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Items: 8


The Mode-of-Action of Targeted Alpha Therapy Radium-223 as an Enabler for Novel Combinations to Treat Patients with Bone Metastasis.

Suominen MI, Wilson T, Käkönen SM, Scholz A.

Int J Mol Sci. 2019 Aug 10;20(16). pii: E3899. doi: 10.3390/ijms20163899. Review.


Human Immune System Increases Breast Cancer-Induced Osteoblastic Bone Growth in a Humanized Mouse Model without Affecting Normal Bone.

Kähkönen TE, Suominen MI, Mäki-Jouppila JHE, Halleen JM, Tanaka A, Seiler M, Bernoulli J.

J Immunol Res. 2019 May 9;2019:4260987. doi: 10.1155/2019/4260987. eCollection 2019.


Radium-223 Inhibits Osseous Prostate Cancer Growth by Dual Targeting of Cancer Cells and Bone Microenvironment in Mouse Models.

Suominen MI, Fagerlund KM, Rissanen JP, Konkol YM, Morko JP, Peng Z, Alhoniemi EJ, Laine SK, Corey E, Mumberg D, Ziegelbauer K, Käkönen SM, Halleen JM, Vessella RL, Scholz A.

Clin Cancer Res. 2017 Aug 1;23(15):4335-4346. doi: 10.1158/1078-0432.CCR-16-2955. Epub 2017 Mar 31.


Survival benefit with radium-223 dichloride in a mouse model of breast cancer bone metastasis.

Suominen MI, Rissanen JP, Käkönen R, Fagerlund KM, Alhoniemi E, Mumberg D, Ziegelbauer K, Halleen JM, Käkönen SM, Scholz A.

J Natl Cancer Inst. 2013 Jun 19;105(12):908-16. doi: 10.1093/jnci/djt116. Epub 2013 May 16.


Improved statistical modeling of tumor growth and treatment effect in preclinical animal studies with highly heterogeneous responses in vivo.

Laajala TD, Corander J, Saarinen NM, Mäkelä K, Savolainen S, Suominen MI, Alhoniemi E, Mäkelä S, Poutanen M, Aittokallio T.

Clin Cancer Res. 2012 Aug 15;18(16):4385-96. doi: 10.1158/1078-0432.CCR-11-3215. Epub 2012 Jun 27.


The anti-tumor agent sagopilone shows antiresorptive effects both in vitro and in vivo.

Strube A, Suominen MI, Rissanen JP, Mumberg D, Klar U, Halleen JM, Käkönen SM.

Osteoporos Int. 2011 Nov;22(11):2887-93. doi: 10.1007/s00198-010-1486-9. Epub 2010 Nov 23.


Short-term changes in serum PINP predict long-term changes in trabecular bone in the rat ovariectomy model.

Rissanen JP, Suominen MI, Peng Z, Morko J, Rasi S, Risteli J, Halleen JM.

Calcif Tissue Int. 2008 Feb;82(2):155-61. doi: 10.1007/s00223-007-9101-6. Epub 2008 Jan 25.


Secreted tartrate-resistant acid phosphatase 5b is a Marker of osteoclast number in human osteoclast cultures and the rat ovariectomy model.

Rissanen JP, Suominen MI, Peng Z, Halleen JM.

Calcif Tissue Int. 2008 Feb;82(2):108-15. Epub 2007 Dec 15.


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