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Items: 1 to 50 of 215

1.

A multimodal molecular imaging study evaluates pharmacological alteration of the tumor microenvironment to improve radiation response.

Takakusagi Y, Naz S, Takakusagi K, Ishima M, Murata H, Ohta K, Miura M, Sugawara F, Sakaguchi K, Kishimoto S, Munasinghe JP, Mitchell JB, Krishna MC.

Cancer Res. 2018 Oct 9. pii: canres.1654.2018. doi: 10.1158/0008-5472.CAN-18-1654. [Epub ahead of print]

PMID:
30301838
2.

Using the QCM Biosensor-Based T7 Phage Display Combined with Bioinformatics Analysis for Target Identification of Bioactive Small Molecule.

Takakusagi Y, Takakusagi K, Sugawara F, Sakaguchi K.

Methods Mol Biol. 2018;1795:159-172. doi: 10.1007/978-1-4939-7874-8_14.

PMID:
29846927
3.

Distribution and metabolism of 14C-Sulfoquinovosylacylpropanediol (14C-SQAP) after a single intravenous administration in tumor-bearing mice.

Ruike T, Kanai Y, Iwabata K, Matsumoto Y, Murata H, Ishima M, Ohta K, Oshige M, Katsura S, Kuramochi K, Kamisuki S, Sahara H, Miura M, Sugawara F, Sakaguchi K.

Xenobiotica. 2018 Mar 15:1-45. doi: 10.1080/00498254.2018.1448949. [Epub ahead of print]

PMID:
29543539
4.

Identification of proteins that bind to the neuroprotective agent neoechinulin A.

Kamisuki S, Himeno N, Tsurukawa Y, Kusayanagi T, Takeno M, Kamakura T, Kuramochi K, Sugawara F.

Biosci Biotechnol Biochem. 2018 Mar;82(3):442-448. doi: 10.1080/09168451.2018.1433018. Epub 2018 Feb 15.

PMID:
29447077
5.

TRPA1-dependent reversible opening of tight junction by natural compounds with an α,β-unsaturated moiety and capsaicin.

Kanda Y, Yamasaki Y, Sasaki-Yamaguchi Y, Ida-Koga N, Kamisuki S, Sugawara F, Nagumo Y, Usui T.

Sci Rep. 2018 Feb 2;8(1):2251. doi: 10.1038/s41598-018-20526-7.

6.

MA026, an anti-hepatitis C virus compound, opens tight junctions of the epithelial cell membrane.

Kanda Y, Yamasaki Y, Shimura S, Kamisuki S, Sugawara F, Nagumo Y, Usui T.

J Antibiot (Tokyo). 2017 May;70(5):691-694. doi: 10.1038/ja.2016.168. Epub 2017 Jan 18.

PMID:
28096546
7.

Neoechinulin A induced memory improvements and antidepressant-like effects in mice.

Sasaki-Hamada S, Hoshi M, Niwa Y, Ueda Y, Kokaji A, Kamisuki S, Kuramochi K, Sugawara F, Oka J.

Prog Neuropsychopharmacol Biol Psychiatry. 2016 Nov 3;71:155-61. doi: 10.1016/j.pnpbp.2016.08.002. Epub 2016 Aug 2.

PMID:
27495355
8.

Fungus-Derived Neoechinulin B as a Novel Antagonist of Liver X Receptor, Identified by Chemical Genetics Using a Hepatitis C Virus Cell Culture System.

Nakajima S, Watashi K, Ohashi H, Kamisuki S, Izaguirre-Carbonell J, Kwon AT, Suzuki H, Kataoka M, Tsukuda S, Okada M, Moi ML, Takeuchi T, Arita M, Suzuki R, Aizaki H, Kato T, Suzuki T, Hasegawa H, Takasaki T, Sugawara F, Wakita T.

J Virol. 2016 Sep 29;90(20):9058-74. doi: 10.1128/JVI.00856-16. Print 2016 Oct 15.

9.

Low doses of the mycotoxin citrinin protect cortical neurons against glutamate-induced excitotoxicity.

Nakajima Y, Iguchi H, Kamisuki S, Sugawara F, Furuichi T, Shinoda Y.

J Toxicol Sci. 2016 Apr;41(2):311-9. doi: 10.2131/jts.41.311.

10.

Anti-hepatitis C Virus Natural Product from a Fungus, Penicillium herquei.

Nishikori S, Takemoto K, Kamisuki S, Nakajima S, Kuramochi K, Tsukuda S, Iwamoto M, Katayama Y, Suzuki T, Kobayashi S, Watashi K, Sugawara F.

J Nat Prod. 2016 Feb 26;79(2):442-6. doi: 10.1021/acs.jnatprod.5b00555. Epub 2016 Feb 5.

PMID:
26848504
11.

Novel anticancer agent, SQAP, binds to focal adhesion kinase and modulates its activity.

Izaguirre-Carbonell J, Kawakubo H, Murata H, Tanabe A, Takeuchi T, Kusayanagi T, Tsukuda S, Hirakawa T, Iwabata K, Kanai Y, Ohta K, Miura M, Sakaguchi K, Matsunaga S, Sahara H, Kamisuki S, Sugawara F.

Sci Rep. 2015 Oct 12;5:15136. doi: 10.1038/srep15136.

12.

Enhancement of Cellulose Degradation by Cattle Saliva.

Seki Y, Kikuchi Y, Kimura Y, Yoshimoto R, Takahashi M, Aburai K, Kanai Y, Ruike T, Iwabata K, Sugawara F, Sakai H, Abe M, Sakaguchi K.

PLoS One. 2015 Sep 24;10(9):e0138902. doi: 10.1371/journal.pone.0138902. eCollection 2015.

13.

A Novel Tricyclic Polyketide, Vanitaracin A, Specifically Inhibits the Entry of Hepatitis B and D Viruses by Targeting Sodium Taurocholate Cotransporting Polypeptide.

Kaneko M, Watashi K, Kamisuki S, Matsunaga H, Iwamoto M, Kawai F, Ohashi H, Tsukuda S, Shimura S, Suzuki R, Aizaki H, Sugiyama M, Park SY, Ito T, Ohtani N, Sugawara F, Tanaka Y, Mizokami M, Sureau C, Wakita T.

J Virol. 2015 Dec;89(23):11945-53. doi: 10.1128/JVI.01855-15. Epub 2015 Sep 16.

14.

Ridaifen G, tamoxifen analog, is a potent anticancer drug working through a combinatorial association with multiple cellular factors.

Ikeda K, Kamisuki S, Uetake S, Mizusawa A, Ota N, Sasaki T, Tsukuda S, Kusayanagi T, Takakusagi Y, Morohashi K, Yamori T, Dan S, Shiina I, Sugawara F.

Bioorg Med Chem. 2015 Sep 15;23(18):6118-24. doi: 10.1016/j.bmc.2015.08.001. Epub 2015 Aug 5.

PMID:
26314924
15.

Isolation and structure of vanitaracin A, a novel anti-hepatitis B virus compound from Talaromyces sp.

Matsunaga H, Kamisuki S, Kaneko M, Yamaguchi Y, Takeuchi T, Watashi K, Sugawara F.

Bioorg Med Chem Lett. 2015 Oct 1;25(19):4325-8. doi: 10.1016/j.bmcl.2015.07.067. Epub 2015 Jul 26.

16.

Inhibition of hypoxia-inducible factor via upregulation of von Hippel-Lindau protein induces "angiogenic switch off" in a hepatoma mouse model.

Iwamoto H, Nakamura T, Koga H, Izaguirre-Carbonell J, Kamisuki S, Sugawara F, Abe M, Iwabata K, Ikezono Y, Sakaue T, Masuda A, Yano H, Ohta K, Nakano M, Shimose S, Shirono T, Torimura T.

Mol Ther Oncolytics. 2015 Dec 2;2:15020. doi: 10.1038/mto.2015.20. eCollection 2015.

17.

Multimodal biopanning of T7 phage-displayed peptides reveals angiomotin as a potential receptor of the anti-angiogenic macrolide Roxithromycin.

Takakusagi K, Takakusagi Y, Suzuki T, Toizaki A, Suzuki A, Kawakatsu Y, Watanabe M, Saito Y, Fukuda R, Nakazaki A, Kobayashi S, Sakaguchi K, Sugawara F.

Eur J Med Chem. 2015 Jan 27;90:809-21. doi: 10.1016/j.ejmech.2014.12.015. Epub 2014 Dec 12.

PMID:
25528335
18.

Promotion of crystalline cellulose degradation by expansins from Oryza sativa.

Seki Y, Kikuchi Y, Yoshimoto R, Aburai K, Kanai Y, Ruike T, Iwabata K, Goitsuka R, Sugawara F, Abe M, Sakaguchi K.

Planta. 2015 Jan;241(1):83-93. doi: 10.1007/s00425-014-2163-6. Epub 2014 Sep 14.

PMID:
25218793
19.

EpsinR, a target for pyrenocine B, role in endogenous MHC-II-restricted antigen presentation.

Shishido T, Hachisuka M, Ryuzaki K, Miura Y, Tanabe A, Tamura Y, Kusayanagi T, Takeuchi T, Kamisuki S, Sugawara F, Sahara H.

Eur J Immunol. 2014 Nov;44(11):3220-31. doi: 10.1002/eji.201444475. Epub 2014 Oct 30.

20.

Bioactive dihydronaphthoquinone derivatives from Fusarium solani.

Takemoto K, Kamisuki S, Chia PT, Kuriyama I, Mizushina Y, Sugawara F.

J Nat Prod. 2014 Sep 26;77(9):1992-6. doi: 10.1021/np500175j. Epub 2014 Aug 28.

PMID:
25163667
21.

Inhibition of mammalian DNA polymerases and the suppression of inflammatory and allergic responses by tyrosol from used activated charcoal waste generated during sake production.

Mizushina Y, Ogawa Y, Onodera T, Kuriyama I, Sakamoto Y, Nishikori S, Kamisuki S, Sugawara F.

J Agric Food Chem. 2014 Aug 6;62(31):7779-86. doi: 10.1021/jf502095p. Epub 2014 Jul 28.

PMID:
25029297
22.

Cytotoxic alkylated hydroquinone, phenol, and cyclohexenone derivatives from Aspergillus violaceofuscus Gasperini.

Myobatake Y, Takemoto K, Kamisuki S, Inoue N, Takasaki A, Takeuchi T, Mizushina Y, Sugawara F.

J Nat Prod. 2014 May 23;77(5):1236-40. doi: 10.1021/np401017g. Epub 2014 May 1.

PMID:
24786915
23.

Formosusin A, a novel specific inhibitor of mammalian DNA polymerase β from the fungus Paecilomyces formosus.

Mizushina Y, Suzuki-Fukudome H, Takeuchi T, Takemoto K, Kuriyama I, Yoshida H, Kamisuki S, Sugawara F.

Bioorg Med Chem. 2014 Feb 1;22(3):1070-6. doi: 10.1016/j.bmc.2013.12.038. Epub 2013 Dec 25.

PMID:
24411199
24.

Total synthesis and anti-hepatitis C virus activity of MA026.

Shimura S, Ishima M, Nakajima S, Fujii T, Himeno N, Ikeda K, Izaguirre-Carbonell J, Murata H, Takeuchi T, Kamisuki S, Suzuki T, Kuramochi K, Watashi K, Kobayashi S, Sugawara F.

J Am Chem Soc. 2013 Dec 18;135(50):18949-56. doi: 10.1021/ja410145x. Epub 2013 Dec 6.

PMID:
24251365
25.

Specific inhibition of hepatitis C virus entry into host hepatocytes by fungi-derived sulochrin and its derivatives.

Nakajima S, Watashi K, Kamisuki S, Tsukuda S, Takemoto K, Matsuda M, Suzuki R, Aizaki H, Sugawara F, Wakita T.

Biochem Biophys Res Commun. 2013 Nov 1;440(4):515-20. doi: 10.1016/j.bbrc.2013.09.100. Epub 2013 Oct 5.

PMID:
24099774
26.

Synthesis, structure, and cytotoxicity studies of some fungal isochromanes.

Kuramochi K, Tsubaki K, Kuriyama I, Mizushina Y, Yoshida H, Takeuchi T, Kamisuki S, Sugawara F, Kobayashi S.

J Nat Prod. 2013 Sep 27;76(9):1737-45. doi: 10.1021/np400460m. Epub 2013 Sep 13.

PMID:
24033077
27.

A eukaryotic molecular target candidate of roxithromycin: fungal differentiation as a sensitive drug target analysis system.

Ishii A, Kumasaka M, Nagashima Y, Nakajima Y, Kuramochi K, Sugawara F, Narukawa M, Kamakura T.

Biosci Biotechnol Biochem. 2013;77(7):1539-47. Epub 2013 Jul 7.

28.

Inhibitory effects of low molecular weight polyphenolics from Inonotus obliquus on human DNA topoisomerase activity and cancer cell proliferation.

Kuriyama I, Nakajima Y, Nishida H, Konishi T, Takeuchi T, Sugawara F, Yoshida H, Mizushina Y.

Mol Med Rep. 2013 Aug;8(2):535-42. doi: 10.3892/mmr.2013.1547. Epub 2013 Jun 25.

PMID:
23799608
29.

Identification and characterization of the direct interaction between methotrexate (MTX) and high-mobility group box 1 (HMGB1) protein.

Kuroiwa Y, Takakusagi Y, Kusayanagi T, Kuramochi K, Imai T, Hirayama T, Ito I, Yoshida M, Sakaguchi K, Sugawara F.

PLoS One. 2013 May 3;8(5):e63073. doi: 10.1371/journal.pone.0063073. Print 2013.

30.

Mapping a disordered portion of the Brz2001-binding site on a plant monooxygenase, DWARF4, using a quartz-crystal microbalance biosensor-based T7 phage display.

Takakusagi Y, Manita D, Kusayanagi T, Izaguirre-Carbonell J, Takakusagi K, Kuramochi K, Iwabata K, Kanai Y, Sakaguchi K, Sugawara F.

Assay Drug Dev Technol. 2013 Apr;11(3):206-15. doi: 10.1089/adt.2012.478. Epub 2013 Mar 20.

PMID:
23514038
31.

Ridaifen B, a tamoxifen derivative, directly binds to Grb10 interacting GYF protein 2.

Tsukuda S, Kusayanagi T, Umeda E, Watanabe C, Tosaki YT, Kamisuki S, Takeuchi T, Takakusagi Y, Shiina I, Sugawara F.

Bioorg Med Chem. 2013 Jan 1;21(1):311-20. doi: 10.1016/j.bmc.2012.10.037. Epub 2012 Oct 29.

PMID:
23199482
32.

The antitumor agent doxorubicin binds to Fanconi anemia group F protein.

Kusayanagi T, Tsukuda S, Shimura S, Manita D, Iwakiri K, Kamisuki S, Takakusagi Y, Takeuchi T, Kuramochi K, Nakazaki A, Sakaguchi K, Kobayashi S, Sugawara F.

Bioorg Med Chem. 2012 Nov 1;20(21):6248-55. doi: 10.1016/j.bmc.2012.09.015. Epub 2012 Sep 16.

PMID:
23026082
33.

Total synthesis of (+)-Sch 725680: inhibitor of mammalian A-, B-, and Y-family DNA polymerases.

Takeuchi T, Mizushina Y, Takaichi S, Inoue N, Kuramochi K, Shimura S, Myobatake Y, Katayama Y, Takemoto K, Endo S, Kamisuki S, Sugawara F.

Org Lett. 2012 Sep 7;14(17):4303-5. Epub 2012 Aug 28.

PMID:
22928597
34.

Anti-cancer targeting telomerase inhibitors: β-rubromycin and oleic acid.

Mizushina Y, Takeuchi T, Sugawara F, Yoshida H.

Mini Rev Med Chem. 2012 Oct;12(11):1135-43. Review.

PMID:
22876944
35.

Bicarbonate plays a critical role in the generation of cytotoxicity during SIN-1 decomposition in culture medium.

Shirai K, Okada T, Konishi K, Murata H, Akashi S, Sugawara F, Watanabe N, Arai T.

Oxid Med Cell Longev. 2012;2012:326731. doi: 10.1155/2012/326731. Epub 2012 Jul 9.

36.

Neoechinulin a imparts resistance to acute nitrosative stress in PC12 cells: a potential link of an elevated cellular reserve capacity for pyridine nucleotide redox turnover with cytoprotection.

Akashi S, Shirai K, Okada T, Konishi K, Takeuchi T, Kuramochi K, Takahashi M, Nakagawa T, Ogura Y, Fujieda S, Shibata Y, Sugawara F, Kobayashi S, Watanabe N, Arai T.

Biol Pharm Bull. 2012;35(7):1105-17.

37.

Exploration of the binding proteins of perfluorooctane sulfonate by a T7 phage display screen.

Miyano Y, Tsukuda S, Sakimoto I, Takeuchi R, Shimura S, Takahashi N, Kusayanagi T, Takakusagi Y, Okado M, Matsumoto Y, Takakusagi K, Takeuchi T, Kamisuki S, Nakazaki A, Ohta K, Miura M, Kuramochi K, Mizushina Y, Kobayashi S, Sugawara F, Sakaguchi K.

Bioorg Med Chem. 2012 Jul 1;20(13):3985-90. doi: 10.1016/j.bmc.2012.05.016. Epub 2012 May 15.

PMID:
22658539
38.

Anti-angiogenesis effect of 3'-sulfoquinovosyl-1'-monoacylglycerol via upregulation of thrombospondin 1.

Matsuki K, Tanabe A, Hongo A, Sugawara F, Sakaguchi K, Takahashi N, Sato N, Sahara H.

Cancer Sci. 2012 Aug;103(8):1546-52. doi: 10.1111/j.1349-7006.2012.02333.x. Epub 2012 Jun 20.

39.

Pinophilins A and B, inhibitors of mammalian A-, B-, and Y-family DNA polymerases and human cancer cell proliferation.

Myobatake Y, Takeuchi T, Kuramochi K, Kuriyama I, Ishido T, Hirano K, Sugawara F, Yoshida H, Mizushina Y.

J Nat Prod. 2012 Feb 24;75(2):135-41. doi: 10.1021/np200523b. Epub 2012 Jan 20.

PMID:
22264170
40.

Camptothecin (CPT) directly binds to human heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) and inhibits the hnRNP A1/topoisomerase I interaction.

Manita D, Toba Y, Takakusagi Y, Matsumoto Y, Kusayanagi T, Takakusagi K, Tsukuda S, Takada K, Kanai Y, Kamisuki S, Sakaguchi K, Sugawara F.

Bioorg Med Chem. 2011 Dec 15;19(24):7690-7. doi: 10.1016/j.bmc.2011.09.059. Epub 2011 Oct 5.

PMID:
22071521
41.

Characterization of marine X-family DNA polymerases and comparative analysis of base excision repair proteins.

Kodera H, Takeuchi R, Uchiyama Y, Takakusagi Y, Iwabata K, Miwa H, Hanzawa N, Sugawara F, Sakaguchi K.

Biochem Biophys Res Commun. 2011 Nov 11;415(1):193-9. doi: 10.1016/j.bbrc.2011.10.058. Epub 2011 Oct 18.

PMID:
22033415
42.

Screening of a library of T7 phage-displayed peptides identifies alphaC helix in 14-3-3 protein as a CBP501-binding site.

Matsumoto Y, Shindo Y, Takakusagi Y, Takakusagi K, Tsukuda S, Kusayanagi T, Sato H, Kawabe T, Sugawara F, Sakaguchi K.

Bioorg Med Chem. 2011 Dec 1;19(23):7049-56. doi: 10.1016/j.bmc.2011.10.004. Epub 2011 Oct 7.

PMID:
22032894
43.

Transformation of thiols to disulfides by epolactaene and its derivatives.

Kuramochi K, Sunoki T, Tsubaki K, Mizushina Y, Sakaguchi K, Sugawara F, Ikekita M, Kobayashi S.

Bioorg Med Chem. 2011 Jul 15;19(14):4162-72. doi: 10.1016/j.bmc.2011.06.015. Epub 2011 Jun 13.

PMID:
21708466
44.

A screening of a library of T7 phage-displayed peptide identifies E2F-4 as an etoposide-binding protein.

Takami M, Takakusagi Y, Kuramochi K, Tsukuda S, Aoki S, Morohashi K, Ohta K, Kobayashi S, Sakaguchi K, Sugawara F.

Molecules. 2011 May 24;16(5):4278-94. doi: 10.3390/molecules16054278.

45.

Cyclosporin A associated helicase-like protein facilitates the association of hepatitis C virus RNA polymerase with its cellular cyclophilin B.

Morohashi K, Sahara H, Watashi K, Iwabata K, Sunoki T, Kuramochi K, Takakusagi K, Miyashita H, Sato N, Tanabe A, Shimotohno K, Kobayashi S, Sakaguchi K, Sugawara F.

PLoS One. 2011 Apr 29;6(4):e18285. doi: 10.1371/journal.pone.0018285.

46.

Neoechinulin a impedes the progression of rotenone-induced cytotoxicity in PC12 cells.

Akashi S, Kimura T, Takeuchi T, Kuramochi K, Kobayashi S, Sugawara F, Watanabe N, Arai T.

Biol Pharm Bull. 2011;34(2):243-8.

47.

Inhibitory effect of somatostatin Peptide analogues on DNA polymerase activity and human cancer cell proliferation.

Kuriyama I, Miyazaki A, Tsuda Y, Yokoi T, Okada Y, Takeuchi T, Sugawara F, Yoshida H, Mizushina Y.

Anticancer Res. 2010 Dec;30(12):4841-9.

PMID:
21187461
48.

Remodeling of the tumor microenvironment by combined treatment with a novel radiosensitizer, {alpha}-sulfoquinovosylmonoacylglycerol ({alpha}-SQMG) and X-irradiation.

Ohta K, Murata H, Mori Y, Ishima M, Sugawara F, Sakaguchi K, Miura M.

Anticancer Res. 2010 Nov;30(11):4397-404.

PMID:
21115885
49.

β-Sitosteryl (6'-O-linoleoyl)-glucoside of soybean (Glycine max L.) crude extract inhibits Y-family DNA polymerases.

Horie S, Okuda C, Yamashita T, Watanabe K, Sato Y, Yamaguchi Y, Takeuchi T, Sugawara F, Yoshida H, Mizushina Y.

J Oleo Sci. 2010;59(11):621-30.

50.

Inhibitory effects of docosyl p-coumarate on DNA topoisomerase activity and human cancer cell growth.

Mizushina Y, Nishimura K, Takenaka Y, Takeuchi T, Sugawara F, Yoshida H, Tanahashi T.

Int J Oncol. 2010 Oct;37(4):993-1000.

PMID:
20811721

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