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Vet Rec. 2019 Aug 13. pii: vetrec-2018-104953. doi: 10.1136/vr.104953. [Epub ahead of print]

Ropinirole eye drops induce vomiting effectively in dogs: a randomised, double-blind, placebo-controlled clinical study.

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Department of Research and Development, Orion Pharma Orion Corporation, Espoo, Finland
Department of Research and Development, Orion Pharma Orion Corporation, Espoo, Finland.
Department of Comparative Biomedical Sciences, Royal Veterinary College, University of London, London, UK.


There is a need for an effective and safe emetic agent that dog owners could easily administer to their dogs following veterinary advice in cases of potential poisoning. As a response to this need, a randomised, double-blind, multi-site, clinical field study was performed to assess the efficacy, safety and usability of ropinirole eye drops to induce vomiting in dogs. Ropinirole (target dose 3.75 mg/m2) was applied to eyes of 100 dogs, and 32 dogs received placebo. The drug was administered by the dog owner at a veterinary clinic under the supervision of a veterinarian and led to vomition in 95% of the ropinirole-treated dogs within 30 min. The median time to first vomit was 10 min (range: 3-37 min). None of the dogs receiving placebo vomited in this time period. All owners were able to administer the product and 96% of them assessed the administration to be very easy or easy, which was confirmed by the observing veterinarian. Some ocular signs were seen both with ropinirole and placebo, hyperaemia being the most common. All observed signs were transient and in most cases mild. Ropinirole eye drops provided an effective, safe and reliable means to induce emesis in dogs.


clinical practice; clinical trials; dogs; emesis; eye drops; toxin


Conflict of interest statement

Competing interests: MS, LS, TL and TL are employees of Orion Corporation. JE is a paid consultant of Orion Corporation.

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