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A novel GCN5b lysine acetyltransferase complex associates with distinct transcription factors in the protozoan parasite Toxoplasma gondii.

Harris MT, Jeffers V, Martynowicz J, True JD, Mosley AL, Sullivan WJ Jr.

Mol Biochem Parasitol. 2019 Sep;232:111203. doi: 10.1016/j.molbiopara.2019.111203. Epub 2019 Aug 2.


Regulation of arginine transport by GCN2 eIF2 kinase is important for replication of the intracellular parasite Toxoplasma gondii.

Augusto L, Amin PH, Wek RC, Sullivan WJ Jr.

PLoS Pathog. 2019 Jun 13;15(6):e1007746. doi: 10.1371/journal.ppat.1007746. eCollection 2019 Jun.


Simultaneous Ribosome Profiling of Human Host Cells Infected with Toxoplasma gondii.

Holmes MJ, Shah P, Wek RC, Sullivan WJ Jr.

mSphere. 2019 Jun 5;4(3). pii: e00292-19. doi: 10.1128/mSphere.00292-19.


Characterization of protein arginine methyltransferase of TgPRMT5 in Toxoplasma gondii.

Liu M, Li FX, Li CY, Li XC, Chen LF, Wu K, Yang PL, Lai ZF, Liu TK, Sullivan WJ Jr, Cui L, Chen XG.

Parasit Vectors. 2019 May 8;12(1):221. doi: 10.1186/s13071-019-3464-1.


Guanabenz Reverses a Key Behavioral Change Caused by Latent Toxoplasmosis in Mice by Reducing Neuroinflammation.

Martynowicz J, Augusto L, Wek RC, Boehm SL 2nd, Sullivan WJ Jr.

MBio. 2019 Apr 30;10(2). pii: e00381-19. doi: 10.1128/mBio.00381-19.


The utility of magnetic resonance imaging results in physician decision-making before initial lumbar spinal injection.

Akuthota V, Meron AJ, Singh JR, Boimbo S, Laker SR, Brakke Holman R, Sridhar BV, Friedrich J, Sullivan WJ.

Spine J. 2019 Sep;19(9):1455-1462. doi: 10.1016/j.spinee.2019.04.016. Epub 2019 Apr 19.


Evaluation of ATM Kinase Inhibitor KU-55933 as Potential Anti-Toxoplasma gondii Agent.

Munera López J, Ganuza A, Bogado SS, Muñoz D, Ruiz DM, Sullivan WJ Jr, Vanagas L, Angel SO.

Front Cell Infect Microbiol. 2019 Feb 13;9:26. doi: 10.3389/fcimb.2019.00026. eCollection 2019.


TgDrpC, an atypical dynamin-related protein in Toxoplasma gondii, is associated with vesicular transport factors and parasite division.

Heredero-Bermejo I, Varberg JM, Charvat R, Jacobs K, Garbuz T, Sullivan WJ Jr, Arrizabalaga G.

Mol Microbiol. 2019 Jan;111(1):46-64. doi: 10.1111/mmi.14138. Epub 2018 Nov 28.


Improving Physical Activity Through Adjunct Telerehabilitation Following Total Knee Arthroplasty: Randomized Controlled Trial Protocol.

Kline PW, Melanson EL, Sullivan WJ, Blatchford PJ, Miller MJ, Stevens-Lapsley JE, Christiansen CL.

Phys Ther. 2019 Jan 1;99(1):37-45. doi: 10.1093/ptj/pzy119.


Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP Destabilization.

Sullivan WJ, Mullen PJ, Schmid EW, Flores A, Momcilovic M, Sharpley MS, Jelinek D, Whiteley AE, Maxwell MB, Wilde BR, Banerjee U, Coller HA, Shackelford DB, Braas D, Ayer DE, de Aguiar Vallim TQ, Lowry WE, Christofk HR.

Cell. 2018 Sep 20;175(1):117-132.e21. doi: 10.1016/j.cell.2018.08.017. Epub 2018 Sep 6.


Effects of PERK eIF2α Kinase Inhibitor against Toxoplasma gondii.

Augusto L, Martynowicz J, Staschke KA, Wek RC, Sullivan WJ Jr.

Antimicrob Agents Chemother. 2018 Oct 24;62(11). pii: e01442-18. doi: 10.1128/AAC.01442-18. Print 2018 Nov.


Transcriptional repression by ApiAP2 factors is central to chronic toxoplasmosis.

Radke JB, Worth D, Hong D, Huang S, Sullivan WJ Jr, Wilson EH, White MW.

PLoS Pathog. 2018 May 2;14(5):e1007035. doi: 10.1371/journal.ppat.1007035. eCollection 2018 May.


A latent ability to persist: differentiation in Toxoplasma gondii.

Jeffers V, Tampaki Z, Kim K, Sullivan WJ Jr.

Cell Mol Life Sci. 2018 Jul;75(13):2355-2373. doi: 10.1007/s00018-018-2808-x. Epub 2018 Mar 30. Review.


Elp3 and RlmN: A tale of two mitochondrial tail-anchored radical SAM enzymes in Toxoplasma gondii.

Padgett LR, Lentini JM, Holmes MJ, Stilger KL, Fu D, Sullivan WJ Jr.

PLoS One. 2018 Jan 2;13(1):e0189688. doi: 10.1371/journal.pone.0189688. eCollection 2018.


Inhibiting the Plasmodium eIF2α Kinase PK4 Prevents Artemisinin-Induced Latency.

Zhang M, Gallego-Delgado J, Fernandez-Arias C, Waters NC, Rodriguez A, Tsuji M, Wek RC, Nussenzweig V, Sullivan WJ Jr.

Cell Host Microbe. 2017 Dec 13;22(6):766-776.e4. doi: 10.1016/j.chom.2017.11.005.


Characterization of Plasmodium Atg3-Atg8 Interaction Inhibitors Identifies Novel Alternative Mechanisms of Action in Toxoplasma gondii.

Varberg JM, LaFavers KA, Arrizabalaga G, Sullivan WJ Jr.

Antimicrob Agents Chemother. 2018 Jan 25;62(2). pii: e01489-17. doi: 10.1128/AAC.01489-17. Print 2018 Feb.


Transient Hypokalemic Quadriplegia After a Lumbar Transforaminal Epidural Dexamethasone Injection: A Case Report.

Tahmasbi Sohi M, Sullivan WJ, Anderson DJM.

PM R. 2018 May;10(5):544-547. doi: 10.1016/j.pmrj.2017.10.003. Epub 2017 Oct 24.


Translational Control in the Latency of Apicomplexan Parasites.

Holmes MJ, Augusto LDS, Zhang M, Wek RC, Sullivan WJ Jr.

Trends Parasitol. 2017 Dec;33(12):947-960. doi: 10.1016/ Epub 2017 Sep 20. Review.


Autophagy participates in the unfolded protein response in Toxoplasma gondii.

Nguyen HM, Berry L, Sullivan WJ Jr, Besteiro S.

FEMS Microbiol Lett. 2017 Aug 15;364(15). doi: 10.1093/femsle/fnx153.


The common parasite Toxoplasma gondii induces prostatic inflammation and microglandular hyperplasia in a mouse model.

Colinot DL, Garbuz T, Bosland MC, Wang L, Rice SE, Sullivan WJ Jr, Arrizabalaga G, Jerde TJ.

Prostate. 2017 Jul;77(10):1066-1075. doi: 10.1002/pros.23362. Epub 2017 May 12.


Toxoplasma gondii AP2IX-4 Regulates Gene Expression during Bradyzoite Development.

Huang S, Holmes MJ, Radke JB, Hong DP, Liu TK, White MW, Sullivan WJ Jr.

mSphere. 2017 Mar 15;2(2). pii: e00054-17. doi: 10.1128/mSphere.00054-17. eCollection 2017 Mar-Apr.


Mitochondrial behaviour throughout the lytic cycle of Toxoplasma gondii.

Ovciarikova J, Lemgruber L, Stilger KL, Sullivan WJ, Sheiner L.

Sci Rep. 2017 Feb 16;7:42746. doi: 10.1038/srep42746.


TgPRELID, a Mitochondrial Protein Linked to Multidrug Resistance in the Parasite Toxoplasma gondii.

Jeffers V, Kamau ET, Srinivasan AR, Harper J, Sankaran P, Post SE, Varberg JM, Sullivan WJ Jr, Boyle JP.

mSphere. 2017 Feb 1;2(1). pii: e00229-16. doi: 10.1128/mSphere.00229-16. eCollection 2017 Jan-Feb.


Bromodomains in Protozoan Parasites: Evolution, Function, and Opportunities for Drug Development.

Jeffers V, Yang C, Huang S, Sullivan WJ Jr.

Microbiol Mol Biol Rev. 2017 Jan 11;81(1). pii: e00047-16. doi: 10.1128/MMBR.00047-16. Print 2017 Mar. Review.


Targeting of tail-anchored membrane proteins to subcellular organelles in Toxoplasma gondii.

Padgett LR, Arrizabalaga G, Sullivan WJ Jr.

Traffic. 2017 Mar;18(3):149-158. doi: 10.1111/tra.12464. Epub 2017 Jan 17.


Phosphorylation of Eukaryotic Initiation Factor-2α during Stress and Encystation in Entamoeba Species.

Hendrick HM, Welter BH, Hapstack MA, Sykes SE, Sullivan WJ Jr, Temesvari LA.

PLoS Pathog. 2016 Dec 8;12(12):e1006085. doi: 10.1371/journal.ppat.1006085. eCollection 2016 Dec.


Predicting benefit from lumbar epidural steroid injection: commentary.

Sullivan WJ.

Spine J. 2016 Aug;16(8):935-6. doi: 10.1016/j.spinee.2016.02.017.


TgATAT-Mediated α-Tubulin Acetylation Is Required for Division of the Protozoan Parasite Toxoplasma gondii.

Varberg JM, Padgett LR, Arrizabalaga G, Sullivan WJ Jr.

mSphere. 2016 Jan 20;1(1). pii: e00088-15. doi: 10.1128/mSphere.00088-15. eCollection 2016 Jan-Feb.


Garcinol Inhibits GCN5-Mediated Lysine Acetyltransferase Activity and Prevents Replication of the Parasite Toxoplasma gondii.

Jeffers V, Gao H, Checkley LA, Liu Y, Ferdig MT, Sullivan WJ Jr.

Antimicrob Agents Chemother. 2016 Mar 25;60(4):2164-70. doi: 10.1128/AAC.03059-15. Print 2016 Apr.


An ensemble of specifically targeted proteins stabilizes cortical microtubules in the human parasite Toxoplasma gondii.

Liu J, He Y, Benmerzouga I, Sullivan WJ Jr, Morrissette NS, Murray JM, Hu K.

Mol Biol Cell. 2016 Feb 1;27(3):549-71. doi: 10.1091/mbc.E15-11-0754. Epub 2015 Dec 17.


Preventing friendly fire in the war on microbes.

Sullivan WJ Jr, Gilk SD.

Sci Transl Med. 2015 Oct 28;7(311):311fs43. doi: 10.1126/scitranslmed.aad4922.


Guanabenz repurposed as an antiparasitic with activity against acute and latent toxoplasmosis.

Benmerzouga I, Checkley LA, Ferdig MT, Arrizabalaga G, Wek RC, Sullivan WJ Jr.

Antimicrob Agents Chemother. 2015 Nov;59(11):6939-45. doi: 10.1128/AAC.01683-15. Epub 2015 Aug 24.


The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs.

Herman JD, Pepper LR, Cortese JF, Estiu G, Galinsky K, Zuzarte-Luis V, Derbyshire ER, Ribacke U, Lukens AK, Santos SA, Patel V, Clish CB, Sullivan WJ Jr, Zhou H, Bopp SE, Schimmel P, Lindquist S, Clardy J, Mota MM, Keller TL, Whitman M, Wiest O, Wirth DF, Mazitschek R.

Sci Transl Med. 2015 May 20;7(288):288ra77. doi: 10.1126/scitranslmed.aaa3575.


Proteome-wide lysine acetylation in cortical astrocytes and alterations that occur during infection with brain parasite Toxoplasma gondii.

Bouchut A, Chawla AR, Jeffers V, Hudmon A, Sullivan WJ Jr.

PLoS One. 2015 Mar 18;10(3):e0117966. doi: 10.1371/journal.pone.0117966. eCollection 2015.


The metabolic milieu of metastases.

Sullivan WJ, Christofk HR.

Cell. 2015 Jan 29;160(3):363-4. doi: 10.1016/j.cell.2015.01.023.


Canonical histone H2Ba and H2A.X dimerize in an opposite genomic localization to H2A.Z/H2B.Z dimers in Toxoplasma gondii.

Bogado SS, Dalmasso MC, Ganuza A, Kim K, Sullivan WJ Jr, Angel SO, Vanagas L.

Mol Biochem Parasitol. 2014 Oct;197(1-2):36-42. doi: 10.1016/j.molbiopara.2014.09.009. Epub 2014 Oct 5.


Characterization of TgPuf1, a member of the Puf family RNA-binding proteins from Toxoplasma gondii.

Liu M, Miao J, Liu T, Sullivan WJ Jr, Cui L, Chen X.

Parasit Vectors. 2014 Mar 31;7:141. doi: 10.1186/1756-3305-7-141.


Lysine acetyltransferase GCN5b interacts with AP2 factors and is required for Toxoplasma gondii proliferation.

Wang J, Dixon SE, Ting LM, Liu TK, Jeffers V, Croken MM, Calloway M, Cannella D, Hakimi MA, Kim K, Sullivan WJ Jr.

PLoS Pathog. 2014 Jan;10(1):e1003830. doi: 10.1371/journal.ppat.1003830. Epub 2014 Jan 2.


The histone code of Toxoplasma gondii comprises conserved and unique posttranslational modifications.

Nardelli SC, Che FY, Silmon de Monerri NC, Xiao H, Nieves E, Madrid-Aliste C, Angel SO, Sullivan WJ Jr, Angeletti RH, Kim K, Weiss LM.

MBio. 2013 Dec 10;4(6):e00922-13. doi: 10.1128/mBio.00922-13.


GCN2-like eIF2α kinase manages the amino acid starvation response in Toxoplasma gondii.

Konrad C, Wek RC, Sullivan WJ Jr.

Int J Parasitol. 2014 Feb;44(2):139-46. doi: 10.1016/j.ijpara.2013.08.005. Epub 2013 Oct 12.


Elongator protein 3 (Elp3) lysine acetyltransferase is a tail-anchored mitochondrial protein in Toxoplasma gondii.

Stilger KL, Sullivan WJ Jr.

J Biol Chem. 2013 Aug 30;288(35):25318-29. doi: 10.1074/jbc.M113.491373. Epub 2013 Jul 22.


Extensive lysine acetylation occurs in evolutionarily conserved metabolic pathways and parasite-specific functions during Plasmodium falciparum intraerythrocytic development.

Miao J, Lawrence M, Jeffers V, Zhao F, Parker D, Ge Y, Sullivan WJ Jr, Cui L.

Mol Microbiol. 2013 Aug;89(4):660-75. doi: 10.1111/mmi.12303. Epub 2013 Jul 12.


Doxycycline alters metabolism and proliferation of human cell lines.

Ahler E, Sullivan WJ, Cass A, Braas D, York AG, Bensinger SJ, Graeber TG, Christofk HR.

PLoS One. 2013 May 31;8(5):e64561. doi: 10.1371/journal.pone.0064561. Print 2013.


The effect of new electromyography and nerve conduction studies: fiscal cliff or slippery slope?

Sullivan WJ, Zuhosky JP.

PM R. 2013 May;5(5 Suppl):S112-4. doi: 10.1016/j.pmrj.2013.04.006. No abstract available.


The unfolded protein response in the protozoan parasite Toxoplasma gondii features translational and transcriptional control.

Joyce BR, Tampaki Z, Kim K, Wek RC, Sullivan WJ Jr.

Eukaryot Cell. 2013 Jul;12(7):979-89. doi: 10.1128/EC.00021-13. Epub 2013 May 10.


ApiAP2 transcription factor restricts development of the Toxoplasma tissue cyst.

Radke JB, Lucas O, De Silva EK, Ma Y, Sullivan WJ Jr, Weiss LM, Llinas M, White MW.

Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):6871-6. doi: 10.1073/pnas.1300059110. Epub 2013 Apr 9.


Protein intrinsic disorder in the acetylome of intracellular and extracellular Toxoplasma gondii.

Xue B, Jeffers V, Sullivan WJ, Uversky VN.

Mol Biosyst. 2013 Apr 5;9(4):645-57. doi: 10.1039/c3mb25517d.


Inhibitors of eIF2α dephosphorylation slow replication and stabilize latency in Toxoplasma gondii.

Konrad C, Queener SF, Wek RC, Sullivan WJ Jr.

Antimicrob Agents Chemother. 2013 Apr;57(4):1815-22. doi: 10.1128/AAC.01899-12. Epub 2013 Feb 4.


Perturbations of Plasmodium Puf2 expression and RNA-seq of Puf2-deficient sporozoites reveal a critical role in maintaining RNA homeostasis and parasite transmissibility.

Lindner SE, Mikolajczak SA, Vaughan AM, Moon W, Joyce BR, Sullivan WJ Jr, Kappe SH.

Cell Microbiol. 2013 Jul;15(7):1266-83. doi: 10.1111/cmi.12116. Epub 2013 Feb 27.


Translational control in Plasmodium and toxoplasma parasites.

Zhang M, Joyce BR, Sullivan WJ Jr, Nussenzweig V.

Eukaryot Cell. 2013 Feb;12(2):161-7. doi: 10.1128/EC.00296-12. Epub 2012 Dec 14. Review.

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