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Items: 16


DNA-PK Is Targeted by Multiple Vaccinia Virus Proteins to Inhibit DNA Sensing.

Scutts SR, Ember SW, Ren H, Ye C, Lovejoy CA, Mazzon M, Veyer DL, Sumner RP, Smith GL.

Cell Rep. 2018 Nov 13;25(7):1953-1965.e4. doi: 10.1016/j.celrep.2018.10.034.


KAP1 regulates endogenous retroviruses in adult human cells and contributes to innate immune control.

Tie CH, Fernandes L, Conde L, Robbez-Masson L, Sumner RP, Peacock T, Rodriguez-Plata MT, Mickute G, Gifford R, Towers GJ, Herrero J, Rowe HM.

EMBO Rep. 2018 Oct;19(10). pii: e45000. doi: 10.15252/embr.201745000. Epub 2018 Jul 30.


Virulent poxviruses inhibit DNA sensing by preventing STING activation.

Georgana I, Sumner RP, Towers GJ, Maluquer de Motes C.

J Virol. 2018 Feb 28. pii: JVI.02145-17. doi: 10.1128/JVI.02145-17. [Epub ahead of print]


Are Evolution and the Intracellular Innate Immune System Key Determinants in HIV Transmission?

Sumner RP, Thorne LG, Fink DL, Khan H, Milne RS, Towers GJ.

Front Immunol. 2017 Oct 6;8:1246. doi: 10.3389/fimmu.2017.01246. eCollection 2017. Review.


Vaccinia Virus Protein C6 Inhibits Type I IFN Signalling in the Nucleus and Binds to the Transactivation Domain of STAT2.

Stuart JH, Sumner RP, Lu Y, Snowden JS, Smith GL.

PLoS Pathog. 2016 Dec 1;12(12):e1005955. doi: 10.1371/journal.ppat.1005955. eCollection 2016 Dec.


Increased attenuation but decreased immunogenicity by deletion of multiple vaccinia virus immunomodulators.

Sumner RP, Ren H, Ferguson BJ, Smith GL.

Vaccine. 2016 Sep 14;34(40):4827-34. doi: 10.1016/j.vaccine.2016.08.002. Epub 2016 Aug 17.


Enhancement of CD8(+) T-cell memory by removal of a vaccinia virus nuclear factor-κB inhibitor.

Ren H, Ferguson BJ, Maluquer de Motes C, Sumner RP, Harman LE, Smith GL.

Immunology. 2015 May;145(1):34-49. doi: 10.1111/imm.12422.


Analysis of the anti-apoptotic activity of four vaccinia virus proteins demonstrates that B13 is the most potent inhibitor in isolation and during viral infection.

Veyer DL, Maluquer de Motes C, Sumner RP, Ludwig L, Johnson BF, Smith GL.

J Gen Virol. 2014 Dec;95(Pt 12):2757-68. doi: 10.1099/vir.0.068833-0. Epub 2014 Aug 4.


Vaccinia virus virulence factor N1 can be ubiquitylated on multiple lysine residues.

Maluquer de Motes C, Schiffner T, Sumner RP, Smith GL.

J Gen Virol. 2014 Sep;95(Pt 9):2038-49. doi: 10.1099/vir.0.065664-0. Epub 2014 Jun 8.


Vaccinia virus inhibits NF-κB-dependent gene expression downstream of p65 translocation.

Sumner RP, Maluquer de Motes C, Veyer DL, Smith GL.

J Virol. 2014 Mar;88(6):3092-102. doi: 10.1128/JVI.02627-13. Epub 2013 Dec 26.


Vaccinia virus immune evasion: mechanisms, virulence and immunogenicity.

Smith GL, Benfield CT, Maluquer de Motes C, Mazzon M, Ember SW, Ferguson BJ, Sumner RP.

J Gen Virol. 2013 Nov;94(Pt 11):2367-92. doi: 10.1099/vir.0.055921-0. Epub 2013 Sep 2. Review.


Vaccinia virus protein N2 is a nuclear IRF3 inhibitor that promotes virulence.

Ferguson BJ, Benfield CT, Ren H, Lee VH, Frazer GL, Strnadova P, Sumner RP, Smith GL.

J Gen Virol. 2013 Sep;94(Pt 9):2070-81. doi: 10.1099/vir.0.054114-0. Epub 2013 Jun 12.


Poxvirus targeting of E3 ligase β-TrCP by molecular mimicry: a mechanism to inhibit NF-κB activation and promote immune evasion and virulence.

Mansur DS, Maluquer de Motes C, Unterholzner L, Sumner RP, Ferguson BJ, Ren H, Strnadova P, Bowie AG, Smith GL.

PLoS Pathog. 2013 Feb;9(2):e1003183. doi: 10.1371/journal.ppat.1003183. Epub 2013 Feb 28.


Deletion of immunomodulator C6 from vaccinia virus strain Western Reserve enhances virus immunogenicity and vaccine efficacy.

Sumner RP, Ren H, Smith GL.

J Gen Virol. 2013 May;94(Pt 5):1121-6. doi: 10.1099/vir.0.049700-0. Epub 2013 Jan 3.


Vaccinia virus protein C6 is a virulence factor that binds TBK-1 adaptor proteins and inhibits activation of IRF3 and IRF7.

Unterholzner L, Sumner RP, Baran M, Ren H, Mansur DS, Bourke NM, Randow F, Smith GL, Bowie AG.

PLoS Pathog. 2011 Sep;7(9):e1002247. doi: 10.1371/journal.ppat.1002247. Epub 2011 Sep 8.


Vasopressor and depressor actions of angiotensin in the anesthetized fowl.

Nishimura H, Nakamura Y, Sumner RP, Khosla MC.

Am J Physiol. 1982 Mar;242(3):H314-24.


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