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Items: 34


Conformational heterogeneity of the allosteric drug and metabolite (ADaM) site in AMP-activated protein kinase (AMPK).

Gu X, Bridges MD, Yan Y, de Waal PW, Zhou XE, Suino-Powell KM, Xu HE, Hubbell WL, Melcher K.

J Biol Chem. 2018 Nov 2;293(44):16994-17007. doi: 10.1074/jbc.RA118.004101. Epub 2018 Sep 11.


Crystal structure of the Frizzled 4 receptor in a ligand-free state.

Yang S, Wu Y, Xu TH, de Waal PW, He Y, Pu M, Chen Y, DeBruine ZJ, Zhang B, Zaidi SA, Popov P, Guo Y, Han GW, Lu Y, Suino-Powell K, Dong S, Harikumar KG, Miller LJ, Katritch V, Xu HE, Shui W, Stevens RC, Melcher K, Zhao S, Xu F.

Nature. 2018 Aug;560(7720):666-670. doi: 10.1038/s41586-018-0447-x. Epub 2018 Aug 22.


Identification of a novel selective PPARγ ligand with a unique binding mode and improved therapeutic profile in vitro.

Yi W, Shi J, Zhao G, Zhou XE, Suino-Powell K, Melcher K, Xu HE.

Sci Rep. 2017 Jan 27;7:41487. doi: 10.1038/srep41487.


X-ray laser diffraction for structure determination of the rhodopsin-arrestin complex.

Zhou XE, Gao X, Barty A, Kang Y, He Y, Liu W, Ishchenko A, White TA, Yefanov O, Han GW, Xu Q, de Waal PW, Suino-Powell KM, Boutet S, Williams GJ, Wang M, Li D, Caffrey M, Chapman HN, Spence JC, Fromme P, Weierstall U, Stevens RC, Cherezov V, Melcher K, Xu HE.

Sci Data. 2016 Apr 12;3:160021. doi: 10.1038/sdata.2016.21.


FXR Primes the Liver for Intestinal FGF15 Signaling by Transient Induction of β-Klotho.

Fu T, Kim YC, Byun S, Kim DH, Seok S, Suino-Powell K, Xu HE, Kemper B, Kemper JK.

Mol Endocrinol. 2016 Jan;30(1):92-103. doi: 10.1210/me.2015-1226. Epub 2015 Oct 27.


Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser.

Kang Y, Zhou XE, Gao X, He Y, Liu W, Ishchenko A, Barty A, White TA, Yefanov O, Han GW, Xu Q, de Waal PW, Ke J, Tan MH, Zhang C, Moeller A, West GM, Pascal BD, Van Eps N, Caro LN, Vishnivetskiy SA, Lee RJ, Suino-Powell KM, Gu X, Pal K, Ma J, Zhi X, Boutet S, Williams GJ, Messerschmidt M, Gati C, Zatsepin NA, Wang D, James D, Basu S, Roy-Chowdhury S, Conrad CE, Coe J, Liu H, Lisova S, Kupitz C, Grotjohann I, Fromme R, Jiang Y, Tan M, Yang H, Li J, Wang M, Zheng Z, Li D, Howe N, Zhao Y, Standfuss J, Diederichs K, Dong Y, Potter CS, Carragher B, Caffrey M, Jiang H, Chapman HN, Spence JC, Fromme P, Weierstall U, Ernst OP, Katritch V, Gurevich VV, Griffin PR, Hubbell WL, Stevens RC, Cherezov V, Melcher K, Xu HE.

Nature. 2015 Jul 30;523(7562):561-7. doi: 10.1038/nature14656. Epub 2015 Jul 22.


MicroRNA 34a inhibits beige and brown fat formation in obesity in part by suppressing adipocyte fibroblast growth factor 21 signaling and SIRT1 function.

Fu T, Seok S, Choi S, Huang Z, Suino-Powell K, Xu HE, Kemper B, Kemper JK.

Mol Cell Biol. 2014 Nov 15;34(22):4130-42. doi: 10.1128/MCB.00596-14. Epub 2014 Sep 2.


Cytoplasmic tyrosine phosphatase Shp2 coordinates hepatic regulation of bile acid and FGF15/19 signaling to repress bile acid synthesis.

Li S, Hsu DD, Li B, Luo X, Alderson N, Qiao L, Ma L, Zhu HH, He Z, Suino-Powell K, Ji K, Li J, Shao J, Xu HE, Li T, Feng GS.

Cell Metab. 2014 Aug 5;20(2):320-32. doi: 10.1016/j.cmet.2014.05.020. Epub 2014 Jun 26.


Structures and mechanism for the design of highly potent glucocorticoids.

He Y, Yi W, Suino-Powell K, Zhou XE, Tolbert WD, Tang X, Yang J, Yang H, Shi J, Hou L, Jiang H, Melcher K, Xu HE.

Cell Res. 2014 Jun;24(6):713-26. doi: 10.1038/cr.2014.52. Epub 2014 Apr 25.


Structural insights into gene repression by the orphan nuclear receptor SHP.

Zhi X, Zhou XE, He Y, Zechner C, Suino-Powell KM, Kliewer SA, Melcher K, Mangelsdorf DJ, Xu HE.

Proc Natl Acad Sci U S A. 2014 Jan 14;111(2):839-44. doi: 10.1073/pnas.1322827111. Epub 2013 Dec 30. Erratum in: Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3895.


Bile acid signal-induced phosphorylation of small heterodimer partner by protein kinase Cζ is critical for epigenomic regulation of liver metabolic genes.

Seok S, Kanamaluru D, Xiao Z, Ryerson D, Choi SE, Suino-Powell K, Xu HE, Veenstra TD, Kemper JK.

J Biol Chem. 2013 Aug 9;288(32):23252-63. doi: 10.1074/jbc.M113.452037. Epub 2013 Jul 3.


Abscisic acid signaling: thermal stability shift assays as tool to analyze hormone perception and signal transduction.

Soon FF, Suino-Powell KM, Li J, Yong EL, Xu HE, Melcher K.

PLoS One. 2012;7(10):e47857. doi: 10.1371/journal.pone.0047857. Epub 2012 Oct 24.


Aberrantly elevated microRNA-34a in obesity attenuates hepatic responses to FGF19 by targeting a membrane coreceptor β-Klotho.

Fu T, Choi SE, Kim DH, Seok S, Suino-Powell KM, Xu HE, Kemper JK.

Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16137-42. doi: 10.1073/pnas.1205951109. Epub 2012 Sep 17.


Catalytic mechanism and kinase interactions of ABA-signaling PP2C phosphatases.

Zhou XE, Soon FF, Ng LM, Kovach A, Suino-Powell KM, Li J, Yong EL, Zhu JK, Xu HE, Melcher K.

Plant Signal Behav. 2012 May;7(5):581-8. doi: 10.4161/psb.19694. Epub 2012 Apr 20.


Structural basis for basal activity and autoactivation of abscisic acid (ABA) signaling SnRK2 kinases.

Ng LM, Soon FF, Zhou XE, West GM, Kovach A, Suino-Powell KM, Chalmers MJ, Li J, Yong EL, Zhu JK, Griffin PR, Melcher K, Xu HE.

Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):21259-64. doi: 10.1073/pnas.1118651109. Epub 2011 Dec 12.


Molecular mimicry regulates ABA signaling by SnRK2 kinases and PP2C phosphatases.

Soon FF, Ng LM, Zhou XE, West GM, Kovach A, Tan MH, Suino-Powell KM, He Y, Xu Y, Chalmers MJ, Brunzelle JS, Zhang H, Yang H, Jiang H, Li J, Yong EL, Cutler S, Zhu JK, Griffin PR, Melcher K, Xu HE.

Science. 2012 Jan 6;335(6064):85-8. doi: 10.1126/science.1215106. Epub 2011 Nov 24.


FGF15/19 regulates hepatic glucose metabolism by inhibiting the CREB-PGC-1α pathway.

Potthoff MJ, Boney-Montoya J, Choi M, He T, Sunny NE, Satapati S, Suino-Powell K, Xu HE, Gerard RD, Finck BN, Burgess SC, Mangelsdorf DJ, Kliewer SA.

Cell Metab. 2011 Jun 8;13(6):729-38. doi: 10.1016/j.cmet.2011.03.019.


FGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis.

Kir S, Beddow SA, Samuel VT, Miller P, Previs SF, Suino-Powell K, Xu HE, Shulman GI, Kliewer SA, Mangelsdorf DJ.

Science. 2011 Mar 25;331(6024):1621-4. doi: 10.1126/science.1198363.


The orphan nuclear receptor TR4 is a vitamin A-activated nuclear receptor.

Zhou XE, Suino-Powell KM, Xu Y, Chan CW, Tanabe O, Kruse SW, Reynolds R, Engel JD, Xu HE.

J Biol Chem. 2011 Jan 28;286(4):2877-85. doi: 10.1074/jbc.M110.168740. Epub 2010 Nov 9.


Identification and mechanism of ABA receptor antagonism.

Melcher K, Xu Y, Ng LM, Zhou XE, Soon FF, Chinnusamy V, Suino-Powell KM, Kovach A, Tham FS, Cutler SR, Li J, Yong EL, Zhu JK, Xu HE.

Nat Struct Mol Biol. 2010 Sep;17(9):1102-8. doi: 10.1038/nsmb.1887. Epub 2010 Aug 22.


Coordination of centrosome homeostasis and DNA repair is intact in MCF-7 and disrupted in MDA-MB 231 breast cancer cells.

Acu ID, Liu T, Suino-Powell K, Mooney SM, D'Assoro AB, Rowland N, Muotri AR, Correa RG, Niu Y, Kumar R, Salisbury JL.

Cancer Res. 2010 Apr 15;70(8):3320-8. doi: 10.1158/0008-5472.CAN-09-3800. Epub 2010 Apr 13.


Identification of SRC3/AIB1 as a preferred coactivator for hormone-activated androgen receptor.

Zhou XE, Suino-Powell KM, Li J, He Y, Mackeigan JP, Melcher K, Yong EL, Xu HE.

J Biol Chem. 2010 Mar 19;285(12):9161-71. doi: 10.1074/jbc.M109.085779. Epub 2010 Jan 19.


Expression, purification and primary crystallographic study of human androgen receptor in complex with DNA and coactivator motifs.

Zhou XE, Suino-Powell K, Ludidi PL, McDonnell DP, Xu HE.

Protein Expr Purif. 2010 May;71(1):21-7. doi: 10.1016/j.pep.2009.12.002. Epub 2009 Dec 6.


A gate-latch-lock mechanism for hormone signalling by abscisic acid receptors.

Melcher K, Ng LM, Zhou XE, Soon FF, Xu Y, Suino-Powell KM, Park SY, Weiner JJ, Fujii H, Chinnusamy V, Kovach A, Li J, Wang Y, Li J, Peterson FC, Jensen DR, Yong EL, Volkman BF, Cutler SR, Zhu JK, Xu HE.

Nature. 2009 Dec 3;462(7273):602-8. doi: 10.1038/nature08613.


Identification of the nuclear receptor DAF-12 as a therapeutic target in parasitic nematodes.

Wang Z, Zhou XE, Motola DL, Gao X, Suino-Powell K, Conneely A, Ogata C, Sharma KK, Auchus RJ, Lok JB, Hawdon JM, Kliewer SA, Xu HE, Mangelsdorf DJ.

Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9138-43. doi: 10.1073/pnas.0904064106. Epub 2009 Jun 2.


Bile acid signaling pathways increase stability of Small Heterodimer Partner (SHP) by inhibiting ubiquitin-proteasomal degradation.

Miao J, Xiao Z, Kanamaluru D, Min G, Yau PM, Veenstra TD, Ellis E, Strom S, Suino-Powell K, Xu HE, Kemper JK.

Genes Dev. 2009 Apr 15;23(8):986-96. doi: 10.1101/gad.1773909.


Molecular recognition of corticotropin-releasing factor by its G-protein-coupled receptor CRFR1.

Pioszak AA, Parker NR, Suino-Powell K, Xu HE.

J Biol Chem. 2008 Nov 21;283(47):32900-12. doi: 10.1074/jbc.M805749200. Epub 2008 Sep 17.


Identification of COUP-TFII orphan nuclear receptor as a retinoic acid-activated receptor.

Kruse SW, Suino-Powell K, Zhou XE, Kretschman JE, Reynolds R, Vonrhein C, Xu Y, Wang L, Tsai SY, Tsai MJ, Xu HE.

PLoS Biol. 2008 Sep 16;6(9):e227. doi: 10.1371/journal.pbio.0060227.


Molecular recognition of nitrated fatty acids by PPAR gamma.

Li Y, Zhang J, Schopfer FJ, Martynowski D, Garcia-Barrio MT, Kovach A, Suino-Powell K, Baker PR, Freeman BA, Chen YE, Xu HE.

Nat Struct Mol Biol. 2008 Aug;15(8):865-7. doi: 10.1038/nsmb.1447. Epub 2008 Jul 6.


Structural and biochemical basis for the binding selectivity of peroxisome proliferator-activated receptor gamma to PGC-1alpha.

Li Y, Kovach A, Suino-Powell K, Martynowski D, Xu HE.

J Biol Chem. 2008 Jul 4;283(27):19132-9. doi: 10.1074/jbc.M802040200. Epub 2008 May 9.


Doubling the size of the glucocorticoid receptor ligand binding pocket by deacylcortivazol.

Suino-Powell K, Xu Y, Zhang C, Tao YG, Tolbert WD, Simons SS Jr, Xu HE.

Mol Cell Biol. 2008 Mar;28(6):1915-23. Epub 2007 Dec 26.


Induction of nuclear translocation of constitutive androstane receptor by peroxisome proliferator-activated receptor alpha synthetic ligands in mouse liver.

Guo D, Sarkar J, Suino-Powell K, Xu Y, Matsumoto K, Jia Y, Yu S, Khare S, Haldar K, Rao MS, Foreman JE, Monga SP, Peters JM, Xu HE, Reddy JK.

J Biol Chem. 2007 Dec 14;282(50):36766-76. Epub 2007 Oct 25.


Identification of a hormonal basis for gallbladder filling.

Choi M, Moschetta A, Bookout AL, Peng L, Umetani M, Holmstrom SR, Suino-Powell K, Xu HE, Richardson JA, Gerard RD, Mangelsdorf DJ, Kliewer SA.

Nat Med. 2006 Nov;12(11):1253-5. Epub 2006 Oct 29.


Identification of ligands for DAF-12 that govern dauer formation and reproduction in C. elegans.

Motola DL, Cummins CL, Rottiers V, Sharma KK, Li T, Li Y, Suino-Powell K, Xu HE, Auchus RJ, Antebi A, Mangelsdorf DJ.

Cell. 2006 Mar 24;124(6):1209-23. Epub 2006 Mar 9.

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