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Items: 23

1.

Synthesis and biological evaluation of ((4-keto)-phenoxy)methyl biphenyl-4-sulfonamides: a class of potent aggrecanase-1 inhibitors.

Hopper DW, Vera MD, How D, Sabatini J, Xiang JS, Ipek M, Thomason J, Hu Y, Feyfant E, Wang Q, Georgiadis KE, Reifenberg E, Sheldon RT, Keohan CC, Majumdar MK, Morris EA, Skotnicki J, Sum PE.

Bioorg Med Chem Lett. 2009 May 1;19(9):2487-91. doi: 10.1016/j.bmcl.2009.03.056. Epub 2009 Mar 18.

PMID:
19329309
2.

Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5.

Mosyak L, Georgiadis K, Shane T, Svenson K, Hebert T, McDonagh T, Mackie S, Olland S, Lin L, Zhong X, Kriz R, Reifenberg EL, Collins-Racie LA, Corcoran C, Freeman B, Zollner R, Marvell T, Vera M, Sum PE, Lavallie ER, Stahl M, Somers W.

Protein Sci. 2008 Jan;17(1):16-21. Epub 2007 Nov 27.

3.

Tigecycline: a case study.

Loh E, Ellis-Grosse E, Petersen PJ, Sum PE, Projan S.

Expert Opin Drug Discov. 2007 Mar;2(3):403-18. doi: 10.1517/17460441.2.3.403.

PMID:
23484649
4.

Case studies in current drug development: 'glycylcyclines'.

Sum PE.

Curr Opin Chem Biol. 2006 Aug;10(4):374-9. Epub 2006 Jun 27. Review.

PMID:
16807065
5.
6.

Synthesis and biological evaluation of biphenylsulfonamide carboxylate aggrecanase-1 inhibitors.

Xiang JS, Hu Y, Rush TS, Thomason JR, Ipek M, Sum PE, Abrous L, Sabatini JJ, Georgiadis K, Reifenberg E, Majumdar M, Morris EA, Tam S.

Bioorg Med Chem Lett. 2006 Jan 15;16(2):311-6. Epub 2005 Nov 3.

PMID:
16275085
7.

Synthesis and antibacterial activity of 9-substituted minocycline derivatives.

Sum PE, Ross AT, Petersen PJ, Testa RT.

Bioorg Med Chem Lett. 2006 Jan 15;16(2):400-3. Epub 2005 Oct 21.

PMID:
16246559
8.

Hydrophobic acetal and ketal derivatives of mannopeptimycin-alpha and desmethylhexahydromannopeptimycin-alpha: semisynthetic glycopeptides with potent activity against Gram-positive bacteria.

Dushin RG, Wang TZ, Sum PE, He H, Sutherland AG, Ashcroft JS, Graziani EI, Koehn FE, Bradford PA, Petersen PJ, Wheless KL, How D, Torres N, Lenoy EB, Weiss WJ, Lang SA, Projan SJ, Shlaes DM, Mansour TS.

J Med Chem. 2004 Jul 1;47(14):3487-90.

PMID:
15214775
9.

Synthesis and evaluation of ether and halogenated derivatives of mannopeptimycin glycopeptide antibiotics.

Sum PE, How D, Torres N, Petersen PJ, Ashcroft J, Graziani EI, Koehn FE, Mansour TS.

Bioorg Med Chem Lett. 2003 Aug 18;13(16):2805-8.

PMID:
12873519
10.

Synthesis and activity of novel benzoxazole derivatives of mannopeptimycin glycopeptide antibiotics.

Sum PE, How D, Torres N, Newman H, Petersen PJ, Mansour TS.

Bioorg Med Chem Lett. 2003 Aug 4;13(15):2607-10.

PMID:
12852976
11.

Novel ether derivatives of mannopeptimycin glycopeptide antibiotic.

Sum PE, How D, Torres N, Petersen PJ, Lenoy EB, Weiss WJ, Mansour TS.

Bioorg Med Chem Lett. 2003 Mar 24;13(6):1151-5.

PMID:
12643932
12.

Efflux-mediated resistance to tigecycline (GAR-936) in Pseudomonas aeruginosa PAO1.

Dean CR, Visalli MA, Projan SJ, Sum PE, Bradford PA.

Antimicrob Agents Chemother. 2003 Mar;47(3):972-8.

14.
15.

Recent developments in tetracycline antibiotics.

Sum PE, Sum FW, Projan SJ.

Curr Pharm Des. 1998 Apr;4(2):119-32. Review.

PMID:
10197036
16.

In vitro and in vivo antibacterial activities of a novel glycylcycline, the 9-t-butylglycylamido derivative of minocycline (GAR-936).

Petersen PJ, Jacobus NV, Weiss WJ, Sum PE, Testa RT.

Antimicrob Agents Chemother. 1999 Apr;43(4):738-44.

17.

Crystal structure of the tet repressor in complex with a novel tetracycline, 9-(N,N-dimethylglycylamido)- 6-demethyl-6-deoxy-tetracycline.

Orth P, Schnappinger D, Sum PE, Ellestad GA, Hillen W, Saenger W, Hinrichs W.

J Mol Biol. 1999 Jan 15;285(2):455-61.

PMID:
9878420
18.

Tetracycline analogs affecting binding to Tn10-Encoded Tet repressor trigger the same mechanism of induction.

Lederer T, Kintrup M, Takahashi M, Sum PE, Ellestad GA, Hillen W.

Biochemistry. 1996 Jun 11;35(23):7439-46.

PMID:
8652521
19.

Glycylcyclines. 1. A new generation of potent antibacterial agents through modification of 9-aminotetracyclines.

Sum PE, Lee VJ, Testa RT, Hlavka JJ, Ellestad GA, Bloom JD, Gluzman Y, Tally FP.

J Med Chem. 1994 Jan 7;37(1):184-8.

PMID:
8289194
20.

In vitro and in vivo antibacterial activities of the glycylcyclines, a new class of semisynthetic tetracyclines.

Testa RT, Petersen PJ, Jacobus NV, Sum PE, Lee VJ, Tally FP.

Antimicrob Agents Chemother. 1993 Nov;37(11):2270-7.

21.

Analogues of platelet activating factor. 4. Some modifications of the phosphocholine moiety.

Wissner A, Schaub RE, Sum PE, Kohler CA, Goldstein BM.

J Med Chem. 1986 Mar;29(3):328-33.

PMID:
3950913
22.

Analogues of platelet activating factor (PAF). 2. Some modifications of the glycerine backbone.

Wissner A, Schaub RE, Sum PE, Kohler CA, Goldstein BM.

J Med Chem. 1985 Sep;28(9):1181-7.

PMID:
4032422
23.

Analogues of platelet activating factor (PAF). 1. Some modifications of the alkoxy chain.

Wissner A, Sum PE, Schaub RE, Kohler CA, Goldstein BM.

J Med Chem. 1984 Sep;27(9):1174-81.

PMID:
6471071

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