.1016/j.ejmech.2018.06.021. [Epub ahead of print]

PMID:
29909339
14.

pH regulators to target the tumor immune microenvironment in human hepatocellular carcinoma.

Kuchuk O, Tuccitto A, Citterio D, Huber V, Camisaschi C, Milione M, Vergani B, Villa A, Alison MR, Carradori S, Supuran CT, Rivoltini L, Castelli C, Mazzaferro V.

Oncoimmunology. 2018 Mar 26;7(7):e1445452. doi: 10.1080/2162402X.2018.1445452. eCollection 2018.

15.

The first activation studies of the η-carbonic anhydrase from the malaria parasite Plasmodium falciparum with amines and amino acids.

Angeli A, Del Prete S, Alasmary FAS, Alqahtani LS, AlOthman Z, Donald WA, Capasso C, Supuran CT.

Bioorg Chem. 2018 Jun 4;80:94-98. doi: 10.1016/j.bioorg.2018.06.002. [Epub ahead of print]

PMID:
29894892
16.

CAIX furthers tumour progression in the hypoxic tumour microenvironment of esophageal carcinoma and is a possible therapeutic target.

Drenckhan A, Freytag M, Supuran CT, Sauter G, Izbicki JR, Gros SJ.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):1024-1033. doi: 10.1080/14756366.2018.1475369.

17.

Benzamide-4-Sulfonamides Are Effective Human Carbonic Anhydrase I, II, VII, and IX Inhibitors.

Abdoli M, Bozdag M, Angeli A, Supuran CT.

Metabolites. 2018 Jun 1;8(2). pii: E37. doi: 10.3390/metabo8020037.

18.

Discovery of β-Adrenergic Receptors Blocker-Carbonic Anhydrase Inhibitor Hybrids for Multitargeted Antiglaucoma Therapy.

Nocentini A, Ceruso M, Bua S, Lomelino CL, Andring JT, McKenna R, Lanzi C, Sgambellone S, Pecori R, Matucci R, Filippi L, Gratteri P, Carta F, Masini E, Selleri S, Supuran CT.

J Med Chem. 2018 Jun 28;61(12):5380-5394. doi: 10.1021/acs.jmedchem.8b00625. Epub 2018 Jun 13.

PMID:
29851481
19.

Dioxygen, an unexpected carbonic anhydrase ligand.

Ferraroni M, Gaspari R, Scozzafava A, Cavalli A, Supuran CT.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):999-1005. doi: 10.1080/14756366.2018.1475371.

20.

Design, synthesis and X-ray crystallography of selenides bearing benzenesulfonamide moiety with neuropathic pain modulating effects.

Angeli A, di Cesare Mannelli L, Lucarini E, Peat TS, Ghelardini C, Supuran CT.

Eur J Med Chem. 2018 Jun 25;154:210-219. doi: 10.1016/j.ejmech.2018.05.026. Epub 2018 May 19.

PMID:
29803994
21.

Selenides bearing benzenesulfonamide show potent inhibition activity against carbonic anhydrases from pathogenic bacteria Vibrio cholerae and Burkholderia pseudomallei.

Angeli A, Abbas G, Del Prete S, Capasso C, Supuran CT.

Bioorg Chem. 2018 Sep;79:319-322. doi: 10.1016/j.bioorg.2018.05.015. Epub 2018 May 18.

PMID:
29803078
22.

Design, Synthesis, and X-ray of Selenides as New Class of Agents for Prevention of Diabetic Cerebrovascular Pathology.

Angeli A, di Cesare Mannelli L, Trallori E, Peat TS, Ghelardini C, Carta F, Supuran CT.

ACS Med Chem Lett. 2018 Apr 9;9(5):462-467. doi: 10.1021/acsmedchemlett.8b00076. eCollection 2018 May 10.

PMID:
29795760
23.

The Crystal Structure of a hCA VII Variant Provides Insights into the Molecular Determinants Responsible for Its Catalytic Behavior.

Buonanno M, Di Fiore A, Langella E, D'Ambrosio K, Supuran CT, Monti SM, De Simone G.

Int J Mol Sci. 2018 May 24;19(6). pii: E1571. doi: 10.3390/ijms19061571.

24.

Amino Acids as Building Blocks for Carbonic Anhydrase Inhibitors.

Chiaramonte N, Romanelli MN, Teodori E, Supuran CT.

Metabolites. 2018 May 24;8(2). pii: E36. doi: 10.3390/metabo8020036. Review.

25.

Evaluation of 99mTc-sulfonamide and sulfocoumarin derivatives for imaging carbonic anhydrase IX expression.

Nakai M, Pan J, Lin KS, Thompson JR, Nocentini A, Supuran CT, Nakabayashi Y, Storr T.

J Inorg Biochem. 2018 Aug;185:63-70. doi: 10.1016/j.jinorgbio.2018.04.009. Epub 2018 Apr 13.

PMID:
29778927
26.

Evaluation of sulphonamide derivatives acting as inhibitors of human carbonic anhydrase isoforms I, II and Mycobacterium tuberculosis β-class enzyme Rv3273.

Wani TV, Bua S, Khude PS, Chowdhary AH, Supuran CT, Toraskar MP.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):962-971. doi: 10.1080/14756366.2018.1471475.

27.

Activation of β- and γ-carbonic anhydrases from pathogenic bacteria with tripeptides.

Stefanucci A, Angeli A, Dimmito MP, Luisi G, Del Prete S, Capasso C, Donald WA, Mollica A, Supuran CT.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):945-950. doi: 10.1080/14756366.2018.1468530.

28.

Discovery of Novel Nonsteroidal Anti-Inflammatory Drugs and Carbonic Anhydrase Inhibitors Hybrids (NSAIDs-CAIs) for the Management of Rheumatoid Arthritis.

Akgul O, Di Cesare Mannelli L, Vullo D, Angeli A, Ghelardini C, Bartolucci G, Alfawaz Altamimi AS, Scozzafava A, Supuran CT, Carta F.

J Med Chem. 2018 Jun 14;61(11):4961-4977. doi: 10.1021/acs.jmedchem.8b00420. Epub 2018 May 21.

PMID:
29746127
29.

pH-Sensitive Multiligand Gold Nanoplatform Targeting Carbonic Anhydrase IX Enhances the Delivery of Doxorubicin to Hypoxic Tumor Spheroids and Overcomes the Hypoxia-Induced Chemoresistance.

Shabana AM, Mondal UK, Alam MR, Spoon T, Ross CA, Madesh M, Supuran CT, Ilies MA.

ACS Appl Mater Interfaces. 2018 May 30;10(21):17792-17808. doi: 10.1021/acsami.8b05607. Epub 2018 May 15.

PMID:
29733576
30.

Benzoxaborole compounds for therapeutic uses: a patent review (2010- 2018).

Nocentini A, Supuran CT, Winum JY.

Expert Opin Ther Pat. 2018 Jun;28(6):493-504. doi: 10.1080/13543776.2018.1473379. Epub 2018 May 11. Review. Erratum in: Expert Opin Ther Pat. 2018 Jun;28(6):vii.

PMID:
29727210
31.

Antileishmanial activity of sulphonamide nanoemulsions targeting the β-carbonic anhydrase from Leishmania species.

da Silva Cardoso V, Vermelho AB, Ricci Junior E, Almeida Rodrigues I, Mazotto AM, Supuran CT.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):850-857. doi: 10.1080/14756366.2018.1463221.

32.

Fluoroenesulphonamides: N-sulphonylurea isosteres showing nanomolar selective cancer-related transmembrane human carbonic anhydrase inhibition.

Métayer B, Angeli A, Mingot A, Jouvin K, Evano G, Supuran CT, Thibaudeau S.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):804-808. doi: 10.1080/14756366.2018.1461097.

33.

Activation studies with amines and amino acids of the β-carbonic anhydrase from the pathogenic protozoan Leishmania donovani chagasi.

Angeli A, Donald WA, Parkkila S, Supuran CT.

Bioorg Chem. 2018 Aug;78:406-410. doi: 10.1016/j.bioorg.2018.04.010. Epub 2018 Apr 16.

PMID:
29689418
34.

Synthesis, structure and bioactivity of primary sulfamate-containing natural products.

Mujumdar P, Bua S, Supuran CT, Peat TS, Poulsen SA.

Bioorg Med Chem Lett. 2018 Apr 16. pii: S0960-894X(18)30350-0. doi: 10.1016/j.bmcl.2018.04.038. [Epub ahead of print]

PMID:
29685656
35.

CO2 Permeability of Rat Hepatocytes and Relation of CO2 Permeability to CO2 Production.

Arias-Hidalgo M, Yuan Q, Carta F, Supuran CT, Gros G, Endeward V.

Cell Physiol Biochem. 2018;46(3):1198-1208. doi: 10.1159/000489070. Epub 2018 Apr 16.

36.

Dual-tail arylsulfone-based benzenesulfonamides differently match the hydrophobic and hydrophilic halves of human carbonic anhydrases active sites: Selective inhibitors for the tumor-associated hCA IX isoform.

Ibrahim HS, Allam HA, Mahmoud WR, Bonardi A, Nocentini A, Gratteri P, Ibrahim ES, Abdel-Aziz HA, Supuran CT.

Eur J Med Chem. 2018 May 25;152:1-9. doi: 10.1016/j.ejmech.2018.04.016. Epub 2018 Apr 10.

PMID:
29684705
37.

Synthesis and Biological Evaluation of 4-Sulfamoylphenyl/Sulfocoumarin Carboxamides as Selective Inhibitors of Carbonic Anhydrase Isoforms hCA II, IX, and XII.

Angapelly S, Angeli A, Khan AJ, Sri Ramya PV, Supuran CT, Arifuddin M.

ChemMedChem. 2018 Jun 20;13(12):1165-1171. doi: 10.1002/cmdc.201800180. Epub 2018 May 22.

PMID:
29675887
38.

The time-course of red blood cell intracellular pH recovery following short-circuiting in relation to venous transit times in rainbow trout, Oncorhynchus mykiss.

Harter TS, May AG, Federspiel WJ, Supuran CT, Brauner CJ.

Am J Physiol Regul Integr Comp Physiol. 2018 Apr 11. doi: 10.1152/ajpregu.00062.2018. [Epub ahead of print]

PMID:
29641235
39.

Inhibition of carbonic anhydrase IX targets primary tumors, metastases, and cancer stem cells: Three for the price of one.

Supuran CT, Alterio V, Di Fiore A, D' Ambrosio K, Carta F, Monti SM, De Simone G.

Med Res Rev. 2018 Apr 10. doi: 10.1002/med.21497. [Epub ahead of print] Review.

PMID:
29635752
40.

2-Benzylpiperazine: A new scaffold for potent human carbonic anhydrase inhibitors. Synthesis, enzyme inhibition, enantioselectivity, computational and crystallographic studies and in vivo activity for a new class of intraocular pressure lowering agents.

Chiaramonte N, Bua S, Ferraroni M, Nocentini A, Bonardi A, Bartolucci G, Durante M, Lucarini L, Chiapponi D, Dei S, Manetti D, Teodori E, Gratteri P, Masini E, Supuran CT, Romanelli MN.

Eur J Med Chem. 2018 May 10;151:363-375. doi: 10.1016/j.ejmech.2018.04.002. Epub 2018 Apr 3.

PMID:
29635168
41.

Anticancer effects of new dibenzenesulfonamides by inducing apoptosis and autophagy pathways and their carbonic anhydrase inhibitory effects on hCA I, hCA II, hCA IX, hCA XII isoenzymes.

Gul HI, Yamali C, Bulbuller M, Kirmizibayrak PB, Gul M, Angeli A, Bua S, Supuran CT.

Bioorg Chem. 2018 Aug;78:290-297. doi: 10.1016/j.bioorg.2018.03.027. Epub 2018 Mar 30.

PMID:
29621641
42.

Deciphering the Mechanism of Human Carbonic Anhydrases Inhibition with Sulfocoumarins: Computational and Experimental Studies.

Nocentini A, Carta F, Tanc M, Selleri S, Supuran CT, Bazzicalupi C, Gratteri P.

Chemistry. 2018 Jun 4;24(31):7840-7844. doi: 10.1002/chem.201800941. Epub 2018 May 3.

PMID:
29603439
43.

Are Carbonic Anhydrases Suitable Targets to Fight Protozoan Parasitic Diseases?

D'Ambrosio K, Supuran CT, De Simone G.

Curr Med Chem. 2018 Mar 26. doi: 10.2174/0929867325666180326160121. [Epub ahead of print]

PMID:
29589529
44.

Mono- and di-thiocarbamate inhibition studies of the δ-carbonic anhydrase TweCAδ from the marine diatom Thalassiosira weissflogii.

Bua S, Bozdag M, Del Prete S, Carta F, Donald WA, Capasso C, Supuran CT.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):707-713. doi: 10.1080/14756366.2018.1450400.

45.

Natural Polyphenols Selectively Inhibit β-Carbonic Anhydrase from the Dandruff-Producing Fungus Malassezia globosa: Activity and Modeling Studies.

Nocentini A, Bua S, Del Prete S, Heravi YE, Saboury AA, Karioti A, Bilia AR, Capasso C, Gratteri P, Supuran CT.

ChemMedChem. 2018 Apr 23;13(8):816-823. doi: 10.1002/cmdc.201800015. Epub 2018 Mar 25.

PMID:
29575699
46.

Synthesis of novel 4-functionalized 1,5-diaryl-1,2,3-triazoles containing benzenesulfonamide moiety as carbonic anhydrase I, II, IV and IX inhibitors.

Vats L, Sharma V, Angeli A, Kumar R, Supuran CT, Sharma PK.

Eur J Med Chem. 2018 Apr 25;150:678-686. doi: 10.1016/j.ejmech.2018.03.030. Epub 2018 Mar 14.

PMID:
29571155
47.

Discovery of Benzenesulfonamide Derivatives as Carbonic Anhydrase Inhibitors with Effective Anticonvulsant Action: Design, Synthesis, and Pharmacological Evaluation.

Mishra CB, Kumari S, Angeli A, Bua S, Tiwari M, Supuran CT.

J Med Chem. 2018 Apr 12;61(7):3151-3165. doi: 10.1021/acs.jmedchem.8b00208. Epub 2018 Mar 30.

PMID:
29566486
48.

Biochemical, biophysical and molecular dynamics studies on the proteoglycan-like domain of carbonic anhydrase IX.

Langella E, Buonanno M, Vullo D, Dathan N, Leone M, Supuran CT, De Simone G, Monti SM.

Cell Mol Life Sci. 2018 Mar 21. doi: 10.1007/s00018-018-2798-8. [Epub ahead of print]

PMID:
29564477
49.

Carbonic Anhydrases and Metabolism.

Supuran CT.

Metabolites. 2018 Mar 21;8(2). pii: E25. doi: 10.3390/metabo8020025.

50.

Inhibition studies on a panel of human carbonic anhydrases with N1-substituted secondary sulfonamides incorporating thiazolinone or imidazolone-indole tails.

Awadallah FM, Bua S, Mahmoud WR, Nada HH, Nocentini A, Supuran CT.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):629-638. doi: 10.1080/14756366.2018.1446432.

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