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Low flow rate alters haemostatic parameters in an ex-vivo extracorporeal membrane oxygenation circuit.

Ki KK, Passmore MR, Chan CHH, Malfertheiner MV, Fanning JP, Bouquet M, Millar JE, Fraser JF, Suen JY.

Intensive Care Med Exp. 2019 Aug 20;7(1):51. doi: 10.1186/s40635-019-0264-z.


Hurdles to Cardioprotection in the Critically Ill.

See Hoe LE, Bartnikowski N, Wells MA, Suen JY, Fraser JF.

Int J Mol Sci. 2019 Aug 5;20(15). pii: E3823. doi: 10.3390/ijms20153823. Review.


Protease-activated receptor 2 does not contribute to renal inflammation or fibrosis in the obstructed kidney.

Ma FY, Han Y, Ozols E, Chew P, Vesey DA, Gobe GC, Morais C, Lohman RJ, Suen JY, Johnson DW, Fairlie DP, Nikolic-Paterson DJ.

Nephrology (Carlton). 2019 Sep;24(9):983-991. doi: 10.1111/nep.13635. Epub 2019 Jul 31.


In vivo liquid biopsy using Cytophone platform for photoacoustic detection of circulating tumor cells in patients with melanoma.

Galanzha EI, Menyaev YA, Yadem AC, Sarimollaoglu M, Juratli MA, Nedosekin DA, Foster SR, Jamshidi-Parsian A, Siegel ER, Makhoul I, Hutchins LF, Suen JY, Zharov VP.

Sci Transl Med. 2019 Jun 12;11(496). pii: eaat5857. doi: 10.1126/scitranslmed.aat5857. Erratum in: Sci Transl Med. 2019 Sep 18;11(510):.


Travel in city road networks follows similar transport trade-off principles to neural and plant arbors.

Suen JY, Navlakha S.

J R Soc Interface. 2019 May 31;16(154):20190041. doi: 10.1098/rsif.2019.0041.


Mesenchymal stem cells may ameliorate inflammation in an ex vivo model of extracorporeal membrane oxygenation.

von Bahr V, Millar JE, Malfertheiner MV, Ki KK, Passmore MR, Bartnikowski N, Redd MA, Cavaye M, Suen JY, McAuley DF, Fraser JF.

Perfusion. 2019 Apr;34(1_suppl):15-21. doi: 10.1177/0267659119830857.


Effect of ex vivo extracorporeal membrane oxygenation flow dynamics on immune response.

Ki KK, Passmore MR, Chan CHH, Malfertheiner MV, Bouquet M, Cho HJ, Suen JY, Fraser JF.

Perfusion. 2019 Apr;34(1_suppl):5-14. doi: 10.1177/0267659119830012.


Extracorporeal membrane oxygenation (ECMO) and the acute respiratory distress syndrome (ARDS): a systematic review of pre-clinical models.

Millar JE, Bartnikowski N, von Bahr V, Malfertheiner MV, Obonyo NG, Belliato M, Suen JY, Combes A, McAuley DF, Lorusso R, Fraser JF; European Extracorporeal Life Support Organisation (EuroELSO) Innovations Workgroup; National Health Medical Research Council Australia Centre of Research Excellence for Advanced Cardio-respiratory Therapies Improving Organ Support (NHMRC CREACTIONS).

Intensive Care Med Exp. 2019 Mar 25;7(1):18. doi: 10.1186/s40635-019-0232-7. Review.


Pharmacological inhibition of protease-activated receptor-2 reduces crescent formation in rat nephrotoxic serum nephritis.

Han Y, Tian L, Ma F, Tesch G, Vesey DA, Gobe GC, Lohman RJ, Morais C, Suen JY, Fairlie DP, Nikolic-Paterson DJ.

Clin Exp Pharmacol Physiol. 2019 May;46(5):456-464. doi: 10.1111/1440-1681.13077. Epub 2019 Mar 25.


Endothelialized flow models for blood transfusion research.

Ng MSY, Suen JY, Tung JP, Fraser JF.

Haematologica. 2019 Mar;104(3):428-434. doi: 10.3324/haematol.2018.205203. Epub 2019 Feb 14. No abstract available.


Neuron-Specific Enolase and Matrix Metalloproteinase 9 Signal Perioperative Silent Brain Infarction During or After Transcatheter Aortic Valve Implantation.

Fanning JP, See Hoe LE, Passmore MR, Barnett AG, Obonyo NG, Millar JE, Wesley AJ, Suen JY, Fraser JF.

Am J Cardiol. 2019 Feb 1;123(3):434-439. doi: 10.1016/j.amjcard.2018.10.022. Epub 2018 Nov 6.


Inflammation and lung injury in an ovine model of fluid resuscitated endotoxemic shock.

Passmore MR, Byrne L, Obonyo NG, See Hoe LE, Boon AC, Diab SD, Dunster KR, Bisht K, Tung JP, Fauzi MH, Narula M, Pedersen SE, Esguerra-Lallen A, Simonova G, Sultana A, Anstey CM, Shekar K, Maitland K, Suen JY, Fraser JF.

Respir Res. 2018 Nov 22;19(1):231. doi: 10.1186/s12931-018-0935-4.


Noninvasive label-free detection of circulating white and red blood clots in deep vessels with a focused photoacoustic probe.

Juratli MA, Menyaev YA, Sarimollaoglu M, Melerzanov AV, Nedosekin DA, Culp WC, Suen JY, Galanzha EI, Zharov VP.

Biomed Opt Express. 2018 Oct 23;9(11):5667-5677. doi: 10.1364/BOE.9.005667. eCollection 2018 Nov 1.


Estrogen is involved in hemangioma regression associated with mast cells.

Hou F, Dai Y, Fan CY, Suen JY, Richter GT.

Orphanet J Rare Dis. 2018 Oct 19;13(1):181. doi: 10.1186/s13023-018-0928-x.


Cancer patient perspectives regarding preparedness for end-of-life care: A qualitative study.

Sherman AC, Simonton-Atchley S, Mikeal CW, Anderson KM, Arnaoutakis K, Hutchins LF, Makhoul I, Mahmoud F, Milojkovic N, Harrington SE, Suen JY.

J Psychosoc Oncol. 2018 Jul-Aug;36(4):454-469. doi: 10.1080/07347332.2018.1466845. Epub 2018 Jun 4.


Transfusion of packed red blood cells at the end of shelf life is associated with increased risk of mortality - a pooled patient data analysis of 16 observational trials.

Ng MSY, David M, Middelburg RA, Ng ASY, Suen JY, Tung JP, Fraser JF.

Haematologica. 2018 Sep;103(9):1542-1548. doi: 10.3324/haematol.2018.191932. Epub 2018 May 24.


Administration of mesenchymal stem cells during ECMO results in a rapid decline in oxygenator performance.

Millar JE, von Bahr V, Malfertheiner MV, Ki KK, Redd MA, Bartnikowski N, Suen JY, McAuley DF, Fraser JF.

Thorax. 2019 Feb;74(2):194-196. doi: 10.1136/thoraxjnl-2017-211439. Epub 2018 Apr 5.


A Potent Antagonist of Protease-Activated Receptor 2 That Inhibits Multiple Signaling Functions in Human Cancer Cells.

Jiang Y, Yau MK, Lim J, Wu KC, Xu W, Suen JY, Fairlie DP.

J Pharmacol Exp Ther. 2018 Feb;364(2):246-257. doi: 10.1124/jpet.117.245027. Epub 2017 Dec 20.


Arteriovenous Malformations of the Head and Neck.

Rosenberg TL, Suen JY, Richter GT.

Otolaryngol Clin North Am. 2018 Feb;51(1):185-195. doi: 10.1016/j.otc.2017.09.005. Review.


Acquired von Willebrand syndrome in respiratory extracorporeal life support: a systematic review of the literature.

Malfertheiner MV, Pimenta LP, Bahr VV, Millar JE, Obonyo NG, Suen JY, Pellegrino V, Fraser JF.

Crit Care Resusc. 2017 Oct;19(Suppl 1):45-52.


Multiplexed coded time domain sampling with metamaterials.

Nadell CC, Fan K, Suen JY, Padilla WJ.

Opt Express. 2017 Oct 16;25(21):25797-25808. doi: 10.1364/OE.25.025797.


Graphene metamaterial spatial light modulator for infrared single pixel imaging.

Fan K, Suen JY, Padilla WJ.

Opt Express. 2017 Oct 16;25(21):25318-25325. doi: 10.1364/OE.25.025318.


Effects of supramaximal balloon dilatation pressures on adult cricoid and tracheal cartilage: A cadaveric study.

Durvasula VSPB, Shalin SC, Tulunay-Ugur OE, Suen JY, Richter GT.

Laryngoscope. 2018 Jun;128(6):1304-1309. doi: 10.1002/lary.26872. Epub 2017 Oct 8.


Exploiting a novel conformational switch to control innate immunity mediated by complement protein C3a.

Lohman RJ, Hamidon JK, Reid RC, Rowley JA, Yau MK, Halili MA, Nielsen DS, Lim J, Wu KC, Loh Z, Do A, Suen JY, Iyer A, Fairlie DP.

Nat Commun. 2017 Aug 24;8(1):351. doi: 10.1038/s41467-017-00414-w.


Using Inspiration from Synaptic Plasticity Rules to Optimize Traffic Flow in Distributed Engineered Networks.

Suen JY, Navlakha S.

Neural Comput. 2017 May;29(5):1204-1228. doi: 10.1162/NECO_a_00945. Epub 2017 Feb 9.


Biased Signaling by Agonists of Protease Activated Receptor 2.

Jiang Y, Yau MK, Kok WM, Lim J, Wu KC, Liu L, Hill TA, Suen JY, Fairlie DP.

ACS Chem Biol. 2017 May 19;12(5):1217-1226. doi: 10.1021/acschembio.6b01088. Epub 2017 Mar 14.


PAR2 Modulators Derived from GB88.

Yau MK, Liu L, Suen JY, Lim J, Lohman RJ, Jiang Y, Cotterell AJ, Barry GD, Mak JY, Vesey DA, Reid RC, Fairlie DP.

ACS Med Chem Lett. 2016 Oct 10;7(12):1179-1184. eCollection 2016 Dec 8.


Mapping transmembrane residues of proteinase activated receptor 2 (PAR2) that influence ligand-modulated calcium signaling.

Suen JY, Adams MN, Lim J, Madala PK, Xu W, Cotterell AJ, He Y, Yau MK, Hooper JD, Fairlie DP.

Pharmacol Res. 2017 Mar;117:328-342. doi: 10.1016/j.phrs.2016.12.020. Epub 2016 Dec 16.


Real-Time Label-Free Embolus Detection Using In Vivo Photoacoustic Flow Cytometry.

Juratli MA, Menyaev YA, Sarimollaoglu M, Siegel ER, Nedosekin DA, Suen JY, Melerzanov AV, Juratli TA, Galanzha EI, Zharov VP.

PLoS One. 2016 May 26;11(5):e0156269. doi: 10.1371/journal.pone.0156269. eCollection 2016.


Receptor residence time trumps drug-likeness and oral bioavailability in determining efficacy of complement C5a antagonists.

Seow V, Lim J, Cotterell AJ, Yau MK, Xu W, Lohman RJ, Kok WM, Stoermer MJ, Sweet MJ, Reid RC, Suen JY, Fairlie DP.

Sci Rep. 2016 Apr 20;6:24575. doi: 10.1038/srep24575.


Elevated Expression of Matrix Metalloproteinase-9 not Matrix Metalloproteinase-2 Contributes to Progression of Extracranial Arteriovenous Malformation.

Wei T, Zhang H, Cetin N, Miller E, Moak T, Suen JY, Richter GT.

Sci Rep. 2016 Apr 14;6:24378. doi: 10.1038/srep24378.


Potent Small Agonists of Protease Activated Receptor 2.

Yau MK, Suen JY, Xu W, Lim J, Liu L, Adams MN, He Y, Hooper JD, Reid RC, Fairlie DP.

ACS Med Chem Lett. 2015 Nov 30;7(1):105-10. doi: 10.1021/acsmedchemlett.5b00429. eCollection 2016 Jan 14.


Benzylamide antagonists of protease activated receptor 2 with anti-inflammatory activity.

Yau MK, Liu L, Lim J, Lohman RJ, Cotterell AJ, Suen JY, Vesey DA, Reid RC, Fairlie DP.

Bioorg Med Chem Lett. 2016 Feb 1;26(3):986-991. doi: 10.1016/j.bmcl.2015.12.048. Epub 2015 Dec 17.


Dual mTOR inhibitor MLN0128 suppresses Merkel cell carcinoma (MCC) xenograft tumor growth.

Kannan A, Lin Z, Shao Q, Zhao S, Fang B, Moreno MA, Vural E, Stack BC Jr, Suen JY, Kannan K, Gao L.

Oncotarget. 2016 Feb 9;7(6):6576-92. doi: 10.18632/oncotarget.5878.


Potent complement C3a receptor agonists derived from oxazole amino acids: Structure-activity relationships.

Singh R, Reed AN, Chu P, Scully CC, Yau MK, Suen JY, Durek T, Reid RC, Fairlie DP.

Bioorg Med Chem Lett. 2015 Dec 1;25(23):5604-8. doi: 10.1016/j.bmcl.2015.10.038. Epub 2015 Oct 23.


Repurposing Registered Drugs as Antagonists for Protease-Activated Receptor 2.

Xu W, Lim J, Goh CY, Suen JY, Jiang Y, Yau MK, Wu KC, Liu L, Fairlie DP.

J Chem Inf Model. 2015 Oct 26;55(10):2079-84. doi: 10.1021/acs.jcim.5b00500. Epub 2015 Oct 12.


In Vivo Long-Term Monitoring of Circulating Tumor Cells Fluctuation during Medical Interventions.

Juratli MA, Siegel ER, Nedosekin DA, Sarimollaoglu M, Jamshidi-Parsian A, Cai C, Menyaev YA, Suen JY, Galanzha EI, Zharov VP.

PLoS One. 2015 Sep 14;10(9):e0137613. doi: 10.1371/journal.pone.0137613. eCollection 2015.


Comorbidities and factors associated with endoscopic surgical outcomes in adult laryngotracheal stenosis.

Kocdor P, Siegel ER, Suen JY, Richter G, Tulunay-Ugur OE.

Eur Arch Otorhinolaryngol. 2016 Feb;273(2):419-24. doi: 10.1007/s00405-015-3750-2. Epub 2015 Sep 3.


Disruption of BRD4 at H3K27Ac-enriched enhancer region correlates with decreased c-Myc expression in Merkel cell carcinoma.

Sengupta D, Kannan A, Kern M, Moreno MA, Vural E, Stack B Jr, Suen JY, Tackett AJ, Gao L.

Epigenetics. 2015;10(6):460-6. doi: 10.1080/15592294.2015.1034416. Epub 2015 May 5.


Short Hydrophobic Peptides with Cyclic Constraints Are Potent Glucagon-like Peptide-1 Receptor (GLP-1R) Agonists.

Hoang HN, Song K, Hill TA, Derksen DR, Edmonds DJ, Kok WM, Limberakis C, Liras S, Loria PM, Mascitti V, Mathiowetz AM, Mitchell JM, Piotrowski DW, Price DA, Stanton RV, Suen JY, Withka JM, Griffith DA, Fairlie DP.

J Med Chem. 2015 May 14;58(9):4080-5. doi: 10.1021/acs.jmedchem.5b00166. Epub 2015 Apr 16.


BET protein inhibitor JQ1 attenuates Myc-amplified MCC tumor growth in vivo.

Shao Q, Kannan A, Lin Z, Stack BC Jr, Suen JY, Gao L.

Cancer Res. 2014 Dec 1;74(23):7090-102. doi: 10.1158/0008-5472.CAN-14-0305. Epub 2014 Oct 2.


Loss of cytokeratin 20 and acquisition of thyroid transcription factor-1 expression in a merkel cell carcinoma metastasis to the brain.

Shalin SC, Cifarelli CP, Suen JY, Gao L.

Am J Dermatopathol. 2014 Nov;36(11):904-6. doi: 10.1097/DAD.0000000000000124.


Pathway-selective antagonism of proteinase activated receptor 2.

Suen JY, Cotterell A, Lohman RJ, Lim J, Han A, Yau MK, Liu L, Cooper MA, Vesey DA, Fairlie DP.

Br J Pharmacol. 2014 Sep;171(17):4112-24. doi: 10.1111/bph.12757. Epub 2014 Jul 2.


A xenograft animal model of human arteriovenous malformations.

Hou F, Dai Y, Suen JY, Fan C, Saad AG, Richter GT.

Orphanet J Rare Dis. 2013 Dec 30;8:199. doi: 10.1186/1750-1172-8-199.


Biased signalling and proteinase-activated receptors (PARs): targeting inflammatory disease.

Hollenberg MD, Mihara K, Polley D, Suen JY, Han A, Fairlie DP, Ramachandran R.

Br J Pharmacol. 2014 Mar;171(5):1180-94. doi: 10.1111/bph.12544. Review.


Downsizing a human inflammatory protein to a small molecule with equal potency and functionality.

Reid RC, Yau MK, Singh R, Hamidon JK, Reed AN, Chu P, Suen JY, Stoermer MJ, Blakeney JS, Lim J, Faber JM, Fairlie DP.

Nat Commun. 2013;4:2802. doi: 10.1038/ncomms3802.


Inflammatory responses induced by lipopolysaccharide are amplified in primary human monocytes but suppressed in macrophages by complement protein C5a.

Seow V, Lim J, Iyer A, Suen JY, Ariffin JK, Hohenhaus DM, Sweet MJ, Fairlie DP.

J Immunol. 2013 Oct 15;191(8):4308-16. doi: 10.4049/jimmunol.1301355. Epub 2013 Sep 16.


Diet-induced obesity, adipose inflammation, and metabolic dysfunction correlating with PAR2 expression are attenuated by PAR2 antagonism.

Lim J, Iyer A, Liu L, Suen JY, Lohman RJ, Seow V, Yau MK, Brown L, Fairlie DP.

FASEB J. 2013 Dec;27(12):4757-67. doi: 10.1096/fj.13-232702. Epub 2013 Aug 20.


Real-time monitoring of circulating tumor cell release during tumor manipulation using in vivo photoacoustic and fluorescent flow cytometry.

Juratli MA, Sarimollaoglu M, Siegel ER, Nedosekin DA, Galanzha EI, Suen JY, Zharov VP.

Head Neck. 2014 Aug;36(8):1207-15. doi: 10.1002/hed.23439. Epub 2013 Nov 29.


Guidelines for the treatment of head and neck venous malformations.

Zheng JW, Mai HM, Zhang L, Wang YA, Fan XD, Su LX, Qin ZP, Yang YW, Jiang YH, Zhao YF, Suen JY.

Int J Clin Exp Med. 2013 May 22;6(5):377-89. Print 2013.

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