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Items: 1 to 50 of 149

1.

A Bioreductive Prodrug of Cucurbitacin B Significantly Inhibits Tumor Growth in the 4T1 Xenograft Mice Model.

Suebsakwong P, Wang J, Khetkam P, Weerapreeyakul N, Wu J, Du Y, Yao ZJ, Li JX, Suksamrarn A.

ACS Med Chem Lett. 2019 Sep 10;10(10):1400-1406. doi: 10.1021/acsmedchemlett.9b00161. eCollection 2019 Oct 10.

PMID:
31620225
2.

Crinamine Induces Apoptosis and Inhibits Proliferation, Migration, and Angiogenesis in Cervical Cancer SiHa Cells.

Khumkhrong P, Piboonprai K, Chaichompoo W, Pimtong W, Khongkow M, Namdee K, Jantimaporn A, Japrung D, Asawapirom U, Suksamrarn A, Iempridee T.

Biomolecules. 2019 Sep 16;9(9). pii: E494. doi: 10.3390/biom9090494.

3.

Synergistic effects of the capsaicinoid nonivamide and rosuvastatin on obesity-related endothelial dysfunction in rat fed a high-fat diet.

Sivasinprasasn S, Wikan N, Tocharus J, Pantan R, Chaichompoo W, Suksamrarn A, Tocharus C.

Phytother Res. 2019 Jul;33(7):1815-1826. doi: 10.1002/ptr.6369. Epub 2019 May 29.

PMID:
31141276
4.

A new pyrrole alkaloid from the roots of Cissampelos pareira.

Rukachaisirikul T, Kumjun S, Suebsakwong P, Apiratikul N, Suksamrarn A.

Nat Prod Res. 2019 May 28:1-8. doi: 10.1080/14786419.2019.1614576. [Epub ahead of print]

PMID:
31135214
5.

Diarylheptanoid 1-(4-hydroxyphenyl)-7-phenyl-(6E)-6-hepten-3-one enhances C2C12 myoblast differentiation by targeting membrane estrogen receptors and activates Akt-mTOR and p38 MAPK-NF-κB signaling axes.

Tipbunjong C, Khuituan P, Kitiyanant Y, Suksamrarn A, Pholpramool C.

J Nat Med. 2019 Sep;73(4):735-744. doi: 10.1007/s11418-019-01322-7. Epub 2019 May 13.

PMID:
31087251
6.

Endothelium-dependent and endothelium-independent vasorelaxant effects of tiliacorinine 12'-O-acetate and mechanisms on isolated rat aorta.

Panthiya L, Pantan R, Tocharus J, Nakaew A, Suksamrarn A, Tocharus C.

Biomed Pharmacother. 2019 Jan;109:2090-2099. doi: 10.1016/j.biopha.2018.11.062. Epub 2018 Nov 26.

7.

Cucurbitacin B Induces Hypermethylation of Oncogenes in Breast Cancer Cells.

Dittharot K, Dakeng S, Suebsakwong P, Suksamrarn A, Patmasiriwat P, Promkan M.

Planta Med. 2019 Mar;85(5):370-378. doi: 10.1055/a-0791-1591. Epub 2018 Nov 21.

PMID:
30463098
8.

Microbial transformation of isocoronarin D by Cunninghamella echinulata NRRL 1386.

Chokchaisiri R, Chaichompoo W, Sukcharoen O, Suksamrarn A, Ganranoo L.

Nat Prod Res. 2019 Oct;33(20):2890-2896. doi: 10.1080/14786419.2018.1509331. Epub 2018 Nov 20.

PMID:
30453782
9.

Phosphodiesterase 5 Inhibitors from Derris scandens.

Chaichamnong N, Temkitthawon P, Khorana N, Pitpakdeeanan P, Taepavarapruk P, Nuengchamnong N, Siriwattanasathien Y, Suksamrarn A, Ingkaninan K.

Planta Med. 2018 Oct;84(15):1134-1140. doi: 10.1055/a-0619-5547. Epub 2018 Apr 27.

PMID:
29702722
10.

Cyanidin attenuates Aβ25-35-induced neuroinflammation by suppressing NF-κB activity downstream of TLR4/NOX4 in human neuroblastoma cells.

Thummayot S, Tocharus C, Jumnongprakhon P, Suksamrarn A, Tocharus J.

Acta Pharmacol Sin. 2018 Sep;39(9):1439-1452. doi: 10.1038/aps.2017.203. Epub 2018 Apr 19.

11.

Diterpenoid trigonoreidon B isolated from Trigonostemon reidioides alleviates inflammation in models of LPS-stimulated murine macrophages and inflammatory liver injury in mice.

Utaipan T, Suksamrarn A, Kaemchantuek P, Chokchaisiri R, Stremmel W, Chamulitrat W, Chunglok W.

Biomed Pharmacother. 2018 May;101:961-971. doi: 10.1016/j.biopha.2018.02.144. Epub 2018 Mar 22.

PMID:
29635906
12.

Cyperenoic acid suppresses osteoclast differentiation and delays bone loss in a senile osteoporosis mouse model by inhibiting non-canonical NF-κB pathway.

Chawalitpong S, Chokchaisiri R, Suksamrarn A, Katayama S, Mitani T, Nakamura S, Athamneh AA, Ritprajak P, Leelahavanichkul A, Aeimlapa R, Charoenphandhu N, Palaga T.

Sci Rep. 2018 Apr 4;8(1):5625. doi: 10.1038/s41598-018-23912-3.

13.

Synthetic analogues of durantoside I from Citharexylum spinosum L. and their cytotoxic activity.

Apisornopas J, Silalai P, Kasemsuk T, Athipornchai A, Sirion U, Suksen K, Piyachaturawat P, Suksamrarn A, Saeeng R.

Bioorg Med Chem Lett. 2018 May 15;28(9):1558-1561. doi: 10.1016/j.bmcl.2018.03.068. Epub 2018 Mar 27.

PMID:
29606574
14.

Ethyl rosmarinate inhibits lipopolysaccharide-induced nitric oxide and prostaglandin E2 production in alveolar macrophages.

Thammason H, Khetkam P, Pabuprapap W, Suksamrarn A, Kunthalert D.

Eur J Pharmacol. 2018 Apr 5;824:17-23. doi: 10.1016/j.ejphar.2018.01.042. Epub 2018 Jan 31.

PMID:
29391157
15.

Curcuma comosa reduces visceral adipose tissue and improves dyslipidemia in ovariectomized rats.

Sutjarit N, Sueajai J, Boonmuen N, Sornkaew N, Suksamrarn A, Tuchinda P, Zhu W, Weerachayaphorn J, Piyachaturawat P.

J Ethnopharmacol. 2018 Apr 6;215:167-175. doi: 10.1016/j.jep.2017.12.027. Epub 2017 Dec 20.

PMID:
29273438
16.

Curcumin pyrazole blocks lipopolysaccharide-induced inflammation via suppression of JNK activation in RAW 264.7 macrophages.

Somchit N, Kimseng R, Dhar R, Hiransai P, Changtam C, Suksamrarn A, Chunglok W, Chunglok W.

Asian Pac J Allergy Immunol. 2018 Sep;36(3):184-190. doi: 10.12932/AP-130417-0073.

17.

Hexahydrocurcumin protects against cerebral ischemia/reperfusion injury, attenuates inflammation, and improves antioxidant defenses in a rat stroke model.

Wicha P, Tocharus J, Janyou A, Jittiwat J, Changtam C, Suksamrarn A, Tocharus C.

PLoS One. 2017 Dec 8;12(12):e0189211. doi: 10.1371/journal.pone.0189211. eCollection 2017.

18.

2',4-Dihydroxy-3',4',6'-trimethoxychalcone from Chromolaena odorata possesses anti-inflammatory effects via inhibition of NF-κB and p38 MAPK in lipopolysaccharide-activated RAW 264.7 macrophages.

Dhar R, Kimseng R, Chokchaisiri R, Hiransai P, Utaipan T, Suksamrarn A, Chunglok W.

Immunopharmacol Immunotoxicol. 2018 Feb;40(1):43-51. doi: 10.1080/08923973.2017.1405437. Epub 2017 Dec 4.

PMID:
29199487
19.

Synthesis of 14-deoxy-11,12-didehydroandrographolide analogues as potential cytotoxic agents for cholangiocarcinoma.

Sombut S, Bunthawong R, Sirion U, Kasemsuk T, Piyachaturawat P, Suksen K, Suksamrarn A, Saeeng R.

Bioorg Med Chem Lett. 2017 Dec 1;27(23):5139-5143. doi: 10.1016/j.bmcl.2017.10.063. Epub 2017 Oct 30.

PMID:
29097170
20.

Determination of the Marker Diarylheptanoid Phytoestrogens in Curcuma comosa Rhizomes and Selected Herbal Medicinal Products by HPLC-DAD.

Yingngam B, Brantner A, Jinarat D, Kaewamatawong R, Rungseevijitprapa W, Suksamrarn A, Piyachaturawat P, Chokchaisiri R.

Chem Pharm Bull (Tokyo). 2018 Jan 1;66(1):65-70. doi: 10.1248/cpb.c17-00517. Epub 2017 Oct 26.

21.

Mahanine enhances the glucose-lowering mechanisms in skeletal muscle and adipocyte cells.

Nooron N, Athipornchai A, Suksamrarn A, Chiabchalard A.

Biochem Biophys Res Commun. 2017 Dec 9;494(1-2):101-106. doi: 10.1016/j.bbrc.2017.10.075. Epub 2017 Oct 16.

PMID:
29050941
22.

6-Hydroxy-3-O-methyl-kaempferol 6-O-glucopyranoside potentiates the anti-proliferative effect of interferon α/β by promoting activation of the JAK/STAT signaling by inhibiting SOCS3 in hepatocellular carcinoma cells.

Wonganan O, He YJ, Shen XF, Wongkrajang K, Suksamrarn A, Zhang GL, Wang F.

Toxicol Appl Pharmacol. 2017 Dec 1;336:31-39. doi: 10.1016/j.taap.2017.10.004. Epub 2017 Oct 12.

PMID:
29031523
23.

Dihydrocapsaicin Attenuates Blood Brain Barrier and Cerebral Damage in Focal Cerebral Ischemia/Reperfusion via Oxidative Stress and Inflammatory.

Janyou A, Wicha P, Jittiwat J, Suksamrarn A, Tocharus C, Tocharus J.

Sci Rep. 2017 Sep 5;7(1):10556. doi: 10.1038/s41598-017-11181-5.

24.

One-pot three steps cascade synthesis of novel isoandrographolide analogues and their cytotoxic activity.

Kasemsuk T, Piyachaturawat P, Bunthawong R, Sirion U, Suksen K, Suksamrarn A, Saeeng R.

Eur J Med Chem. 2017 Sep 29;138:952-963. doi: 10.1016/j.ejmech.2017.07.035. Epub 2017 Jul 21.

PMID:
28755636
25.

Characterization of synthetic ecdysteroid analogues as functional mimics of brassinosteroids in plant growth.

Thussagunpanit J, Jutamanee K, Homvisasevongsa S, Suksamrarn A, Yamagami A, Nakano T, Asami T.

J Steroid Biochem Mol Biol. 2017 Sep;172:1-8. doi: 10.1016/j.jsbmb.2017.05.003. Epub 2017 May 4.

PMID:
28479230
26.

Selective Estrogen Receptor Modulator (SERM)-like Activities of Diarylheptanoid, a Phytoestrogen from Curcuma comosa, in Breast Cancer Cells, Pre-osteoblast Cells, and Rat Uterine Tissues.

Thongon N, Boonmuen N, Suksen K, Wichit P, Chairoungdua A, Tuchinda P, Suksamrarn A, Winuthayanon W, Piyachaturawat P.

J Agric Food Chem. 2017 May 3;65(17):3490-3496. doi: 10.1021/acs.jafc.7b00769. Epub 2017 Apr 24.

PMID:
28412809
27.

A New Ajmaline-type Alkaloid from the Roots of Rauvolfia serpentina.

Rukachaisirikul T, Chokchaisiri S, Suebsakwong P, Suksamrarn A, Tocharus C.

Nat Prod Commun. 2017 Apr;12(4):495-498.

PMID:
30520580
28.

Isomahanine induces endoplasmic reticulum stress and simultaneously triggers p38 MAPK-mediated apoptosis and autophagy in multidrug-resistant human oral squamous cell carcinoma cells.

Utaipan T, Athipornchai A, Suksamrarn A, Chunsrivirot S, Chunglok W.

Oncol Rep. 2017 Feb;37(2):1243-1252. doi: 10.3892/or.2017.5352. Epub 2017 Jan 4.

PMID:
28075474
29.

Cyanidin-3-glucoside attenuates angiotensin II-induced oxidative stress and inflammation in vascular endothelial cells.

Sivasinprasasn S, Pantan R, Thummayot S, Tocharus J, Suksamrarn A, Tocharus C.

Chem Biol Interact. 2016 Oct 28. pii: S0009-2797(16)30510-5. doi: 10.1016/j.cbi.2016.10.022. [Epub ahead of print]

PMID:
27983965
30.

Effect of 20-Hydroxyecdysone on Proteolytic Regulation in Skeletal Muscle Atrophy.

Hirunsai M, Yimlamai T, Suksamrarn A.

In Vivo. 2016 11-12;30(6):869-877.

PMID:
27815474
31.

Neuroprotective effects of cyanidin against Aβ-induced oxidative and ER stress in SK-N-SH cells.

Thummayot S, Tocharus C, Suksamrarn A, Tocharus J.

Neurochem Int. 2016 Dec;101:15-21. doi: 10.1016/j.neuint.2016.09.016. Epub 2016 Sep 30.

PMID:
27697517
32.

Carbazole alkaloids from Murraya koenigii trigger apoptosis and autophagic flux inhibition in human oral squamous cell carcinoma cells.

Utaipan T, Athipornchai A, Suksamrarn A, Jirachotikoon C, Yuan X, Lertcanawanichakul M, Chunglok W.

J Nat Med. 2017 Jan;71(1):158-169. doi: 10.1007/s11418-016-1045-6. Epub 2016 Sep 28.

PMID:
27680541
33.
34.

Germacrene Analogs are Anti-androgenic on Androgen-dependent Cells.

Srivflai J, Khorana N, Waranuch N, Wisuitiprot W, Suphrom N, Suksamrarn A, Ingkaninan K.

Nat Prod Commun. 2016 Sep;11(9):1225-1228.

PMID:
30807005
35.

Diarylheptanoid from Curcuma comosa Roxb. suppresses RANKL-induced osteoclast differentiation by decreasing NFATc1 and c-Fos expression via MAPK pathway.

Chawalitpong S, Sornkaew N, Suksamrarn A, Palaga T.

Eur J Pharmacol. 2016 Oct 5;788:351-359. doi: 10.1016/j.ejphar.2016.08.012. Epub 2016 Aug 12.

PMID:
27523282
36.

Effects of andrographolide on intrahepatic cholestasis induced by alpha-naphthylisothiocyanate in rats.

Khamphaya T, Chansela P, Piyachaturawat P, Suksamrarn A, Nathanson MH, Weerachayaphorn J.

Eur J Pharmacol. 2016 Oct 15;789:254-264. doi: 10.1016/j.ejphar.2016.07.032. Epub 2016 Jul 27.

PMID:
27475677
37.

Serum lipidomics analysis of ovariectomized rats under Curcuma comosa treatment.

Vinayavekhin N, Sueajai J, Chaihad N, Panrak R, Chokchaisiri R, Sangvanich P, Suksamrarn A, Piyachaturawat P.

J Ethnopharmacol. 2016 Nov 4;192:273-282. doi: 10.1016/j.jep.2016.07.054. Epub 2016 Jul 19.

PMID:
27448454
38.

Synergistic effect of atorvastatin and Cyanidin-3-glucoside on angiotensin II-induced inflammation in vascular smooth muscle cells.

Pantan R, Tocharus J, Suksamrarn A, Tocharus C.

Exp Cell Res. 2016 Mar 15;342(2):104-12. doi: 10.1016/j.yexcr.2016.02.017. Epub 2016 Mar 5.

PMID:
26957227
39.

Emodin potentiates the antiproliferative effect of interferon α/β by activation of JAK/STAT pathway signaling through inhibition of the 26S proteasome.

He Y, Huang J, Wang P, Shen X, Li S, Yang L, Liu W, Suksamrarn A, Zhang G, Wang F.

Oncotarget. 2016 Jan 26;7(4):4664-79. doi: 10.18632/oncotarget.6616.

40.

Coumarins and flavonoid from Murraya paniculata (L.) Jack: Antibacterial and anti-inflammation activity.

Rodanant P, Khetkam P, Suksamrarn A, Kuvatanasuchati J.

Pak J Pharm Sci. 2015 Nov;28(6):1947-51.

PMID:
26639491
41.

Protective effect of diarylheptanoids from Curcuma comosa on primary rat hepatocytes against t-butyl hydroperoxide-induced toxicity.

Suksen K, Charaslertrangsi T, Noonin C, Jariyawat S, Devakul Na Ayutthaya W, Suksamrarn A, Tuchinda P, Piyachaturawat P.

Pharm Biol. 2016;54(5):853-62. doi: 10.3109/13880209.2015.1088550. Epub 2015 Oct 10.

PMID:
26455646
42.

Ethyl rosmarinate relaxes rat aorta by an endothelium-independent pathway.

Wicha P, Tocharus J, Nakaew A, Pantan R, Suksamrarn A, Tocharus C.

Eur J Pharmacol. 2015 Nov 5;766:9-15. doi: 10.1016/j.ejphar.2015.09.003. Epub 2015 Sep 8.

PMID:
26362751
43.

Mechanisms of Vasorelaxation Induced by Hexahydrocurcuminin Isolated Rat Thoracic Aorta.

Moohammadaree A, Changtam C, Wicha P, Suksamrarn A, Tocharus J, Tocharus C.

Phytother Res. 2015 Nov;29(11):1806-13. doi: 10.1002/ptr.5448. Epub 2015 Sep 11.

PMID:
26360646
44.

Association of Neuroprotective Effect of Di-O-Demethylcurcumin on Aβ25-35-Induced Neurotoxicity with Suppression of NF-κB and Activation of Nrf2.

Pinkaew D, Changtam C, Tocharus C, Govitrapong P, Jumnongprakhon P, Suksamrarn A, Tocharus J.

Neurotox Res. 2016 Jan;29(1):80-91. doi: 10.1007/s12640-015-9558-4. Epub 2015 Sep 10.

PMID:
26358194
45.

Suppression effects of O-demethyldemethoxycurcumin on thapsigargin triggered on endoplasmic reticulum stress in SK-N-SH cells.

Janyou A, Changtam C, Suksamrarn A, Tocharus C, Tocharus J.

Neurotoxicology. 2015 Sep;50:92-100. doi: 10.1016/j.neuro.2015.08.005. Epub 2015 Aug 8.

PMID:
26264395
46.

Diarylheptanoids of Curcuma comosa with inhibitory effects on nitric oxide production in macrophage RAW 264.7 cells.

Sornkaewa N, Lin Y, Wang F, Zhang G, Chokchaisiri R, Zhang A, Wongkrajang K, Suebsakwong P, Piyachaturawat P, Suksamrarn A.

Nat Prod Commun. 2015 Jan;10(1):89-93.

PMID:
25920227
47.

Corrigendum to "Cucurbitacin B Causes Increased Radiation Sensitivity of Human Breast Cancer Cells via G2/M Cell Cycle Arrest".

Duangmano S, Sae-Lim P, Suksamrarn A, Patmasiriwat P, Domann FE.

J Oncol. 2015;2015:486850. doi: 10.1155/2015/486850. Epub 2015 Feb 2.

48.

Development of phenotypic and transcriptional biomarkers to evaluate relative activity of potentially estrogenic chemicals in ovariectomized mice.

Hewitt SC, Winuthayanon W, Pockette B, Kerns RT, Foley JF, Flagler N, Ney E, Suksamrarn A, Piyachaturawat P, Bushel PR, Korach KS.

Environ Health Perspect. 2015 Apr;123(4):344-52. doi: 10.1289/ehp.1307935. Epub 2015 Jan 9.

49.

Potent trypanocidal curcumin analogs bearing a monoenone linker motif act on trypanosoma brucei by forming an adduct with trypanothione.

Alkhaldi AA, Creek DJ, Ibrahim H, Kim DH, Quashie NB, Burgess KE, Changtam C, Barrett MP, Suksamrarn A, de Koning HP.

Mol Pharmacol. 2015;87(3):451-64. doi: 10.1124/mol.114.096016. Epub 2014 Dec 19.

PMID:
25527638
50.

Di-O-demethylcurcumin protects SK-N-SH cells against mitochondrial and endoplasmic reticulum-mediated apoptotic cell death induced by Aβ25-35.

Pinkaew D, Changtam C, Tocharus C, Thummayot S, Suksamrarn A, Tocharus J.

Neurochem Int. 2015 Jan;80:110-9. doi: 10.1016/j.neuint.2014.10.008. Epub 2014 Oct 24.

PMID:
25451798

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