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Rapid Identification of New Delhi Metallo-β-Lactamase (NDM) Using Tryptic Peptides and LC-MS/MS.

Wang H, Strich JR, Drake SK, Chen Y, Youn JH, Rosenberg AZ, Gucek M, Dekker JP, Suffredini AF.

Antimicrob Agents Chemother. 2019 Aug 23;63(9). pii: e00461-19. doi: 10.1128/AAC.00461-19. Print 2019 Sep.


Rapid detection of colistin resistance protein MCR-1 by LC-MS/MS.

Wang H, Chen Y, Strich JR, Drake SK, Youn JH, Rosenberg AZ, Gucek M, McGann PT, Suffredini AF, Dekker JP.

Clin Proteomics. 2019 Feb 26;16:8. doi: 10.1186/s12014-019-9228-2. eCollection 2019.


Identification of the OXA-48 Carbapenemase Family by Use of Tryptic Peptides and Liquid Chromatography-Tandem Mass Spectrometry.

Strich JR, Wang H, Cissé OH, Youn JH, Drake SK, Chen Y, Rosenberg AZ, Gucek M, McGann PT, Dekker JP, Suffredini AF.

J Clin Microbiol. 2019 Apr 26;57(5). pii: e01240-18. doi: 10.1128/JCM.01240-18. Print 2019 May.


Does Obesity Protect Against Death in Sepsis? A Retrospective Cohort Study of 55,038 Adult Patients.

Pepper DJ, Demirkale CY, Sun J, Rhee C, Fram D, Eichacker P, Klompas M, Suffredini AF, Kadri SS.

Crit Care Med. 2019 May;47(5):643-650. doi: 10.1097/CCM.0000000000003692.


Low-dose, short course alteplase treatment of submassive pulmonary embolism: a case series from the National Institutes of Health Clinical Center.

Lozier JN, Elinoff JM, Suffredini AF, Rosing DR, Sidenko S, Sherry RM, Metwalli AR, Sachdev V, Danner RL, Chang R.

Blood Coagul Fibrinolysis. 2018 Dec;29(8):701-707. doi: 10.1097/MBC.0000000000000774.


Difficult-to-Treat Resistance in Gram-negative Bacteremia at 173 US Hospitals: Retrospective Cohort Analysis of Prevalence, Predictors, and Outcome of Resistance to All First-line Agents.

Kadri SS, Adjemian J, Lai YL, Spaulding AB, Ricotta E, Prevots DR, Palmore TN, Rhee C, Klompas M, Dekker JP, Powers JH 3rd, Suffredini AF, Hooper DC, Fridkin S, Danner RL; National Institutes of Health Antimicrobial Resistance Outcomes Research Initiative (NIH–ARORI).

Clin Infect Dis. 2018 Nov 28;67(12):1803-1814. doi: 10.1093/cid/ciy378.


A Role for Hydrocortisone Therapy in Septic Shock?

Suffredini AF.

N Engl J Med. 2018 Mar 1;378(9):860-861. doi: 10.1056/NEJMe1801463. No abstract available.


Body-mass index and all-cause mortality.

Pepper DJ, Sun J, Suffredini AF, Kadri S.

Lancet. 2017 Jun 10;389(10086):2284. doi: 10.1016/S0140-6736(17)31436-8. No abstract available.


A Genoproteomic Approach to Detect Peptide Markers of Bacterial Respiratory Pathogens.

Wang H, Drake SK, Yong C, Gucek M, Lyes MA, Rosenberg AZ, Soderblom E, Arthur Moseley M, Dekker JP, Suffredini AF.

Clin Chem. 2017 Aug;63(8):1398-1408. doi: 10.1373/clinchem.2016.269647. Epub 2017 Jun 6.


Peptide Markers for Rapid Detection of KPC Carbapenemase by LC-MS/MS.

Wang H, Drake SK, Youn JH, Rosenberg AZ, Chen Y, Gucek M, Suffredini AF, Dekker JP.

Sci Rep. 2017 May 31;7(1):2531. doi: 10.1038/s41598-017-02749-2.


Impact of Intravenous Immunoglobulin on Survival in Necrotizing Fasciitis With Vasopressor-Dependent Shock: A Propensity Score-Matched Analysis From 130 US Hospitals.

Kadri SS, Swihart BJ, Bonne SL, Hohmann SF, Hennessy LV, Louras P, Evans HL, Rhee C, Suffredini AF, Hooper DC, Follmann DA, Bulger EM, Danner RL.

Clin Infect Dis. 2017 Apr 1;64(7):877-885. doi: 10.1093/cid/ciw871.


Decreased Rate of Plasma Arginine Appearance in Murine Malaria May Explain Hypoargininemia in Children With Cerebral Malaria.

Alkaitis MS, Wang H, Ikeda AK, Rowley CA, MacCormick IJ, Chertow JH, Billker O, Suffredini AF, Roberts DJ, Taylor TE, Seydel KB, Ackerman HC.

J Infect Dis. 2016 Dec 15;214(12):1840-1849.


Temporal Changes in Microrna Expression in Blood Leukocytes from Patients with the Acute Respiratory Distress Syndrome.

Narute P, Seam N, Tropea M, Logun C, Cai R, Sun J, Shelhamer JH, Meduri GU, Suffredini AF.

Shock. 2017 Jun;47(6):688-695. doi: 10.1097/SHK.0000000000000806.


Estimating Ten-Year Trends in Septic Shock Incidence and Mortality in United States Academic Medical Centers Using Clinical Data.

Kadri SS, Rhee C, Strich JR, Morales MK, Hohmann S, Menchaca J, Suffredini AF, Danner RL, Klompas M.

Chest. 2017 Feb;151(2):278-285. doi: 10.1016/j.chest.2016.07.010. Epub 2016 Jul 22.


Risk Factors for In-Hospital Mortality in Smoke Inhalation-Associated Acute Lung Injury: Data From 68 United States Hospitals.

Kadri SS, Miller AC, Hohmann S, Bonne S, Nielsen C, Wells C, Gruver C, Quraishi SA, Sun J, Cai R, Morris PE, Freeman BD, Holmes JH, Cairns BA, Suffredini AF; US Critical Illness and Injury Trials Group: Smoke Inhalation-associated Acute Lung Injury (SI-ALI) Investigators (USCIIT-SI-ALI).

Chest. 2016 Dec;150(6):1260-1268. doi: 10.1016/j.chest.2016.06.008. Epub 2016 Jun 15.


Increased body mass index and adjusted mortality in ICU patients with sepsis or septic shock: a systematic review and meta-analysis.

Pepper DJ, Sun J, Welsh J, Cui X, Suffredini AF, Eichacker PQ.

Crit Care. 2016 Jun 15;20(1):181. doi: 10.1186/s13054-016-1360-z.


Use of Postexposure Prophylaxis After Occupational Exposure to Zaire ebolavirus.

Wong KK, Davey RT Jr, Hewlett AL, Kraft CS, Mehta AK, Mulligan MJ, Beck A, Dorman W, Kratochvil CJ, Lai L, Palmore TN, Rogers S, Smith PW, Suffredini AF, Wolcott M, Ströher U, Uyeki TM.

Clin Infect Dis. 2016 Aug 1;63(3):376-9. doi: 10.1093/cid/ciw256. Epub 2016 Apr 26.


A Novel Peptidomic Approach to Strain Typing of Clinical Acinetobacter baumannii Isolates Using Mass Spectrometry.

Wang H, Drake SK, Yong C, Gucek M, Tropea M, Rosenberg AZ, Dekker JP, Suffredini AF.

Clin Chem. 2016 Jun;62(6):866-75. doi: 10.1373/clinchem.2015.253468. Epub 2016 Apr 26.


Diagnosing sepsis is subjective and highly variable: a survey of intensivists using case vignettes.

Rhee C, Kadri SS, Danner RL, Suffredini AF, Massaro AF, Kitch BT, Lee G, Klompas M.

Crit Care. 2016 Apr 6;20:89. doi: 10.1186/s13054-016-1266-9.


Severe Meningoencephalitis in a Case of Ebola Virus Disease: A Case Report.

Chertow DS, Nath A, Suffredini AF, Danner RL, Reich DS, Bishop RJ, Childs RW, Arai AE, Palmore TN, Lane HC, Fauci AS, Davey RT.

Ann Intern Med. 2016 Aug 16;165(4):301-4. doi: 10.7326/M15-3066. Epub 2016 Apr 5. No abstract available.


Steroids are part of rescue therapy in ARDS patients with refractory hypoxemia: we are not sure.

Seam N, Suffredini AF.

Intensive Care Med. 2016 May;42(5):924-927. doi: 10.1007/s00134-015-4160-z. Epub 2016 Jan 29. No abstract available.


Identification of Microorganisms by High Resolution Tandem Mass Spectrometry with Accurate Statistical Significance.

Alves G, Wang G, Ogurtsov AY, Drake SK, Gucek M, Suffredini AF, Sacks DB, Yu YK.

J Am Soc Mass Spectrom. 2016 Feb;27(2):194-210. doi: 10.1007/s13361-015-1271-2. Epub 2015 Oct 28.


Caring for Critically Ill Ebola Virus Disease Patients With One Hand Tied Behind Your Back.

Suffredini AF.

Crit Care Med. 2015 Oct;43(10):2249-50. doi: 10.1097/CCM.0000000000001221. No abstract available.



Torabi-Parizi P, Davey RT Jr, Suffredini AF, Chertow DS.

Chest. 2015 Aug;148(2):e65. doi: 10.1378/chest.15-0986. No abstract available.


Inflammatory remodeling of the HDL proteome impairs cholesterol efflux capacity.

Vaisar T, Tang C, Babenko I, Hutchins P, Wimberger J, Suffredini AF, Heinecke JW.

J Lipid Res. 2015 Aug;56(8):1519-30. doi: 10.1194/jlr.M059089. Epub 2015 May 20.


Targeting sirtuin to modulate human inflammation.

Suffredini AF.

Crit Care Med. 2015 Jun;43(6):1348-9. doi: 10.1097/CCM.0000000000001030. No abstract available.


Characteristics and Clinical Management of a Cluster of 3 Patients With Ebola Virus Disease, Including the First Domestically Acquired Cases in the United States.

Liddell AM, Davey RT Jr, Mehta AK, Varkey JB, Kraft CS, Tseggay GK, Badidi O, Faust AC, Brown KV, Suffredini AF, Barrett K, Wolcott MJ, Marconi VC, Lyon GM 3rd, Weinstein GL, Weinmeister K, Sutton S, Hazbun M, Albariño CG, Reed Z, Cannon D, Ströher U, Feldman M, Ribner BS, Lane HC, Fauci AS, Uyeki TM.

Ann Intern Med. 2015 Jul 21;163(2):81-90. doi: 10.7326/M15-0530.


Identification of Helicobacter pylori VacA in human lung and its effects on lung cells.

Nakashima S, Kakugawa T, Yura H, Tomonaga M, Harada T, Hara A, Hara S, Nakano M, Yamasaki E, Sakamoto N, Ishimatsu Y, Isomoto H, Gochuico BR, Suffredini AF, Mukae H, Kurazono H, Hirayama T, Moss J, Kohno S.

Biochem Biophys Res Commun. 2015 May 8;460(3):721-726. doi: 10.1016/j.bbrc.2015.03.096. Epub 2015 Mar 25.


Ethical and practical considerations in providing critical care to patients with Ebola virus disease.

Torabi-Parizi P, Davey RT Jr, Suffredini AF, Chertow DS.

Chest. 2015 Jun;147(6):1460-1466. doi: 10.1378/chest.15-0278.


Emergency postexposure vaccination with vesicular stomatitis virus-vectored Ebola vaccine after needlestick.

Lai L, Davey R, Beck A, Xu Y, Suffredini AF, Palmore T, Kabbani S, Rogers S, Kobinger G, Alimonti J, Link CJ Jr, Rubinson L, Ströher U, Wolcott M, Dorman W, Uyeki TM, Feldmann H, Lane HC, Mulligan MJ.

JAMA. 2015 Mar 24-31;313(12):1249-55. doi: 10.1001/jama.2015.1995.


Is antithrombin treatment of disseminated intravascular coagulation a quixotic goal?

Seam N, Suffredini AF.

Crit Care. 2014 Nov 25;18(6):639. doi: 10.1186/s13054-014-0639-1.


Management of pediatric septic shock. Progress through applied insight.

Kavanagh BP, Suffredini AF.

Am J Respir Crit Care Med. 2015 Feb 1;191(3):247-8. doi: 10.1164/rccm.201412-2299ED. No abstract available.


Correction to "a generic approach to pathological lung segmentation".

Mansoor A, Bagci U, Xu Z, Foster B, Olivier KN, Elinoff JM, Suffredini AF, Udupa JK, Mollura DJ.

IEEE Trans Med Imaging. 2015 Jan;34(1):354. doi: 10.1109/TMI.2014.2384693. No abstract available.


Reply to "Tn4401 carrying blaKPC is inserted within another insertion in pKpQIL and related plasmids".

Lau AF, Wang H, Weingarten RA, Drake SK, Suffredini AF, Chen Y, Gucek M, Youn JH, Stock F, Tso H, DeLeo J, Cimino JJ, Frank KM, Dekker JP.

J Clin Microbiol. 2014 Dec;52(12):4450. doi: 10.1128/JCM.02614-14. No abstract available.


Human endotoxin administration as an experimental model in drug development.

Suffredini AF, Noveck RJ.

Clin Pharmacol Ther. 2014 Oct;96(4):418-22. doi: 10.1038/clpt.2014.146. Review.


Isolation of a circulating CD45-, CD34dim cell population and validation of their endothelial phenotype.

Tropea MM, Harper BJ, Graninger GM, Phillips TM, Ferreyra G, Mostowski HS, Danner RL, Suffredini AF, Solomon MA.

Thromb Haemost. 2014 Oct;112(4):770-80. doi: 10.1160/TH14-01-0043. Epub 2014 Jul 24.


A generic approach to pathological lung segmentation.

Mansoor A, Bagci U, Xu Z, Foster B, Olivier KN, Elinoff JM, Suffredini AF, Udupa JK, Mollura DJ.

IEEE Trans Med Imaging. 2014 Dec;33(12):2293-310. doi: 10.1109/TMI.2014.2337057. Epub 2014 Jul 8. Erratum in: IEEE Trans Med Imaging. 2015 Jan;34(1):354.


Endogenous intrahepatic IFNs and association with IFN-free HCV treatment outcome.

Meissner EG, Wu D, Osinusi A, Bon D, Virtaneva K, Sturdevant D, Porcella S, Wang H, Herrmann E, McHutchison J, Suffredini AF, Polis M, Hewitt S, Prokunina-Olsson L, Masur H, Fauci AS, Kottilil S.

J Clin Invest. 2014 Aug;124(8):3352-63. doi: 10.1172/JCI75938. Epub 2014 Jul 1.


Exploring the boundaries of systemic inflammation*.

Elinoff JM, Suffredini AF.

Crit Care Med. 2014 Jul;42(7):1735-7. doi: 10.1097/CCM.0000000000000365. No abstract available.


Inteleukin-23 promotes interferon-α responsiveness in hepatitis C virus/HIV-coinfected patients.

Odigie M, Osinusi A, Barrett L, Townsend K, Wang H, Suffredini AF, Masur H, Polis MA, Kottilil S.

AIDS Res Hum Retroviruses. 2014 Aug;30(8):775-82. doi: 10.1089/AID.2014.0003. Epub 2014 Jun 30.


A rapid matrix-assisted laser desorption ionization-time of flight mass spectrometry-based method for single-plasmid tracking in an outbreak of carbapenem-resistant Enterobacteriaceae.

Lau AF, Wang H, Weingarten RA, Drake SK, Suffredini AF, Garfield MK, Chen Y, Gucek M, Youn JH, Stock F, Tso H, DeLeo J, Cimino JJ, Frank KM, Dekker JP.

J Clin Microbiol. 2014 Aug;52(8):2804-12. doi: 10.1128/JCM.00694-14. Epub 2014 May 21.


Recombinant human factor VIIa for alveolar hemorrhage following allogeneic stem cell transplantation.

Elinoff JM, Bagci U, Moriyama B, Dreiling JL, Foster B, Gormley NJ, Salit RB, Cai R, Sun J, Beri A, Reda DJ, Fakhrejahani F, Battiwalla M, Baird K, Cuellar-Rodriguez JM, Kang EM, Pavletic SZ, Fowler DH, John Barrett A, Lozier JN, Kleiner DE Jr, Mollura DJ, Childs RW, Suffredini AF.

Biol Blood Marrow Transplant. 2014 Jul;20(7):969-78. doi: 10.1016/j.bbmt.2014.03.015. Epub 2014 Mar 20.


A systematic review and pooled analysis of CPR-associated cardiovascular and thoracic injuries.

Miller AC, Rosati SF, Suffredini AF, Schrump DS.

Resuscitation. 2014 Jun;85(6):724-31. doi: 10.1016/j.resuscitation.2014.01.028. Epub 2014 Feb 10. Review.


Impaired HCV clearance in HIV/HCV coinfected subjects treated with PegIFN and RBV due to interference of IFN signaling by IFNαR2a.

Lee YJ, Zhang X, Vazquez E, Shivasabesan G, Young HA, Murphy A, Wang H, Suffredini AF, Siebenlist U, Kottilil S.

J Interferon Cytokine Res. 2014 Jan;34(1):28-34. doi: 10.1089/jir.2013.0032. Epub 2013 Oct 30.


Inhaled anticoagulation regimens for the treatment of smoke inhalation-associated acute lung injury: a systematic review.

Miller AC, Elamin EM, Suffredini AF.

Crit Care Med. 2014 Feb;42(2):413-9. doi: 10.1097/CCM.0b013e3182a645e5. Review.


Beneficial effects of stress-dose corticosteroid therapy in canines depend on the severity of staphylococcal pneumonia.

Hicks CW, Sweeney DA, Danner RL, Eichacker PQ, Suffredini AF, Feng J, Sun J, Moriyama B, Wesley R, Behrend EN, Solomon SB, Natanson C.

Intensive Care Med. 2012 Dec;38(12):2063-71. doi: 10.1007/s00134-012-2735-5. Epub 2012 Oct 31.


Opportunities in proteomics to understand hepatitis C and HIV coinfection.

Meissner EG, Suffredini AF, Kottilil S.

Future Virol. 2012 Aug;7(8):759-765.


Protein biomarkers in patients with subarachnoid hemorrhage, vasospasm, and delayed ischemic neurological deficits.

Nyquist PA, Wang H, Suffredini AF.

Acta Neurochir Suppl. 2013;115:23-5. doi: 10.1007/978-3-7091-1192-5_6.


An official multi-society statement: the role of clinical research results in the practice of critical care medicine.

Tonelli MR, Curtis JR, Guntupalli KK, Rubenfeld GD, Arroliga AC, Brochard L, Douglas IS, Gutterman DD, Hall JR, Kavanagh BP, Mancebo J, Misak CJ, Simpson SQ, Slutsky AS, Suffredini AF, Thompson BT, Ware LB, Wheeler AP, Levy MM; ACCP/ATS/SCCM Working Group.

Am J Respir Crit Care Med. 2012 May 15;185(10):1117-24. doi: 10.1164/rccm.201204-0638ST.


Automatic detection and quantification of tree-in-bud (TIB) opacities from CT scans.

Bagci U, Yao J, Wu A, Caban J, Palmore TN, Suffredini AF, Aras O, Mollura DJ.

IEEE Trans Biomed Eng. 2012 Jun;59(6):1620-32. doi: 10.1109/TBME.2012.2190984. Epub 2012 Mar 14.

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