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Items: 1 to 50 of 120

1.

A genetics-led approach defines the drug target landscape of 30 immune-related traits.

Fang H; ULTRA-DD Consortium, De Wolf H, Knezevic B, Burnham KL, Osgood J, Sanniti A, Lledó Lara A, Kasela S, De Cesco S, Wegner JK, Handunnetthi L, McCann FE, Chen L, Sekine T, Brennan PE, Marsden BD, Damerell D, O'Callaghan CA, Bountra C, Bowness P, Sundström Y, Milani L, Berg L, Göhlmann HW, Peeters PJ, Fairfax BP, Sundström M, Knight JC.

Nat Genet. 2019 Jul;51(7):1082-1091. doi: 10.1038/s41588-019-0456-1. Epub 2019 Jun 28.

PMID:
31253980
2.

Consequences of a high incidence of microsatellite instability and BRAF-mutated tumors: A population-based cohort of metastatic colorectal cancer patients.

Aasebø KØ, Dragomir A, Sundström M, Mezheyeuski A, Edqvist PH, Eide GE, Ponten F, Pfeiffer P, Glimelius B, Sorbye H.

Cancer Med. 2019 Jul;8(7):3623-3635. doi: 10.1002/cam4.2205. Epub 2019 May 9.

3.

Is moving to a greener or less green area followed by changes in physical activity?

Persson Å, Möller J, Engström K, Sundström ML, Nooijen CFJ.

Health Place. 2019 May;57:165-170. doi: 10.1016/j.healthplace.2019.04.006. Epub 2019 May 2.

PMID:
31055106
4.

The context of care matters: Older people's existential loneliness from the perspective of healthcare professionals-A multiple case study.

Sundström M, Blomqvist K, Edberg AK, Rämgård M.

Int J Older People Nurs. 2019 Sep;14(3):e12234. doi: 10.1111/opn.12234. Epub 2019 Apr 26.

5.

Mutation patterns in a population-based non-small cell lung cancer cohort and prognostic impact of concomitant mutations in KRAS and TP53 or STK11.

La Fleur L, Falk-Sörqvist E, Smeds P, Berglund A, Sundström M, Mattsson JS, Brandén E, Koyi H, Isaksson J, Brunnström H, Nilsson M, Micke P, Moens L, Botling J.

Lung Cancer. 2019 Apr;130:50-58. doi: 10.1016/j.lungcan.2019.01.003. Epub 2019 Jan 9.

6.

Encountering existential loneliness among older people: perspectives of health care professionals.

Sundström M, Edberg AK, Rämgård M, Blomqvist K.

Int J Qual Stud Health Well-being. 2018 Dec;13(1):1474673. doi: 10.1080/17482631.2018.1474673.

7.

Amphetamine primes enhanced motivation toward uncertain choices in rats with genetic alcohol preference.

Oinio V, Sundström M, Bäckström P, Uhari-Väänänen J, Kiianmaa K, Raasmaja A, Piepponen P.

Psychopharmacology (Berl). 2018 May;235(5):1361-1370. doi: 10.1007/s00213-018-4847-2. Epub 2018 Feb 9.

PMID:
29427080
8.

Prevalence and Correlates of Sexual, Physical, and Psychological Violence Against Women and Men of 60 to 74 Years in Sweden.

Ahnlund P, Andersson T, Snellman F, Sundström M, Heimer G.

J Interpers Violence. 2017 Mar 1:886260517696874. doi: 10.1177/0886260517696874. [Epub ahead of print]

PMID:
29294678
9.

Assessing speech perception in Swedish school-aged children: preliminary data on the Listen-Say test.

Nakeva von Mentzer C, Sundström M, Enqvist K, Hällgren M.

Logoped Phoniatr Vocol. 2018 Oct;43(3):106-119. doi: 10.1080/14015439.2017.1380076. Epub 2017 Oct 10.

PMID:
28994616
10.

Comparison of Post-targeted and Pre-targeted Urine Drug Screening by UHPLC-HR-QTOFMS.

Sundström M, Pelander A, Ojanperä I.

J Anal Toxicol. 2017 Sep 1;41(7):623-630. doi: 10.1093/jat/bkx044.

PMID:
28873975
11.

Health and social care planning in collaboration in older persons' homes: the perspectives of older persons, family members and professionals.

Sundström M, Petersson P, Rämgård M, Varland L, Blomqvist K.

Scand J Caring Sci. 2018 Mar;32(1):147-156. doi: 10.1111/scs.12440. Epub 2017 May 24.

PMID:
28543670
12.

Somatic Ephrin Receptor Mutations Are Associated with Metastasis in Primary Colorectal Cancer.

Mathot L, Kundu S, Ljungström V, Svedlund J, Moens L, Adlerteg T, Falk-Sörqvist E, Rendo V, Bellomo C, Mayrhofer M, Cortina C, Sundström M, Micke P, Botling J, Isaksson A, Moustakas A, Batlle E, Birgisson H, Glimelius B, Nilsson M, Sjöblom T.

Cancer Res. 2017 Apr 1;77(7):1730-1740. doi: 10.1158/0008-5472.CAN-16-1921. Epub 2017 Jan 20.

13.

Clonal Variation in Drug and Radiation Response among Glioma-Initiating Cells Is Linked to Proneural-Mesenchymal Transition.

Segerman A, Niklasson M, Haglund C, Bergström T, Jarvius M, Xie Y, Westermark A, Sönmez D, Hermansson A, Kastemar M, Naimaie-Ali Z, Nyberg F, Berglund M, Sundström M, Hesselager G, Uhrbom L, Gustafsson M, Larsson R, Fryknäs M, Segerman B, Westermark B.

Cell Rep. 2016 Dec 13;17(11):2994-3009. doi: 10.1016/j.celrep.2016.11.056.

14.

Ameloblastoma RNA profiling uncovers a distinct non-coding RNA signature.

Davanian H, Balasiddaiah A, Heymann R, Sundström M, Redenström P, Silfverberg M, Brodin D, Sällberg M, Lindskog S, Kruger Weiner C, Chen M.

Oncotarget. 2017 Jan 17;8(3):4530-4542. doi: 10.18632/oncotarget.13889.

15.

Associations of defect mismatch repair genes with prognosis and heredity in sporadic colorectal cancer.

Ghanipour L, Jirström K, Sundström M, Glimelius B, Birgisson H.

Eur J Surg Oncol. 2017 Feb;43(2):311-321. doi: 10.1016/j.ejso.2016.10.013. Epub 2016 Oct 31.

PMID:
27836416
16.

High sensitivity isoelectric focusing to establish a signaling biomarker for the diagnosis of human colorectal cancer.

Padhan N, Nordling TE, Sundström M, Åkerud P, Birgisson H, Nygren P, Nelander S, Claesson-Welsh L.

BMC Cancer. 2016 Aug 25;16(1):683. doi: 10.1186/s12885-016-2725-z.

17.

Increased expression of TACI on NOD B cells results in germinal centre reaction anomalies, enhanced plasma cell differentiation and immunoglobulin production.

Banday VS, Thyagarajan R, Sundström M, Lejon K.

Immunology. 2016 Nov;149(3):297-305. doi: 10.1111/imm.12651. Epub 2016 Aug 23.

18.

Significant association and synergistic adverse prognostic effect of podocalyxin-like protein and epidermal growth factor receptor expression in colorectal cancer.

Larsson AH, Lehn S, Wangefjord S, Karnevi E, Kuteeva E, Sundström M, Nodin B, Uhlén M, Eberhard J, Birgisson H, Jirström K.

J Transl Med. 2016 May 10;14(1):128. doi: 10.1186/s12967-016-0882-0.

19.

A high-throughput analysis of the IDH1(R132H) protein expression in pituitary adenomas.

Casar-Borota O, Øystese KA, Sundström M, Melchior L, Popovic V.

Pituitary. 2016 Aug;19(4):407-14. doi: 10.1007/s11102-016-0720-7.

PMID:
27097804
20.

Large-Scale Biophysical Evaluation of Protein PEGylation Effects: In Vitro Properties of 61 Protein Entities.

Vernet E, Popa G, Pozdnyakova I, Rasmussen JE, Grohganz H, Giehm L, Jensen MH, Wang H, Plesner B, Nielsen HM, Jensen KJ, Berthelsen J, Sundström M, van de Weert M.

Mol Pharm. 2016 May 2;13(5):1587-98. doi: 10.1021/acs.molpharmaceut.6b00049. Epub 2016 Apr 12.

PMID:
27043713
21.

Approximation of Resting Energy Expenditure in Intensive Care Unit Patients Using the SenseWear Bracelet: A Comparison With Indirect Calorimetry.

Sundström M, Mehrabi M, Tjäder I, Rooyackers O, Hammarqvist F.

JPEN J Parenter Enteral Nutr. 2017 Aug;41(6):976-980. doi: 10.1177/0148607116633808. Epub 2016 Mar 15.

PMID:
26979281
22.

New psychoactive substances as part of polydrug abuse within opioid maintenance treatment revealed by comprehensive high-resolution mass spectrometric urine drug screening.

Heikman P, Sundström M, Pelander A, Ojanperä I.

Hum Psychopharmacol. 2016 Jan;31(1):44-52. doi: 10.1002/hup.2512. Epub 2016 Jan 13.

PMID:
26763789
23.

Corrigendum: The promise and peril of chemical probes.

Arrowsmith CH, Audia JE, Austin C, Baell J, Bennett J, Blagg J, Bountra C, Brennan PE, Brown PJ, Bunnage ME, Buser-Doepner C, Campbell RM, Carter AJ, Cohen P, Copeland RA, Cravatt B, Dahlin JL, Dhanak D, Edwards AM, Frederiksen M, Frye SV, Gray N, Grimshaw CE, Hepworth D, Howe T, Huber KV, Jin J, Knapp S, Kotz JD, Kruger RG, Lowe D, Mader MM, Marsden B, Mueller-Fahrnow A, Müller S, O'Hagan RC, Overington JP, Owen DR, Rosenberg SH, Ross R, Roth B, Schapira M, Schreiber SL, Shoichet B, Sundström M, Superti-Furga G, Taunton J, Toledo-Sherman L, Walpole C, Walters MA, Willson TM, Workman P, Young RN, Zuercher WJ.

Nat Chem Biol. 2015 Nov;11(11):887. doi: 10.1038/nchembio1115-887c. No abstract available.

PMID:
26485080
24.

Mitochondrial respiratory dysfunction due to the conversion of substituted cathinones to methylbenzamides in SH-SY5Y cells.

den Hollander B, Sundström M, Pelander A, Siltanen A, Ojanperä I, Mervaala E, Korpi ER, Kankuri E.

Sci Rep. 2015 Oct 14;5:14924. doi: 10.1038/srep14924.

25.

HaloPlex Targeted Resequencing for Mutation Detection in Clinical Formalin-Fixed, Paraffin-Embedded Tumor Samples.

Moens LN, Falk-Sörqvist E, Ljungström V, Mattsson J, Sundström M, La Fleur L, Mathot L, Micke P, Nilsson M, Botling J.

J Mol Diagn. 2015 Nov;17(6):729-39. doi: 10.1016/j.jmoldx.2015.06.009. Epub 2015 Sep 3.

PMID:
26354930
26.

The promise and peril of chemical probes.

Arrowsmith CH, Audia JE, Austin C, Baell J, Bennett J, Blagg J, Bountra C, Brennan PE, Brown PJ, Bunnage ME, Buser-Doepner C, Campbell RM, Carter AJ, Cohen P, Copeland RA, Cravatt B, Dahlin JL, Dhanak D, Edwards AM, Frederiksen M, Frye SV, Gray N, Grimshaw CE, Hepworth D, Howe T, Huber KV, Jin J, Knapp S, Kotz JD, Kruger RG, Lowe D, Mader MM, Marsden B, Mueller-Fahrnow A, Müller S, O'Hagan RC, Overington JP, Owen DR, Rosenberg SH, Roth B, Ross R, Schapira M, Schreiber SL, Shoichet B, Sundström M, Superti-Furga G, Taunton J, Toledo-Sherman L, Walpole C, Walters MA, Willson TM, Workman P, Young RN, Zuercher WJ.

Nat Chem Biol. 2015 Aug;11(8):536-41. doi: 10.1038/nchembio.1867. No abstract available. Erratum in: Nat Chem Biol. 2015 Aug;11(8):541. Roth, Brian [Corrected to Roth, Bryan] and Frederiksen, Mathias [Added]. Nat Chem Biol. 2015 Nov;11(11):887.

27.

Patients with Non-small Cell Lung Cancer Analyzed for EGFR: Adherence to Guidelines, Prevalence and Outcome.

Sandelin M, Berglund A, Sundström M, Micke P, Ekman S, Bergqvist M, Bergström S, Koyi H, Brandén E, Janson C, Botling J.

Anticancer Res. 2015 Jul;35(7):3979-85.

PMID:
26124345
28.

High BRAF Mutation Frequency and Marked Survival Differences in Subgroups According to KRAS/BRAF Mutation Status and Tumor Tissue Availability in a Prospective Population-Based Metastatic Colorectal Cancer Cohort.

Sorbye H, Dragomir A, Sundström M, Pfeiffer P, Thunberg U, Bergfors M, Aasebø K, Eide GE, Ponten F, Qvortrup C, Glimelius B.

PLoS One. 2015 Jun 29;10(6):e0131046. doi: 10.1371/journal.pone.0131046. eCollection 2015.

29.

Influence of contaminated drinking water on perfluoroalkyl acid levels in human serum--A case study from Uppsala, Sweden.

Gyllenhammar I, Berger U, Sundström M, McCleaf P, Eurén K, Eriksson S, Ahlgren S, Lignell S, Aune M, Kotova N, Glynn A.

Environ Res. 2015 Jul;140:673-83. doi: 10.1016/j.envres.2015.05.019. Epub 2015 Jun 14.

PMID:
26079316
30.

Patterns of drug abuse among drug users with regular and irregular attendance for treatment as detected by comprehensive UHPLC-HR-TOF-MS.

Sundström M, Pelander A, Simojoki K, Ojanperä I.

Drug Test Anal. 2016 Jan;8(1):39-45. doi: 10.1002/dta.1818. Epub 2015 May 28.

PMID:
26017246
31.

Tissue uptake, distribution and elimination of (14)C-PFOA in zebrafish (Danio rerio).

Ulhaq M, Sundström M, Larsson P, Gabrielsson J, Bergman Å, Norrgren L, Örn S.

Aquat Toxicol. 2015 Jun;163:148-57. doi: 10.1016/j.aquatox.2015.04.003. Epub 2015 Apr 3.

PMID:
25897689
32.

Microsatellite instability and mutations in BRAF and KRAS are significant predictors of disseminated disease in colon cancer.

Birgisson H, Edlund K, Wallin U, Påhlman L, Kultima HG, Mayrhofer M, Micke P, Isaksson A, Botling J, Glimelius B, Sundström M.

BMC Cancer. 2015 Mar 14;15:125. doi: 10.1186/s12885-015-1144-x.

33.

Short-term amino acid infusion improves protein balance in critically ill patients.

Liebau F, Sundström M, van Loon LJ, Wernerman J, Rooyackers O.

Crit Care. 2015 Mar 12;19:106. doi: 10.1186/s13054-015-0844-6.

34.

Preclinical target validation using patient-derived cells.

Edwards AM, Arrowsmith CH, Bountra C, Bunnage ME, Feldmann M, Knight JC, Patel DD, Prinos P, Taylor MD, Sundström M; SGC Open Source Target-Discovery Partnership.

Nat Rev Drug Discov. 2015 Mar;14(3):149-50. doi: 10.1038/nrd4565. Epub 2015 Feb 20.

PMID:
25722227
35.

1p36 deletion is a marker for tumour dissemination in microsatellite stable stage II-III colon cancer.

Mayrhofer M, Kultima HG, Birgisson H, Sundström M, Mathot L, Edlund K, Viklund B, Sjöblom T, Botling J, Micke P, Påhlman L, Glimelius B, Isaksson A.

BMC Cancer. 2014 Nov 24;14:872. doi: 10.1186/1471-2407-14-872.

36.

Recently targeted kinases and their inhibitors-the path to clinical trials.

Knapp S, Sundström M.

Curr Opin Pharmacol. 2014 Aug;17:58-63. doi: 10.1016/j.coph.2014.07.015. Epub 2014 Aug 9. Review.

PMID:
25113945
37.

Noncontaminated dietary oats may hamper normalization of the intestinal immune status in childhood celiac disease.

Sjöberg V, Hollén E, Pietz G, Magnusson KE, Fälth-Magnusson K, Sundström M, Holmgren Peterson K, Sandström O, Hernell O, Hammarström S, Högberg L, Hammarström ML.

Clin Transl Gastroenterol. 2014 Jun 26;5:e58. doi: 10.1038/ctg.2014.9.

38.

Utility of urinary ethyl glucuronide analysis in post-mortem toxicology when investigating alcohol-related deaths.

Sundström M, Jones AW, Ojanperä I.

Forensic Sci Int. 2014 Aug;241:178-82. doi: 10.1016/j.forsciint.2014.05.022. Epub 2014 Jun 2.

PMID:
24954799
39.

Comparison between drug screening by immunoassay and ultra-high performance liquid chromatography/high-resolution time-of-flight mass spectrometry in post-mortem urine.

Sundström M, Pelander A, Ojanperä I.

Drug Test Anal. 2015 May;7(5):420-7. doi: 10.1002/dta.1683. Epub 2014 Jun 20.

PMID:
24953563
40.

Associations of anthropometric factors with KRAS and BRAF mutation status of primary colorectal cancer in men and women: a cohort study.

Brändstedt J, Wangefjord S, Nodin B, Eberhard J, Sundström M, Manjer J, Jirström K.

PLoS One. 2014 Jun 11;9(2):e98964. doi: 10.1371/journal.pone.0098964. eCollection 2014.

41.

Keto amphetamine toxicity-focus on the redox reactivity of the cathinone designer drug mephedrone.

den Hollander B, Sundström M, Pelander A, Ojanperä I, Mervaala E, Korpi ER, Kankuri E.

Toxicol Sci. 2014 Sep;141(1):120-31. doi: 10.1093/toxsci/kfu108. Epub 2014 Jun 9.

42.

In situ mutation detection and visualization of intratumor heterogeneity for cancer research and diagnostics.

Grundberg I, Kiflemariam S, Mignardi M, Imgenberg-Kreuz J, Edlund K, Micke P, Sundström M, Sjöblom T, Botling J, Nilsson M.

Oncotarget. 2013 Dec;4(12):2407-18.

43.

Tissue distribution of 35S-labelled perfluorobutanesulfonic acid in adult mice following dietary exposure for 1-5 days.

Bogdanska J, Sundström M, Bergström U, Borg D, Abedi-Valugerdi M, Bergman Å, DePierre J, Nobel S.

Chemosphere. 2014 Mar;98:28-36. doi: 10.1016/j.chemosphere.2013.09.062. Epub 2013 Nov 14.

PMID:
24238775
44.

Heterologous expression and purification of an active human TRPV3 ion channel.

Kol S, Braun C, Thiel G, Doyle DA, Sundström M, Gourdon P, Nissen P.

FEBS J. 2013 Dec;280(23):6010-21. doi: 10.1111/febs.12520. Epub 2013 Sep 30.

45.

Sex differences in the prognostic significance of KRAS codons 12 and 13, and BRAF mutations in colorectal cancer: a cohort study.

Wangefjord S, Sundström M, Zendehrokh N, Lindquist KE, Nodin B, Jirström K, Eberhard J.

Biol Sex Differ. 2013 Sep 10;4(1):17. doi: 10.1186/2042-6410-4-17.

46.

Functional proteomics defines the molecular switch underlying FGF receptor trafficking and cellular outputs.

Francavilla C, Rigbolt KT, Emdal KB, Carraro G, Vernet E, Bekker-Jensen DB, Streicher W, Wikström M, Sundström M, Bellusci S, Cavallaro U, Blagoev B, Olsen JV.

Mol Cell. 2013 Sep 26;51(6):707-22. doi: 10.1016/j.molcel.2013.08.002. Epub 2013 Sep 5.

47.

A high-sensitivity ultra-high performance liquid chromatography/high-resolution time-of-flight mass spectrometry (UHPLC-HR-TOFMS) method for screening synthetic cannabinoids and other drugs of abuse in urine.

Sundström M, Pelander A, Angerer V, Hutter M, Kneisel S, Ojanperä I.

Anal Bioanal Chem. 2013 Oct;405(26):8463-74. doi: 10.1007/s00216-013-7272-8. Epub 2013 Aug 18.

PMID:
23954996
48.

Clinicopathological correlates and prognostic significance of KRAS mutation status in a pooled prospective cohort of epithelial ovarian cancer.

Nodin B, Zendehrokh N, Sundström M, Jirström K.

Diagn Pathol. 2013 Jun 25;8:106. doi: 10.1186/1746-1596-8-106.

49.

Design and synthesis of β-site amyloid precursor protein cleaving enzyme (BACE1) inhibitors with in vivo brain reduction of β-amyloid peptides.

Swahn BM, Kolmodin K, Karlström S, von Berg S, Söderman P, Holenz J, Berg S, Lindström J, Sundström M, Turek D, Kihlström J, Slivo C, Andersson L, Pyring D, Rotticci D, Ohberg L, Kers A, Bogar K, von Kieseritzky F, Bergh M, Olsson LL, Janson J, Eketjäll S, Georgievska B, Jeppsson F, Fälting J.

J Med Chem. 2012 Nov 8;55(21):9346-61. doi: 10.1021/jm3009025. Epub 2012 Sep 17.

PMID:
22924815
50.

Indirect calorimetry in mechanically ventilated patients. A systematic comparison of three instruments.

Sundström M, Tjäder I, Rooyackers O, Wernerman J.

Clin Nutr. 2013 Feb;32(1):118-21. doi: 10.1016/j.clnu.2012.06.004. Epub 2012 Jul 3.

PMID:
22763268

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