Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 117

1.

Publisher Correction: Structural insights into binding specificity, efficacy and bias of a β2AR partial agonist.

Masureel M, Zou Y, Picard LP, van der Westhuizen E, Mahoney JP, Rodrigues JPGLM, Mildorf TJ, Dror RO, Shaw DE, Bouvier M, Pardon E, Steyaert J, Sunahara RK, Weis WI, Zhang C, Kobilka BK.

Nat Chem Biol. 2019 Feb;15(2):205. doi: 10.1038/s41589-018-0182-5.

PMID:
30504785
2.

Structure-guided development of selective M3 muscarinic acetylcholine receptor antagonists.

Liu H, Hofmann J, Fish I, Schaake B, Eitel K, Bartuschat A, Kaindl J, Rampp H, Banerjee A, Hübner H, Clark MJ, Vincent SG, Fisher JT, Heinrich MR, Hirata K, Liu X, Sunahara RK, Shoichet BK, Kobilka BK, Gmeiner P.

Proc Natl Acad Sci U S A. 2018 Nov 20;115(47):12046-12050. doi: 10.1073/pnas.1813988115. Epub 2018 Nov 7.

3.

Structural insights into binding specificity, efficacy and bias of a β2AR partial agonist.

Masureel M, Zou Y, Picard LP, van der Westhuizen E, Mahoney JP, Rodrigues JPGLM, Mildorf TJ, Dror RO, Shaw DE, Bouvier M, Pardon E, Steyaert J, Sunahara RK, Weis WI, Zhang C, Kobilka BK.

Nat Chem Biol. 2018 Nov;14(11):1059-1066. doi: 10.1038/s41589-018-0145-x. Epub 2018 Oct 16. Erratum in: Nat Chem Biol. 2019 Feb;15(2):205.

4.

Functional dissection of the N-terminal extracellular domains of Frizzled 6 reveals their roles for receptor localization and Dishevelled recruitment.

Valnohova J, Kowalski-Jahn M, Sunahara RK, Schulte G.

J Biol Chem. 2018 Nov 16;293(46):17875-17887. doi: 10.1074/jbc.RA118.004763. Epub 2018 Sep 20.

PMID:
30237173
5.

Measuring ligand efficacy at the mu-opioid receptor using a conformational biosensor.

Livingston KE, Mahoney JP, Manglik A, Sunahara RK, Traynor JR.

Elife. 2018 Jun 22;7. pii: e32499. doi: 10.7554/eLife.32499.

6.

Mechanistic insights into allosteric regulation of the A2A adenosine G protein-coupled receptor by physiological cations.

Ye L, Neale C, Sljoka A, Lyda B, Pichugin D, Tsuchimura N, Larda ST, Pomès R, García AE, Ernst OP, Sunahara RK, Prosser RS.

Nat Commun. 2018 Apr 10;9(1):1372. doi: 10.1038/s41467-018-03314-9.

7.

Structure-based discovery of selective positive allosteric modulators of antagonists for the M2 muscarinic acetylcholine receptor.

Korczynska M, Clark MJ, Valant C, Xu J, Moo EV, Albold S, Weiss DR, Torosyan H, Huang W, Kruse AC, Lyda BR, May LT, Baltos JA, Sexton PM, Kobilka BK, Christopoulos A, Shoichet BK, Sunahara RK.

Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):E2419-E2428. doi: 10.1073/pnas.1718037115. Epub 2018 Feb 16.

8.

Structure-Based Design and Discovery of New M2 Receptor Agonists.

Fish I, Stößel A, Eitel K, Valant C, Albold S, Huebner H, Möller D, Clark MJ, Sunahara RK, Christopoulos A, Shoichet BK, Gmeiner P.

J Med Chem. 2017 Nov 22;60(22):9239-9250. doi: 10.1021/acs.jmedchem.7b01113. Epub 2017 Nov 13.

9.

ER/K linked GPCR-G protein fusions systematically modulate second messenger response in cells.

Malik RU, Dysthe M, Ritt M, Sunahara RK, Sivaramakrishnan S.

Sci Rep. 2017 Aug 10;7(1):7749. doi: 10.1038/s41598-017-08029-3.

10.

Genetic evidence that β-arrestins are dispensable for the initiation of β2-adrenergic receptor signaling to ERK.

O'Hayre M, Eichel K, Avino S, Zhao X, Steffen DJ, Feng X, Kawakami K, Aoki J, Messer K, Sunahara R, Inoue A, von Zastrow M, Gutkind JS.

Sci Signal. 2017 Jun 20;10(484). pii: eaal3395. doi: 10.1126/scisignal.aal3395.

11.

Purification of family B G protein-coupled receptors using nanodiscs: Application to human glucagon-like peptide-1 receptor.

Cai Y, Liu Y, Culhane KJ, DeVree BT, Yang Y, Sunahara RK, Yan ECY.

PLoS One. 2017 Jun 13;12(6):e0179568. doi: 10.1371/journal.pone.0179568. eCollection 2017.

12.

In Situ Reconstitution of the Adenosine A2A Receptor in Spontaneously Formed Synthetic Liposomes.

Brea RJ, Cole CM, Lyda BR, Ye L, Prosser RS, Sunahara RK, Devaraj NK.

J Am Chem Soc. 2017 Mar 15;139(10):3607-3610. doi: 10.1021/jacs.6b12830. Epub 2017 Mar 6.

13.

Mechanistic insights into GPCR-G protein interactions.

Mahoney JP, Sunahara RK.

Curr Opin Struct Biol. 2016 Dec;41:247-254. doi: 10.1016/j.sbi.2016.11.005. Epub 2016 Nov 18. Review.

14.

GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling.

Thomsen ARB, Plouffe B, Cahill TJ 3rd, Shukla AK, Tarrasch JT, Dosey AM, Kahsai AW, Strachan RT, Pani B, Mahoney JP, Huang L, Breton B, Heydenreich FM, Sunahara RK, Skiniotis G, Bouvier M, Lefkowitz RJ.

Cell. 2016 Aug 11;166(4):907-919. doi: 10.1016/j.cell.2016.07.004. Epub 2016 Aug 4.

15.

Allosteric coupling from G protein to the agonist-binding pocket in GPCRs.

DeVree BT, Mahoney JP, Vélez-Ruiz GA, Rasmussen SG, Kuszak AJ, Edwald E, Fung JJ, Manglik A, Masureel M, Du Y, Matt RA, Pardon E, Steyaert J, Kobilka BK, Sunahara RK.

Nature. 2016 Jul 7;535(7610):182-6. Epub 2016 Jun 29.

16.

The Molecular Pharmacology of G Protein Signaling Then and Now: A Tribute to Alfred G. Gilman.

Sunahara RK, Insel PA.

Mol Pharmacol. 2016 May;89(5):585-92. doi: 10.1124/mol.116.104216. Epub 2016 Mar 16.

PMID:
26984025
17.

Pharmacological chaperone for α-crystallin partially restores transparency in cataract models.

Makley LN, McMenimen KA, DeVree BT, Goldman JW, McGlasson BN, Rajagopal P, Dunyak BM, McQuade TJ, Thompson AD, Sunahara R, Klevit RE, Andley UP, Gestwicki JE.

Science. 2015 Nov 6;350(6261):674-7. doi: 10.1126/science.aac9145.

18.

Electron Microscopic Visualization of Protein Assemblies on Flattened DNA Origami.

Mallik L, Dhakal S, Nichols J, Mahoney J, Dosey AM, Jiang S, Sunahara RK, Skiniotis G, Walter NG.

ACS Nano. 2015 Jul 28;9(7):7133-41. doi: 10.1021/acsnano.5b01841. Epub 2015 Jul 13.

19.

SIGNAL TRANSDUCTION. Structural basis for nucleotide exchange in heterotrimeric G proteins.

Dror RO, Mildorf TJ, Hilger D, Manglik A, Borhani DW, Arlow DH, Philippsen A, Villanueva N, Yang Z, Lerch MT, Hubbell WL, Kobilka BK, Sunahara RK, Shaw DE.

Science. 2015 Jun 19;348(6241):1361-5. doi: 10.1126/science.aaa5264.

20.

A thermostable bacterial cocaine esterase rapidly eliminates cocaine from brain in nonhuman primates.

Howell LL, Nye JA, Stehouwer JS, Voll RJ, Mun J, Narasimhan D, Nichols J, Sunahara R, Goodman MM, Carroll FI, Woods JH.

Transl Psychiatry. 2014 Jul 1;4:e407. doi: 10.1038/tp.2014.48.

21.

Detection of G protein-selective G protein-coupled receptor (GPCR) conformations in live cells.

Malik RU, Ritt M, DeVree BT, Neubig RR, Sunahara RK, Sivaramakrishnan S.

J Biol Chem. 2013 Jun 14;288(24):17167-78. doi: 10.1074/jbc.M113.464065. Epub 2013 Apr 29.

22.

Conformational biosensors reveal GPCR signalling from endosomes.

Irannejad R, Tomshine JC, Tomshine JR, Chevalier M, Mahoney JP, Steyaert J, Rasmussen SG, Sunahara RK, El-Samad H, Huang B, von Zastrow M.

Nature. 2013 Mar 28;495(7442):534-8. doi: 10.1038/nature12000. Epub 2013 Mar 20.

23.

Identification of GPCR-interacting cytosolic proteins using HDL particles and mass spectrometry-based proteomic approach.

Chung KY, Day PW, Vélez-Ruiz G, Sunahara RK, Kobilka BK.

PLoS One. 2013;8(1):e54942. doi: 10.1371/journal.pone.0054942. Epub 2013 Jan 25.

24.

Calcium-dependent ligand binding and G-protein signaling of family B GPCR parathyroid hormone 1 receptor purified in nanodiscs.

Mitra N, Liu Y, Liu J, Serebryany E, Mooney V, DeVree BT, Sunahara RK, Yan EC.

ACS Chem Biol. 2013 Mar 15;8(3):617-25. doi: 10.1021/cb300466n. Epub 2013 Jan 30.

25.

Inflammation and circulating endothelial progenitor cells in patients with coronary artery disease and residual platelet reactivity.

Pesaro AE, Serrano CV Jr, Katz M, Campos AH, Lopes RD, Marti LC, Martins HS, Sunahara RS, Maranhão RC, Nicolau JC.

Clinics (Sao Paulo). 2012 Sep;67(9):1117-21. No abstract available.

26.

Repeated administration of a mutant cocaine esterase: effects on plasma cocaine levels, cocaine-induced cardiovascular activity, and immune responses in rhesus monkeys.

Collins GT, Brim RL, Noon KR, Narasimhan D, Lukacs NW, Sunahara RK, Woods JH, Ko MC.

J Pharmacol Exp Ther. 2012 Jul;342(1):205-13. doi: 10.1124/jpet.112.194639. Epub 2012 Apr 19.

27.

Crystal structure of the µ-opioid receptor bound to a morphinan antagonist.

Manglik A, Kruse AC, Kobilka TS, Thian FS, Mathiesen JM, Sunahara RK, Pardo L, Weis WI, Kobilka BK, Granier S.

Nature. 2012 Mar 21;485(7398):321-6. doi: 10.1038/nature10954.

28.

Cell permeable cocaine esterases constructed by chemical conjugation and genetic recombination.

Lee TY, Park YS, Garcia GA, Sunahara RK, Woods JH, Yang VC.

Mol Pharm. 2012 May 7;9(5):1361-73. doi: 10.1021/mp200623w. Epub 2012 Mar 28.

29.

Bacterial cocaine esterase: a protein-based therapy for cocaine overdose and addiction.

Narasimhan D, Woods JH, Sunahara RK.

Future Med Chem. 2012 Feb;4(2):137-50. doi: 10.4155/fmc.11.194. Review.

30.

Long-lasting effects of a PEGylated mutant cocaine esterase (CocE) on the reinforcing and discriminative stimulus effects of cocaine in rats.

Collins GT, Narasimhan D, Cunningham AR, Zaks ME, Nichols J, Ko MC, Sunahara RK, Woods JH.

Neuropsychopharmacology. 2012 Apr;37(5):1092-103. doi: 10.1038/npp.2011.226. Epub 2011 Oct 12.

31.

The fate of bacterial cocaine esterase (CocE): an in vivo study of CocE-mediated cocaine hydrolysis, CocE pharmacokinetics, and CocE elimination.

Brim RL, Noon KR, Collins GT, Stein A, Nichols J, Narasimhan D, Ko MC, Woods JH, Sunahara RK.

J Pharmacol Exp Ther. 2012 Jan;340(1):83-95. doi: 10.1124/jpet.111.186049. Epub 2011 Oct 11.

32.

Conformational changes in the G protein Gs induced by the β2 adrenergic receptor.

Chung KY, Rasmussen SG, Liu T, Li S, DeVree BT, Chae PS, Calinski D, Kobilka BK, Woods VL Jr, Sunahara RK.

Nature. 2011 Sep 28;477(7366):611-5. doi: 10.1038/nature10488.

33.

Structural flexibility of the G alpha s alpha-helical domain in the beta2-adrenoceptor Gs complex.

Westfield GH, Rasmussen SG, Su M, Dutta S, DeVree BT, Chung KY, Calinski D, Velez-Ruiz G, Oleskie AN, Pardon E, Chae PS, Liu T, Li S, Woods VL Jr, Steyaert J, Kobilka BK, Sunahara RK, Skiniotis G.

Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):16086-91. doi: 10.1073/pnas.1113645108. Epub 2011 Sep 13.

34.

Subunit stabilization and polyethylene glycolation of cocaine esterase improves in vivo residence time.

Narasimhan D, Collins GT, Nance MR, Nichols J, Edwald E, Chan J, Ko MC, Woods JH, Tesmer JJ, Sunahara RK.

Mol Pharmacol. 2011 Dec;80(6):1056-65. doi: 10.1124/mol.111.074997. Epub 2011 Sep 2.

35.

The ability of bacterial cocaine esterase to hydrolyze cocaine metabolites and their simultaneous quantification using high-performance liquid chromatography-tandem mass spectrometry.

Brim RL, Noon KR, Collins GT, Nichols J, Narasimhan D, Sunahara RK, Woods JH.

Mol Pharmacol. 2011 Dec;80(6):1119-27. doi: 10.1124/mol.111.074534. Epub 2011 Sep 1.

36.

Reconstitution of G protein-coupled receptors into a model bilayer system: reconstituted high-density lipoprotein particles.

Vélez-Ruiz GA, Sunahara RK.

Methods Mol Biol. 2011;756:167-82. doi: 10.1007/978-1-61779-160-4_8.

37.

Evaluation of the hydrolytic activity of a long-acting mutant bacterial cocaine in the presence of commonly co-administered drugs.

Brim RL, Noon KR, Nichols J, Narasimhan D, Woods JH, Sunahara RK.

Drug Alcohol Depend. 2011 Dec 15;119(3):224-8. doi: 10.1016/j.drugalcdep.2011.06.018. Epub 2011 Jul 19.

38.

Crystal structure of the β2 adrenergic receptor-Gs protein complex.

Rasmussen SG, DeVree BT, Zou Y, Kruse AC, Chung KY, Kobilka TS, Thian FS, Chae PS, Pardon E, Calinski D, Mathiesen JM, Shah ST, Lyons JA, Caffrey M, Gellman SH, Steyaert J, Skiniotis G, Weis WI, Sunahara RK, Kobilka BK.

Nature. 2011 Jul 19;477(7366):549-55. doi: 10.1038/nature10361.

39.

Effects of a long-acting mutant bacterial cocaine esterase on acute cocaine toxicity in rats.

Collins GT, Zaks ME, Cunningham AR, St Clair C, Nichols J, Narasimhan D, Ko MC, Sunahara RK, Woods JH.

Drug Alcohol Depend. 2011 Nov 1;118(2-3):158-65. doi: 10.1016/j.drugalcdep.2011.03.015. Epub 2011 Apr 11.

40.

Amelioration of the cardiovascular effects of cocaine in rhesus monkeys by a long-acting mutant form of cocaine esterase.

Collins GT, Carey KA, Narasimhan D, Nichols J, Berlin AA, Lukacs NW, Sunahara RK, Woods JH, Ko MC.

Neuropsychopharmacology. 2011 Apr;36(5):1047-59. doi: 10.1038/npp.2010.242. Epub 2011 Feb 2.

41.

Structure and function of an irreversible agonist-β(2) adrenoceptor complex.

Rosenbaum DM, Zhang C, Lyons JA, Holl R, Aragao D, Arlow DH, Rasmussen SG, Choi HJ, Devree BT, Sunahara RK, Chae PS, Gellman SH, Dror RO, Shaw DE, Weis WI, Caffrey M, Gmeiner P, Kobilka BK.

Nature. 2011 Jan 13;469(7329):236-40. doi: 10.1038/nature09665.

42.

Structure of a nanobody-stabilized active state of the β(2) adrenoceptor.

Rasmussen SG, Choi HJ, Fung JJ, Pardon E, Casarosa P, Chae PS, Devree BT, Rosenbaum DM, Thian FS, Kobilka TS, Schnapp A, Konetzki I, Sunahara RK, Gellman SH, Pautsch A, Steyaert J, Weis WI, Kobilka BK.

Nature. 2011 Jan 13;469(7329):175-80. doi: 10.1038/nature09648.

43.

Cigarette smoke condensate extracts augment collagen-induced arthritis in mice.

Chujo S, Okamoto S, Sunahara R, Adachi M, Yamada K, Hayashi H, Takii T, Hayakawa K, Onozaki K.

Int Immunopharmacol. 2010 Oct;10(10):1194-9. doi: 10.1016/j.intimp.2010.06.026. Epub 2010 Jul 8.

PMID:
20620226
44.

Structural analysis of thermostabilizing mutations of cocaine esterase.

Narasimhan D, Nance MR, Gao D, Ko MC, Macdonald J, Tamburi P, Yoon D, Landry DM, Woods JH, Zhan CG, Tesmer JJ, Sunahara RK.

Protein Eng Des Sel. 2010 Jul;23(7):537-47. doi: 10.1093/protein/gzq025. Epub 2010 Apr 30.

45.

A thermally stable form of bacterial cocaine esterase: a potential therapeutic agent for treatment of cocaine abuse.

Brim RL, Nance MR, Youngstrom DW, Narasimhan D, Zhan CG, Tesmer JJ, Sunahara RK, Woods JH.

Mol Pharmacol. 2010 Apr;77(4):593-600. doi: 10.1124/mol.109.060806. Epub 2010 Jan 19.

46.

PEGylation of bacterial cocaine esterase for protection against protease digestion and immunogenicity.

Park JB, Kwon YM, Lee TY, Brim R, Ko MC, Sunahara RK, Woods JH, Yang VC.

J Control Release. 2010 Mar 3;142(2):174-9. doi: 10.1016/j.jconrel.2009.10.015. Epub 2009 Oct 24.

47.

Prevention and reversal by cocaine esterase of cocaine-induced cardiovascular effects in rats.

Wood SK, Narasimhan D, Cooper Z, Sunahara RK, Woods JH.

Drug Alcohol Depend. 2010 Jan 15;106(2-3):219-29. doi: 10.1016/j.drugalcdep.2009.09.001. Epub 2009 Oct 1.

48.

Ligand-regulated oligomerization of beta(2)-adrenoceptors in a model lipid bilayer.

Fung JJ, Deupi X, Pardo L, Yao XJ, Velez-Ruiz GA, Devree BT, Sunahara RK, Kobilka BK.

EMBO J. 2009 Nov 4;28(21):3315-28. doi: 10.1038/emboj.2009.267. Epub 2009 Sep 17.

49.

Cocaine esterase prevents cocaine-induced toxicity and the ongoing intravenous self-administration of cocaine in rats.

Collins GT, Brim RL, Narasimhan D, Ko MC, Sunahara RK, Zhan CG, Woods JH.

J Pharmacol Exp Ther. 2009 Nov;331(2):445-55. doi: 10.1124/jpet.108.150029. Epub 2009 Aug 26.

50.

Purification and functional reconstitution of monomeric mu-opioid receptors: allosteric modulation of agonist binding by Gi2.

Kuszak AJ, Pitchiaya S, Anand JP, Mosberg HI, Walter NG, Sunahara RK.

J Biol Chem. 2009 Sep 25;284(39):26732-41. doi: 10.1074/jbc.M109.026922. Epub 2009 Jun 19.

Supplemental Content

Loading ...
Support Center