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Gastrointestinal disease burden and mortality: A public hospital based study from 2005 to 2014.

Chan JSH, Chao ACW, Cheung VCH, Wong SSK, Tang W, Wu JCY, Chan HLY, Chan FKL, Sung JJY, Ng SC.

J Gastroenterol Hepatol. 2018 Jul 11. doi: 10.1111/jgh.14377. [Epub ahead of print]


Pathological Modification of TDP-43 in Amyotrophic Lateral Sclerosis with SOD1 Mutations.

Jeon GS, Shim YM, Lee DY, Kim JS, Kang M, Ahn SH, Shin JY, Geum D, Hong YH, Sung JJ.

Mol Neurobiol. 2018 Jul 7. doi: 10.1007/s12035-018-1218-2. [Epub ahead of print]


Correction: Myasthenia gravis seronegative for acetylcholine receptor antibodies in South Korea: Autoantibody profiles and clinical features.

Park KH, Waters P, Woodhall M, Lang B, Smith T, Sung JJ, Kim KK, Lim YM, Kim JE, Kim BJ, Park JS, Lim JG, Kim DS, Kwon O, Sohn EH, Bae JS, Yoon BN, Kim NH, Ahn SW, Oh J, Park HJ, Shin KJ, Hong YH.

PLoS One. 2018 Jun 29;13(6):e0200225. doi: 10.1371/journal.pone.0200225. eCollection 2018.


Risk factors for advanced colorectal neoplasms in the proximal colon in 6218 subjects undergoing complete colonoscopy.

Hirai HW, Ching JYL, Wu JCY, Sung JJY, Chan FKL, Ng SC.

J Gastroenterol Hepatol. 2018 Jun 22. doi: 10.1111/jgh.14357. [Epub ahead of print]


Prophylactic angiographic embolisation after endoscopic control of bleeding to high-risk peptic ulcers: a randomised controlled trial.

Lau JYW, Pittayanon R, Wong KT, Pinjaroen N, Chiu PWY, Rerknimitr R, Holster IL, Kuipers EJ, Wu KC, Au KWL, Chan FKL, Sung JJY.

Gut. 2018 May 25. pii: gutjnl-2018-316074. doi: 10.1136/gutjnl-2018-316074. [Epub ahead of print]


The effect of off-hours hospital admission on mortality and clinical outcomes for patients with upper gastrointestinal hemorrhage: A systematic review and meta-analysis of 20 cohorts.

Xia XF, Chiu PWY, Tsoi KKF, Chan FKL, Sung JJY, Lau JYW.

United European Gastroenterol J. 2018 Apr;6(3):367-381. doi: 10.1177/2050640617732651. Epub 2017 Sep 14.


Association Between Bacteremia from Specific Microbes and Subsequent Diagnosis of Colorectal Cancer.

Kwong TNY, Wang X, Nakatsu G, Chow TC, Tipoe T, Dai RZW, Tsoi KKK, Wong MCS, Tse G, Chan MTV, Chan FKL, Ng SC, Wu JCY, Wu WKK, Yu J, Sung JJY, Wong SH.

Gastroenterology. 2018 May 2. pii: S0016-5085(18)30489-X. doi: 10.1053/j.gastro.2018.04.028. [Epub ahead of print]


Asia-Pacific working group consensus on non-variceal upper gastrointestinal bleeding: an update 2018.

Sung JJ, Chiu PC, Chan FKL, Lau JY, Goh KL, Ho LH, Jung HY, Sollano JD, Gotoda T, Reddy N, Singh R, Sugano K, Wu KC, Wu CY, Bjorkman DJ, Jensen DM, Kuipers EJ, Lanas A.

Gut. 2018 Apr 24. pii: gutjnl-2018-316276. doi: 10.1136/gutjnl-2018-316276. [Epub ahead of print]


Non-variceal upper gastrointestinal bleeding.

Lanas A, Dumonceau JM, Hunt RH, Fujishiro M, Scheiman JM, Gralnek IM, Campbell HE, Rostom A, Villanueva C, Sung JJY.

Nat Rev Dis Primers. 2018 Apr 19;4:18020. doi: 10.1038/nrdp.2018.20. Review.


Squalene epoxidase drives NAFLD-induced hepatocellular carcinoma and is a pharmaceutical target.

Liu D, Wong CC, Fu L, Chen H, Zhao L, Li C, Zhou Y, Zhang Y, Xu W, Yang Y, Wu B, Cheng G, Lai PB, Wong N, Sung JJY, Yu J.

Sci Transl Med. 2018 Apr 18;10(437). pii: eaap9840. doi: 10.1126/scitranslmed.aap9840.


Risk of gastrointestinal bleeding and benefit from colorectal cancer reduction from long-term use of low-dose aspirin: A retrospective study of 612 509 patients.

Tsoi KK, Chan FC, Hirai HW, Sung JJ.

J Gastroenterol Hepatol. 2018 Apr 17. doi: 10.1111/jgh.14261. [Epub ahead of print]


Multi-cohort analysis of colorectal cancer metagenome identified altered bacteria across populations and universal bacterial markers.

Dai Z, Coker OO, Nakatsu G, Wu WKK, Zhao L, Chen Z, Chan FKL, Kristiansen K, Sung JJY, Wong SH, Yu J.

Microbiome. 2018 Apr 11;6(1):70. doi: 10.1186/s40168-018-0451-2.


CREPT facilitates colorectal cancer growth through inducing Wnt/β-catenin pathway by enhancing p300-mediated β-catenin acetylation.

Zhang Y, Wang S, Kang W, Liu C, Dong Y, Ren F, Wang Y, Zhang J, Wang G, To KF, Zhang X, Sung JJ, Chang Z, Yu J.

Oncogene. 2018 Jun;37(26):3485-3500. doi: 10.1038/s41388-018-0161-z. Epub 2018 Mar 22.


Genomic analysis of liver cancer unveils novel driver genes and distinct prognostic features.

Li X, Xu W, Kang W, Wong SH, Wang M, Zhou Y, Fang X, Zhang X, Yang H, Wong CH, To KF, Chan SL, Chan MTV, Sung JJY, Wu WKK, Yu J.

Theranostics. 2018 Feb 12;8(6):1740-1751. doi: 10.7150/thno.22010. eCollection 2018.


Global Incidence and mortality of oesophageal cancer and their correlation with socioeconomic indicators temporal patterns and trends in 41 countries.

Wong MCS, Hamilton W, Whiteman DC, Jiang JY, Qiao Y, Fung FDH, Wang HHX, Chiu PWY, Ng EKW, Wu JCY, Yu J, Chan FKL, Sung JJY.

Sci Rep. 2018 Mar 14;8(1):4522. doi: 10.1038/s41598-018-19819-8.


DEAD-box helicase 27 promotes colorectal cancer growth and metastasis and predicts poor survival in CRC patients.

Tang J, Chen H, Wong CC, Liu D, Li T, Wang X, Ji J, Sung JJ, Fang JY, Yu J.

Oncogene. 2018 May;37(22):3006-3021. doi: 10.1038/s41388-018-0196-1. Epub 2018 Mar 14.


Responses are durable for up to 5 years after completion of peginterferon alfa-2a treatment in hepatitis B e antigen-positive patients.

Chuang WL, Jia J, Chan HLY, Han KH, Tanwandee T, Tan D, Chen X, Gane E, Piratvisuth T, Chen L, Xie Q, Sung JJ, Messinger D, Wat C, Bakalos G, Liaw YF.

Aliment Pharmacol Ther. 2018 May;47(9):1306-1316. doi: 10.1111/apt.14595. Epub 2018 Mar 9.


Myasthenia gravis seronegative for acetylcholine receptor antibodies in South Korea: Autoantibody profiles and clinical features.

Park KH, Waters P, Woodhall M, Lang B, Smith T, Sung JJ, Kim KK, Lim YM, Kim JE, Kim BJ, Park JS, Lim JG, Kim DS, Kwon O, Sohn EH, Bae JS, Yoon BN, Kim NH, Ahn SW, Oh J, Park HJ, Shin KJ, Hong YH.

PLoS One. 2018 Mar 8;13(3):e0193723. doi: 10.1371/journal.pone.0193723. eCollection 2018. Erratum in: PLoS One. 2018 Jun 29;13(6):e0200225.


A novel susceptibility locus in MST1 and gene-gene interaction network for Crohn's disease in the Chinese population.

Wu WKK, Sun R, Zuo T, Tian Y, Zeng Z, Ho J, Wu JCY, Chan FKL, Chan MTV, Yu J, Sung JJY, Wong SH, Wang MH, Ng SC.

J Cell Mol Med. 2018 Apr;22(4):2368-2377. doi: 10.1111/jcmm.13530. Epub 2018 Feb 14.


Rituximab-induced interstitial lung disease in a patient with aquaporin-4 immunoglobulin G-positive neuromyelitis optica spectrum disorder.

Ahn SH, Kim SM, Sung JJ.

Mult Scler Relat Disord. 2018 Feb;20:192-193. doi: 10.1016/j.msard.2018.01.006. Epub 2018 Mar 20.


RNF6 Promotes Colorectal Cancer by Activating the Wnt/β-Catenin Pathway via Ubiquitination of TLE3.

Liu L, Zhang Y, Wong CC, Zhang J, Dong Y, Li X, Kang W, Chan FKL, Sung JJY, Yu J.

Cancer Res. 2018 Apr 15;78(8):1958-1971. doi: 10.1158/0008-5472.CAN-17-2683. Epub 2018 Jan 26.


Forkhead Box F2 Suppresses Gastric Cancer through a Novel FOXF2-IRF2BPL-β-Catenin Signaling Axis.

Higashimori A, Dong Y, Zhang Y, Kang W, Nakatsu G, Ng SSM, Arakawa T, Sung JJY, Chan FKL, Yu J.

Cancer Res. 2018 Apr 1;78(7):1643-1656. doi: 10.1158/0008-5472.CAN-17-2403. Epub 2018 Jan 26.


Association between investigator-measured body-mass index and colorectal adenoma: a systematic review and meta-analysis of 168,201 subjects.

Wong MC, Chan CH, Cheung W, Fung DH, Liang M, Huang JL, Wang YH, Jiang JY, Yu CP, Wang HH, Wu JC, Chan FK, Sung JJ.

Eur J Epidemiol. 2018 Jan;33(1):15-26. doi: 10.1007/s10654-017-0336-x. Epub 2017 Dec 29.


Spinobulbar muscular atrophy combined with atypical hereditary neuropathy with liability to pressure palsy.

Choi K, Ahn SH, Baek SH, Kim JS, Choi SJ, Shin JY, Kim SM, Hong YH, Sung JJ.

J Clin Neurosci. 2018 Feb;48:90-92. doi: 10.1016/j.jocn.2017.10.049. Epub 2017 Nov 11.


Extrinsic Apoptosis Pathway Altered by Glycogen Synthase Kinase-3β Inhibitor Influences the Net Drug Effect on NSC-34 Motor Neuron-Like Cell Survival.

Kim JE, Lim JH, Jeon GS, Shin JY, Ahn SW, Kim SH, Lee KW, Hong YH, Sung JJ.

Biomed Res Int. 2017;2017:4163839. doi: 10.1155/2017/4163839. Epub 2017 Sep 10.


Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies.

Ng SC, Shi HY, Hamidi N, Underwood FE, Tang W, Benchimol EI, Panaccione R, Ghosh S, Wu JCY, Chan FKL, Sung JJY, Kaplan GG.

Lancet. 2018 Dec 23;390(10114):2769-2778. doi: 10.1016/S0140-6736(17)32448-0. Epub 2017 Oct 16. Review.


Cancer Risk in 2621 Chinese Patients with Inflammatory Bowel Disease: A Population-based Cohort Study.

So J, Tang W, Leung WK, Li M, Lo FH, Wong MTL, Sze ASF, Leung CM, Tsang SWC, Shan EHS, Chan KH, Lam BCY, Hui AJ, Chow WH, Lam TY, Lam V, Lee TW, Lo HHH, Tang CM, Wong CL, Wu JCY, Chan FKL, Sung JJY, Harbord M, Ng SC.

Inflamm Bowel Dis. 2017 Nov;23(11):2061-2068. doi: 10.1097/MIB.0000000000001240.


Endoscopic and Histological Mucosal Healing in Ulcerative Colitis in the First Year of Diagnosis: Results from a Population-based Inception Cohort from Six Countries in Asia.

Leung CM, Tang W, Kyaw M, Niamul G, Aniwan S, Limsrivilai J, Wang YF, Ouyang Q, Simadibrata M, Abdullah M, Ong DE, Yu HH, Zhang J, Ching J, Wu JCY, Chan FKL, Sung JJY, Ng SC.

J Crohns Colitis. 2017 Dec 4;11(12):1440-1448. doi: 10.1093/ecco-jcc/jjx103.


Hepatoma-intrinsic CCRK inhibition diminishes myeloid-derived suppressor cell immunosuppression and enhances immune-checkpoint blockade efficacy.

Zhou J, Liu M, Sun H, Feng Y, Xu L, Chan AWH, Tong JH, Wong J, Chong CCN, Lai PBS, Wang HK, Tsang SW, Goodwin T, Liu R, Huang L, Chen Z, Sung JJ, Chow KL, To KF, Cheng AS.

Gut. 2018 May;67(5):931-944. doi: 10.1136/gutjnl-2017-314032. Epub 2017 Sep 22.


Disease Burden of Clostridium difficile Infections in Adults, Hong Kong, China, 2006-2014.

Ho J, Dai RZW, Kwong TNY, Wang X, Zhang L, Ip M, Chan R, Hawkey PMK, Lam KLY, Wong MCS, Tse G, Chan MTV, Chan FKL, Yu J, Ng SC, Lee N, Wu JCY, Sung JJY, Wu WKK, Wong SH.

Emerg Infect Dis. 2017 Oct;23(10):1671-1679. doi: 10.3201/eid2310.170797.


Accuracy of Faecal Immunochemical Test to Predict Endoscopic and Histological Healing in Ulcerative Colitis: A Prospective Study Based on Validated Histological Scores.

Shi HY, Chan FKL, Chan AWH, Higashimori A, Kyaw M, Ching JYL, Luk AKC, Wong SH, Wu JCY, Sung JJY, Ng SC.

J Crohns Colitis. 2017 Sep 1;11(9):1071-1077. doi: 10.1093/ecco-jcc/jjx088.


Defective lysosomal clearance of autophagosomes and its clinical implications in nonalcoholic steatohepatitis.

Wang X, Zhang X, Chu ESH, Chen X, Kang W, Wu F, To KF, Wong VWS, Chan HLY, Chan MTV, Sung JJY, Wu WKK, Yu J.

FASEB J. 2018 Jan;32(1):37-51. doi: 10.1096/fj.201601393R. Epub 2017 Aug 25.


Gavage of Fecal Samples From Patients With Colorectal Cancer Promotes Intestinal Carcinogenesis in Germ-Free and Conventional Mice.

Wong SH, Zhao L, Zhang X, Nakatsu G, Han J, Xu W, Xiao X, Kwong TNY, Tsoi H, Wu WKK, Zeng B, Chan FKL, Sung JJY, Wei H, Yu J.

Gastroenterology. 2017 Dec;153(6):1621-1633.e6. doi: 10.1053/j.gastro.2017.08.022. Epub 2017 Aug 18.


The Anti-Inflammatory Effects of Oral-Formulated Tacrolimus in Mice with Experimental Autoimmune Encephalomyelitis.

Kim MJ, Sung JJ, Kim SH, Kim JM, Jeon GS, Mun SK, Ahn SW.

J Korean Med Sci. 2017 Sep;32(9):1502-1507. doi: 10.3346/jkms.2017.32.9.1502.


Epidemiology and Clinical Characteristics of Zika Virus Infections Imported into Korea from March to October 2016.

Yoon D, Shin SH, Jang HC, Kim ES, Song EH, Moon SM, Shin SY, Choe PG, Sung JJ, Choi EH, Oh MD, Jee Y, Kim NJ.

J Korean Med Sci. 2017 Sep;32(9):1440-1444. doi: 10.3346/jkms.2017.32.9.1440.


Mucosal microbiome dysbiosis in gastric carcinogenesis.

Coker OO, Dai Z, Nie Y, Zhao G, Cao L, Nakatsu G, Wu WK, Wong SH, Chen Z, Sung JJY, Yu J.

Gut. 2018 Jun;67(6):1024-1032. doi: 10.1136/gutjnl-2017-314281. Epub 2017 Aug 1.


A multicenter prospective observational study on the safety and efficacy of tacrolimus in patients with myasthenia gravis.

Ahn SW, Joo IS, Kim BJ, Sung JJ, Kang SY, Oh J, Minn YK, Suh BC, Oh SY, Hong YH, Nam TS, Seok JI, Park YE, Shin HY, Cho EB, Shin JY, Seok HY, Park JS, Min JH, Seok JM, Kim BJ.

J Neurol Sci. 2017 Aug 15;379:271-275. doi: 10.1016/j.jns.2017.05.060. Epub 2017 May 30.


A prospective study on second-generation colon capsule endoscopy to detect mucosal lesions and disease activity in ulcerative colitis (with video).

Shi HY, Chan FKL, Higashimori A, Kyaw M, Ching JYL, Chan HCH, Chan JCH, Chan AWH, Lam KLY, Tang RSY, Wu JCY, Sung JJY, Ng SC.

Gastrointest Endosc. 2017 Dec;86(6):1139-1146.e6. doi: 10.1016/j.gie.2017.07.007. Epub 2017 Jul 14.


Global temporal patterns of pancreatic cancer and association with socioeconomic development.

Wong MCS, Jiang JY, Liang M, Fang Y, Yeung MS, Sung JJY.

Sci Rep. 2017 Jun 9;7(1):3165. doi: 10.1038/s41598-017-02997-2.


Response to the letter to the editor regarding an article, "Takotsubo cardiomyopathy in amyotrophic lateral sclerosis".

Choi SJ, Hong YH, Shin JY, Yoon BN, Sohn SY, Park CS, Sung JJ.

J Neurol Sci. 2017 Aug 15;379:341-342. doi: 10.1016/j.jns.2017.05.016. Epub 2017 May 10. No abstract available.


A modified colorectal screening score for prediction of advanced neoplasia: A prospective study of 5744 subjects.

Sung JJY, Wong MCS, Lam TYT, Tsoi KKF, Chan VCW, Cheung W, Ching JYL.

J Gastroenterol Hepatol. 2018 Jan;33(1):187-194. doi: 10.1111/jgh.13835.


Bacteriophage transfer during faecal microbiota transplantation in Clostridium difficile infection is associated with treatment outcome.

Zuo T, Wong SH, Lam K, Lui R, Cheung K, Tang W, Ching JYL, Chan PKS, Chan MCW, Wu JCY, Chan FKL, Yu J, Sung JJY, Ng SC.

Gut. 2018 Apr;67(4):634-643. doi: 10.1136/gutjnl-2017-313952. Epub 2017 May 24.


Global Prevalence of Helicobacter pylori Infection: Systematic Review and Meta-Analysis.

Hooi JKY, Lai WY, Ng WK, Suen MMY, Underwood FE, Tanyingoh D, Malfertheiner P, Graham DY, Wong VWS, Wu JCY, Chan FKL, Sung JJY, Kaplan GG, Ng SC.

Gastroenterology. 2017 Aug;153(2):420-429. doi: 10.1053/j.gastro.2017.04.022. Epub 2017 Apr 27. Review.


Altered nucleocytoplasmic proteome and transcriptome distributions in an in vitro model of amyotrophic lateral sclerosis.

Kim JE, Hong YH, Kim JY, Jeon GS, Jung JH, Yoon BN, Son SY, Lee KW, Kim JI, Sung JJ.

PLoS One. 2017 Apr 28;12(4):e0176462. doi: 10.1371/journal.pone.0176462. eCollection 2017.


Efficacy and safety of novel digital single-operator peroral cholangioscopy-guided laser lithotripsy for complicated biliary stones.

Wong JC, Tang RS, Teoh AY, Sung JJ, Lau JY.

Endosc Int Open. 2017 Jan;5(1):E54-E58. doi: 10.1055/s-0042-118701.


Takotsubo cardiomyopathy in amyotrophic lateral sclerosis.

Choi SJ, Hong YH, Shin JY, Yoon BN, Sohn SY, Park CS, Sung JJ.

J Neurol Sci. 2017 Apr 15;375:289-293. doi: 10.1016/j.jns.2017.02.012. Epub 2017 Feb 8.


Sodium Channel Subunit SCNN1B Suppresses Gastric Cancer Growth and Metastasis via GRP78 Degradation.

Qian Y, Wong CC, Xu J, Chen H, Zhang Y, Kang W, Wang H, Zhang L, Li W, Chu ESH, Go MYY, Chiu PWY, Ng EKW, Chan FKL, Sung JJY, Si J, Yu J.

Cancer Res. 2017 Apr 15;77(8):1968-1982. doi: 10.1158/0008-5472.CAN-16-1595. Epub 2017 Feb 15.


Peptostreptococcus anaerobius Induces Intracellular Cholesterol Biosynthesis in Colon Cells to Induce Proliferation and Causes Dysplasia in Mice.

Tsoi H, Chu ESH, Zhang X, Sheng J, Nakatsu G, Ng SC, Chan AWH, Chan FKL, Sung JJY, Yu J.

Gastroenterology. 2017 May;152(6):1419-1433.e5. doi: 10.1053/j.gastro.2017.01.009. Epub 2017 Jan 23.


Reassessment of Rebleeding Risk of Forrest IB (Oozing) Peptic Ulcer Bleeding in a Large International Randomized Trial.

Jensen DM, Eklund S, Persson T, Ahlbom H, Stuart R, Barkun AN, Kuipers EJ, Mössner J, Lau JY, Sung JJ, Kilhamn J, Lind T.

Am J Gastroenterol. 2017 Mar;112(3):441-446. doi: 10.1038/ajg.2016.582. Epub 2017 Jan 17.


25-Hydroxycholesterol is involved in the pathogenesis of amyotrophic lateral sclerosis.

Kim SM, Noh MY, Kim H, Cheon SY, Lee KM, Lee J, Cha E, Park KS, Lee KW, Sung JJ, Kim SH.

Oncotarget. 2017 Feb 14;8(7):11855-11867. doi: 10.18632/oncotarget.14416.

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