Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 1365

1.

Selective inhibition of carbonic anhydrase IX over carbonic anhydrase XII in breast cancer cells using benzene sulfonamides: Disconnect between activity and growth inhibition.

Mboge MY, Chen Z, Wolff A, Mathias JV, Tu C, Brown KD, Bozdag M, Carta F, Supuran CT, McKenna R, Frost SC.

PLoS One. 2018 Nov 19;13(11):e0207417. doi: 10.1371/journal.pone.0207417. eCollection 2018.

2.

Enhancement of the tail hydrophobic interactions within the carbonic anhydrase IX active site via structural extension: Design and synthesis of novel N-substituted isatins-SLC-0111 hybrids as carbonic anhydrase inhibitors and antitumor agents.

Eldehna WM, Abo-Ashour MF, Nocentini A, El-Haggar RS, Bua S, Bonardi A, Al-Rashood ST, Hassan GS, Gratteri P, Abdel-Aziz HA, Supuran CT.

Eur J Med Chem. 2018 Nov 2;162:147-160. doi: 10.1016/j.ejmech.2018.10.068. [Epub ahead of print]

PMID:
30445264
3.

4-Hydroxy-3-nitro-5-ureido-benzenesulfonamides selectively target the tumor-associated carbonic anhydrase isoforms IX and XII showing hypoxia-enhanced anti-proliferative profiles.

Nocentini A, Trallori E, Singh S, Lomelino CL, Bartolucci G, Di Cesare Mannelli L, Ghelardini C, McKenna R, Gratteri P, Supuran CT.

J Med Chem. 2018 Nov 15. doi: 10.1021/acs.jmedchem.8b01504. [Epub ahead of print]

PMID:
30433782
4.

Carbonic anhydrase inhibitors as emerging agents for the treatment and imaging of hypoxic tumors.

Supuran CT.

Expert Opin Investig Drugs. 2018 Nov 14. doi: 10.1080/13543784.2018.1548608. [Epub ahead of print]

PMID:
30426805
5.

Synthesis and carbonic anhydrase inhibitory properties of novel 4-(2-aminoethyl)benzenesulfonamide-dipeptide conjugates.

Küçükbay H, Buğday N, Küçükbay FZ, Berrino E, Bartolucci G, Del Prete S, Capasso C, Supuran CT.

Bioorg Chem. 2018 Nov 3;83:414-423. doi: 10.1016/j.bioorg.2018.11.003. [Epub ahead of print]

PMID:
30419497
6.

Carbonic Anhydrase Inhibitors as Novel Drugs against Mycobacterial β-Carbonic Anhydrases: An Update on In Vitro and In Vivo Studies.

Aspatwar A, Winum JY, Carta F, Supuran CT, Hammaren M, Parikka M, Parkkila S.

Molecules. 2018 Nov 8;23(11). pii: E2911. doi: 10.3390/molecules23112911. Review.

7.

4-Substituted benzenesulfonamides featuring cyclic imides moieties exhibit potent and isoform-selective carbonic anhydrase II/IX inhibition.

Abdel-Aziz AA, El-Azab AS, Ghiaty AH, Gratteri P, Supuran CT, Nocentini A.

Bioorg Chem. 2018 Oct 19;83:198-204. doi: 10.1016/j.bioorg.2018.10.037. [Epub ahead of print]

PMID:
30380448
8.

Determination of the inhibitory effects of N-methylpyrrole derivatives on glutathione reductase enzyme.

Kocaoğlu E, Talaz O, Çavdar H, Şentürk M, Supuran CT, Ekinci D.

J Enzyme Inhib Med Chem. 2019 Dec;34(1):51-54. doi: 10.1080/14756366.2018.1520228.

9.

Synthesis and cytotoxic activities of novel copper and silver complexes of 1,3-diaryltriazene-substituted sulfonamides.

Canakci D, Koyuncu I, Lolak N, Durgun M, Akocak S, Supuran CT.

J Enzyme Inhib Med Chem. 2019 Dec;34(1):110-116. doi: 10.1080/14756366.2018.1530994.

10.

Assessment of the antiproliferative and apoptotic roles of sulfonamide carbonic anhydrase IX inhibitors in HeLa cancer cell line.

Koyuncu I, Gonel A, Durgun M, Kocyigit A, Yuksekdag O, Supuran CT.

J Enzyme Inhib Med Chem. 2019 Dec;34(1):75-86. doi: 10.1080/14756366.2018.1524380.

11.

The carbonic anhydrase IX inhibitor SLC-0111 sensitises cancer cells to conventional chemotherapy.

Andreucci E, Ruzzolini J, Peppicelli S, Bianchini F, Laurenzana A, Carta F, Supuran CT, Calorini L.

J Enzyme Inhib Med Chem. 2019 Dec;34(1):117-123. doi: 10.1080/14756366.2018.1532419.

12.

Tuning the Dual Inhibition of Carbonic Anhydrase and Cyclooxygenase by Dihydrothiazole Benzensulfonamides.

Meleddu R, Distinto S, Cottiglia F, Angius R, Gaspari M, Taverna D, Melis C, Angeli A, Bianco G, Deplano S, Fois B, Del Prete S, Capasso C, Alcaro S, Ortuso F, Yanez M, Supuran CT, Maccioni E.

ACS Med Chem Lett. 2018 Sep 17;9(10):1045-1050. doi: 10.1021/acsmedchemlett.8b00352. eCollection 2018 Oct 11.

PMID:
30344915
13.

Famotidine, an Antiulcer Agent, Strongly Inhibits Helicobacter pylori and Human Carbonic Anhydrases.

Angeli A, Ferraroni M, Supuran CT.

ACS Med Chem Lett. 2018 Sep 4;9(10):1035-1038. doi: 10.1021/acsmedchemlett.8b00334. eCollection 2018 Oct 11.

PMID:
30344913
14.

3-Aminobenzenesulfonamides incorporating acylthiourea moieties selectively inhibit the tumor-associated carbonic anhydrase isoform IX over the off-target isoforms I, II and IV.

Fattah TA, Bua S, Saeed A, Shabir G, Supuran CT.

Bioorg Chem. 2018 Oct 4;82:123-128. doi: 10.1016/j.bioorg.2018.10.006. [Epub ahead of print]

PMID:
30312867
15.

Design, synthesis and biological evaluation of novel ureido benzenesulfonamides incorporating 1,3,5-triazine moieties as potent carbonic anhydrase IX inhibitors.

Lolak N, Akocak S, Bua S, Supuran CT.

Bioorg Chem. 2018 Oct 5;82:117-122. doi: 10.1016/j.bioorg.2018.10.005. [Epub ahead of print]

PMID:
30312866
16.

1,2,4-Trisubstituted imidazolinones with dual carbonic anhydrase and p38 mitogen-activated protein kinase inhibitory activity.

Georgey HH, Manhi FM, Mahmoud WR, Mohamed NA, Berrino E, Supuran CT.

Bioorg Chem. 2018 Oct 1;82:109-116. doi: 10.1016/j.bioorg.2018.09.037. [Epub ahead of print]

PMID:
30312865
17.

Discovery of novel 1,3-diaryltriazene sulfonamides as carbonic anhydrase I, II, VII, and IX inhibitors.

Akocak S, Lolak N, Bua S, Supuran CT.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):1575-1580. doi: 10.1080/14756366.2018.1515933.

18.

Discovering a new class of antifungal agents that selectively inhibits microbial carbonic anhydrases.

Annunziato G, Giovati L, Angeli A, Pavone M, Del Prete S, Pieroni M, Capasso C, Bruno A, Conti S, Magliani W, Supuran CT, Costantino G.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):1537-1544. doi: 10.1080/14756366.2018.1516652.

19.

Carbonic anhydrase inhibition with a series of novel benzenesulfonamide-triazole conjugates.

El-Gazzar MG, Nafie NH, Nocentini A, Ghorab MM, Heiba HI, Supuran CT.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):1565-1574. doi: 10.1080/14756366.2018.1513927.

20.

Heterocoumarins Are Selective Carbonic Anhydrase IX and XII Inhibitors with Cytotoxic Effects against Cancer Cells Lines.

Angeli A, Trallori E, Carta F, Di Cesare Mannelli L, Ghelardini C, Supuran CT.

ACS Med Chem Lett. 2018 Aug 29;9(9):947-951. doi: 10.1021/acsmedchemlett.8b00362. eCollection 2018 Sep 13.

PMID:
30258546
21.

Synthesis of different thio-scaffolds bearing sulfonamide with subnanomolar carbonic anhydrase II and IX inhibitory properties and X-ray investigations for their inhibitory mechanism.

Angeli A, Tanini D, Capperucci A, Malevolti G, Turco F, Ferraroni M, Supuran CT.

Bioorg Chem. 2018 Dec;81:642-648. doi: 10.1016/j.bioorg.2018.09.028. Epub 2018 Sep 20.

22.

Novel thiazolidinone-containing compounds, without the well-known sulphonamide zinc-binding group acting as human carbonic anhydrase IX inhibitors.

Güzel-Akdemir Ö, Angeli A, Demir K, Supuran CT, Akdemir A.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):1299-1308. doi: 10.1080/14756366.2018.1499628.

23.

New azafluorenones with cytotoxic and carbonic anhydrase inhibitory properties: 2-Aryl-4-(4-hydroxyphenyl)-5H-indeno[1,2-b]pyridin-5-ones.

Tugrak M, Inci Gul H, Sakagami H, Gulcin I, Supuran CT.

Bioorg Chem. 2018 Dec;81:433-439. doi: 10.1016/j.bioorg.2018.09.013. Epub 2018 Sep 8.

PMID:
30223148
24.

Steroids interfere with human carbonic anhydrase activity by using alternative binding mechanisms.

Nocentini A, Bonardi A, Gratteri P, Cerra B, Gioiello A, Supuran CT.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):1453-1459. doi: 10.1080/14756366.2018.1512597.

PMID:
30221552
25.

Target-based drug discovery through inversion of quantitative structure-drug-property relationships and molecular simulation: CA IX-sulphonamide complexes.

Žuvela P, Liu JJ, Yi M, Pomastowski PP, Sagandykova G, Belka M, David J, Bączek T, Szafrański K, Żołnowska B, Sławiński J, Supuran CT, Wong MW, Buszewski B.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):1430-1443. doi: 10.1080/14756366.2018.1511551.

26.

Tumor-associated carbonic anhydrase isoform IX and XII inhibitory properties of certain isatin-bearing sulfonamides endowed with in vitro antitumor activity towards colon cancer.

Eldehna WM, Nocentini A, Al-Rashood ST, Hassan GS, Alkahtani HM, Almehizia AA, Reda AM, Abdel-Aziz HA, Supuran CT.

Bioorg Chem. 2018 Dec;81:425-432. doi: 10.1016/j.bioorg.2018.09.007. Epub 2018 Sep 7.

PMID:
30219719
27.

Carbonic anhydrase inhibitors and their potential in a range of therapeutic areas.

Supuran CT.

Expert Opin Ther Pat. 2018 Oct;28(10):709-712. doi: 10.1080/13543776.2018.1523897. Epub 2018 Sep 19. No abstract available.

PMID:
30217119
28.

Blocking HIF signaling via novel inhibitors of CA9 and APE1/Ref-1 dramatically affects pancreatic cancer cell survival.

Logsdon DP, Shah F, Carta F, Supuran CT, Kamocka M, Jacobsen MH, Sandusky GE, Kelley MR, Fishel ML.

Sci Rep. 2018 Sep 13;8(1):13759. doi: 10.1038/s41598-018-32034-9.

29.

Discovery of new 2, 5-disubstituted 1,3-selenazoles as selective human carbonic anhydrase IX inhibitors with potent anti-tumor activity.

Angeli A, Trallori E, Ferraroni M, Di Cesare Mannelli L, Ghelardini C, Supuran CT.

Eur J Med Chem. 2018 Sep 5;157:1214-1222. doi: 10.1016/j.ejmech.2018.08.096. Epub 2018 Sep 3.

PMID:
30193219
30.

Synthesis of novel dipeptide sulfonamide conjugates with effective carbonic anhydrase I, II, IX, and XII inhibitory properties.

Buğday N, Küçükbay FZ, Küçükbay H, Bua S, Bartolucci G, Leitans J, Kazaks A, Tars K, Supuran CT.

Bioorg Chem. 2018 Dec;81:311-318. doi: 10.1016/j.bioorg.2018.08.032. Epub 2018 Aug 27.

PMID:
30176570
31.

Applications of carbonic anhydrases inhibitors in renal and central nervous system diseases.

Supuran CT.

Expert Opin Ther Pat. 2018 Oct;28(10):713-721. doi: 10.1080/13543776.2018.1519023. Epub 2018 Sep 10. Review.

PMID:
30175635
32.

Novel sulfonamides incorporating 1,3,5-triazine and amino acid structural motifs as inhibitors of the physiological carbonic anhydrase isozymes I, II and IV and tumor-associated isozyme IX.

Mikuš P, Krajčiová D, Mikulová M, Horváth B, Pecher D, Garaj V, Bua S, Angeli A, Supuran CT.

Bioorg Chem. 2018 Dec;81:241-252. doi: 10.1016/j.bioorg.2018.08.005. Epub 2018 Aug 16.

PMID:
30153589
33.

Inhibition of carbonic anhydrases by a substrate analog: benzyl carbamate directly coordinates the catalytic zinc ion mimicking bicarbonate binding.

De Simone G, Angeli A, Bozdag M, Supuran CT, Winum JY, Monti SM, Alterio V.

Chem Commun (Camb). 2018 Sep 11;54(73):10312-10315. doi: 10.1039/c8cc05755a.

PMID:
30140816
34.

Identification of Bivalent Ligands with Melatonin Receptor Agonist and Fatty Acid Amide Hydrolase (FAAH) Inhibitory Activity That Exhibit Ocular Hypotensive Effect in the Rabbit.

Spadoni G, Bedini A, Furiassi L, Mari M, Mor M, Scalvini L, Lodola A, Ghidini A, Lucini V, Dugnani S, Scaglione F, Piomelli D, Jung KM, Supuran CT, Lucarini L, Durante M, Sgambellone S, Masini E, Rivara S.

J Med Chem. 2018 Sep 13;61(17):7902-7916. doi: 10.1021/acs.jmedchem.8b00893. Epub 2018 Sep 4.

PMID:
30126274
35.

Structural Mapping of Anion Inhibitors to β-Carbonic Anhydrase psCA3 from Pseudomonas aeruginosa.

Murray AB, Aggarwal M, Pinard M, Vullo D, Patrauchan M, Supuran CT, McKenna R.

ChemMedChem. 2018 Oct 8;13(19):2024-2029. doi: 10.1002/cmdc.201800375. Epub 2018 Sep 13.

PMID:
30088334
36.

Carbonic anhydrase inhibitors as antitumor/antimetastatic agents: a patent review (2008-2018).

Nocentini A, Supuran CT.

Expert Opin Ther Pat. 2018 Oct;28(10):729-740. doi: 10.1080/13543776.2018.1508453. Epub 2018 Aug 9. Review.

PMID:
30074415
37.

Novel hydrazido benzenesulfonamides-isatin conjugates: Synthesis, carbonic anhydrase inhibitory activity and molecular modeling studies.

Abo-Ashour MF, Eldehna WM, Nocentini A, Ibrahim HS, Bua S, Abou-Seri SM, Supuran CT.

Eur J Med Chem. 2018 Sep 5;157:28-36. doi: 10.1016/j.ejmech.2018.07.054. Epub 2018 Jul 24.

PMID:
30071407
38.

Synthesis of novel isoindoline-1,3-dione-based oximes and benzenesulfonamide hydrazones as selective inhibitors of the tumor-associated carbonic anhydrase IX.

Abdel-Aziz AA, El-Azab AS, Abu El-Enin MA, Almehizia AA, Supuran CT, Nocentini A.

Bioorg Chem. 2018 Oct;80:706-713. doi: 10.1016/j.bioorg.2018.07.027. Epub 2018 Jul 24.

PMID:
30064081
39.

Inhibition of α-, β-, γ-, and δ-carbonic anhydrases from bacteria and diatoms with N'-aryl-N-hydroxy-ureas.

Berrino E, Bozdag M, Del Prete S, Alasmary FAS, Alqahtani LS, AlOthman Z, Capasso C, Supuran CT.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):1194-1198. doi: 10.1080/14756366.2018.1490733.

40.

Comparison of the Anion Inhibition Profiles of the α-CA Isoforms (SpiCA1, SpiCA2 and SpiCA3) from the Scleractinian Coral Stylophora pistillata.

Del Prete S, Bua S, Zoccola D, Alasmary FAS, AlOthman Z, Alqahtani LS, Techer N, Supuran CT, Tambutté S, Capasso C.

Int J Mol Sci. 2018 Jul 21;19(7). pii: E2128. doi: 10.3390/ijms19072128.

41.

Targeting Tumor Associated Carbonic Anhydrases IX and XII: Highly Isozyme Selective Coumarin and Psoralen Inhibitors.

Melis C, Distinto S, Bianco G, Meleddu R, Cottiglia F, Fois B, Taverna D, Angius R, Alcaro S, Ortuso F, Gaspari M, Angeli A, Del Prete S, Capasso C, Supuran CT, Maccioni E.

ACS Med Chem Lett. 2018 Jun 6;9(7):725-729. doi: 10.1021/acsmedchemlett.8b00170. eCollection 2018 Jul 12.

PMID:
30034608
42.

Sweet Binders: Carbonic Anhydrase IX in Complex with Sucralose.

Lomelino CL, Murray AB, Supuran CT, McKenna R.

ACS Med Chem Lett. 2018 May 10;9(7):657-661. doi: 10.1021/acsmedchemlett.8b00100. eCollection 2018 Jul 12.

PMID:
30034596
43.

Discovery of potent anti-convulsant carbonic anhydrase inhibitors: Design, synthesis, in vitro and in vivo appraisal.

Mishra CB, Kumari S, Angeli A, Bua S, Buonanno M, Monti SM, Tiwari M, Supuran CT.

Eur J Med Chem. 2018 Aug 5;156:430-443. doi: 10.1016/j.ejmech.2018.07.019. Epub 2018 Jul 9.

PMID:
30015076
44.

Advances in microwave-assisted synthesis and the impact of novel drug discovery.

Berrino E, Supuran CT.

Expert Opin Drug Discov. 2018 Sep;13(9):861-873. doi: 10.1080/17460441.2018.1494721. Epub 2018 Jul 16.

PMID:
30010444
45.

Activation studies with amines and amino acids of the α-carbonic anhydrase from the pathogenic protozoan Trypanosoma cruzi.

Angeli A, Kuuslahti M, Parkkila S, Supuran CT.

Bioorg Med Chem. 2018 Aug 7;26(14):4187-4190. doi: 10.1016/j.bmc.2018.07.011. Epub 2018 Jul 7.

PMID:
30007565
46.

Synthesis, X-ray structure, in silico calculation, and carbonic anhydrase inhibitory properties of benzylimidazole metal complexes.

Bouchouit M, Bouacida S, Zouchoune B, Merazig H, Bua S, Bouaziz Z, Le Borgne M, Supuran CT, Bouraiou A.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):1150-1159. doi: 10.1080/14756366.2018.1481404.

47.

Selective inhibition of carbonic anhydrase-IX by sulphonamide derivatives induces pH and reactive oxygen species-mediated apoptosis in cervical cancer HeLa cells.

Koyuncu I, Gonel A, Kocyigit A, Temiz E, Durgun M, Supuran CT.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):1137-1149. doi: 10.1080/14756366.2018.1481403.

48.

Synthesis of novel benzenesulfamide derivatives with inhibitory activity against human cytosolic carbonic anhydrase I and II and Vibrio cholerae α- and β-class enzymes.

Bua S, Berrino E, Del Prete S, Murthy VS, Vijayakumar V, Tamboli Y, Capasso C, Cerbai E, Mugelli A, Carta F, Supuran CT.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):1125-1136. doi: 10.1080/14756366.2018.1467901.

49.

Intermolecular amination of allylic and benzylic alcohols leads to effective inhibitions of acetylcholinesterase enzyme and carbonic anhydrase I and II isoenzymes.

Atmaca U, Yıldırım A, Taslimi P, Çelik ST, Gülçin İ, Supuran CT, Çelik M.

J Biochem Mol Toxicol. 2018 Aug;32(8):e22173. doi: 10.1002/jbt.22173. Epub 2018 Jul 5.

PMID:
29975450
50.

Biomedical applications of prokaryotic carbonic anhydrases.

Supuran CT, Capasso C.

Expert Opin Ther Pat. 2018 Oct;28(10):745-754. doi: 10.1080/13543776.2018.1497161. Epub 2018 Jul 16. Review.

PMID:
29973089

Supplemental Content

Loading ...
Support Center