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Items: 20


Epidermal growth factor receptor promotes glomerular injury and renal failure in rapidly progressive crescentic glomerulonephritis.

Bollée G, Flamant M, Schordan S, Fligny C, Rumpel E, Milon M, Schordan E, Sabaa N, Vandermeersch S, Galaup A, Rodenas A, Casal I, Sunnarborg SW, Salant DJ, Kopp JB, Threadgill DW, Quaggin SE, Dussaule JC, Germain S, Mesnard L, Endlich K, Boucheix C, Belenfant X, Callard P, Endlich N, Tharaux PL.

Nat Med. 2011 Sep 25;17(10):1242-50. doi: 10.1038/nm.2491. Erratum in: Nat Med. 2011 Nov;17(11):1521. Nat Med. 2011 Oct;17(10):2 p following 1250.


TNF-α-converting enzyme/a disintegrin and metalloprotease-17 mediates mechanotransduction in murine tracheal epithelial cells.

Shiomi T, Tschumperlin DJ, Park JA, Sunnarborg SW, Horiuchi K, Blobel CP, Drazen JM.

Am J Respir Cell Mol Biol. 2011 Aug;45(2):376-85. doi: 10.1165/rcmb.2010-0234OC. Epub 2010 Nov 19.


Amphiregulin is not essential for induction of contact hypersensitivity.

Yagami A, Kajiwara N, Oboki K, Ohno T, Morita H, Sunnarborg SW, Okumura K, Ogawa H, Saito H, Nakae S.

Allergol Int. 2010 Sep;59(3):277-284. doi: 10.2332/allergolint.09-OA-0149. Epub 2010 Jun 25.


Amphiregulin is not essential for ovalbumin-induced acute airway inflammation in mice.

Kajiwara N, Oboki K, Ohno T, Ishii A, Sunnarborg SW, Okumura K, Saito H, Nakae S.

Allergol Int. 2010 Jun;59(2):207-11. doi: 10.2332/allergolint.09-OA-0144. Epub 2010 Apr 24.


Heparin binding epidermal growth factor in renal ischaemia/reperfusion injury.

Mulder GM, Nijboer WN, Seelen MA, Sandovici M, Bos EM, Melenhorst WB, Trzpis M, Kloosterhuis NJ, Visser L, Henning RH, Leuvenink HG, Ploeg RJ, Sunnarborg SW, van Goor H.

J Pathol. 2010 Jun;221(2):183-92. doi: 10.1002/path.2698.


Mitochondrial reactive oxygen species mediate GPCR-induced TACE/ADAM17-dependent transforming growth factor-alpha shedding.

Myers TJ, Brennaman LH, Stevenson M, Higashiyama S, Russell WE, Lee DC, Sunnarborg SW.

Mol Biol Cell. 2009 Dec;20(24):5236-49. doi: 10.1091/mbc.E08-12-1256.


The ADAM17-amphiregulin-EGFR axis in mammary development and cancer.

Sternlicht MD, Sunnarborg SW.

J Mammary Gland Biol Neoplasia. 2008 Jun;13(2):181-94. doi: 10.1007/s10911-008-9084-6. Epub 2008 May 10. Review.


Heparin-binding epidermal growth factor-like growth factor signaling in flow-induced arterial remodeling.

Zhang H, Sunnarborg SW, McNaughton KK, Johns TG, Lee DC, Faber JE.

Circ Res. 2008 May 23;102(10):1275-85. doi: 10.1161/CIRCRESAHA.108.171728. Epub 2008 Apr 24.


Timp3 deficiency in insulin receptor-haploinsufficient mice promotes diabetes and vascular inflammation via increased TNF-alpha.

Federici M, Hribal ML, Menghini R, Kanno H, Marchetti V, Porzio O, Sunnarborg SW, Rizza S, Serino M, Cunsolo V, Lauro D, Mauriello A, Smookler DS, Sbraccia P, Sesti G, Lee DC, Khokha R, Accili D, Lauro R.

J Clin Invest. 2005 Dec;115(12):3494-505. Epub 2005 Nov 17.


Mammary ductal morphogenesis requires paracrine activation of stromal EGFR via ADAM17-dependent shedding of epithelial amphiregulin.

Sternlicht MD, Sunnarborg SW, Kouros-Mehr H, Yu Y, Lee DC, Werb Z.

Development. 2005 Sep;132(17):3923-33. Epub 2005 Aug 3. Erratum in: Development. 2006 Mar;133(6):1203.


Angiotensin II and EGF receptor cross-talk in chronic kidney diseases: a new therapeutic approach.

Lautrette A, Li S, Alili R, Sunnarborg SW, Burtin M, Lee DC, Friedlander G, Terzi F.

Nat Med. 2005 Aug;11(8):867-74. Epub 2005 Jul 24.


Heparin-binding epidermal growth factor-like growth factor, collateral vessel development, and angiogenesis in skeletal muscle ischemia.

Chalothorn D, Moore SM, Zhang H, Sunnarborg SW, Lee DC, Faber JE.

Arterioscler Thromb Vasc Biol. 2005 Sep;25(9):1884-90. Epub 2005 Jun 30.


Selective roles for tumor necrosis factor alpha-converting enzyme/ADAM17 in the shedding of the epidermal growth factor receptor ligand family: the juxtamembrane stalk determines cleavage efficiency.

Hinkle CL, Sunnarborg SW, Loiselle D, Parker CE, Stevenson M, Russell WE, Lee DC.

J Biol Chem. 2004 Jun 4;279(23):24179-88. Epub 2004 Apr 5.


Substrate specificity and inducibility of TACE (tumour necrosis factor alpha-converting enzyme) revisited: the Ala-Val preference, and induced intrinsic activity.

Black RA, Doedens JR, Mahimkar R, Johnson R, Guo L, Wallace A, Virca D, Eisenman J, Slack J, Castner B, Sunnarborg SW, Lee DC, Cowling R, Jin G, Charrier K, Peschon JJ, Paxton R.

Biochem Soc Symp. 2003;(70):39-52. Review.


TACE/ADAM17 processing of EGFR ligands indicates a role as a physiological convertase.

Lee DC, Sunnarborg SW, Hinkle CL, Myers TJ, Stevenson MY, Russell WE, Castner BJ, Gerhart MJ, Paxton RJ, Black RA, Chang A, Jackson LF.

Ann N Y Acad Sci. 2003 May;995:22-38. Review.


Defective valvulogenesis in HB-EGF and TACE-null mice is associated with aberrant BMP signaling.

Jackson LF, Qiu TH, Sunnarborg SW, Chang A, Zhang C, Patterson C, Lee DC.

EMBO J. 2003 Jun 2;22(11):2704-16.


Tumor necrosis factor-alpha converting enzyme (TACE) regulates epidermal growth factor receptor ligand availability.

Sunnarborg SW, Hinkle CL, Stevenson M, Russell WE, Raska CS, Peschon JJ, Castner BJ, Gerhart MJ, Paxton RJ, Black RA, Lee DC.

J Biol Chem. 2002 Apr 12;277(15):12838-45. Epub 2002 Jan 31.


An essential role for ectodomain shedding in mammalian development.

Peschon JJ, Slack JL, Reddy P, Stocking KL, Sunnarborg SW, Lee DC, Russell WE, Castner BJ, Johnson RS, Fitzner JN, Boyce RW, Nelson N, Kozlosky CJ, Wolfson MF, Rauch CT, Cerretti DP, Paxton RJ, March CJ, Black RA.

Science. 1998 Nov 13;282(5392):1281-4.

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