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Histone demethylase JMJD1C is phosphorylated by mTOR to activate de novo lipogenesis.

Viscarra JA, Wang Y, Nguyen HP, Choi YG, Sul HS.

Nat Commun. 2020 Feb 7;11(1):796. doi: 10.1038/s41467-020-14617-1.


Aifm2, a NADH Oxidase, Supports Robust Glycolysis and Is Required for Cold- and Diet-Induced Thermogenesis.

Nguyen HP, Yi D, Lin F, Viscarra JA, Tabuchi C, Ngo K, Shin G, Lee AY, Wang Y, Sul HS.

Mol Cell. 2020 Feb 6;77(3):600-617.e4. doi: 10.1016/j.molcel.2019.12.002. Epub 2020 Jan 14.


Zc3h10 Acts as a Transcription Factor and Is Phosphorylated to Activate the Thermogenic Program.

Yi D, Dempersmier JM, Nguyen HP, Viscarra JA, Dinh J, Tabuchi C, Wang Y, Sul HS.

Cell Rep. 2019 Nov 26;29(9):2621-2633.e4. doi: 10.1016/j.celrep.2019.10.099.


PDGFRα+ stromal adipocyte progenitors transition into epithelial cells during lobulo-alveologenesis in the murine mammary gland.

Joshi PA, Waterhouse PD, Kasaian K, Fang H, Gulyaeva O, Sul HS, Boutros PC, Khokha R.

Nat Commun. 2019 Apr 15;10(1):1760. doi: 10.1038/s41467-019-09748-z.


Sox9-Meis1 Inactivation Is Required for Adipogenesis, Advancing Pref-1+ to PDGFRα+ Cells.

Gulyaeva O, Nguyen H, Sambeat A, Heydari K, Sul HS.

Cell Rep. 2018 Oct 23;25(4):1002-1017.e4. doi: 10.1016/j.celrep.2018.09.086.


Genetic and epigenetic control of adipose development.

Gulyaeva O, Dempersmier J, Sul HS.

Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Jan;1864(1):3-12. doi: 10.1016/j.bbalip.2018.04.016. Epub 2018 Apr 25. Review.


Actomyosin-Mediated Tension Orchestrates Uncoupled Respiration in Adipose Tissues.

Tharp KM, Kang MS, Timblin GA, Dempersmier J, Dempsey GE, Zushin PH, Benavides J, Choi C, Li CX, Jha AK, Kajimura S, Healy KE, Sul HS, Saijo K, Kumar S, Stahl A.

Cell Metab. 2018 Mar 6;27(3):602-615.e4. doi: 10.1016/j.cmet.2018.02.005.


Targeting lipogenesis in the treatment of metabolic diseases and cancer.

Viscarra JA, Sul HS.

Oncotarget. 2017 Dec 6;9(3):2969-2970. doi: 10.18632/oncotarget.23004. eCollection 2018 Jan 9. No abstract available.


Transcriptional activation of lipogenesis by insulin requires phosphorylation of MED17 by CK2.

Viscarra JA, Wang Y, Hong IH, Sul HS.

Sci Signal. 2017 Feb 21;10(467). pii: eaai8596. doi: 10.1126/scisignal.aai8596.


Epigenetic Regulation of the Thermogenic Adipose Program.

Sambeat A, Gulyaeva O, Dempersmier J, Sul HS.

Trends Endocrinol Metab. 2017 Jan;28(1):19-31. doi: 10.1016/j.tem.2016.09.003. Epub 2016 Sep 28. Review.


LSD1 Interacts with Zfp516 to Promote UCP1 Transcription and Brown Fat Program.

Sambeat A, Gulyaeva O, Dempersmier J, Tharp KM, Stahl A, Paul SM, Sul HS.

Cell Rep. 2016 Jun 14;15(11):2536-49. doi: 10.1016/j.celrep.2016.05.019. Epub 2016 Jun 2.


AMPK Phosphorylates Desnutrin/ATGL and Hormone-Sensitive Lipase To Regulate Lipolysis and Fatty Acid Oxidation within Adipose Tissue.

Kim SJ, Tang T, Abbott M, Viscarra JA, Wang Y, Sul HS.

Mol Cell Biol. 2016 Jun 29;36(14):1961-76. doi: 10.1128/MCB.00244-16. Print 2016 Jul 15.


Preadipocyte factor 1 induces pancreatic ductal cell differentiation into insulin-producing cells.

Rhee M, Lee SH, Kim JW, Ham DS, Park HS, Yang HK, Shin JY, Cho JH, Kim YB, Youn BS, Sul HS, Yoon KH.

Sci Rep. 2016 Apr 5;6:23960. doi: 10.1038/srep23960.


Transcriptional regulation of hepatic lipogenesis.

Wang Y, Viscarra J, Kim SJ, Sul HS.

Nat Rev Mol Cell Biol. 2015 Nov;16(11):678-89. doi: 10.1038/nrm4074. Review. Erratum in: Nat Rev Mol Cell Biol. 2016 Jan;17(1):64.


Shades of brown: a model for thermogenic fat.

Dempersmier J, Sul HS.

Front Endocrinol (Lausanne). 2015 May 8;6:71. doi: 10.3389/fendo.2015.00071. eCollection 2015. Review.


Overexpression of Pref-1 in pancreatic islet β-cells in mice causes hyperinsulinemia with increased islet mass and insulin secretion.

Wang Y, Lee K, Moon YS, Ahmadian M, Kim KH, Roder K, Kang C, Sul HS.

Biochem Biophys Res Commun. 2015 Jun 12;461(4):630-5. doi: 10.1016/j.bbrc.2015.04.078. Epub 2015 Apr 24.


Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes.

Perry RJ, Camporez JG, Kursawe R, Titchenell PM, Zhang D, Perry CJ, Jurczak MJ, Abudukadier A, Han MS, Zhang XM, Ruan HB, Yang X, Caprio S, Kaech SM, Sul HS, Birnbaum MJ, Davis RJ, Cline GW, Petersen KF, Shulman GI.

Cell. 2015 Feb 12;160(4):745-758. doi: 10.1016/j.cell.2015.01.012. Epub 2015 Feb 5.


Cold-inducible Zfp516 activates UCP1 transcription to promote browning of white fat and development of brown fat.

Dempersmier J, Sambeat A, Gulyaeva O, Paul SM, Hudak CS, Raposo HF, Kwan HY, Kang C, Wong RH, Sul HS.

Mol Cell. 2015 Jan 22;57(2):235-46. doi: 10.1016/j.molcel.2014.12.005. Epub 2015 Jan 8.


Pref-1 marks very early mesenchymal precursors required for adipose tissue development and expansion.

Hudak CS, Gulyaeva O, Wang Y, Park SM, Lee L, Kang C, Sul HS.

Cell Rep. 2014 Aug 7;8(3):678-87. doi: 10.1016/j.celrep.2014.06.060. Epub 2014 Jul 31.


Desnutrin/ATGL activates PPARδ to promote mitochondrial function for insulin secretion in islet β cells.

Tang T, Abbott MJ, Ahmadian M, Lopes AB, Wang Y, Sul HS.

Cell Metab. 2013 Dec 3;18(6):883-95. doi: 10.1016/j.cmet.2013.10.012. Epub 2013 Nov 21.


Pref-1, a gatekeeper of adipogenesis.

Hudak CS, Sul HS.

Front Endocrinol (Lausanne). 2013 Jul 3;4:79. doi: 10.3389/fendo.2013.00079. eCollection 2013.


Phosphorylation and recruitment of BAF60c in chromatin remodeling for lipogenesis in response to insulin.

Wang Y, Wong RH, Tang T, Hudak CS, Yang D, Duncan RE, Sul HS.

Mol Cell. 2013 Jan 24;49(2):283-97. doi: 10.1016/j.molcel.2012.10.028. Epub 2012 Dec 6.


Pref-1 in brown adipose tissue: specific involvement in brown adipocyte differentiation and regulatory role of C/EBPδ.

Armengol J, Villena JA, Hondares E, Carmona MC, Sul HS, Iglesias R, Giralt M, Villarroya F.

Biochem J. 2012 May 1;443(3):799-810. doi: 10.1042/BJ20111714.


Desnutrin/ATGL is regulated by AMPK and is required for a brown adipose phenotype.

Ahmadian M, Abbott MJ, Tang T, Hudak CS, Kim Y, Bruss M, Hellerstein MK, Lee HY, Samuel VT, Shulman GI, Wang Y, Duncan RE, Kang C, Sul HS.

Cell Metab. 2011 Jun 8;13(6):739-48. doi: 10.1016/j.cmet.2011.05.002.


Insulin signaling in fatty acid and fat synthesis: a transcriptional perspective.

Wong RH, Sul HS.

Curr Opin Pharmacol. 2010 Dec;10(6):684-91. doi: 10.1016/j.coph.2010.08.004. Review.


Pref-1 interacts with fibronectin to inhibit adipocyte differentiation.

Wang Y, Zhao L, Smas C, Sul HS.

Mol Cell Biol. 2010 Jul;30(14):3480-92. doi: 10.1128/MCB.00057-10. Epub 2010 May 10.


Role of preadipocyte factor 1 in adipocyte differentiation.

Wang Y, Hudak C, Sul HS.

Clin Lipidol. 2010 Feb;5(1):109-115.


The Role of Phospholipase A(2)-derived Mediators in Obesity.

Abbott MJ, Tang T, Sul HS.

Drug Discov Today Dis Mech. 2010 Winter;7(3-4):e213-e218.


Lipolysis in adipocytes.

Ahmadian M, Wang Y, Sul HS.

Int J Biochem Cell Biol. 2010 May;42(5):555-9. doi: 10.1016/j.biocel.2009.12.009. Epub 2009 Dec 16. Review.


The skinny on fat: lipolysis and fatty acid utilization in adipocytes.

Ahmadian M, Duncan RE, Sul HS.

Trends Endocrinol Metab. 2009 Nov;20(9):424-8. doi: 10.1016/j.tem.2009.06.002. Epub 2009 Sep 30. Review.


Characterization of desnutrin functional domains: critical residues for triacylglycerol hydrolysis in cultured cells.

Duncan RE, Wang Y, Ahmadian M, Lu J, Sarkadi-Nagy E, Sul HS.

J Lipid Res. 2010 Feb;51(2):309-17. doi: 10.1194/jlr.M000729. Epub 2009 Aug 19.


DNA-PK: relaying the insulin signal to USF in lipogenesis.

Wong RH, Sul HS.

Cell Cycle. 2009 Jul 1;8(13):1977-8. Epub 2009 Jul 15. No abstract available.


Minireview: Pref-1: role in adipogenesis and mesenchymal cell fate.

Sul HS.

Mol Endocrinol. 2009 Nov;23(11):1717-25. doi: 10.1210/me.2009-0160. Epub 2009 Jun 18. Review.


Identification of Dlk1, Ptpru and Klhl1 as novel Nurr1 target genes in meso-diencephalic dopamine neurons.

Jacobs FM, van der Linden AJ, Wang Y, von Oerthel L, Sul HS, Burbach JP, Smidt MP.

Development. 2009 Jul;136(14):2363-73. doi: 10.1242/dev.037556. Epub 2009 Jun 10.


A role of DNA-PK for the metabolic gene regulation in response to insulin.

Wong RH, Chang I, Hudak CS, Hyun S, Kwan HY, Sul HS.

Cell. 2009 Mar 20;136(6):1056-72. doi: 10.1016/j.cell.2008.12.040.


Pref-1 regulates mesenchymal cell commitment and differentiation through Sox9.

Wang Y, Sul HS.

Cell Metab. 2009 Mar;9(3):287-302. doi: 10.1016/j.cmet.2009.01.013.


AdPLA ablation increases lipolysis and prevents obesity induced by high-fat feeding or leptin deficiency.

Jaworski K, Ahmadian M, Duncan RE, Sarkadi-Nagy E, Varady KA, Hellerstein MK, Lee HY, Samuel VT, Shulman GI, Kim KH, de Val S, Kang C, Sul HS.

Nat Med. 2009 Feb;15(2):159-68. doi: 10.1038/nm.1904. Epub 2009 Jan 11.


Adipose overexpression of desnutrin promotes fatty acid use and attenuates diet-induced obesity.

Ahmadian M, Duncan RE, Varady KA, Frasson D, Hellerstein MK, Birkenfeld AL, Samuel VT, Shulman GI, Wang Y, Kang C, Sul HS.

Diabetes. 2009 Apr;58(4):855-66. doi: 10.2337/db08-1644. Epub 2009 Jan 9.


Resistance to high-fat diet-induced obesity but exacerbated insulin resistance in mice overexpressing preadipocyte factor-1 (Pref-1): a new model of partial lipodystrophy.

Villena JA, Choi CS, Wang Y, Kim S, Hwang YJ, Kim YB, Cline G, Shulman GI, Sul HS.

Diabetes. 2008 Dec;57(12):3258-66. doi: 10.2337/db07-1739. Epub 2008 Oct 3.


Identification and functional characterization of adipose-specific phospholipase A2 (AdPLA).

Duncan RE, Sarkadi-Nagy E, Jaworski K, Ahmadian M, Sul HS.

J Biol Chem. 2008 Sep 12;283(37):25428-36. doi: 10.1074/jbc.M804146200. Epub 2008 Jul 9.


Triacylglycerol metabolism in adipose tissue.

Ahmadian M, Duncan RE, Jaworski K, Sarkadi-Nagy E, Sul HS.

Future Lipidol. 2007 Apr;2(2):229-237.


Regulation of lipolysis in adipocytes.

Duncan RE, Ahmadian M, Jaworski K, Sarkadi-Nagy E, Sul HS.

Annu Rev Nutr. 2007;27:79-101. Review.


Regulation of triglyceride metabolism. IV. Hormonal regulation of lipolysis in adipose tissue.

Jaworski K, Sarkadi-Nagy E, Duncan RE, Ahmadian M, Sul HS.

Am J Physiol Gastrointest Liver Physiol. 2007 Jul;293(1):G1-4. Epub 2007 Jan 11. Review.


Direct interaction between USF and SREBP-1c mediates synergistic activation of the fatty-acid synthase promoter.

Griffin MJ, Wong RH, Pandya N, Sul HS.

J Biol Chem. 2007 Feb 23;282(8):5453-67. Epub 2006 Dec 31.


Dissociation between adipose tissue fluxes and lipogenic gene expression in ob/ob mice.

Turner SM, Roy S, Sul HS, Neese RA, Murphy EJ, Samandi W, Roohk DJ, Hellerstein MK.

Am J Physiol Endocrinol Metab. 2007 Apr;292(4):E1101-9. Epub 2006 Dec 12.


Pref-1, a preadipocyte secreted factor that inhibits adipogenesis.

Wang Y, Kim KA, Kim JH, Sul HS.

J Nutr. 2006 Dec;136(12):2953-6.


Dlk1 in normal and abnormal hematopoiesis.

Sakajiri S, O'kelly J, Yin D, Miller CW, Hofmann WK, Oshimi K, Shih LY, Kim KH, Sul HS, Jensen CH, Teisner B, Kawamata N, Koeffler HP.

Leukemia. 2005 Aug;19(8):1404-10.


Insulin regulation of fatty acid synthase gene transcription: roles of USF and SREBP-1c.

Griffin MJ, Sul HS.

IUBMB Life. 2004 Oct;56(10):595-600. Review.

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