Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 118

1.

Risky lipids: refining the ceramide score that measures cardiovascular health.

Poss AM, Holland WL, Summers SA.

Eur Heart J. 2019 Aug 1. pii: ehz525. doi: 10.1093/eurheartj/ehz525. [Epub ahead of print] No abstract available.

PMID:
31369077
2.

Targeting a ceramide double bond improves insulin resistance and hepatic steatosis.

Chaurasia B, Tippetts TS, Mayoral Monibas R, Liu J, Li Y, Wang L, Wilkerson JL, Sweeney CR, Pereira RF, Sumida DH, Maschek JA, Cox JE, Kaddai V, Lancaster GI, Siddique MM, Poss A, Pearson M, Satapati S, Zhou H, McLaren DG, Previs SF, Chen Y, Qian Y, Petrov A, Wu M, Shen X, Yao J, Nunes CN, Howard AD, Wang L, Erion MD, Rutter J, Holland WL, Kelley DE, Summers SA.

Science. 2019 Jul 26;365(6451):386-392. doi: 10.1126/science.aav3722. Epub 2019 Jul 4.

PMID:
31273070
3.

Listen to your heart when ceramide's calling for higher glucose.

Wilkerson JL, Summers SA, Holland WL.

EBioMedicine. 2019 Mar;41:3-4. doi: 10.1016/j.ebiom.2019.02.004. Epub 2019 Feb 7. No abstract available.

4.

Conditional deletion of Des1 in the mouse retina does not impair the visual cycle in cones.

Kiser PD, Kolesnikov AV, Kiser JZ, Dong Z, Chaurasia B, Wang L, Summers SA, Hoang T, Blackshaw S, Peachey NS, Kefalov VJ, Palczewski K.

FASEB J. 2019 Apr;33(4):5782-5792. doi: 10.1096/fj.201802493R. Epub 2019 Jan 15.

PMID:
30645148
5.

Autophagy Ablation in Adipocytes Induces Insulin Resistance and Reveals Roles for Lipid Peroxide and Nrf2 Signaling in Adipose-Liver Crosstalk.

Cai J, Pires KM, Ferhat M, Chaurasia B, Buffolo MA, Smalling R, Sargsyan A, Atkinson DL, Summers SA, Graham TE, Boudina S.

Cell Rep. 2018 Nov 13;25(7):1708-1717.e5. doi: 10.1016/j.celrep.2018.10.040.

6.

Plasma Ceramides as Prognostic Biomarkers and Their Arterial and Myocardial Tissue Correlates in Acute Myocardial Infarction.

de Carvalho LP, Tan SH, Ow GS, Tang Z, Ching J, Kovalik JP, Poh SC, Chin CT, Richards AM, Martinez EC, Troughton RW, Fong AY, Yan BP, Seneviratna A, Sorokin V, Summers SA, Kuznetsov VA, Chan MY.

JACC Basic Transl Sci. 2018 May 30;3(2):163-175. doi: 10.1016/j.jacbts.2017.12.005. eCollection 2018 Apr.

7.

Strong Heart, Low Ceramides.

Holland WL, Summers SA.

Diabetes. 2018 Aug;67(8):1457-1460. doi: 10.2337/dbi18-0018. No abstract available.

8.

The ceramide ratio: a predictor of cardiometabolic risk.

Tippetts TS, Holland WL, Summers SA.

J Lipid Res. 2018 Sep;59(9):1549-1550. doi: 10.1194/jlr.C088377. Epub 2018 Jul 9. No abstract available.

9.

Does This Schlank Make Me Look Fat?

Chaurasia B, Holland WL, Summers SA.

Trends Endocrinol Metab. 2018 Sep;29(9):597-599. doi: 10.1016/j.tem.2018.04.003. Epub 2018 Apr 21.

10.

Physiological mechanisms of sustained fumagillin-induced weight loss.

An J, Wang L, Patnode ML, Ridaura VK, Haldeman JM, Stevens RD, Ilkayeva O, Bain JR, Muehlbauer MJ, Glynn EL, Thomas S, Muoio D, Summers SA, Vath JE, Hughes TE, Gordon JI, Newgard CB.

JCI Insight. 2018 Mar 8;3(5). pii: 99453. doi: 10.1172/jci.insight.99453.

11.

Could Ceramides Become the New Cholesterol?

Summers SA.

Cell Metab. 2018 Feb 6;27(2):276-280. doi: 10.1016/j.cmet.2017.12.003. Epub 2018 Jan 4. Review.

12.

Profiling of Plasma Metabolites Suggests Altered Mitochondrial Fuel Usage and Remodeling of Sphingolipid Metabolism in Individuals With Type 2 Diabetes and Kidney Disease.

Liu JJ, Ghosh S, Kovalik JP, Ching J, Choi HW, Tavintharan S, Ong CN, Sum CF, Summers SA, Tai ES, Lim SC.

Kidney Int Rep. 2016 Dec 16;2(3):470-480. doi: 10.1016/j.ekir.2016.12.003. eCollection 2017 May.

13.

Ceramides - Lipotoxic Inducers of Metabolic Disorders: (Trends in Endocrinology and Metabolism 26, 538-550; 2015).

Chaurasia B, Summers SA.

Trends Endocrinol Metab. 2018 Jan;29(1):66-67. doi: 10.1016/j.tem.2017.09.005. Epub 2017 Oct 5. No abstract available.

PMID:
28988873
14.

Early serum creatinine accurately predicts acute kidney injury post cardiac surgery.

Grynberg K, Polkinghorne KR, Ford S, Stenning F, Lew TE, Barrett JA, Summers SA.

BMC Nephrol. 2017 Mar 16;18(1):93. doi: 10.1186/s12882-017-0504-y.

15.

Adipocyte Ceramides Regulate Subcutaneous Adipose Browning, Inflammation, and Metabolism.

Chaurasia B, Kaddai VA, Lancaster GI, Henstridge DC, Sriram S, Galam DL, Gopalan V, Prakash KN, Velan SS, Bulchand S, Tsong TJ, Wang M, Siddique MM, Yuguang G, Sigmundsson K, Mellet NA, Weir JM, Meikle PJ, Bin M Yassin MS, Shabbir A, Shayman JA, Hirabayashi Y, Shiow ST, Sugii S, Summers SA.

Cell Metab. 2016 Dec 13;24(6):820-834. doi: 10.1016/j.cmet.2016.10.002. Epub 2016 Nov 3.

16.

Sphingolipids and phospholipids in insulin resistance and related metabolic disorders.

Meikle PJ, Summers SA.

Nat Rev Endocrinol. 2017 Feb;13(2):79-91. doi: 10.1038/nrendo.2016.169. Epub 2016 Oct 21. Review.

PMID:
27767036
17.

A Role for Ceramides, but Not Sphingomyelins, as Antagonists of Insulin Signaling and Mitochondrial Metabolism in C2C12 Myotubes.

Park M, Kaddai V, Ching J, Fridianto KT, Sieli RJ, Sugii S, Summers SA.

J Biol Chem. 2016 Nov 11;291(46):23978-23988. Epub 2016 Oct 4.

18.

Rebuttal from Scott A. Summers and Bret H. Goodpaster.

Summers SA, Goodpaster BH.

J Physiol. 2016 Jun 15;594(12):3175-6. doi: 10.1113/JP272136. Epub 2016 Mar 20. No abstract available.

19.

CrossTalk proposal: Intramyocellular ceramide accumulation does modulate insulin resistance.

Summers SA, Goodpaster BH.

J Physiol. 2016 Jun 15;594(12):3167-70. doi: 10.1113/JP271676. Epub 2016 Mar 20. No abstract available.

20.

ECM microenvironment unlocks brown adipogenic potential of adult human bone marrow-derived MSCs.

Lee MH, Goralczyk AG, Kriszt R, Ang XM, Badowski C, Li Y, Summers SA, Toh SA, Yassin MS, Shabbir A, Sheppard A, Raghunath M.

Sci Rep. 2016 Feb 17;6:21173. doi: 10.1038/srep21173.

21.

Ceramides - Lipotoxic Inducers of Metabolic Disorders.

Chaurasia B, Summers SA.

Trends Endocrinol Metab. 2015 Oct;26(10):538-550. doi: 10.1016/j.tem.2015.07.006. Review. Erratum in: Trends Endocrinol Metab. 2018 Jan;29(1):66-67.

PMID:
26412155
22.

Mast Cell Stabilization Ameliorates Autoimmune Anti-Myeloperoxidase Glomerulonephritis.

Gan PY, O'Sullivan KM, Ooi JD, Alikhan MA, Odobasic D, Summers SA, Kitching AR, Holdsworth SR.

J Am Soc Nephrol. 2016 May;27(5):1321-33. doi: 10.1681/ASN.2014090906. Epub 2015 Sep 15.

23.

Ceramide-Initiated Protein Phosphatase 2A Activation Contributes to Arterial Dysfunction In Vivo.

Bharath LP, Ruan T, Li Y, Ravindran A, Wan X, Nhan JK, Walker ML, Deeter L, Goodrich R, Johnson E, Munday D, Mueller R, Kunz D, Jones D, Reese V, Summers SA, Babu PV, Holland WL, Zhang QJ, Abel ED, Symons JD.

Diabetes. 2015 Nov;64(11):3914-26. doi: 10.2337/db15-0244. Epub 2015 Aug 7.

24.

The ART of Lowering Ceramides.

Summers SA.

Cell Metab. 2015 Aug 4;22(2):195-6. doi: 10.1016/j.cmet.2015.07.019.

25.

Renal participation of myeloperoxidase in antineutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis.

O'Sullivan KM, Lo CY, Summers SA, Elgass KD, McMillan PJ, Longano A, Ford SL, Gan PY, Kerr PG, Kitching AR, Holdsworth SR.

Kidney Int. 2015 Nov;88(5):1030-46. doi: 10.1038/ki.2015.202. Epub 2015 Jul 15.

PMID:
26176828
26.

Endogenous Toll-Like Receptor 9 Regulates AKI by Promoting Regulatory T Cell Recruitment.

Alikhan MA, Summers SA, Gan PY, Chan AJ, Khouri MB, Ooi JD, Ghali JR, Odobasic D, Hickey MJ, Kitching AR, Holdsworth SR.

J Am Soc Nephrol. 2016 Mar;27(3):706-14. doi: 10.1681/ASN.2014090927. Epub 2015 Jun 26.

27.

Dihydroceramides: From Bit Players to Lead Actors.

Siddique MM, Li Y, Chaurasia B, Kaddai VA, Summers SA.

J Biol Chem. 2015 Jun 19;290(25):15371-9. doi: 10.1074/jbc.R115.653204. Epub 2015 May 6. Review.

28.

Suppression of Autoimmunity and Renal Disease in Pristane-Induced Lupus by Myeloperoxidase.

Odobasic D, Muljadi RC, O'Sullivan KM, Kettle AJ, Dickerhof N, Summers SA, Kitching AR, Holdsworth SR.

Arthritis Rheumatol. 2015 Jul;67(7):1868-80. doi: 10.1002/art.39109.

29.

Essential nutrient supplementation prevents heritable metabolic disease in multigenerational intrauterine growth-restricted rats.

Goodspeed D, Seferovic MD, Holland W, Mcknight RA, Summers SA, Branch DW, Lane RH, Aagaard KM.

FASEB J. 2015 Mar;29(3):807-19. doi: 10.1096/fj.14-259614. Epub 2014 Nov 13.

30.

CerS2 Haploinsufficiency Inhibits β-Oxidation and Confers Susceptibility to Diet-Induced Steatohepatitis and Insulin Resistance.

Raichur S, Wang ST, Chan PW, Li Y, Ching J, Chaurasia B, Dogra S, Öhman MK, Takeda K, Sugii S, Pewzner-Jung Y, Futerman AH, Summers SA.

Cell Metab. 2014 Nov 4;20(5):919. doi: 10.1016/j.cmet.2014.10.007. Epub 2014 Nov 4. No abstract available.

31.

Increased dihydroceramide/ceramide ratio mediated by defective expression of degs1 impairs adipocyte differentiation and function.

Barbarroja N, Rodriguez-Cuenca S, Nygren H, Camargo A, Pirraco A, Relat J, Cuadrado I, Pellegrinelli V, Medina-Gomez G, Lopez-Pedrera C, Tinahones FJ, Symons JD, Summers SA, Oresic M, Vidal-Puig A.

Diabetes. 2015 Apr;64(4):1180-92. doi: 10.2337/db14-0359. Epub 2014 Oct 28.

32.

CerS2 haploinsufficiency inhibits β-oxidation and confers susceptibility to diet-induced steatohepatitis and insulin resistance.

Raichur S, Wang ST, Chan PW, Li Y, Ching J, Chaurasia B, Dogra S, Öhman MK, Takeda K, Sugii S, Pewzner-Jung Y, Futerman AH, Summers SA.

Cell Metab. 2014 Oct 7;20(4):687-95. doi: 10.1016/j.cmet.2014.09.015. Erratum in: Cell Metab. 2014 Nov 4;20(5):919. Chaurasia, Bghagirath [corrected to Chaurasia, Bhagirath]. Erratum in: Cell Metab. 2014 Nov 4;20(5):919.

33.

Isoprenylcysteine carboxylmethyltransferase regulates mitochondrial respiration and cancer cell metabolism.

Teh JT, Zhu WL, Ilkayeva OR, Li Y, Gooding J, Casey PJ, Summers SA, Newgard CB, Wang M.

Oncogene. 2015 Jun;34(25):3296-304. doi: 10.1038/onc.2014.260. Epub 2014 Aug 25.

PMID:
25151967
34.

Molecular pathways reflecting poor intrauterine growth are found in Wharton's jelly-derived mesenchymal stem cells.

Sukarieh R, Joseph R, Leow SC, Li Y, Löffler M, Aris IM, Tan JH, Teh AL, Chen L, Holbrook JD, Ng KL, Lee YS, Chong YS, Summers SA, Gluckman PD, Stünkel W.

Hum Reprod. 2014 Oct 10;29(10):2287-301. doi: 10.1093/humrep/deu209. Epub 2014 Aug 16.

PMID:
25129543
35.

Deletion of bone-marrow-derived receptor for AGEs (RAGE) improves renal function in an experimental mouse model of diabetes.

Tesch G, Sourris KC, Summers SA, McCarthy D, Ward MS, Borg DJ, Gallo LA, Fotheringham AK, Pettit AR, Yap FY, Harcourt BE, Tan AL, Kausman JY, Nikolic-Paterson D, Kitching AR, Forbes JM.

Diabetologia. 2014 Sep;57(9):1977-85. doi: 10.1007/s00125-014-3291-z. Epub 2014 Jun 24.

PMID:
24957662
36.

Innate IL-17A-producing leukocytes promote acute kidney injury via inflammasome and Toll-like receptor activation.

Chan AJ, Alikhan MA, Odobasic D, Gan PY, Khouri MB, Steinmetz OM, Mansell AS, Kitching AR, Holdsworth SR, Summers SA.

Am J Pathol. 2014 May;184(5):1411-8. doi: 10.1016/j.ajpath.2014.01.023. Epub 2014 Mar 14.

37.

Endogenous interleukin (IL)-17A promotes pristane-induced systemic autoimmunity and lupus nephritis induced by pristane.

Summers SA, Odobasic D, Khouri MB, Steinmetz OM, Yang Y, Holdsworth SR, Kitching AR.

Clin Exp Immunol. 2014 Jun;176(3):341-50. doi: 10.1111/cei.12287.

38.

Ceramides and glucosylceramides are independent antagonists of insulin signaling.

Chavez JA, Siddique MM, Wang ST, Ching J, Shayman JA, Summers SA.

J Biol Chem. 2014 Jan 10;289(2):723-34. doi: 10.1074/jbc.M113.522847. Epub 2013 Nov 8.

39.

Histopathologic and clinical predictors of kidney outcomes in ANCA-associated vasculitis.

Ford SL, Polkinghorne KR, Longano A, Dowling J, Dayan S, Kerr PG, Holdsworth SR, Kitching AR, Summers SA.

Am J Kidney Dis. 2014 Feb;63(2):227-35. doi: 10.1053/j.ajkd.2013.08.025. Epub 2013 Oct 30.

PMID:
24183110
40.

MicroRNA-155 a new therapeutic target in crescentic GN.

Holdsworth SR, Summers SA.

J Am Soc Nephrol. 2013 Dec;24(12):1927-9. doi: 10.1681/ASN.2013090924. Epub 2013 Oct 24. No abstract available.

41.

Extensive diversity in circadian regulation of plasma lipids and evidence for different circadian metabolic phenotypes in humans.

Chua EC, Shui G, Lee IT, Lau P, Tan LC, Yeo SC, Lam BD, Bulchand S, Summers SA, Puvanendran K, Rozen SG, Wenk MR, Gooley JJ.

Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14468-73. doi: 10.1073/pnas.1222647110. Epub 2013 Aug 14.

42.

Caffeine stimulates hepatic lipid metabolism by the autophagy-lysosomal pathway in mice.

Sinha RA, Farah BL, Singh BK, Siddique MM, Li Y, Wu Y, Ilkayeva OR, Gooding J, Ching J, Zhou J, Martinez L, Xie S, Bay BH, Summers SA, Newgard CB, Yen PM.

Hepatology. 2014 Apr;59(4):1366-80. doi: 10.1002/hep.26667. Epub 2014 Feb 18.

PMID:
23929677
43.

Ablation of dihydroceramide desaturase 1, a therapeutic target for the treatment of metabolic diseases, simultaneously stimulates anabolic and catabolic signaling.

Siddique MM, Li Y, Wang L, Ching J, Mal M, Ilkayeva O, Wu YJ, Bay BH, Summers SA.

Mol Cell Biol. 2013 Jun;33(11):2353-69. doi: 10.1128/MCB.00226-13. Epub 2013 Apr 1.

44.

Neutrophil myeloperoxidase regulates T-cell-driven tissue inflammation in mice by inhibiting dendritic cell function.

Odobasic D, Kitching AR, Yang Y, O'Sullivan KM, Muljadi RC, Edgtton KL, Tan DS, Summers SA, Morand EF, Holdsworth SR.

Blood. 2013 May 16;121(20):4195-204. doi: 10.1182/blood-2012-09-456483. Epub 2013 Mar 18.

45.

Thymic deletion and regulatory T cells prevent antimyeloperoxidase GN.

Tan DS, Gan PY, O'Sullivan KM, Hammett MV, Summers SA, Ooi JD, Lundgren BA, Boyd RL, Scott HS, Kitching AR, Chidgey AP, Holdsworth SR.

J Am Soc Nephrol. 2013 Mar;24(4):573-85. doi: 10.1681/ASN.2012090898. Epub 2013 Feb 7.

46.

Soluble epoxide hydrolase dimerization is required for hydrolase activity.

Nelson JW, Subrahmanyan RM, Summers SA, Xiao X, Alkayed NJ.

J Biol Chem. 2013 Mar 15;288(11):7697-703. doi: 10.1074/jbc.M112.429258. Epub 2013 Jan 28.

47.

Mast cells contribute to peripheral tolerance and attenuate autoimmune vasculitis.

Gan PY, Summers SA, Ooi JD, O'Sullivan KM, Tan DS, Muljadi RC, Odobasic D, Kitching AR, Holdsworth SR.

J Am Soc Nephrol. 2012 Dec;23(12):1955-66. doi: 10.1681/ASN.2012060572. Epub 2012 Nov 8.

48.

Ablation of dihydroceramide desaturase confers resistance to etoposide-induced apoptosis in vitro.

Siddique MM, Bikman BT, Wang L, Ying L, Reinhardt E, Shui G, Wenk MR, Summers SA.

PLoS One. 2012;7(9):e44042. doi: 10.1371/journal.pone.0044042. Epub 2012 Sep 11.

49.

Expression of ceramide-metabolising enzymes in subcutaneous and intra-abdominal human adipose tissue.

Kolak M, Gertow J, Westerbacka J, Summers SA, Liska J, Franco-Cereceda A, Orešič M, Yki-Järvinen H, Eriksson P, Fisher RM.

Lipids Health Dis. 2012 Sep 13;11:115. doi: 10.1186/1476-511X-11-115.

50.

Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy.

Sinha RA, You SH, Zhou J, Siddique MM, Bay BH, Zhu X, Privalsky ML, Cheng SY, Stevens RD, Summers SA, Newgard CB, Lazar MA, Yen PM.

J Clin Invest. 2012 Jul;122(7):2428-38. doi: 10.1172/JCI60580. Epub 2012 Jun 11.

Supplemental Content

Loading ...
Support Center