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Items: 8


Intracellular Delivery of Human Purine Nucleoside Phosphorylase by Engineered Diphtheria Toxin Rescues Function in Target Cells.

Park M, Xu X, Min W, Sugiman-Marangos SN, Beilhartz GL, Adams JJ, Sidhu SS, Grunebaum E, Melnyk RA.

Mol Pharm. 2018 Nov 5;15(11):5217-5226. doi: 10.1021/acs.molpharmaceut.8b00735. Epub 2018 Sep 26.


Identification of a diphtheria toxin-like gene family beyond the Corynebacterium genus.

Mansfield MJ, Sugiman-Marangos SN, Melnyk RA, Doxey AC.

FEBS Lett. 2018 Aug;592(16):2693-2705. doi: 10.1002/1873-3468.13208. Epub 2018 Aug 16.


Functional defects in Clostridium difficile TcdB toxin uptake identify CSPG4 receptor-binding determinants.

Gupta P, Zhang Z, Sugiman-Marangos SN, Tam J, Raman S, Julien JP, Kroh HK, Lacy DB, Murgolo N, Bekkari K, Therien AG, Hernandez LD, Melnyk RA.

J Biol Chem. 2017 Oct 20;292(42):17290-17301. doi: 10.1074/jbc.M117.806687. Epub 2017 Aug 23.


Clostridium difficile toxins A and B: Receptors, pores, and translocation into cells.

Orrell KE, Zhang Z, Sugiman-Marangos SN, Melnyk RA.

Crit Rev Biochem Mol Biol. 2017 Aug;52(4):461-473. doi: 10.1080/10409238.2017.1325831. Epub 2017 May 26. Review.


Repurposing bacterial toxins for intracellular delivery of therapeutic proteins.

Beilhartz GL, Sugiman-Marangos SN, Melnyk RA.

Biochem Pharmacol. 2017 Oct 15;142:13-20. doi: 10.1016/j.bcp.2017.04.009. Epub 2017 Apr 10. Review.


The Conserved Tetratricopeptide Repeat-Containing C-Terminal Domain of Pseudomonas aeruginosa FimV Is Required for Its Cyclic AMP-Dependent and -Independent Functions.

Buensuceso RN, Nguyen Y, Zhang K, Daniel-Ivad M, Sugiman-Marangos SN, Fleetwood AD, Zhulin IB, Junop MS, Howell PL, Burrows LL.

J Bacteriol. 2016 Jul 28;198(16):2263-74. doi: 10.1128/JB.00322-16. Print 2016 Aug 15.


Mechanism for accurate, protein-assisted DNA annealing by Deinococcus radiodurans DdrB.

Sugiman-Marangos SN, Weiss YM, Junop MS.

Proc Natl Acad Sci U S A. 2016 Apr 19;113(16):4308-13. doi: 10.1073/pnas.1520847113. Epub 2016 Apr 4.


Crystal structure of the DdrB/ssDNA complex from Deinococcus radiodurans reveals a DNA binding surface involving higher-order oligomeric states.

Sugiman-Marangos SN, Peel JK, Weiss YM, Ghirlando R, Junop MS.

Nucleic Acids Res. 2013 Nov;41(21):9934-44. doi: 10.1093/nar/gkt759. Epub 2013 Aug 23.

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