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A highly potent long-acting small-molecule HIV-1 capsid inhibitor with efficacy in a humanized mouse model.

Yant SR, Mulato A, Hansen D, Tse WC, Niedziela-Majka A, Zhang JR, Stepan GJ, Jin D, Wong MH, Perreira JM, Singer E, Papalia GA, Hu EY, Zheng J, Lu B, Schroeder SD, Chou K, Ahmadyar S, Liclican A, Yu H, Novikov N, Paoli E, Gonik D, Ram RR, Hung M, McDougall WM, Brass AL, Sundquist WI, Cihlar T, Link JO.

Nat Med. 2019 Sep;25(9):1377-1384. doi: 10.1038/s41591-019-0560-x. Epub 2019 Sep 9.


Structure of Vps4 with circular peptides and implications for translocation of two polypeptide chains by AAA+ ATPases.

Han H, Fulcher JM, Dandey VP, Iwasa JH, Sundquist WI, Kay MS, Shen PS, Hill CP.

Elife. 2019 Jun 11;8. pii: e44071. doi: 10.7554/eLife.44071.


Retrovirus Restriction by TRIM5α: RINGside at a Cage Fight.

Sundquist WI, Pornillos O.

Cell Host Microbe. 2018 Dec 12;24(6):751-753. doi: 10.1016/j.chom.2018.11.013.


A cancer-associated polymorphism in ESCRT-III disrupts the abscission checkpoint and promotes genome instability.

Sadler JBA, Wenzel DM, Williams LK, Guindo-Martínez M, Alam SL, Mercader JM, Torrents D, Ullman KS, Sundquist WI, Martin-Serrano J.

Proc Natl Acad Sci U S A. 2018 Sep 18;115(38):E8900-E8908. doi: 10.1073/pnas.1805504115. Epub 2018 Sep 4.


Structures, Functions, and Dynamics of ESCRT-III/Vps4 Membrane Remodeling and Fission Complexes.

McCullough J, Frost A, Sundquist WI.

Annu Rev Cell Dev Biol. 2018 Oct 6;34:85-109. doi: 10.1146/annurev-cellbio-100616-060600. Epub 2018 Aug 10. Review.


General Model for Retroviral Capsid Pattern Recognition by TRIM5 Proteins.

Wagner JM, Christensen DE, Bhattacharya A, Dawidziak DM, Roganowicz MD, Wan Y, Pumroy RA, Demeler B, Ivanov DN, Ganser-Pornillos BK, Sundquist WI, Pornillos O.

J Virol. 2018 Jan 30;92(4). pii: e01563-17. doi: 10.1128/JVI.01563-17. Print 2018 Feb 15.


The AAA ATPase Vps4 binds ESCRT-III substrates through a repeating array of dipeptide-binding pockets.

Han H, Monroe N, Sundquist WI, Shen PS, Hill CP.

Elife. 2017 Nov 22;6. pii: e31324. doi: 10.7554/eLife.31324.


What's in a name?

Schaller MD, McDowell G, Porter A, Shippen D, Friedman KL, Gentry MS, Serio TR, Sundquist WI.

Elife. 2017 Oct 24;6. pii: e32437. doi: 10.7554/eLife.32437.


Structural basis of protein translocation by the Vps4-Vta1 AAA ATPase.

Monroe N, Han H, Shen PS, Sundquist WI, Hill CP.

Elife. 2017 Apr 5;6. pii: e24487. doi: 10.7554/eLife.24487.


LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells.

Gu M, LaJoie D, Chen OS, von Appen A, Ladinsky MS, Redd MJ, Nikolova L, Bjorkman PJ, Sundquist WI, Ullman KS, Frost A.

Proc Natl Acad Sci U S A. 2017 Mar 14;114(11):E2166-E2175. doi: 10.1073/pnas.1613916114. Epub 2017 Feb 27.


Designed proteins induce the formation of nanocage-containing extracellular vesicles.

Votteler J, Ogohara C, Yi S, Hsia Y, Nattermann U, Belnap DM, King NP, Sundquist WI.

Nature. 2016 Dec 8;540(7632):292-295. doi: 10.1038/nature20607. Epub 2016 Nov 30.


Primate TRIM5 proteins form hexagonal nets on HIV-1 capsids.

Li YL, Chandrasekaran V, Carter SD, Woodward CL, Christensen DE, Dryden KA, Pornillos O, Yeager M, Ganser-Pornillos BK, Jensen GJ, Sundquist WI.

Elife. 2016 Jun 2;5. pii: e16269. doi: 10.7554/eLife.16269.


Mechanism of B-box 2 domain-mediated higher-order assembly of the retroviral restriction factor TRIM5α.

Wagner JM, Roganowicz MD, Skorupka K, Alam SL, Christensen D, Doss G, Wan Y, Frank GA, Ganser-Pornillos BK, Sundquist WI, Pornillos O.

Elife. 2016 Jun 2;5. pii: e16309. doi: 10.7554/eLife.16309.


Structure and membrane remodeling activity of ESCRT-III helical polymers.

McCullough J, Clippinger AK, Talledge N, Skowyra ML, Saunders MG, Naismith TV, Colf LA, Afonine P, Arthur C, Sundquist WI, Hanson PI, Frost A.

Science. 2015 Dec 18;350(6267):1548-51. doi: 10.1126/science.aad8305. Epub 2015 Dec 3.


Toward a sustainable biomedical research enterprise: Finding consensus and implementing recommendations.

Pickett CL, Corb BW, Matthews CR, Sundquist WI, Berg JM.

Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):10832-6. doi: 10.1073/pnas.1509901112. Epub 2015 Jul 20.


TRIM5α requires Ube2W to anchor Lys63-linked ubiquitin chains and restrict reverse transcription.

Fletcher AJ, Christensen DE, Nelson C, Tan CP, Schaller T, Lehner PJ, Sundquist WI, Towers GJ.

EMBO J. 2015 Aug 4;34(15):2078-95. doi: 10.15252/embj.201490361. Epub 2015 Jun 22.


CELL BIOLOGY. An ESCRT to seal the envelope.

Sundquist WI, Ullman KS.

Science. 2015 Jun 19;348(6241):1314-5. doi: 10.1126/science.aac7083. No abstract available.


ULK3 regulates cytokinetic abscission by phosphorylating ESCRT-III proteins.

Caballe A, Wenzel DM, Agromayor M, Alam SL, Skalicky JJ, Kloc M, Carlton JG, Labrador L, Sundquist WI, Martin-Serrano J.

Elife. 2015 May 26;4:e06547. doi: 10.7554/eLife.06547.


Binding of Substrates to the Central Pore of the Vps4 ATPase Is Autoinhibited by the Microtubule Interacting and Trafficking (MIT) Domain and Activated by MIT Interacting Motifs (MIMs).

Han H, Monroe N, Votteler J, Shakya B, Sundquist WI, Hill CP.

J Biol Chem. 2015 May 22;290(21):13490-9. doi: 10.1074/jbc.M115.642355. Epub 2015 Apr 1.


Angiomotin functions in HIV-1 assembly and budding.

Mercenne G, Alam SL, Arii J, Lalonde MS, Sundquist WI.

Elife. 2015 Jan 29;4. doi: 10.7554/eLife.03778.


Putting a finger in the ring.

McCullough J, Sundquist WI.

Nat Struct Mol Biol. 2014 Dec;21(12):1025-7. doi: 10.1038/nsmb.2928. No abstract available.


The tripartite motif coiled-coil is an elongated antiparallel hairpin dimer.

Sanchez JG, Okreglicka K, Chandrasekaran V, Welker JM, Sundquist WI, Pornillos O.

Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2494-9. doi: 10.1073/pnas.1318962111. Epub 2014 Feb 3.


The oligomeric state of the active Vps4 AAA ATPase.

Monroe N, Han H, Gonciarz MD, Eckert DM, Karren MA, Whitby FG, Sundquist WI, Hill CP.

J Mol Biol. 2014 Feb 6;426(3):510-25. doi: 10.1016/j.jmb.2013.09.043. Epub 2013 Oct 23.


ESCRT requirements for EIAV budding.

Sandrin V, Sundquist WI.

Retrovirology. 2013 Oct 9;10:104. doi: 10.1186/1742-4690-10-104.


Virus budding and the ESCRT pathway.

Votteler J, Sundquist WI.

Cell Host Microbe. 2013 Sep 11;14(3):232-41. doi: 10.1016/j.chom.2013.08.012. Review.


Discovery of novel small-molecule HIV-1 replication inhibitors that stabilize capsid complexes.

Lamorte L, Titolo S, Lemke CT, Goudreau N, Mercier JF, Wardrop E, Shah VB, von Schwedler UK, Langelier C, Banik SS, Aiken C, Sundquist WI, Mason SW.

Antimicrob Agents Chemother. 2013 Oct;57(10):4622-31. doi: 10.1128/AAC.00985-13. Epub 2013 Jul 1.


Macromolecular assemblies.

Rey FA, Sundquist WI.

Curr Opin Struct Biol. 2013 Apr;23(2):224-8. doi: 10.1016/ Epub 2013 May 7. No abstract available.


Building a super elongation complex for HIV.

Hill CP, Sundquist WI.

Elife. 2013 Mar 8;2:e00577. doi: 10.7554/eLife.00577.


Membrane fission reactions of the mammalian ESCRT pathway.

McCullough J, Colf LA, Sundquist WI.

Annu Rev Biochem. 2013;82:663-92. doi: 10.1146/annurev-biochem-072909-101058. Epub 2013 Mar 18. Review.


ALIX is a Lys63-specific polyubiquitin binding protein that functions in retrovirus budding.

Dowlatshahi DP, Sandrin V, Vivona S, Shaler TA, Kaiser SE, Melandri F, Sundquist WI, Kopito RR.

Dev Cell. 2012 Dec 11;23(6):1247-54. doi: 10.1016/j.devcel.2012.10.023. Epub 2012 Nov 29.


How HIV finds the door.

Lalonde MS, Sundquist WI.

Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):18631-2. doi: 10.1073/pnas.1215940109. Epub 2012 Nov 1. No abstract available.


Interactions of the human LIP5 regulatory protein with endosomal sorting complexes required for transport.

Skalicky JJ, Arii J, Wenzel DM, Stubblefield WM, Katsuyama A, Uter NT, Bajorek M, Myszka DG, Sundquist WI.

J Biol Chem. 2012 Dec 21;287(52):43910-26. doi: 10.1074/jbc.M112.417899. Epub 2012 Oct 26.


ESCRT-III CHMP2A and CHMP3 form variable helical polymers in vitro and act synergistically during HIV-1 budding.

Effantin G, Dordor A, Sandrin V, Martinelli N, Sundquist WI, Schoehn G, Weissenhorn W.

Cell Microbiol. 2013 Feb;15(2):213-26. doi: 10.1111/cmi.12041. Epub 2012 Nov 6.


Attenuated protein expression vectors for use in siRNA rescue experiments.

Morita E, Arii J, Christensen D, Votteler J, Sundquist WI.

Biotechniques. 2012 Aug;0(0):1-5. doi: 10.2144/000113909.


HIV-1 assembly, budding, and maturation.

Sundquist WI, Kräusslich HG.

Cold Spring Harb Perspect Med. 2012 Jul;2(7):a006924. doi: 10.1101/cshperspect.a006924. Review. Erratum in: Cold Spring Harb Perspect Med. 2012 Aug;2(8). doi: 10.1101/cshperspect.a015420.


Distinct effects of two HIV-1 capsid assembly inhibitor families that bind the same site within the N-terminal domain of the viral CA protein.

Lemke CT, Titolo S, von Schwedler U, Goudreau N, Mercier JF, Wardrop E, Faucher AM, Coulombe R, Banik SS, Fader L, Gagnon A, Kawai SH, Rancourt J, Tremblay M, Yoakim C, Simoneau B, Archambault J, Sundquist WI, Mason SW.

J Virol. 2012 Jun;86(12):6643-55. doi: 10.1128/JVI.00493-12. Epub 2012 Apr 11.


Assemble, replicate, remodel and evade.

Sundquist WI, Krug RM.

Curr Opin Virol. 2012 Apr;2(2):111-4. doi: 10.1016/j.coviro.2012.02.008. Epub 2012 Mar 10. No abstract available.


Global landscape of HIV-human protein complexes.

Jäger S, Cimermancic P, Gulbahce N, Johnson JR, McGovern KE, Clarke SC, Shales M, Mercenne G, Pache L, Li K, Hernandez H, Jang GM, Roth SL, Akiva E, Marlett J, Stephens M, D'Orso I, Fernandes J, Fahey M, Mahon C, O'Donoghue AJ, Todorovic A, Morris JH, Maltby DA, Alber T, Cagney G, Bushman FD, Young JA, Chanda SK, Sundquist WI, Kortemme T, Hernandez RD, Craik CS, Burlingame A, Sali A, Frankel AD, Krogan NJ.

Nature. 2011 Dec 21;481(7381):365-70. doi: 10.1038/nature10719.


Structure of the Bro1 domain protein BROX and functional analyses of the ALIX Bro1 domain in HIV-1 budding.

Zhai Q, Landesman MB, Robinson H, Sundquist WI, Hill CP.

PLoS One. 2011;6(12):e27466. doi: 10.1371/journal.pone.0027466. Epub 2011 Dec 5.


Activation of the retroviral budding factor ALIX.

Zhai Q, Landesman MB, Chung HY, Dierkers A, Jeffries CM, Trewhella J, Hill CP, Sundquist WI.

J Virol. 2011 Sep;85(17):9222-6. doi: 10.1128/JVI.02653-10. Epub 2011 Jun 29.


Macromolecular assemblages.

Rey FA, Sundquist WI.

Curr Opin Struct Biol. 2011 Apr;21(2):221-2. doi: 10.1016/ Epub 2011 Mar 16. No abstract available.


ESCRT-III protein requirements for HIV-1 budding.

Morita E, Sandrin V, McCullough J, Katsuyama A, Baci Hamilton I, Sundquist WI.

Cell Host Microbe. 2011 Mar 17;9(3):235-242. doi: 10.1016/j.chom.2011.02.004.


Hexagonal assembly of a restricting TRIM5alpha protein.

Ganser-Pornillos BK, Chandrasekaran V, Pornillos O, Sodroski JG, Sundquist WI, Yeager M.

Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):534-9. doi: 10.1073/pnas.1013426108. Epub 2010 Dec 27.


Identification and structural characterization of the ALIX-binding late domains of simian immunodeficiency virus SIVmac239 and SIVagmTan-1.

Zhai Q, Landesman MB, Robinson H, Sundquist WI, Hill CP.

J Virol. 2011 Jan;85(1):632-7. doi: 10.1128/JVI.01683-10. Epub 2010 Oct 20.


Structural and functional studies on the extracellular domain of BST2/tetherin in reduced and oxidized conformations.

Schubert HL, Zhai Q, Sandrin V, Eckert DM, Garcia-Maya M, Saul L, Sundquist WI, Steiner RA, Hill CP.

Proc Natl Acad Sci U S A. 2010 Oct 19;107(42):17951-6. doi: 10.1073/pnas.1008206107. Epub 2010 Sep 29.


Human ESCRT-III and VPS4 proteins are required for centrosome and spindle maintenance.

Morita E, Colf LA, Karren MA, Sandrin V, Rodesch CK, Sundquist WI.

Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):12889-94. doi: 10.1073/pnas.1005938107. Epub 2010 Jun 29.


Structural basis for ESCRT-III protein autoinhibition.

Bajorek M, Schubert HL, McCullough J, Langelier C, Eckert DM, Stubblefield WM, Uter NT, Myszka DG, Hill CP, Sundquist WI.

Nat Struct Mol Biol. 2009 Jul;16(7):754-62. doi: 10.1038/nsmb.1621. Epub 2009 Jun 14.


X-ray structures of the hexameric building block of the HIV capsid.

Pornillos O, Ganser-Pornillos BK, Kelly BN, Hua Y, Whitby FG, Stout CD, Sundquist WI, Hill CP, Yeager M.

Cell. 2009 Jun 26;137(7):1282-92. doi: 10.1016/j.cell.2009.04.063. Epub 2009 Jun 11.


Biochemical analyses of human IST1 and its function in cytokinesis.

Bajorek M, Morita E, Skalicky JJ, Morham SG, Babst M, Sundquist WI.

Mol Biol Cell. 2009 Mar;20(5):1360-73. doi: 10.1091/mbc.E08-05-0475. Epub 2009 Jan 7.


Biochemical and structural studies of yeast Vps4 oligomerization.

Gonciarz MD, Whitby FG, Eckert DM, Kieffer C, Heroux A, Sundquist WI, Hill CP.

J Mol Biol. 2008 Dec 26;384(4):878-95. doi: 10.1016/j.jmb.2008.09.066. Epub 2008 Oct 4.

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