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Items: 1 to 50 of 88

1.

Structural insights into the mechanisms and specificities of IgG-active endoglycosidases.

Du JJ, Klontz EH, Guerin ME, Trastoy B, Sundberg EJ.

Glycobiology. 2019 Jun 7. pii: cwz042. doi: 10.1093/glycob/cwz042. [Epub ahead of print]

PMID:
31172182
2.

Gastric Subserous Vaccination With Helicobacter pylori Vaccine: An Attempt to Establish Tissue-Resident CD4+ Memory T Cells and Induce Prolonged Protection.

Liu W, Zeng Z, Luo S, Hu C, Xu N, Huang A, Zheng L, Sundberg EJ, Xi T, Xing Y.

Front Immunol. 2019 May 17;10:1115. doi: 10.3389/fimmu.2019.01115. eCollection 2019.

3.

Roles of Adhesion to Epithelial Cells in Gastric Colonization by Helicobacter pylori.

Bonsor DA, Sundberg EJ.

Adv Exp Med Biol. 2019 Apr 24. doi: 10.1007/5584_2019_359. [Epub ahead of print]

PMID:
31016628
4.

Direct CD137 costimulation of CD8 T cells promotes retention and innate-like function within nascent atherogenic foci.

Xu MM, Ménoret A, Nicholas SE, Günther S, Sundberg EJ, Zhou B, Rodriguez A, Murphy PA, Vella AT.

Am J Physiol Heart Circ Physiol. 2019 Jun 1;316(6):H1480-H1494. doi: 10.1152/ajpheart.00088.2019. Epub 2019 Apr 12.

PMID:
30978132
5.

Molecular Basis of Broad Spectrum N-Glycan Specificity and Processing of Therapeutic IgG Monoclonal Antibodies by Endoglycosidase S2.

Klontz EH, Trastoy B, Deredge D, Fields JK, Li C, Orwenyo J, Marina A, Beadenkopf R, Günther S, Flores J, Wintrode PL, Wang LX, Guerin ME, Sundberg EJ.

ACS Cent Sci. 2019 Mar 27;5(3):524-538. doi: 10.1021/acscentsci.8b00917. Epub 2019 Feb 6.

6.

Small-Molecule Inhibitor of FosA Expands Fosfomycin Activity to Multidrug-Resistant Gram-Negative Pathogens.

Tomich AD, Klontz EH, Deredge D, Barnard JP, McElheny CL, Eshbach ML, Weisz OA, Wintrode P, Doi Y, Sundberg EJ, Sluis-Cremer N.

Antimicrob Agents Chemother. 2019 Feb 26;63(3). pii: e01524-18. doi: 10.1128/AAC.01524-18. Print 2019 Mar.

PMID:
30642934
7.

High resolution X-ray and NMR structural study of human T-cell immunoglobulin and mucin domain containing protein-3.

Gandhi AK, Kim WM, Sun ZJ, Huang YH, Bonsor DA, Sundberg EJ, Kondo Y, Wagner G, Kuchroo VK, Petsko G, Blumberg RS.

Sci Rep. 2018 Nov 30;8(1):17512. doi: 10.1038/s41598-018-35754-0.

8.

The structure of PilA from Acinetobacter baumannii AB5075 suggests a mechanism for functional specialization in Acinetobacter type IV pili.

Ronish LA, Lillehoj E, Fields JK, Sundberg EJ, Piepenbrink KH.

J Biol Chem. 2019 Jan 4;294(1):218-230. doi: 10.1074/jbc.RA118.005814. Epub 2018 Nov 9.

PMID:
30413536
9.

Structural basis for the recognition of complex-type N-glycans by Endoglycosidase S.

Trastoy B, Klontz E, Orwenyo J, Marina A, Wang LX, Sundberg EJ, Guerin ME.

Nat Commun. 2018 May 14;9(1):1874. doi: 10.1038/s41467-018-04300-x.

10.

The Helicobacter pylori adhesin protein HopQ exploits the dimer interface of human CEACAMs to facilitate translocation of the oncoprotein CagA.

Bonsor DA, Zhao Q, Schmidinger B, Weiss E, Wang J, Deredge D, Beadenkopf R, Dow B, Fischer W, Beckett D, Wintrode PL, Haas R, Sundberg EJ.

EMBO J. 2018 Jul 2;37(13). pii: e98664. doi: 10.15252/embj.201798664. Epub 2018 May 3.

PMID:
29724755
11.

A structural model of flagellar filament switching across multiple bacterial species.

Wang F, Burrage AM, Postel S, Clark RE, Orlova A, Sundberg EJ, Kearns DB, Egelman EH.

Nat Commun. 2017 Oct 16;8(1):960. doi: 10.1038/s41467-017-01075-5.

12.

Target highlights from the first post-PSI CASP experiment (CASP12, May-August 2016).

Kryshtafovych A, Albrecht R, Baslé A, Bule P, Caputo AT, Carvalho AL, Chao KL, Diskin R, Fidelis K, Fontes CMGA, Fredslund F, Gilbert HJ, Goulding CW, Hartmann MD, Hayes CS, Herzberg O, Hill JC, Joachimiak A, Kohring GW, Koning RI, Lo Leggio L, Mangiagalli M, Michalska K, Moult J, Najmudin S, Nardini M, Nardone V, Ndeh D, Nguyen TH, Pintacuda G, Postel S, van Raaij MJ, Roversi P, Shimon A, Singh AK, Sundberg EJ, Tars K, Zitzmann N, Schwede T.

Proteins. 2018 Mar;86 Suppl 1:27-50. doi: 10.1002/prot.25392. Epub 2017 Oct 16.

13.

IL-1 Family Cytokines Use Distinct Molecular Mechanisms to Signal through Their Shared Co-receptor.

Günther S, Deredge D, Bowers AL, Luchini A, Bonsor DA, Beadenkopf R, Liotta L, Wintrode PL, Sundberg EJ.

Immunity. 2017 Sep 19;47(3):510-523.e4. doi: 10.1016/j.immuni.2017.08.004.

14.

Structure and Dynamics of FosA-Mediated Fosfomycin Resistance in Klebsiella pneumoniae and Escherichia coli.

Klontz EH, Tomich AD, Günther S, Lemkul JA, Deredge D, Silverstein Z, Shaw JF, McElheny C, Doi Y, Wintrode PL, MacKerell AD Jr, Sluis-Cremer N, Sundberg EJ.

Antimicrob Agents Chemother. 2017 Oct 24;61(11). pii: e01572-17. doi: 10.1128/AAC.01572-17. Print 2017 Nov.

15.

Structure-Based Design of Hepatitis C Virus Vaccines That Elicit Neutralizing Antibody Responses to a Conserved Epitope.

Pierce BG, Boucher EN, Piepenbrink KH, Ejemel M, Rapp CA, Thomas WD Jr, Sundberg EJ, Weng Z, Wang Y.

J Virol. 2017 Sep 27;91(20). pii: e01032-17. doi: 10.1128/JVI.01032-17. Print 2017 Oct 15.

16.

Infection-derived lipids elicit an immune deficiency circuit in arthropods.

Shaw DK, Wang X, Brown LJ, Chávez AS, Reif KE, Smith AA, Scott AJ, McClure EE, Boradia VM, Hammond HL, Sundberg EJ, Snyder GA, Liu L, DePonte K, Villar M, Ueti MW, de la Fuente J, Ernst RK, Pal U, Fikrig E, Pedra JH.

Nat Commun. 2017 Feb 14;8:14401. doi: 10.1038/ncomms14401.

17.

Getting oriented with antibodies.

Klontz EH, Sundberg EJ.

Biochem J. 2017 Feb 15;474(4):517-519. doi: 10.1042/BCJ20160996.

PMID:
28159897
18.
19.

Motility and adhesion through type IV pili in Gram-positive bacteria.

Piepenbrink KH, Sundberg EJ.

Biochem Soc Trans. 2016 Dec 15;44(6):1659-1666. Review.

20.

Molecular basis for epitope recognition by non-neutralizing anti-gp41 antibody F240.

Gohain N, Tolbert WD, Orlandi C, Richard J, Ding S, Chen X, Bonsor DA, Sundberg EJ, Lu W, Ray K, Finzi A, Lewis GK, Pazgier M.

Sci Rep. 2016 Nov 9;6:36685. doi: 10.1038/srep36685.

21.

Erratum: Helicobacter pylori exploits human CEACAMs via HopQ for adherence and translocation of CagA.

Königer V, Holsten L, Harrison U, Busch B, Loell E, Zhao Q, Bonsor DA, Roth A, Kengmo-Tchoupa A, Smith SI, Mueller S, Sundberg EJ, Zimmermann W, Fischer W, Hauck CR, Haas R.

Nat Microbiol. 2016 Oct 31;2:16233. doi: 10.1038/nmicrobiol.2016.233. No abstract available.

PMID:
27798561
22.

Structural Diversity in the Type IV Pili of Multidrug-resistant Acinetobacter.

Piepenbrink KH, Lillehoj E, Harding CM, Labonte JW, Zuo X, Rapp CA, Munson RS Jr, Goldblum SE, Feldman MF, Gray JJ, Sundberg EJ.

J Biol Chem. 2016 Oct 28;291(44):22924-22935. Epub 2016 Sep 15.

23.

Bacterial flagellar capping proteins adopt diverse oligomeric states.

Postel S, Deredge D, Bonsor DA, Yu X, Diederichs K, Helmsing S, Vromen A, Friedler A, Hust M, Egelman EH, Beckett D, Wintrode PL, Sundberg EJ.

Elife. 2016 Sep 24;5. pii: e18857. doi: 10.7554/eLife.18857.

24.

Helicobacter pylori exploits human CEACAMs via HopQ for adherence and translocation of CagA.

Königer V, Holsten L, Harrison U, Busch B, Loell E, Zhao Q, Bonsor DA, Roth A, Kengmo-Tchoupa A, Smith SI, Mueller S, Sundberg EJ, Zimmermann W, Fischer W, Hauck CR, Haas R.

Nat Microbiol. 2016 Oct 17;2:16188. doi: 10.1038/nmicrobiol.2016.188. Erratum in: Nat Microbiol. 2016 Oct 31;2:16233.

PMID:
27748756
25.

Type IV pili promote early biofilm formation by Clostridium difficile.

Maldarelli GA, Piepenbrink KH, Scott AJ, Freiberg JA, Song Y, Achermann Y, Ernst RK, Shirtliff ME, Sundberg EJ, Donnenberg MS, von Rosenvinge EC.

Pathog Dis. 2016 Aug;74(6). pii: ftw061. doi: 10.1093/femspd/ftw061. Epub 2016 Jun 30.

26.

The NEU1-selective sialidase inhibitor, C9-butyl-amide-DANA, blocks sialidase activity and NEU1-mediated bioactivities in human lung in vitro and murine lung in vivo.

Hyun SW, Liu A, Liu Z, Cross AS, Verceles AC, Magesh S, Kommagalla Y, Kona C, Ando H, Luzina IG, Atamas SP, Piepenbrink KH, Sundberg EJ, Guang W, Ishida H, Lillehoj EP, Goldblum SE.

Glycobiology. 2016 Aug;26(8):834-49. doi: 10.1093/glycob/cww060. Epub 2016 May 25.

27.

The Tick Protein Sialostatin L2 Binds to Annexin A2 and Inhibits NLRC4-Mediated Inflammasome Activation.

Wang X, Shaw DK, Sakhon OS, Snyder GA, Sundberg EJ, Santambrogio L, Sutterwala FS, Dumler JS, Shirey KA, Perkins DJ, Richard K, Chagas AC, Calvo E, Kopecký J, Kotsyfakis M, Pedra JHF.

Infect Immun. 2016 May 24;84(6):1796-1805. doi: 10.1128/IAI.01526-15. Print 2016 Jun.

28.

Diverse oligomeric states of CEACAM IgV domains.

Bonsor DA, Günther S, Beadenkopf R, Beckett D, Sundberg EJ.

Proc Natl Acad Sci U S A. 2015 Nov 3;112(44):13561-6. doi: 10.1073/pnas.1509511112. Epub 2015 Oct 19.

29.

Some of the most interesting CASP11 targets through the eyes of their authors.

Kryshtafovych A, Moult J, Baslé A, Burgin A, Craig TK, Edwards RA, Fass D, Hartmann MD, Korycinski M, Lewis RJ, Lorimer D, Lupas AN, Newman J, Peat TS, Piepenbrink KH, Prahlad J, van Raaij MJ, Rohwer F, Segall AM, Seguritan V, Sundberg EJ, Singh AK, Wilson MA, Schwede T.

Proteins. 2016 Sep;84 Suppl 1:34-50. doi: 10.1002/prot.24942. Epub 2015 Nov 16.

30.

Severe Acute Respiratory Syndrome Coronavirus ORF7a Inhibits Bone Marrow Stromal Antigen 2 Virion Tethering through a Novel Mechanism of Glycosylation Interference.

Taylor JK, Coleman CM, Postel S, Sisk JM, Bernbaum JG, Venkataraman T, Sundberg EJ, Frieman MB.

J Virol. 2015 Dec;89(23):11820-33. doi: 10.1128/JVI.02274-15. Epub 2015 Sep 16.

31.

Structure of the N-terminal dimerization domain of CEACAM7.

Bonsor DA, Beckett D, Sundberg EJ.

Acta Crystallogr F Struct Biol Commun. 2015 Sep;71(Pt 9):1169-75. doi: 10.1107/S2053230X15013576. Epub 2015 Aug 25.

32.

A Decoy Peptide that Disrupts TIRAP Recruitment to TLRs Is Protective in a Murine Model of Influenza.

Piao W, Shirey KA, Ru LW, Lai W, Szmacinski H, Snyder GA, Sundberg EJ, Lakowicz JR, Vogel SN, Toshchakov VY.

Cell Rep. 2015 Jun 30;11(12):1941-52. doi: 10.1016/j.celrep.2015.05.035. Epub 2015 Jun 18.

33.

An Intrinsically Disordered Region in the Proapoptotic ASPP2 Protein Binds to the Helicobacter pylori Oncoprotein CagA.

Reingewertz TH, Iosub-Amir A, Bonsor DA, Mayer G, Amartely H, Friedler A, Sundberg EJ.

Biochemistry. 2015 Jun 2;54(21):3337-47. doi: 10.1021/acs.biochem.5b00084. Epub 2015 May 20.

PMID:
25963096
34.

Integrin engagement by the helical RGD motif of the Helicobacter pylori CagL protein is regulated by pH-induced displacement of a neighboring helix.

Bonsor DA, Pham KT, Beadenkopf R, Diederichs K, Haas R, Beckett D, Fischer W, Sundberg EJ.

J Biol Chem. 2015 May 15;290(20):12929-40. doi: 10.1074/jbc.M115.641829. Epub 2015 Apr 2.

35.

Structural and evolutionary analyses show unique stabilization strategies in the type IV pili of Clostridium difficile.

Piepenbrink KH, Maldarelli GA, Martinez de la Peña CF, Dingle TC, Mulvey GL, Lee A, von Rosenvinge E, Armstrong GD, Donnenberg MS, Sundberg EJ.

Structure. 2015 Feb 3;23(2):385-96. doi: 10.1016/j.str.2014.11.018. Epub 2015 Jan 15.

36.

Molecular determinants of agonist and antagonist signaling through the IL-36 receptor.

Günther S, Sundberg EJ.

J Immunol. 2014 Jul 15;193(2):921-30. doi: 10.4049/jimmunol.1400538. Epub 2014 Jun 16.

37.

Crystal structure of Streptococcus pyogenes EndoS, an immunomodulatory endoglycosidase specific for human IgG antibodies.

Trastoy B, Lomino JV, Pierce BG, Carter LG, Günther S, Giddens JP, Snyder GA, Weiss TM, Weng Z, Wang LX, Sundberg EJ.

Proc Natl Acad Sci U S A. 2014 May 6;111(18):6714-9. doi: 10.1073/pnas.1322908111. Epub 2014 Apr 21.

38.

The tick salivary protein sialostatin L2 inhibits caspase-1-mediated inflammation during Anaplasma phagocytophilum infection.

Chen G, Wang X, Severo MS, Sakhon OS, Sohail M, Brown LJ, Sircar M, Snyder GA, Sundberg EJ, Ulland TK, Olivier AK, Andersen JF, Zhou Y, Shi GP, Sutterwala FS, Kotsyfakis M, Pedra JH.

Infect Immun. 2014 Jun;82(6):2553-64. doi: 10.1128/IAI.01679-14. Epub 2014 Mar 31.

39.

A novel multivalent, single-domain antibody targeting TcdA and TcdB prevents fulminant Clostridium difficile infection in mice.

Yang Z, Schmidt D, Liu W, Li S, Shi L, Sheng J, Chen K, Yu H, Tremblay JM, Chen X, Piepenbrink KH, Sundberg EJ, Kelly CP, Bai G, Shoemaker CB, Feng H.

J Infect Dis. 2014 Sep 15;210(6):964-72. doi: 10.1093/infdis/jiu196. Epub 2014 Mar 27.

40.

Structure of Clostridium difficile PilJ exhibits unprecedented divergence from known type IV pilins.

Piepenbrink KH, Maldarelli GA, de la Peña CF, Mulvey GL, Snyder GA, De Masi L, von Rosenvinge EC, Günther S, Armstrong GD, Donnenberg MS, Sundberg EJ.

J Biol Chem. 2014 Feb 14;289(7):4334-45. doi: 10.1074/jbc.M113.534404. Epub 2013 Dec 21.

41.

Liquid-liquid diffusion crystallization improves the X-ray diffraction of EndoS, an endo-β-N-acetylglucosaminidase from Streptococcus pyogenes with activity on human IgG.

Trastoy B, Lomino JV, Wang LX, Sundberg EJ.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Dec;69(Pt 12):1405-10. doi: 10.1107/S1744309113030650. Epub 2013 Nov 29.

42.

Crystal structures of the Toll/Interleukin-1 receptor (TIR) domains from the Brucella protein TcpB and host adaptor TIRAP reveal mechanisms of molecular mimicry.

Snyder GA, Deredge D, Waldhuber A, Fresquez T, Wilkins DZ, Smith PT, Durr S, Cirl C, Jiang J, Jennings W, Luchetti T, Snyder N, Sundberg EJ, Wintrode P, Miethke T, Xiao TS.

J Biol Chem. 2014 Jan 10;289(2):669-79. doi: 10.1074/jbc.M113.523407. Epub 2013 Nov 25.

43.

Recruitment of TLR adapter TRIF to TLR4 signaling complex is mediated by the second helical region of TRIF TIR domain.

Piao W, Ru LW, Piepenbrink KH, Sundberg EJ, Vogel SN, Toshchakov VY.

Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):19036-41. doi: 10.1073/pnas.1313575110. Epub 2013 Nov 5.

44.

Characterization of the Staphylococcal enterotoxin A: Vβ receptor interaction using human receptor fragments engineered for high affinity.

Sharma P, Postel S, Sundberg EJ, Kranz DM.

Protein Eng Des Sel. 2013 Dec;26(12):781-9. doi: 10.1093/protein/gzt054. Epub 2013 Oct 27.

45.

Characterization of the translocation-competent complex between the Helicobacter pylori oncogenic protein CagA and the accessory protein CagF.

Bonsor DA, Weiss E, Iosub-Amir A, Reingewertz TH, Chen TW, Haas R, Friedler A, Fischer W, Sundberg EJ.

J Biol Chem. 2013 Nov 15;288(46):32897-909. doi: 10.1074/jbc.M113.507657. Epub 2013 Sep 26.

46.

Molecular interactions in interleukin and toll-like receptor signaling pathways.

Snyder GA, Sundberg EJ.

Curr Pharm Des. 2014;20(8):1244-58. Review.

PMID:
23713776
47.

With an antibody whose duty's double, a step towards ending asthma trouble?

Sundberg EJ.

Biochem J. 2013 Apr 15;451(2):e1-3. doi: 10.1042/BJ20130305.

PMID:
23535171
48.

Engineering a soluble high-affinity receptor domain that neutralizes staphylococcal enterotoxin C in rabbit models of disease.

Mattis DM, Spaulding AR, Chuang-Smith ON, Sundberg EJ, Schlievert PM, Kranz DM.

Protein Eng Des Sel. 2013 Feb;26(2):133-42. doi: 10.1093/protein/gzs094. Epub 2012 Nov 15.

49.

R753Q polymorphism inhibits Toll-like receptor (TLR) 2 tyrosine phosphorylation, dimerization with TLR6, and recruitment of myeloid differentiation primary response protein 88.

Xiong Y, Song C, Snyder GA, Sundberg EJ, Medvedev AE.

J Biol Chem. 2012 Nov 2;287(45):38327-37. doi: 10.1074/jbc.M112.375493. Epub 2012 Sep 19.

50.

Molecular basis of a million-fold affinity maturation process in a protein-protein interaction.

Bonsor DA, Postel S, Pierce BG, Wang N, Zhu P, Buonpane RA, Weng Z, Kranz DM, Sundberg EJ.

J Mol Biol. 2011 Aug 12;411(2):321-8. doi: 10.1016/j.jmb.2011.06.009. Epub 2011 Jun 12.

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