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Items: 1 to 50 of 104

1.

Hypotonic Stress-induced Down-regulation of Claudin-1 and -2 Mediated by Dephosphorylation and Clathrin-dependent Endocytosis in Renal Tubular Epithelial Cells.

Fujii N, Matsuo Y, Matsunaga T, Endo S, Sakai H, Yamaguchi M, Yamazaki Y, Sugatani J, Ikari A.

J Biol Chem. 2016 Nov 18;291(47):24787-24799. Epub 2016 Oct 12.

2.

Claudin-18 inhibits cell proliferation and motility mediated by inhibition of phosphorylation of PDK1 and Akt in human lung adenocarcinoma A549 cells.

Shimobaba S, Taga S, Akizuki R, Hichino A, Endo S, Matsunaga T, Watanabe R, Yamaguchi M, Yamazaki Y, Sugatani J, Ikari A.

Biochim Biophys Acta. 2016 Jun;1863(6 Pt A):1170-8. doi: 10.1016/j.bbamcr.2016.02.015. Epub 2016 Feb 24.

3.

Threonine-408 Regulates the Stability of Human Pregnane X Receptor through Its Phosphorylation and the CHIP/Chaperone-Autophagy Pathway.

Sugatani J, Noguchi Y, Hattori Y, Yamaguchi M, Yamazaki Y, Ikari A.

Drug Metab Dispos. 2016 Jan;44(1):137-50. doi: 10.1124/dmd.115.066308. Epub 2015 Nov 3.

PMID:
26534988
4.

Clathrin-dependent endocytosis of claudin-2 by DFYSP peptide causes lysosomal damage in lung adenocarcinoma A549 cells.

Ikari A, Taga S, Watanabe R, Sato T, Shimobaba S, Sonoki H, Endo S, Matsunaga T, Sakai H, Yamaguchi M, Yamazaki Y, Sugatani J.

Biochim Biophys Acta. 2015 Oct;1848(10 Pt A):2326-36. doi: 10.1016/j.bbamem.2015.07.003. Epub 2015 Jul 8.

5.

Quercetin Decreases Claudin-2 Expression Mediated by Up-Regulation of microRNA miR-16 in Lung Adenocarcinoma A549 Cells.

Sonoki H, Sato T, Endo S, Matsunaga T, Yamaguchi M, Yamazaki Y, Sugatani J, Ikari A.

Nutrients. 2015 Jun 8;7(6):4578-92. doi: 10.3390/nu7064578.

6.

Involvement of a cyclic adenosine monophosphate-dependent signal in the diet-induced canalicular trafficking of adenosine triphosphate-binding cassette transporter g5/g8.

Yamazaki Y, Yasui K, Hashizume T, Suto A, Mori A, Murata Y, Yamaguchi M, Ikari A, Sugatani J.

Hepatology. 2015 Oct;62(4):1215-26. doi: 10.1002/hep.27914. Epub 2015 Jun 30.

PMID:
25999152
7.

Hyperosmolarity-Induced Down-Regulation of Claudin-2 Mediated by Decrease in PKCĪ²-Dependent GATA-2 in MDCK Cells.

Ikari A, Fujii N, Hahakabe S, Hayashi H, Yamaguchi M, Yamazaki Y, Endo S, Matsunaga T, Sugatani J.

J Cell Physiol. 2015 Nov;230(11):2776-87. doi: 10.1002/jcp.25004.

PMID:
25825272
8.

A platelet-activating factor (PAF) receptor deficiency exacerbates diet-induced obesity but PAF/PAF receptor signaling does not contribute to the development of obesity-induced chronic inflammation.

Yamaguchi M, Matsui M, Higa R, Yamazaki Y, Ikari A, Miyake M, Miwa M, Ishii S, Sugatani J, Shimizu T.

Biochem Pharmacol. 2015 Feb 15;93(4):482-95. doi: 10.1016/j.bcp.2014.12.022. Epub 2015 Jan 8.

PMID:
25577975
9.

Threonine-290 regulates nuclear translocation of the human pregnane X receptor through its phosphorylation/dephosphorylation by Ca2+/calmodulin-dependent protein kinase II and protein phosphatase 1.

Sugatani J, Hattori Y, Noguchi Y, Yamaguchi M, Yamazaki Y, Ikari A.

Drug Metab Dispos. 2014 Oct;42(10):1708-18. doi: 10.1124/dmd.114.059139. Epub 2014 Jul 29.

PMID:
25074870
10.

Nuclear distribution of claudin-2 increases cell proliferation in human lung adenocarcinoma cells.

Ikari A, Watanabe R, Sato T, Taga S, Shimobaba S, Yamaguchi M, Yamazaki Y, Endo S, Matsunaga T, Sugatani J.

Biochim Biophys Acta. 2014 Sep;1843(9):2079-88. doi: 10.1016/j.bbamcr.2014.05.017. Epub 2014 Jun 4.

11.

Tight junctional localization of claudin-16 is regulated by syntaxin 8 in renal tubular epithelial cells.

Ikari A, Tonegawa C, Sanada A, Kimura T, Sakai H, Hayashi H, Hasegawa H, Yamaguchi M, Yamazaki Y, Endo S, Matsunaga T, Sugatani J.

J Biol Chem. 2014 May 9;289(19):13112-23. doi: 10.1074/jbc.M113.541193. Epub 2014 Mar 21.

12.

Antiobese function of platelet-activating factor: increased adiposity in platelet-activating factor receptor-deficient mice with age.

Sugatani J, Sadamitsu S, Yamaguchi M, Yamazaki Y, Higa R, Hattori Y, Uchida T, Ikari A, Sugiyama W, Watanabe T, Ishii S, Miwa M, Shimizu T.

FASEB J. 2014 Jan;28(1):440-52. doi: 10.1096/fj.13-233262. Epub 2013 Oct 7.

PMID:
24100020
13.

A Penicillium sp. F33 metabolite and its synthetic derivatives inhibit acetyl-CoA:1-O-alkyl-sn-glycero-3-phosphocholine acetyltransferase (a key enzyme in platelet-activating factor biosynthesis) and carrageenan-induced paw edema in mice.

Yamazaki Y, Yasuda K, Matsuyama T, Ishihara T, Higa R, Sawairi T, Yamaguchi M, Egi M, Akai S, Miyase T, Ikari A, Miwa M, Sugatani J.

Biochem Pharmacol. 2013 Sep 1;86(5):632-44. doi: 10.1016/j.bcp.2013.06.021. Epub 2013 Jun 28.

PMID:
23817078
14.

Hyperosmolarity-induced up-regulation of claudin-4 mediated by NADPH oxidase-dependent H2O2 production and Sp1/c-Jun cooperation.

Ikari A, Atomi K, Yamazaki Y, Sakai H, Hayashi H, Yamaguchi M, Sugatani J.

Biochim Biophys Acta. 2013 Dec;1833(12):2617-2627. doi: 10.1016/j.bbamcr.2013.06.016. Epub 2013 Jun 29.

15.

Function, genetic polymorphism, and transcriptional regulation of human UDP-glucuronosyltransferase (UGT) 1A1.

Sugatani J.

Drug Metab Pharmacokinet. 2013;28(2):83-92. Epub 2012 Oct 23. Review.

16.

Regulation of pregnane X receptor (PXR) function and UGT1A1 gene expression by posttranslational modification of PXR protein.

Sugatani J, Uchida T, Kurosawa M, Yamaguchi M, Yamazaki Y, Ikari A, Miwa M.

Drug Metab Dispos. 2012 Oct;40(10):2031-40. doi: 10.1124/dmd.112.046748. Epub 2012 Jul 24.

PMID:
22829544
17.

Increase in claudin-2 expression by an EGFR/MEK/ERK/c-Fos pathway in lung adenocarcinoma A549 cells.

Ikari A, Sato T, Watanabe R, Yamazaki Y, Sugatani J.

Biochim Biophys Acta. 2012 Jun;1823(6):1110-8. doi: 10.1016/j.bbamcr.2012.04.005. Epub 2012 Apr 24.

18.

Effects of dietary inulin, statin, and their co-treatment on hyperlipidemia, hepatic steatosis and changes in drug-metabolizing enzymes in rats fed a high-fat and high-sucrose diet.

Sugatani J, Sadamitsu S, Wada T, Yamazaki Y, Ikari A, Miwa M.

Nutr Metab (Lond). 2012 Mar 27;9(1):23. doi: 10.1186/1743-7075-9-23.

19.

Enhancement of cell-cell contact by claudin-4 in renal epithelial Madin-Darby canine kidney cells.

Ikari A, Atomi K, Takiguchi A, Yamazaki Y, Hayashi H, Hirakawa J, Sugatani J.

J Cell Biochem. 2012 Feb;113(2):499-507. doi: 10.1002/jcb.23373.

PMID:
21938738
20.

Magnesium deficiency suppresses cell cycle progression mediated by increase in transcriptional activity of p21(Cip1) and p27(Kip1) in renal epithelial NRK-52E cells.

Ikari A, Sawada H, Sanada A, Tonegawa C, Yamazaki Y, Sugatani J.

J Cell Biochem. 2011 Dec;112(12):3563-72. doi: 10.1002/jcb.23284.

PMID:
21780161
21.

Epidermal growth factor increases clathrin-dependent endocytosis and degradation of claudin-2 protein in MDCK II cells.

Ikari A, Takiguchi A, Atomi K, Sugatani J.

J Cell Physiol. 2011 Sep;226(9):2448-56. doi: 10.1002/jcp.22590.

PMID:
21660968
22.

Diet-induced lipid accumulation in liver enhances ATP-binding cassette transporter g5/g8 expression in bile canaliculi.

Yamazaki Y, Hashizume T, Morioka H, Sadamitsu S, Ikari A, Miwa M, Sugatani J.

Drug Metab Pharmacokinet. 2011;26(5):442-50. Epub 2011 May 31.

23.

Claudin-2 knockdown decreases matrix metalloproteinase-9 activity and cell migration via suppression of nuclear Sp1 in A549 cells.

Ikari A, Sato T, Takiguchi A, Atomi K, Yamazaki Y, Sugatani J.

Life Sci. 2011 Mar 28;88(13-14):628-33. doi: 10.1016/j.lfs.2011.02.002. Epub 2011 Feb 18.

PMID:
21315735
24.

Decrease in transient receptor potential melastatin 6 mRNA stability caused by rapamycin in renal tubular epithelial cells.

Ikari A, Sanada A, Sawada H, Okude C, Tonegawa C, Sugatani J.

Biochim Biophys Acta. 2011 Jun;1808(6):1502-8. doi: 10.1016/j.bbamem.2010.11.006. Epub 2010 Nov 10.

25.

Decrease in claudin-2 expression enhances cell migration in renal epithelial Madin-Darby canine kidney cells.

Ikari A, Takiguchi A, Atomi K, Sato T, Sugatani J.

J Cell Physiol. 2011 Jun;226(6):1471-8. doi: 10.1002/jcp.22386.

PMID:
20717932
26.

Nutritional status affects fluvastatin-induced hepatotoxicity and myopathy in rats.

Sugatani J, Sadamitsu S, Kurosawa M, Ikushiro S, Sakaki T, Ikari A, Miwa M.

Drug Metab Dispos. 2010 Oct;38(10):1655-64. doi: 10.1124/dmd.110.034090. Epub 2010 Jun 29.

PMID:
20587623
27.

Magnesium deprivation inhibits a MEK-ERK cascade and cell proliferation in renal epithelial Madin-Darby canine kidney cells.

Ikari A, Atomi K, Kinjo K, Sasaki Y, Sugatani J.

Life Sci. 2010 May 8;86(19-20):766-73. doi: 10.1016/j.lfs.2010.03.016. Epub 2010 Mar 22.

PMID:
20338184
28.

Up-regulation of TRPM6 transcriptional activity by AP-1 in renal epithelial cells.

Ikari A, Sanada A, Okude C, Sawada H, Yamazaki Y, Sugatani J, Miwa M.

J Cell Physiol. 2010 Mar;222(3):481-7. doi: 10.1002/jcp.21988.

PMID:
19937979
29.

Extracellular Mg(2+) regulates the tight junctional localization of claudin-16 mediated by ERK-dependent phosphorylation.

Ikari A, Kinjo K, Atomi K, Sasaki Y, Yamazaki Y, Sugatani J.

Biochim Biophys Acta. 2010 Mar;1798(3):415-21. doi: 10.1016/j.bbamem.2009.11.005. Epub 2009 Nov 13.

30.

Induction of UGT1A1 and CYP2B6 by an antimitogenic factor in HepG2 cells is mediated through suppression of cyclin-dependent kinase 2 activity: cell cycle-dependent expression.

Sugatani J, Osabe M, Kurosawa M, Kitamura N, Ikari A, Miwa M.

Drug Metab Dispos. 2010 Jan;38(1):177-86. doi: 10.1124/dmd.109.029785.

PMID:
19797611
31.

Epidermal growth factor increases claudin-4 expression mediated by Sp1 elevation in MDCK cells.

Ikari A, Atomi K, Takiguchi A, Yamazaki Y, Miwa M, Sugatani J.

Biochem Biophys Res Commun. 2009 Jul 3;384(3):306-10. doi: 10.1016/j.bbrc.2009.04.120. Epub 2009 May 3.

PMID:
19409881
32.

Up-regulation of CAR expression through Elk-1 in HepG2 and SW480 cells by serum starvation stress.

Osabe M, Sugatani J, Takemura A, Kurosawa M, Yamazaki Y, Ikari A, Miwa M.

FEBS Lett. 2009 Mar 4;583(5):885-9. doi: 10.1016/j.febslet.2009.01.051. Epub 2009 Feb 6.

33.

Comparison of enzymatically synthesized inulin, resistant maltodextrin and clofibrate effects on biomarkers of metabolic disease in rats fed a high-fat and high-sucrose (cafeteria) diet.

Sugatani J, Osabe M, Wada T, Yamakawa K, Yamazaki Y, Takahashi T, Ikari A, Miwa M.

Eur J Nutr. 2008 Jun;47(4):192-200. doi: 10.1007/s00394-008-0713-z. Epub 2008 Jun 16.

PMID:
18560790
34.

TRPM6 expression and cell proliferation are up-regulated by phosphorylation of ERK1/2 in renal epithelial cells.

Ikari A, Okude C, Sawada H, Yamazaki Y, Sugatani J, Miwa M.

Biochem Biophys Res Commun. 2008 May 16;369(4):1129-33. doi: 10.1016/j.bbrc.2008.03.002. Epub 2008 Mar 11.

PMID:
18339311
35.

Expression of CAR in SW480 and HepG2 cells during G1 is associated with cell proliferation.

Osabe M, Sugatani J, Takemura A, Yamazaki Y, Ikari A, Kitamura N, Negishi M, Miwa M.

Biochem Biophys Res Commun. 2008 May 16;369(4):1027-33. doi: 10.1016/j.bbrc.2008.02.140. Epub 2008 Mar 10.

PMID:
18331826
36.

Surface localization of the nuclear receptor CAR in influenza A virus-infected cells.

Takahashi T, Moriyama Y, Ikari A, Sugatani J, Suzuki T, Miwa M.

Biochem Biophys Res Commun. 2008 Apr 11;368(3):550-5. doi: 10.1016/j.bbrc.2008.01.145. Epub 2008 Feb 7.

PMID:
18261975
37.

PPP1R16A, the membrane subunit of protein phosphatase 1beta, signals nuclear translocation of the nuclear receptor constitutive active/androstane receptor.

Sueyoshi T, Moore R, Sugatani J, Matsumura Y, Negishi M.

Mol Pharmacol. 2008 Apr;73(4):1113-21. doi: 10.1124/mol.107.042960. Epub 2008 Jan 17.

PMID:
18202305
38.

Transcriptional regulation of human UGT1A1 gene expression through distal and proximal promoter motifs: implication of defects in the UGT1A1 gene promoter.

Sugatani J, Mizushima K, Osabe M, Yamakawa K, Kakizaki S, Takagi H, Mori M, Ikari A, Miwa M.

Naunyn Schmiedebergs Arch Pharmacol. 2008 Jun;377(4-6):597-605. doi: 10.1007/s00210-007-0226-y. Epub 2008 Jan 3.

PMID:
18172616
39.

Down-regulation of TRPM6-mediated magnesium influx by cyclosporin A.

Ikari A, Okude C, Sawada H, Takahashi T, Sugatani J, Miwa M.

Naunyn Schmiedebergs Arch Pharmacol. 2008 Jun;377(4-6):333-43. Epub 2007 Nov 17.

PMID:
18026717
40.

Activation of a polyvalent cation-sensing receptor decreases magnesium transport via claudin-16.

Ikari A, Okude C, Sawada H, Sasaki Y, Yamazaki Y, Sugatani J, Degawa M, Miwa M.

Biochim Biophys Acta. 2008 Jan;1778(1):283-90. Epub 2007 Oct 12.

42.

Claudin-16 is directly phosphorylated by protein kinase A independently of a vasodilator-stimulated phosphoprotein-mediated pathway.

Ikari A, Ito M, Okude C, Sawada H, Harada H, Degawa M, Sakai H, Takahashi T, Sugatani J, Miwa M.

J Cell Physiol. 2008 Jan;214(1):221-9.

PMID:
17559069
43.

Dysfunction of paracellin-1 by dephosphorylation in Dahl salt-sensitive hypertensive rats.

Ikari A, Matsumoto S, Harada H, Takagi K, Degawa M, Takahashi T, Sugatani J, Miwa M.

J Physiol Sci. 2006 Oct;56(5):379-83. Epub 2006 Sep 9.

PMID:
16959063
44.

Changes in the expression of cytochromes P450 and nuclear receptors in the liver of genetically diabetic db/db mice.

Yoshinari K, Takagi S, Sugatani J, Miwa M.

Biol Pharm Bull. 2006 Aug;29(8):1634-8.

46.

Hepatic CYP3A expression is attenuated in obese mice fed a high-fat diet.

Yoshinari K, Takagi S, Yoshimasa T, Sugatani J, Miwa M.

Pharm Res. 2006 Jun;23(6):1188-200. Epub 2006 May 25.

PMID:
16715367
47.

A single nucleotide polymorphism in the plasma PAF acetylhydrolase gene and risk of atherosclerosis in Japanese patients with peripheral artery occlusive disease.

Unno N, Sakaguchi T, Nakamura T, Yamamoto N, Sugatani J, Miwa M, Konno H.

J Surg Res. 2006 Jul;134(1):36-43. Epub 2006 May 2.

PMID:
16650870
48.

Induction of detoxifying enzymes in rodent white adipose tissue by aryl hydrocarbon receptor agonists and antioxidants.

Yoshinari K, Okino N, Sato T, Sugatani J, Miwa M.

Drug Metab Dispos. 2006 Jul;34(7):1081-9. Epub 2006 Mar 31.

PMID:
16581946
49.
50.

A polymorphism in plasma platelet-activating factor acetylhydrolase is involved in resistance to immunoglobulin treatment in Kawasaki disease.

Minami T, Suzuki H, Takeuchi T, Uemura S, Sugatani J, Yoshikawa N.

J Pediatr. 2005 Jul;147(1):78-83.

PMID:
16027700

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