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Items: 27


USP14 is a deubiquitinase for Ku70 and critical determinant of non-homologous end joining repair in autophagy and PTEN-deficient cells.

Sharma A, Alswillah T, Kapoor I, Debjani P, Willard B, Summers MK, Gong Z, Almasan A.

Nucleic Acids Res. 2020 Jan 24;48(2):736-747. doi: 10.1093/nar/gkz1103.


Hyperphosphorylation of CDH1 in Glioblastoma Cancer Stem Cells Attenuates APC/CCDH1 Activity and Pharmacologic Inhibition of APC/CCDH1/CDC20 Compromises Viability.

De K, Grubb TM, Zalenski AA, Pfaff KE, Pal D, Majumder S, Summers MK, Venere M.

Mol Cancer Res. 2019 Jul;17(7):1519-1530. doi: 10.1158/1541-7786.MCR-18-1361. Epub 2019 Apr 29.


Targeting BCL-xL improves the efficacy of bromodomain and extra-terminal protein inhibitors in triple-negative breast cancer by eliciting the death of senescent cells.

Gayle SS, Sahni JM, Webb BM, Weber-Bonk KL, Shively MS, Spina R, Bar EE, Summers MK, Keri RA.

J Biol Chem. 2019 Jan 18;294(3):875-886. doi: 10.1074/jbc.RA118.004712. Epub 2018 Nov 27.


USP14 regulates DNA damage repair by targeting RNF168-dependent ubiquitination.

Sharma A, Alswillah T, Singh K, Chatterjee P, Willard B, Venere M, Summers MK, Almasan A.

Autophagy. 2018;14(11):1976-1990. doi: 10.1080/15548627.2018.1496877. Epub 2018 Aug 10.


Mitotic Vulnerability in Triple-Negative Breast Cancer Associated with LIN9 Is Targetable with BET Inhibitors.

Sahni JM, Gayle SS, Webb BM, Weber-Bonk KL, Seachrist DD, Singh S, Sizemore ST, Restrepo NA, Bebek G, Scacheri PC, Varadan V, Summers MK, Keri RA.

Cancer Res. 2017 Oct 1;77(19):5395-5408. doi: 10.1158/0008-5472.CAN-17-1571. Epub 2017 Aug 14.


The mitotic kinesin KIF11 is a driver of invasion, proliferation, and self-renewal in glioblastoma.

Venere M, Horbinski C, Crish JF, Jin X, Vasanji A, Major J, Burrows AC, Chang C, Prokop J, Wu Q, Sims PA, Canoll P, Summers MK, Rosenfeld SS, Rich JN.

Sci Transl Med. 2015 Sep 9;7(304):304ra143. doi: 10.1126/scitranslmed.aac6762.


Chemical dissection of the cell cycle: probes for cell biology and anti-cancer drug development.

Senese S, Lo YC, Huang D, Zangle TA, Gholkar AA, Robert L, Homet B, Ribas A, Summers MK, Teitell MA, Damoiseaux R, Torres JZ.

Cell Death Dis. 2014 Oct 16;5:e1462. doi: 10.1038/cddis.2014.420.


Phosphorylation regulates the p31Comet-mitotic arrest-deficient 2 (Mad2) interaction to promote spindle assembly checkpoint (SAC) activity.

Date DA, Burrows AC, Summers MK.

J Biol Chem. 2014 Apr 18;289(16):11367-73. doi: 10.1074/jbc.M113.520841. Epub 2014 Mar 4.


Coordinated regulation of p31(Comet) and Mad2 expression is required for cellular proliferation.

Date DA, Burrows AC, Venere M, Jackson MW, Summers MK.

Cell Cycle. 2013 Dec 15;12(24):3824-32. doi: 10.4161/cc.26811. Epub 2013 Oct 15.


USP7 and Daxx regulate mitosis progression and taxane sensitivity by affecting stability of Aurora-A kinase.

Giovinazzi S, Morozov VM, Summers MK, Reinhold WC, Ishov AM.

Cell Death Differ. 2013 May;20(5):721-31. doi: 10.1038/cdd.2012.169. Epub 2013 Jan 25.


Skp1-Cul1-F-box ubiquitin ligase (SCF(╬▓TrCP))-mediated destruction of the ubiquitin-specific protease USP37 during G2-phase promotes mitotic entry.

Burrows AC, Prokop J, Summers MK.

J Biol Chem. 2012 Nov 9;287(46):39021-9. doi: 10.1074/jbc.M112.390328. Epub 2012 Oct 1.


The STARD9/Kif16a kinesin associates with mitotic microtubules and regulates spindle pole assembly.

Torres JZ, Summers MK, Peterson D, Brauer MJ, Lee J, Senese S, Gholkar AA, Lo YC, Lei X, Jung K, Anderson DC, Davis DP, Belmont L, Jackson PK.

Cell. 2011 Dec 9;147(6):1309-23. doi: 10.1016/j.cell.2011.11.020.


Regulation of mitosis and taxane response by Daxx and Rassf1.

Giovinazzi S, Lindsay CR, Morozov VM, Escobar-Cabrera E, Summers MK, Han HS, McIntosh LP, Ishov AM.

Oncogene. 2012 Jan 5;31(1):13-26. doi: 10.1038/onc.2011.211. Epub 2011 Jun 6.


Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry.

Huang X, Summers MK, Pham V, Lill JR, Liu J, Lee G, Kirkpatrick DS, Jackson PK, Fang G, Dixit VM.

Mol Cell. 2011 May 20;42(4):511-23. doi: 10.1016/j.molcel.2011.03.027.


APC/C(Cdc20) targets E2F1 for degradation in prometaphase.

Peart MJ, Poyurovsky MV, Kass EM, Urist M, Verschuren EW, Summers MK, Jackson PK, Prives C.

Cell Cycle. 2010 Oct 1;9(19):3956-64. Epub 2010 Oct 26.


Biochemical analysis of the Anaphase Promoting Complex: activities of E2 enzymes and substrate competitive (pseudosubstrate) inhibitors.

Summers MK, Jackson PK.

Methods Mol Biol. 2009;545:313-30. doi: 10.1007/978-1-60327-993-2_20.


Evaluation of factors affecting serum IgG concentrations in bottle-fed calves.

Chigerwe M, Tyler JW, Summers MK, Middleton JR, Schultz LG, Nagy DW.

J Am Vet Med Assoc. 2009 Mar 15;234(6):785-9. doi: 10.2460/javma.234.6.785.


The unique N terminus of the UbcH10 E2 enzyme controls the threshold for APC activation and enhances checkpoint regulation of the APC.

Summers MK, Pan B, Mukhyala K, Jackson PK.

Mol Cell. 2008 Aug 22;31(4):544-56. doi: 10.1016/j.molcel.2008.07.014.


Defective in mitotic arrest 1/ring finger 8 is a checkpoint protein that antagonizes the human mitotic exit network.

Tuttle RL, Bothos J, Summers MK, Luca FC, Halazonetis TD.

Mol Cancer Res. 2007 Dec;5(12):1304-11. doi: 10.1158/1541-7786.MCR-07-0388.


Cyclin E overexpression impairs progression through mitosis by inhibiting APC(Cdh1).

Keck JM, Summers MK, Tedesco D, Ekholm-Reed S, Chuang LC, Jackson PK, Reed SI.

J Cell Biol. 2007 Jul 30;178(3):371-85.


Emi2 at the crossroads: where CSF meets MPF.

Hansen DV, Pomerening JR, Summers MK, Miller JJ, Ferrell JE Jr, Jackson PK.

Cell Cycle. 2007 Mar 15;6(6):732-8. Epub 2007 Mar 14.


Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor.

Miller JJ, Summers MK, Hansen DV, Nachury MV, Lehman NL, Loktev A, Jackson PK.

Genes Dev. 2006 Sep 1;20(17):2410-20. Epub 2006 Aug 18.


A role for the anaphase-promoting complex inhibitor Emi2/XErp1, a homolog of early mitotic inhibitor 1, in cytostatic factor arrest of Xenopus eggs.

Tung JJ, Hansen DV, Ban KH, Loktev AV, Summers MK, Adler JR 3rd, Jackson PK.

Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4318-23. Epub 2005 Mar 7.


The CHFR mitotic checkpoint protein delays cell cycle progression by excluding Cyclin B1 from the nucleus.

Summers MK, Bothos J, Halazonetis TD.

Oncogene. 2005 Apr 14;24(16):2589-98.


Inactivating mutations targeting the chfr mitotic checkpoint gene in human lung cancer.

Mariatos G, Bothos J, Zacharatos P, Summers MK, Scolnick DM, Kittas C, Halazonetis TD, Gorgoulis VG.

Cancer Res. 2003 Nov 1;63(21):7185-9.


The Chfr mitotic checkpoint protein functions with Ubc13-Mms2 to form Lys63-linked polyubiquitin chains.

Bothos J, Summers MK, Venere M, Scolnick DM, Halazonetis TD.

Oncogene. 2003 Oct 16;22(46):7101-7.


Frequent hypermethylation of the 5' CpG island of the mitotic stress checkpoint gene Chfr in colorectal and non-small cell lung cancer.

Corn PG, Summers MK, Fogt F, Virmani AK, Gazdar AF, Halazonetis TD, El-Deiry WS.

Carcinogenesis. 2003 Jan;24(1):47-51.


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