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Detection of neoantigen-reactive T cell clones based on the clonal expansion using next-generation sequencing of T cell receptor β complementarity-determining region 3.

Sumimoto H, Takano A, Teramoto K, Daigo Y.

J Immunol Methods. 2019 Oct 23:112679. doi: 10.1016/j.jim.2019.112679. [Epub ahead of print]


Clinical significance of PD-L1-positive cancer-associated fibroblasts in pN0M0 non-small cell lung cancer.

Teramoto K, Igarashi T, Kataoka Y, Ishida M, Hanaoka J, Sumimoto H, Daigo Y.

Lung Cancer. 2019 Nov;137:56-63. doi: 10.1016/j.lungcan.2019.09.013. Epub 2019 Sep 16.


JunB plays a crucial role in development of regulatory T cells by promoting IL-2 signaling.

Katagiri T, Yamazaki S, Fukui Y, Aoki K, Yagita H, Nishina T, Mikami T, Katagiri S, Shiraishi A, Kimura S, Tateda K, Sumimoto H, Endo S, Kameda H, Nakano H.

Mucosal Immunol. 2019 Sep;12(5):1104-1117. doi: 10.1038/s41385-019-0182-0. Epub 2019 Jul 8.


Soluble Regulatory Proteins for Activation of NOX Family NADPH Oxidases.

Sumimoto H, Minakami R, Miyano K.

Methods Mol Biol. 2019;1982:121-137. doi: 10.1007/978-1-4939-9424-3_8.


Sox9 regulates the luminal stem/progenitor cell properties of salivary glands.

Tanaka J, Mabuchi Y, Hata K, Yasuhara R, Takamatsu K, Kujiraoka S, Yukimori A, Takakura I, Sumimoto H, Fukada T, Azuma M, Akiyama H, Nishimura R, Shimane T, Mishima K.

Exp Cell Res. 2019 Sep 1;382(1):111449. doi: 10.1016/j.yexcr.2019.05.030. Epub 2019 May 31.


Fhod1, an actin-organizing formin family protein, is dispensable for cardiac development and function in mice.

Sanematsu F, Kanai A, Ushijima T, Shiraishi A, Abe T, Kage Y, Sumimoto H, Takeya R.

Cytoskeleton (Hoboken). 2019 Feb;76(2):219-229. doi: 10.1002/cm.21523. Epub 2019 Apr 29.


Differential cell surface recruitment of the superoxide-producing NADPH oxidases Nox1, Nox2 and Nox5: The role of the small GTPase Sar1.

Kiyohara T, Miyano K, Kamakura S, Hayase J, Chishiki K, Kohda A, Sumimoto H.

Genes Cells. 2018 Jun;23(6):480-493. doi: 10.1111/gtc.12590. Epub 2018 May 2.


Interaction between cardiac myosin-binding protein C and formin Fhod3.

Matsuyama S, Kage Y, Fujimoto N, Ushijima T, Tsuruda T, Kitamura K, Shiose A, Asada Y, Sumimoto H, Takeya R.

Proc Natl Acad Sci U S A. 2018 May 8;115(19):E4386-E4395. doi: 10.1073/pnas.1716498115. Epub 2018 Apr 23.


The AP-1 transcription factor JunB is required for Th17 cell differentiation.

Yamazaki S, Tanaka Y, Araki H, Kohda A, Sanematsu F, Arasaki T, Duan X, Miura F, Katagiri T, Shindo R, Nakano H, Ito T, Fukui Y, Endo S, Sumimoto H.

Sci Rep. 2017 Dec 12;7(1):17402. doi: 10.1038/s41598-017-17597-3.


The actin-organizing formin protein Fhod3 is required for postnatal development and functional maintenance of the adult heart in mice.

Ushijima T, Fujimoto N, Matsuyama S, Kan-O M, Kiyonari H, Shioi G, Kage Y, Yamasaki S, Takeya R, Sumimoto H.

J Biol Chem. 2018 Jan 5;293(1):148-162. doi: 10.1074/jbc.M117.813931. Epub 2017 Nov 20.


TRPC3-Nox2 complex mediates doxorubicin-induced myocardial atrophy.

Shimauchi T, Numaga-Tomita T, Ito T, Nishimura A, Matsukane R, Oda S, Hoka S, Ide T, Koitabashi N, Uchida K, Sumimoto H, Mori Y, Nishida M.

JCI Insight. 2017 Aug 3;2(15). pii: 93358. doi: 10.1172/jci.insight.93358. eCollection 2017 Aug 3.


Tropomyosin-related kinase B mediated signaling contributes to the induction of malignant phenotype of gallbladder cancer.

Kawamoto M, Onishi H, Ozono K, Yamasaki A, Imaizumi A, Kamakura S, Nakano K, Oda Y, Sumimoto H, Nakamura M.

Oncotarget. 2017 May 30;8(22):36211-36224. doi: 10.18632/oncotarget.16063.


Ric-8A, an activator protein of Gαi, controls mammalian epithelial cell polarity for tight junction assembly and cystogenesis.

Chishiki K, Kamakura S, Hayase J, Sumimoto H.

Genes Cells. 2017 Mar;22(3):293-309. doi: 10.1111/gtc.12477. Epub 2017 Feb 10.


Ric-8A-mediated stabilization of the trimeric G protein subunit Gαi is inhibited by pertussis toxin-catalyzed ADP-ribosylation.

Chishiki K, Kamakura S, Hayase J, Yuzawa S, Sumimoto H.

Biochem Biophys Res Commun. 2017 Feb 12;483(3):941-945. doi: 10.1016/j.bbrc.2017.01.036. Epub 2017 Jan 10.


TRPC3-GEF-H1 axis mediates pressure overload-induced cardiac fibrosis.

Numaga-Tomita T, Kitajima N, Kuroda T, Nishimura A, Miyano K, Yasuda S, Kuwahara K, Sato Y, Ide T, Birnbaumer L, Sumimoto H, Mori Y, Nishida M.

Sci Rep. 2016 Dec 19;6:39383. doi: 10.1038/srep39383.


RAS-Mitogen-Activated Protein Kinase Signal Is Required for Enhanced PD-L1 Expression in Human Lung Cancers.

Sumimoto H, Takano A, Teramoto K, Daigo Y.

PLoS One. 2016 Nov 15;11(11):e0166626. doi: 10.1371/journal.pone.0166626. eCollection 2016.


TRPC3 positively regulates reactive oxygen species driving maladaptive cardiac remodeling.

Kitajima N, Numaga-Tomita T, Watanabe M, Kuroda T, Nishimura A, Miyano K, Yasuda S, Kuwahara K, Sato Y, Ide T, Birnbaumer L, Sumimoto H, Mori Y, Nishida M.

Sci Rep. 2016 Nov 11;6:37001. doi: 10.1038/srep37001.


The adaptor protein p40phox as a positive regulator of the superoxide-producing phagocyte oxidase.

Kuribayashi F, Nunoi H, Wakamatsu K, Tsunawaki S, Sato K, Ito T, Sumimoto H.

EMBO J. 2016 Feb 1;35(3):369-70. doi: 10.15252/embj.201593689. Epub 2016 Jan 31. No abstract available.


Transgenic Expression of the Formin Protein Fhod3 Selectively in the Embryonic Heart: Role of Actin-Binding Activity of Fhod3 and Its Sarcomeric Localization during Myofibrillogenesis.

Fujimoto N, Kan-O M, Ushijima T, Kage Y, Tominaga R, Sumimoto H, Takeya R.

PLoS One. 2016 Feb 5;11(2):e0148472. doi: 10.1371/journal.pone.0148472. eCollection 2016.


c-Rel Regulates Inscuteable Gene Expression during Mouse Embryonic Stem Cell Differentiation.

Ishibashi R, Kozuki S, Kamakura S, Sumimoto H, Toyoshima F.

J Biol Chem. 2016 Feb 12;291(7):3333-45. doi: 10.1074/jbc.M115.679563. Epub 2015 Dec 22.


Novel human homologues of p47phox and p67phox participate in activation of superoxide-producing NADPH oxidases.

Takeya R, Ueno N, Kami K, Taura M, Kohjima M, Izaki T, Nunoi H, Sumimoto H.

J Biol Chem. 2015 Mar 6;290(10):6003. doi: 10.1074/jbc.A114.212856. No abstract available.


Structural basis for the recognition of the scaffold protein Frmpd4/Preso1 by the TPR domain of the adaptor protein LGN.

Takayanagi H, Yuzawa S, Sumimoto H.

Acta Crystallogr F Struct Biol Commun. 2015 Feb;71(Pt 2):175-83. doi: 10.1107/S2053230X14028143. Epub 2015 Jan 28.


Structural basis of cofactor-mediated stabilization and substrate recognition of the α-tubulin acetyltransferase αTAT1.

Yuzawa S, Kamakura S, Hayase J, Sumimoto H.

Biochem J. 2015 Apr 1;467(1):103-13. doi: 10.1042/BJ20141193.


Glucocorticoid augments lipopolysaccharide-induced activation of the IκBζ-dependent genes encoding the anti-microbial glycoproteins lipocalin 2 and pentraxin 3.

Yamazaki S, Akira S, Sumimoto H.

J Biochem. 2015 May;157(5):399-410. doi: 10.1093/jb/mvu086. Epub 2014 Dec 30.


DOCK2 and DOCK5 act additively in neutrophils to regulate chemotaxis, superoxide production, and extracellular trap formation.

Watanabe M, Terasawa M, Miyano K, Yanagihara T, Uruno T, Sanematsu F, Nishikimi A, Côté JF, Sumimoto H, Fukui Y.

J Immunol. 2014 Dec 1;193(11):5660-7. doi: 10.4049/jimmunol.1400885. Epub 2014 Oct 22.


Arachidonic acid induces direct interaction of the p67(phox)-Rac complex with the phagocyte oxidase Nox2, leading to superoxide production.

Matono R, Miyano K, Kiyohara T, Sumimoto H.

J Biol Chem. 2014 Sep 5;289(36):24874-84. doi: 10.1074/jbc.M114.581785. Epub 2014 Jul 23.


DNA element downstream of the κB site in the Lcn2 promoter is required for transcriptional activation by IκBζ and NF-κB p50.

Kohda A, Yamazaki S, Sumimoto H.

Genes Cells. 2014 Aug;19(8):620-8. doi: 10.1111/gtc.12162. Epub 2014 Jun 20.


Immunosuppression through constitutively activated NF-κB signalling in human ovarian cancer and its reversal by an NF-κB inhibitor.

Nishio H, Yaguchi T, Sugiyama J, Sumimoto H, Umezawa K, Iwata T, Susumu N, Fujii T, Kawamura N, Kobayashi A, Park J, Aoki D, Kawakami Y.

Br J Cancer. 2014 Jun 10;110(12):2965-74. doi: 10.1038/bjc.2014.251. Epub 2014 May 27.


Visualization of phagosomal hydrogen peroxide production by a novel fluorescent probe that is localized via SNAP-tag labeling.

Abo M, Minakami R, Miyano K, Kamiya M, Nagano T, Urano Y, Sumimoto H.

Anal Chem. 2014 Jun 17;86(12):5983-90. doi: 10.1021/ac501041w. Epub 2014 Jun 6.


N-Linked glycosylation of the superoxide-producing NADPH oxidase Nox1.

Miyano K, Sumimoto H.

Biochem Biophys Res Commun. 2014 Jan 17;443(3):1060-5. doi: 10.1016/j.bbrc.2013.12.086. Epub 2013 Dec 21.


Dilated cardiomyopathy-associated FHOD3 variant impairs the ability to induce activation of transcription factor serum response factor.

Arimura T, Takeya R, Ishikawa T, Yamano T, Matsuo A, Tatsumi T, Nomura T, Sumimoto H, Kimura A.

Circ J. 2013;77(12):2990-6. Epub 2013 Oct 1.


Phosphorylation of Noxo1 at threonine 341 regulates its interaction with Noxa1 and the superoxide-producing activity of Nox1.

Yamamoto A, Takeya R, Matsumoto M, Nakayama KI, Sumimoto H.

FEBS J. 2013 Oct;280(20):5145-59. doi: 10.1111/febs.12489. Epub 2013 Sep 12.


The cell polarity protein mInsc regulates neutrophil chemotaxis via a noncanonical G protein signaling pathway.

Kamakura S, Nomura M, Hayase J, Iwakiri Y, Nishikimi A, Takayanagi R, Fukui Y, Sumimoto H.

Dev Cell. 2013 Aug 12;26(3):292-302. doi: 10.1016/j.devcel.2013.06.008. Epub 2013 Jul 25.


Improvement of cancer immunotherapy by combining molecular targeted therapy.

Kawakami Y, Yaguchi T, Sumimoto H, Kudo-Saito C, Iwata-Kajihara T, Nakamura S, Tsujikawa T, Park JH, Popivanova BK, Miyazaki J, Kawamura N.

Front Oncol. 2013 May 28;3:136. doi: 10.3389/fonc.2013.00136. eCollection 2013.


Ubiquitination of the heterotrimeric G protein α subunits Gαi2 and Gαq is prevented by the guanine nucleotide exchange factor Ric-8A.

Chishiki K, Kamakura S, Yuzawa S, Hayase J, Sumimoto H.

Biochem Biophys Res Commun. 2013 Jun 7;435(3):414-9. doi: 10.1016/j.bbrc.2013.04.103. Epub 2013 May 9.


Cancer-induced immunosuppressive cascades and their reversal by molecular-targeted therapy.

Kawakami Y, Yaguchi T, Sumimoto H, Kudo-Saito C, Tsukamoto N, Iwata-Kajihara T, Nakamura S, Nishio H, Satomi R, Kobayashi A, Tanaka M, Park JH, Kamijuku H, Tsujikawa T, Kawamura N.

Ann N Y Acad Sci. 2013 May;1284:80-6. doi: 10.1111/nyas.12094.


The WD40 protein Morg1 facilitates Par6-aPKC binding to Crb3 for apical identity in epithelial cells.

Hayase J, Kamakura S, Iwakiri Y, Yamaguchi Y, Izaki T, Ito T, Sumimoto H.

J Cell Biol. 2013 Mar 4;200(5):635-50. doi: 10.1083/jcb.201208150. Epub 2013 Feb 25.


Interaction of NuMA protein with the kinesin Eg5: its possible role in bipolar spindle assembly and chromosome alignment.

Iwakiri Y, Kamakura S, Hayase J, Sumimoto H.

Biochem J. 2013 Apr 15;451(2):195-204. doi: 10.1042/BJ20121447.


Mammalian formin Fhod3 plays an essential role in cardiogenesis by organizing myofibrillogenesis.

Kan-O M, Takeya R, Abe T, Kitajima N, Nishida M, Tominaga R, Kurose H, Sumimoto H.

Biol Open. 2012 Sep 15;1(9):889-96. doi: 10.1242/bio.20121370. Epub 2012 Jul 18.


High cell-autonomy of the anterior endomesoderm viewed in blastomere fate shift during regulative development in the isolated right halves of four-cell stage Xenopus embryos.

Koga M, Nakashima T, Matsuo S, Takeya R, Sumimoto H, Sakai M, Kageura H.

Dev Growth Differ. 2012 Sep;54(7):717-29. doi: 10.1111/j.1440-169X.2012.01372.x.


Immune suppression and resistance mediated by constitutive activation of Wnt/β-catenin signaling in human melanoma cells.

Yaguchi T, Goto Y, Kido K, Mochimaru H, Sakurai T, Tsukamoto N, Kudo-Saito C, Fujita T, Sumimoto H, Kawakami Y.

J Immunol. 2012 Sep 1;189(5):2110-7. doi: 10.4049/jimmunol.1102282. Epub 2012 Jul 18.


Transplantation of side population cells restores the function of damaged exocrine glands through clusterin.

Mishima K, Inoue H, Nishiyama T, Mabuchi Y, Amano Y, Ide F, Matsui M, Yamada H, Yamamoto G, Tanaka J, Yasuhara R, Sakurai T, Lee MC, Chiba K, Sumimoto H, Kawakami Y, Matsuzaki Y, Tsubota K, Saito I.

Stem Cells. 2012 Sep;30(9):1925-37. doi: 10.1002/stem.1173.


Rab27 effector Slp2-a transports the apical signaling molecule podocalyxin to the apical surface of MDCK II cells and regulates claudin-2 expression.

Yasuda T, Saegusa C, Kamakura S, Sumimoto H, Fukuda M.

Mol Biol Cell. 2012 Aug;23(16):3229-39. doi: 10.1091/mbc.E12-02-0104. Epub 2012 Jul 5.


Suppression of myeloid cell leukemia-1 (Mcl-1) enhances chemotherapy-associated apoptosis in gastric cancer cells.

Akagi H, Higuchi H, Sumimoto H, Igarashi T, Kabashima A, Mizuguchi H, Izumiya M, Sakai G, Adachi M, Funakoshi S, Nakamura S, Hamamoto Y, Kanai T, Takaishi H, Kawakami Y, Hibi T.

Gastric Cancer. 2013 Jan;16(1):100-10. doi: 10.1007/s10120-012-0153-6. Epub 2012 Apr 24.


Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activator DOCK2.

Nishikimi A, Uruno T, Duan X, Cao Q, Okamura Y, Saitoh T, Saito N, Sakaoka S, Du Y, Suenaga A, Kukimoto-Niino M, Miyano K, Gotoh K, Okabe T, Sanematsu F, Tanaka Y, Sumimoto H, Honma T, Yokoyama S, Nagano T, Kohda D, Kanai M, Fukui Y.

Chem Biol. 2012 Apr 20;19(4):488-97. doi: 10.1016/j.chembiol.2012.03.008.


Expression and subcellular localization of mammalian formin Fhod3 in the embryonic and adult heart.

Kan-o M, Takeya R, Taniguchi K, Tanoue Y, Tominaga R, Sumimoto H.

PLoS One. 2012;7(4):e34765. doi: 10.1371/journal.pone.0034765. Epub 2012 Apr 11.


Atypical membrane-embedded phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2)-binding site on p47(phox) Phox homology (PX) domain revealed by NMR.

Stampoulis P, Ueda T, Matsumoto M, Terasawa H, Miyano K, Sumimoto H, Shimada I.

J Biol Chem. 2012 May 18;287(21):17848-59. doi: 10.1074/jbc.M111.332874. Epub 2012 Apr 4.


Noxa1 as a moderate activator of Nox2-based NADPH oxidase.

Kawano M, Miyamoto K, Kaito Y, Sumimoto H, Tamura M.

Arch Biochem Biophys. 2012 Mar 1;519(1):1-7. doi: 10.1016/ Epub 2012 Jan 8.


Assessment of the role for Rho family GTPases in NADPH oxidase activation.

Miyano K, Sumimoto H.

Methods Mol Biol. 2012;827:195-212. doi: 10.1007/978-1-61779-442-1_14.


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