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Signaling incentive and drive in the primate ventral pallidum for motivational control of goal-directed action.

Fujimoto A, Hori Y, Nagai Y, Kikuchi E, Oyama K, Suhara T, Minamimoto T.

J Neurosci. 2019 Jan 9. pii: 2399-18. doi: 10.1523/JNEUROSCI.2399-18.2018. [Epub ahead of print]


Tau imaging detects distinctive distribution of tau pathology in ALS/PDC on the Kii Peninsula.

Shinotoh H, Shimada H, Kokubo Y, Tagai K, Niwa F, Kitamura S, Endo H, Ono M, Kimura Y, Hirano S, Mimuro M, Ichise M, Sahara N, Zhang MR, Suhara T, Higuchi M.

Neurology. 2019 Jan 8;92(2):e136-e147. doi: 10.1212/WNL.0000000000006736. Epub 2018 Dec 7.


Synthesis and characterization of 11 C-labeled benzyl amidine derivatives as PET radioligands for GluN2B subunit of the NMDA receptors.

Fuchigami T, Fujimoto N, Haradahira T, Nojiri Y, Okauchi T, Maeda J, Suhara T, Yamamoto F, Nakayama M, Maeda M, Mukai T.

J Labelled Comp Radiopharm. 2018 Dec;61(14):1095-1105. doi: 10.1002/jlcr.3691. Epub 2018 Nov 18.


Distributions and multiple sources of chlorinated polycyclic aromatic hydrocarbons in the air over Japan.

Ohura T, Suhara T, Kamiya Y, Ikemori F, Kageyama S, Nakajima D.

Sci Total Environ. 2019 Feb 1;649:364-371. doi: 10.1016/j.scitotenv.2018.08.302. Epub 2018 Aug 25.


Amyloid and Tau Positron Emission Tomography in Suggested Diabetesrelated Dementia.

Takenoshita N, Fukasawa R, Ogawa Y, Shimizu S, Umahara T, Ishii K, Shimada H, Higuchi M, Suhara T, Hanyu H.

Curr Alzheimer Res. 2018;15(11):1062-1069. doi: 10.2174/1567205015666180709113338.


Histamine H3 receptor density is negatively correlated with neural activity related to working memory in humans.

Ito T, Kimura Y, Seki C, Ichise M, Yokokawa K, Kawamura K, Takahashi H, Higuchi M, Zhang MR, Suhara T, Yamada M.

EJNMMI Res. 2018 Jun 14;8(1):48. doi: 10.1186/s13550-018-0406-4.


Tau-induced focal neurotoxicity and network disruption related to apathy in Alzheimer's disease.

Kitamura S, Shimada H, Niwa F, Endo H, Shinotoh H, Takahata K, Kubota M, Takado Y, Hirano S, Kimura Y, Zhang MR, Kuwabara S, Suhara T, Higuchi M.

J Neurol Neurosurg Psychiatry. 2018 Nov;89(11):1208-1214. doi: 10.1136/jnnp-2018-317970. Epub 2018 Jun 8.


Pathological Roles of Iron in Cardiovascular Disease.

Kobayashi M, Suhara T, Baba Y, Kawasaki NK, Higa JK, Matsui T.

Curr Drug Targets. 2018;19(9):1068-1076. doi: 10.2174/1389450119666180605112235.


Microglial Activation During Pathogenesis of Tauopathy in rTg4510 Mice: Implications for the Early Diagnosis of Tauopathy.

Sahara N, Maeda J, Ishikawa A, Tokunaga M, Suhara T, Higuchi M.

J Alzheimers Dis. 2018;64(s1):S353-S359. doi: 10.3233/JAD-179933.


Neuromolecular basis of faded perception associated with unreality experience.

Yokokawa K, Ito T, Takahata K, Takano H, Kimura Y, Ichise M, Ikoma Y, Isato A, Zhang MR, Kawamura K, Ito H, Takahashi H, Suhara T, Yamada M.

Sci Rep. 2018 May 23;8(1):8062. doi: 10.1038/s41598-018-26382-9.


Tau Fibril Formation in Cultured Cells Compatible with a Mouse Model of Tauopathy.

Matsumoto G, Matsumoto K, Kimura T, Suhara T, Higuchi M, Sahara N, Mori N.

Int J Mol Sci. 2018 May 17;19(5). pii: E1497. doi: 10.3390/ijms19051497.


Correction: Anatomical relationships between serotonin 5-HT2A and dopamine D2 receptors in living human brain.

Ishii T, Kimura Y, Ichise M, Takahata K, Kitamura S, Moriguchi S, Kubota M, Zhang MR, Yamada M, Higuchi M, Okubo Y, Suhara T.

PLoS One. 2018 May 7;13(5):e0197201. doi: 10.1371/journal.pone.0197201. eCollection 2018.


Cerebral serotonin transporter measurements with [11C]DASB: A review on acquisition and preprocessing across 21 PET centres.

Nørgaard M, Ganz M, Svarer C, Feng L, Ichise M, Lanzenberger R, Lubberink M, Parsey RV, Politis M, Rabiner EA, Slifstein M, Sossi V, Suhara T, Talbot PS, Turkheimer F, Strother SC, Knudsen GM.

J Cereb Blood Flow Metab. 2018 Apr 13:271678X18770107. doi: 10.1177/0271678X18770107. [Epub ahead of print]


Voxel-Based Acetylcholinesterase PET Study in Early and Late Onset Alzheimer's Disease.

Hirano S, Shinotoh H, Shimada H, Ota T, Sato K, Tanaka N, Zhang MR, Higuchi M, Fukushi K, Irie T, Kuwabara S, Suhara T.

J Alzheimers Dis. 2018;62(4):1539-1548. doi: 10.3233/JAD-170749.


The Role of Heat-Tolerant Endotoxin-Retentive Ultrafilters (UFs) for the Remediation of Reverse Osmosis (RO) Plants Employed for Surgical Hand Antisepsis Using Periodic Thermal Disinfection-A Ten Year Longitudinal Experience Study in the Operating Theater.

Uetera Y, Yasuhara H, Kumada N, Misawa Y, Terada Y, Satou Y, Suhara T, Kawamura K.

PDA J Pharm Sci Technol. 2018 Jul-Aug;72(4):420-437. doi: 10.5731/pdajpst.2017.008482. Epub 2018 Mar 15.


Comparative In Vitro and In Vivo Quantifications of Pathologic Tau Deposits and Their Association with Neurodegeneration in Tauopathy Mouse Models.

Ni R, Ji B, Ono M, Sahara N, Zhang MR, Aoki I, Nordberg A, Suhara T, Higuchi M.

J Nucl Med. 2018 Jun;59(6):960-966. doi: 10.2967/jnumed.117.201632. Epub 2018 Feb 1.


In Vivo Tau Imaging for a Diagnostic Platform of Tauopathy Using the rTg4510 Mouse Line.

Sahara N, Shimojo M, Ono M, Takuwa H, Febo M, Higuchi M, Suhara T.

Front Neurol. 2017 Dec 7;8:663. doi: 10.3389/fneur.2017.00663. eCollection 2017. Review.


Imaging of Neuronal Activity in Awake Mice by Measurements of Flavoprotein Autofluorescence Corrected for Cerebral Blood Flow.

Takahashi M, Urushihata T, Takuwa H, Sakata K, Takado Y, Shimizu E, Suhara T, Higuchi M, Ito H.

Front Neurosci. 2018 Jan 4;11:723. doi: 10.3389/fnins.2017.00723. eCollection 2017.


In Vivo Visualization of Tau Accumulation, Microglial Activation, and Brain Atrophy in a Mouse Model of Tauopathy rTg4510.

Ishikawa A, Tokunaga M, Maeda J, Minamihisamatsu T, Shimojo M, Takuwa H, Ono M, Ni R, Hirano S, Kuwabara S, Ji B, Zhang MR, Aoki I, Suhara T, Higuchi M, Sahara N.

J Alzheimers Dis. 2018;61(3):1037-1052. doi: 10.3233/JAD-170509.


Anatomical relationships between serotonin 5-HT2A and dopamine D2 receptors in living human brain.

Ishii T, Kimura Y, Ichise M, Takahata K, Kitamura S, Moriguchi S, Kubota M, Zhang MR, Yamada M, Higuchi M, Okubo Y, Suhara T.

PLoS One. 2017 Dec 8;12(12):e0189318. doi: 10.1371/journal.pone.0189318. eCollection 2017. Erratum in: PLoS One. 2018 May 7;13(5):e0197201.


Steroidogenic abnormalities in translocator protein knockout mice and significance in the aging male.

Barron AM, Ji B, Kito S, Suhara T, Higuchi M.

Biochem J. 2018 Jan 2;475(1):75-85. doi: 10.1042/BCJ20170645.


Protective effects of the mechanistic target of rapamycin against excess iron and ferroptosis in cardiomyocytes.

Baba Y, Higa JK, Shimada BK, Horiuchi KM, Suhara T, Kobayashi M, Woo JD, Aoyagi H, Marh KS, Kitaoka H, Matsui T.

Am J Physiol Heart Circ Physiol. 2018 Mar 1;314(3):H659-H668. doi: 10.1152/ajpheart.00452.2017. Epub 2017 Nov 10.


Neuroticism Associates with Cerebral in Vivo Serotonin Transporter Binding Differently in Males and Females.

Tuominen L, Miettunen J, Cannon DM, Drevets WC, Frokjaer VG, Hirvonen J, Ichise M, Jensen PS, Keltikangas-Järvinen L, Klaver JM, Knudsen GM, Takano A, Suhara T, Hietala J.

Int J Neuropsychopharmacol. 2017 Dec 1;20(12):963-970. doi: 10.1093/ijnp/pyx071.


Occupancy of Norepinephrine Transporter by Duloxetine in Human Brains Measured by Positron Emission Tomography with (S,S)-[18F]FMeNER-D2.

Moriguchi S, Takano H, Kimura Y, Nagashima T, Takahata K, Kubota M, Kitamura S, Ishii T, Ichise M, Zhang MR, Shimada H, Mimura M, Meyer JH, Higuchi M, Suhara T.

Int J Neuropsychopharmacol. 2017 Dec 1;20(12):957-962. doi: 10.1093/ijnp/pyx069.


Affinity States of Striatal Dopamine D2 Receptors in Antipsychotic-Free Patients with Schizophrenia.

Kubota M, Nagashima T, Takano H, Kodaka F, Fujiwara H, Takahata K, Moriguchi S, Kimura Y, Higuchi M, Okubo Y, Takahashi H, Ito H, Suhara T.

Int J Neuropsychopharmacol. 2017 Nov 1;20(11):928-935. doi: 10.1093/ijnp/pyx063.


A migration case of Kii amyotrophic lateral sclerosis/parkinsonism dementia complex with the shortest stay in the endemic area and the longest incubation to develop the disease.

Tsunoda K, Yamashita T, Shimada H, Nomura E, Takahashi Y, Shang J, Sato K, Takemoto M, Hishikawa N, Ohta Y, Higuchi M, Suhara T, Kokubo Y, Kuzuhara S, Abe K.

J Clin Neurosci. 2017 Dec;46:64-67. doi: 10.1016/j.jocn.2017.08.057. Epub 2017 Sep 7.


A human PET study of [11C]HMS011, a potential radioligand for AMPA receptors.

Takahata K, Kimura Y, Seki C, Tokunaga M, Ichise M, Kawamura K, Ono M, Kitamura S, Kubota M, Moriguchi S, Ishii T, Takado Y, Niwa F, Endo H, Nagashima T, Ikoma Y, Zhang MR, Suhara T, Higuchi M.

EJNMMI Res. 2017 Aug 16;7(1):63. doi: 10.1186/s13550-017-0313-0.


Normative data of dopaminergic neurotransmission functions in substantia nigra measured with MRI and PET: Neuromelanin, dopamine synthesis, dopamine transporters, and dopamine D2 receptors.

Ito H, Kawaguchi H, Kodaka F, Takuwa H, Ikoma Y, Shimada H, Kimura Y, Seki C, Kubo H, Ishii S, Takano H, Suhara T.

Neuroimage. 2017 Sep;158:12-17. doi: 10.1016/j.neuroimage.2017.06.066. Epub 2017 Jun 26.


Targeting Oxygen-Sensing Prolyl Hydroxylase for Metformin-Associated Lactic Acidosis Treatment.

Oyaizu-Toramaru T, Suhara T, Hayakawa N, Nakamura T, Kubo A, Minamishima S, Yamaguchi K, Hishiki T, Morisaki H, Suematsu M, Minamishima YA.

Mol Cell Biol. 2017 Jul 28;37(16). pii: e00248-17. doi: 10.1128/MCB.00248-17. Print 2017 Aug 15.


Erratum to "Impact of spillover from white matter by partial volume effect on quantification of amyloid deposition with [11C]PiB PET" [NeuroImage 143 (2016) 316-324].

Matsubara K, Ibaraki M, Shimada H, Ikoma Y, Suhara T, Kinoshita T, Ito H.

Neuroimage. 2017 Jun;153:411. doi: 10.1016/j.neuroimage.2017.04.042. No abstract available.


Possible Role of Organic Cation Transporters in the Distribution of [11C]Sulpiride, a Dopamine D2 Receptor Antagonist.

Takano H, Ito S, Zhang X, Ito H, Zhang MR, Suzuki H, Maeda K, Kusuhara H, Suhara T, Sugiyama Y.

J Pharm Sci. 2017 Sep;106(9):2558-2565. doi: 10.1016/j.xphs.2017.05.006. Epub 2017 May 10.


High-Contrast PET Imaging of Vasopressin V1B Receptors with a Novel Radioligand, 11C-TASP699.

Koga K, Nagai Y, Hanyu M, Yoshinaga M, Chaki S, Ohtake N, Ozaki S, Zhang MR, Suhara T, Higuchi M.

J Nucl Med. 2017 Oct;58(10):1652-1658. doi: 10.2967/jnumed.116.188698. Epub 2017 Apr 27.


The mTOR Signaling Pathway in Myocardial Dysfunction in Type 2 Diabetes Mellitus.

Suhara T, Baba Y, Shimada BK, Higa JK, Matsui T.

Curr Diab Rep. 2017 Jun;17(6):38. doi: 10.1007/s11892-017-0865-4. Review.


Neural basis of negativity bias in the perception of ambiguous facial expression.

Ito T, Yokokawa K, Yahata N, Isato A, Suhara T, Yamada M.

Sci Rep. 2017 Mar 24;7(1):420. doi: 10.1038/s41598-017-00502-3.


Sepsis-induced cardiac dysfunction and β-adrenergic blockade therapy for sepsis.

Suzuki T, Suzuki Y, Okuda J, Kurazumi T, Suhara T, Ueda T, Nagata H, Morisaki H.

J Intensive Care. 2017 Mar 3;5:22. doi: 10.1186/s40560-017-0215-2. eCollection 2017. Review.


Use of human methylation arrays for epigenome research in the common marmoset (Callithrix jacchus).

Ueda J, Murata Y, Bundo M, Oh-Nishi A, Kassai H, Ikegame T, Zhao Z, Jinde S, Aiba A, Suhara T, Kasai K, Kato T, Iwamoto K.

Neurosci Res. 2017 Jul;120:60-65. doi: 10.1016/j.neures.2017.02.005. Epub 2017 Feb 17.


Visual evaluation of kinetic characteristics of PET probe for neuroreceptors using a two-phase graphic plot analysis.

Ito H, Ikoma Y, Seki C, Kimura Y, Kawaguchi H, Takuwa H, Ichise M, Suhara T, Kanno I.

Ann Nucl Med. 2017 May;31(4):273-282. doi: 10.1007/s12149-017-1155-6. Epub 2017 Feb 8.


Association between Aβ and tau accumulations and their influence on clinical features in aging and Alzheimer's disease spectrum brains: A [11C]PBB3-PET study.

Shimada H, Kitamura S, Shinotoh H, Endo H, Niwa F, Hirano S, Kimura Y, Zhang MR, Kuwabara S, Suhara T, Higuchi M.

Alzheimers Dement (Amst). 2016 Dec 22;6:11-20. doi: 10.1016/j.dadm.2016.12.009. eCollection 2017.


Distinct binding of PET ligands PBB3 and AV-1451 to tau fibril strains in neurodegenerative tauopathies.

Ono M, Sahara N, Kumata K, Ji B, Ni R, Koga S, Dickson DW, Trojanowski JQ, Lee VM, Yoshida M, Hozumi I, Yoshiyama Y, van Swieten JC, Nordberg A, Suhara T, Zhang MR, Higuchi M.

Brain. 2017 Mar 1;140(3):764-780. doi: 10.1093/brain/aww339.


Strategies for Utilizing Neuroimaging Biomarkers in CNS Drug Discovery and Development: CINP/JSNP Working Group Report.

Suhara T, Chaki S, Kimura H, Furusawa M, Matsumoto M, Ogura H, Negishi T, Saijo T, Higuchi M, Omura T, Watanabe R, Miyoshi S, Nakatani N, Yamamoto N, Liou SY, Takado Y, Maeda J, Okamoto Y, Okubo Y, Yamada M, Ito H, Walton NM, Yamawaki S.

Int J Neuropsychopharmacol. 2017 Apr 1;20(4):285-294. doi: 10.1093/ijnp/pyw111. Review.


PET Quantification of the Norepinephrine Transporter in Human Brain with (S,S)-18F-FMeNER-D2.

Moriguchi S, Kimura Y, Ichise M, Arakawa R, Takano H, Seki C, Ikoma Y, Takahata K, Nagashima T, Yamada M, Mimura M, Suhara T.

J Nucl Med. 2017 Jul;58(7):1140-1145. doi: 10.2967/jnumed.116.178913. Epub 2016 Dec 15.


PET imaging-guided chemogenetic silencing reveals a critical role of primate rostromedial caudate in reward evaluation.

Nagai Y, Kikuchi E, Lerchner W, Inoue KI, Ji B, Eldridge MA, Kaneko H, Kimura Y, Oh-Nishi A, Hori Y, Kato Y, Hirabayashi T, Fujimoto A, Kumata K, Zhang MR, Aoki I, Suhara T, Higuchi M, Takada M, Richmond BJ, Minamimoto T.

Nat Commun. 2016 Dec 6;7:13605. doi: 10.1038/ncomms13605.


Multimodal Imaging for DREADD-Expressing Neurons in Living Brain and Their Application to Implantation of iPSC-Derived Neural Progenitors.

Ji B, Kaneko H, Minamimoto T, Inoue H, Takeuchi H, Kumata K, Zhang MR, Aoki I, Seki C, Ono M, Tokunaga M, Tsukamoto S, Tanabe K, Shin RM, Minamihisamatsu T, Kito S, Richmond BJ, Suhara T, Higuchi M.

J Neurosci. 2016 Nov 9;36(45):11544-11558.


Measurement of psychological state changes at low dopamine transporter occupancy following a clinical dose of mazindol.

Kimura Y, Maeda J, Yamada M, Takahata K, Yokokawa K, Ikoma Y, Seki C, Ito H, Higuchi M, Suhara T.

Psychopharmacology (Berl). 2017 Feb;234(3):323-328. doi: 10.1007/s00213-016-4464-x. Epub 2016 Oct 20.


Prediction of CNS occupancy of dopamine D2 receptor based on systemic exposure and in vitro experiments.

Kanamitsu K, Arakawa R, Sugiyama Y, Suhara T, Kusuhara H.

Drug Metab Pharmacokinet. 2016 Dec;31(6):395-404. doi: 10.1016/j.dmpk.2016.07.003. Epub 2016 Jul 30.


Calcium dysregulation contributes to neurodegeneration in FTLD patient iPSC-derived neurons.

Imamura K, Sahara N, Kanaan NM, Tsukita K, Kondo T, Kutoku Y, Ohsawa Y, Sunada Y, Kawakami K, Hotta A, Yawata S, Watanabe D, Hasegawa M, Trojanowski JQ, Lee VM, Suhara T, Higuchi M, Inoue H.

Sci Rep. 2016 Oct 10;6:34904. doi: 10.1038/srep34904.


Impact of spillover from white matter by partial volume effect on quantification of amyloid deposition with [11C]PiB PET.

Matsubara K, Ibaraki M, Shimada H, Ikoma Y, Suhara T, Kinoshita T, Ito H.

Neuroimage. 2016 Dec;143:316-324. doi: 10.1016/j.neuroimage.2016.09.028. Epub 2016 Sep 14. Erratum in: Neuroimage. 2017 Jun;153:411.


Norepinephrine Transporter in Major Depressive Disorder: A PET Study.

Moriguchi S, Yamada M, Takano H, Nagashima T, Takahata K, Yokokawa K, Ito T, Ishii T, Kimura Y, Zhang MR, Mimura M, Suhara T.

Am J Psychiatry. 2017 Jan 1;174(1):36-41. doi: 10.1176/appi.ajp.2016.15101334. Epub 2016 Sep 15.


Assessment of neuroinflammation in a mouse model of obesity and β-amyloidosis using PET.

Barron AM, Tokunaga M, Zhang MR, Ji B, Suhara T, Higuchi M.

J Neuroinflammation. 2016 Aug 31;13(1):221. doi: 10.1186/s12974-016-0700-x.


A possible serologic biomarker for maternal immune activation-associated neurodevelopmental disorders found in the rat models.

Oh-Nishi A, Koga K, Maeda T, Suhara T.

Neurosci Res. 2016 Dec;113:63-70. doi: 10.1016/j.neures.2016.07.003. Epub 2016 Jul 15.

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