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Items: 1 to 50 of 408

1.

CAPZA1 determines the risk of gastric carcinogenesis by inhibiting Helicobacter pylori CagA-degraded autophagy.

Tsugawa H, Mori H, Matsuzaki J, Sato A, Saito Y, Imoto M, Suematsu M, Suzuki H.

Autophagy. 2018 Sep 10:1-17. doi: 10.1080/15548627.2018.1515530. [Epub ahead of print]

PMID:
30176157
2.

Myocardial fatty acid uptake through CD36 is indispensable for sufficient bioenergetic metabolism to prevent progression of pressure overload-induced heart failure.

Umbarawan Y, Syamsunarno MRAA, Koitabashi N, Obinata H, Yamaguchi A, Hanaoka H, Hishiki T, Hayakawa N, Sano M, Sunaga H, Matsui H, Tsushima Y, Suematsu M, Kurabayashi M, Iso T.

Sci Rep. 2018 Aug 13;8(1):12035. doi: 10.1038/s41598-018-30616-1.

3.

Quantitative imaging mass spectroscopy reveals roles of heme oxygenase-2 for protecting against transhemispheric diaschisis in the brain ischemia.

Goto S, Morikawa T, Kubo A, Takubo K, Fukuda K, Kajimura M, Suematsu M.

J Clin Biochem Nutr. 2018 Jul;63(1):70-79. doi: 10.3164/jcbn.17-136. Epub 2018 Apr 11.

4.

Function and structural regulation of the carbon monoxide (CO)-responsive membrane protein PGRMC1.

Kabe Y, Handa H, Suematsu M.

J Clin Biochem Nutr. 2018 Jul;63(1):12-17. doi: 10.3164/jcbn.17-132. Epub 2018 Apr 11. Review.

5.

Cholesterol sulfate is a DOCK2 inhibitor that mediates tissue-specific immune evasion in the eye.

Sakurai T, Uruno T, Sugiura Y, Tatsuguchi T, Yamamura K, Ushijima M, Hattori Y, Kukimoto-Niino M, Mishima-Tsumagari C, Watanabe M, Suematsu M, Fukui Y.

Sci Signal. 2018 Jul 31;11(541). pii: eaao4874. doi: 10.1126/scisignal.aao4874.

PMID:
30065028
6.

Development of a Highly Sensitive Device for Counting the Number of Disease-Specific Exosomes in Human Sera.

Kabe Y, Suematsu M, Sakamoto S, Hirai M, Koike I, Hishiki T, Matsuda A, Hasegawa Y, Tsujita K, Ono M, Minegishi N, Hozawa A, Murakami Y, Kubo M, Itonaga M, Handa H.

Clin Chem. 2018 Jul 18. pii: clinchem.2018.291963. doi: 10.1373/clinchem.2018.291963. [Epub ahead of print]

PMID:
30021922
7.

Sodium-glucose cotransporter 2 inhibition normalizes glucose metabolism and suppresses oxidative stress in the kidneys of diabetic mice.

Tanaka S, Sugiura Y, Saito H, Sugahara M, Higashijima Y, Yamaguchi J, Inagi R, Suematsu M, Nangaku M, Tanaka T.

Kidney Int. 2018 Jul 13. pii: S0085-2538(18)30353-3. doi: 10.1016/j.kint.2018.04.025. [Epub ahead of print]

PMID:
30021702
8.

A method for determination of aldosterone in adrenal tributary venous serum by derivatization using Girard P reagent isotopologues followed by LC/ESI-MS/MS.

Higashi T, Akaishi M, Yokota M, Suzuki T, Ogawa S, Sugiura Y, Nishikawa T, Nishimoto K, Suematsu M.

J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Aug 15;1092:106-113. doi: 10.1016/j.jchromb.2018.06.001. Epub 2018 Jun 2.

PMID:
29886288
9.

Optogenetic astrocyte activation evokes BOLD fMRI response with oxygen consumption without neuronal activity modulation.

Takata N, Sugiura Y, Yoshida K, Koizumi M, Hiroshi N, Honda K, Yano R, Komaki Y, Matsui K, Suematsu M, Mimura M, Okano H, Tanaka KF.

Glia. 2018 May 30. doi: 10.1002/glia.23454. [Epub ahead of print]

PMID:
29845643
10.

Neuroprotective Role of Astroglia in Parkinson Disease by Reducing Oxidative Stress Through Dopamine-Induced Activation of Pentose-Phosphate Pathway.

Mashima K, Takahashi S, Minami K, Izawa Y, Abe T, Tsukada N, Hishiki T, Suematsu M, Kajimura M, Suzuki N.

ASN Neuro. 2018 Jan-Dec;10:1759091418775562. doi: 10.1177/1759091418775562.

11.

Deep whole-genome sequencing reveals recent selection signatures linked to evolution and disease risk of Japanese.

Okada Y, Momozawa Y, Sakaue S, Kanai M, Ishigaki K, Akiyama M, Kishikawa T, Arai Y, Sasaki T, Kosaki K, Suematsu M, Matsuda K, Yamamoto K, Kubo M, Hirose N, Kamatani Y.

Nat Commun. 2018 Apr 24;9(1):1631. doi: 10.1038/s41467-018-03274-0.

12.

Gold-nanofève surface-enhanced Raman spectroscopy visualizes hypotaurine as a robust anti-oxidant consumed in cancer survival.

Shiota M, Naya M, Yamamoto T, Hishiki T, Tani T, Takahashi H, Kubo A, Koike D, Itoh M, Ohmura M, Kabe Y, Sugiura Y, Hiraoka N, Morikawa T, Takubo K, Suina K, Nagashima H, Sampetrean O, Nagano O, Saya H, Yamazoe S, Watanabe H, Suematsu M.

Nat Commun. 2018 Apr 19;9(1):1561. doi: 10.1038/s41467-018-03899-1.

13.

Identifying the social capital influencing diabetes control in Japan.

Yamada Y, Suematsu M, Takahashi N, Okazaki K, Yasui H, Hida T, Uemura K, Murotani K, Kuzuya M.

Nagoya J Med Sci. 2018 Feb;80(1):99-107. doi: 10.18999/nagjms.80.1.99.

14.

Glucose is preferentially utilized for biomass synthesis in pressure-overloaded hearts: evidence from fatty acid-binding protein-4 and -5 knockout mice.

Umbarawan Y, Syamsunarno MRAA, Koitabashi N, Yamaguchi A, Hanaoka H, Hishiki T, Nagahata-Naito Y, Obinata H, Sano M, Sunaga H, Matsui H, Tsushima Y, Suematsu M, Kurabayashi M, Iso T.

Cardiovasc Res. 2018 Jul 1;114(8):1132-1144. doi: 10.1093/cvr/cvy063.

15.

PKM1 Confers Metabolic Advantages and Promotes Cell-Autonomous Tumor Cell Growth.

Morita M, Sato T, Nomura M, Sakamoto Y, Inoue Y, Tanaka R, Ito S, Kurosawa K, Yamaguchi K, Sugiura Y, Takizaki H, Yamashita Y, Katakura R, Sato I, Kawai M, Okada Y, Watanabe H, Kondoh G, Matsumoto S, Kishimoto A, Obata M, Matsumoto M, Fukuhara T, Motohashi H, Suematsu M, Komatsu M, Nakayama KI, Watanabe T, Soga T, Shima H, Maemondo M, Tanuma N.

Cancer Cell. 2018 Mar 12;33(3):355-367.e7. doi: 10.1016/j.ccell.2018.02.004.

PMID:
29533781
16.

Characterization and validation of Entamoeba histolytica pantothenate kinase as a novel anti-amebic drug target.

Nurkanto A, Jeelani G, Yamamoto T, Naito Y, Hishiki T, Mori M, Suematsu M, Shiomi K, Hashimoto T, Nozaki T.

Int J Parasitol Drugs Drug Resist. 2018 Apr;8(1):125-136. doi: 10.1016/j.ijpddr.2018.02.004. Epub 2018 Mar 1.

17.

Lumbosacral polyradiculopathy after intrathecal chemotherapy in pediatric acute lymphoblastic leukemia.

Suematsu M, Imamura T, Chiyonobu T, Osone S, Hosoi H.

Int J Hematol. 2018 May;107(5):499-501. doi: 10.1007/s12185-018-2427-1. Epub 2018 Feb 22. No abstract available.

PMID:
29470812
18.

Utilizing mass spectrometry imaging to map the thyroid hormones triiodothyronine and thyroxine in Xenopus tropicalis tadpoles.

Goto-Inoue N, Sato T, Morisasa M, Kashiwagi A, Kashiwagi K, Sugiura Y, Sugiyama E, Suematsu M, Mori T.

Anal Bioanal Chem. 2018 Feb;410(4):1333-1340. doi: 10.1007/s00216-017-0775-y. Epub 2017 Dec 15.

PMID:
29247380
19.

Improved Diagnosis and Care for Rare Diseases through Implementation of Precision Public Health Framework.

Baynam G, Bowman F, Lister K, Walker CE, Pachter N, Goldblatt J, Boycott KM, Gahl WA, Kosaki K, Adachi T, Ishii K, Mahede T, McKenzie F, Townshend S, Slee J, Kiraly-Borri C, Vasudevan A, Hawkins A, Broley S, Schofield L, Verhoef H, Groza T, Zankl A, Robinson PN, Haendel M, Brudno M, Mattick JS, Dinger ME, Roscioli T, Cowley MJ, Olry A, Hanauer M, Alkuraya FS, Taruscio D, Posada de la Paz M, Lochmüller H, Bushby K, Thompson R, Hedley V, Lasko P, Mina K, Beilby J, Tifft C, Davis M, Laing NG, Julkowska D, Le Cam Y, Terry SF, Kaufmann P, Eerola I, Norstedt I, Rath A, Suematsu M, Groft SC, Austin CP, Draghia-Akli R, Weeramanthri TS, Molster C, Dawkins HJS.

Adv Exp Med Biol. 2017;1031:55-94. doi: 10.1007/978-3-319-67144-4_4. Review.

PMID:
29214566
20.

Metabolic shift induced by systemic activation of T cells in PD-1-deficient mice perturbs brain monoamines and emotional behavior.

Miyajima M, Zhang B, Sugiura Y, Sonomura K, Guerrini MM, Tsutsui Y, Maruya M, Vogelzang A, Chamoto K, Honda K, Hikida T, Ito S, Qin H, Sanuki R, Suzuki K, Furukawa T, Ishihama Y, Matsuda F, Suematsu M, Honjo T, Fagarasan S.

Nat Immunol. 2017 Dec;18(12):1342-1352. doi: 10.1038/ni.3867. Epub 2017 Oct 23.

PMID:
29058703
21.

Robust suppression of cardiac energy catabolism with marked accumulation of energy substrates during lipopolysaccharide-induced cardiac dysfunction in mice.

Umbarawan Y, Syamsunarno MRAA, Obinata H, Yamaguchi A, Sunaga H, Matsui H, Hishiki T, Matsuura T, Koitabashi N, Obokata M, Hanaoka H, Haque A, Kunimoto F, Tsushima Y, Suematsu M, Kurabayashi M, Iso T.

Metabolism. 2017 Dec;77:47-57. doi: 10.1016/j.metabol.2017.09.003. Epub 2017 Sep 20.

22.

Arl8b is required for lysosomal degradation of maternal proteins in the visceral yolk sac endoderm of mouse embryos.

Oka M, Hashimoto K, Yamaguchi Y, Saitoh SI, Sugiura Y, Motoi Y, Honda K, Kikko Y, Ohata S, Suematsu M, Miura M, Miyake K, Katada T, Kontani K.

J Cell Sci. 2017 Oct 15;130(20):3568-3577. doi: 10.1242/jcs.200519. Epub 2017 Aug 21.

23.

Future of Rare Diseases Research 2017-2027: An IRDiRC Perspective.

Austin CP, Cutillo CM, Lau LPL, Jonker AH, Rath A, Julkowska D, Thomson D, Terry SF, de Montleau B, Ardigò D, Hivert V, Boycott KM, Baynam G, Kaufmann P, Taruscio D, Lochmüller H, Suematsu M, Incerti C, Draghia-Akli R, Norstedt I, Wang L, Dawkins HJS; International Rare Diseases Research Consortium (IRDiRC).

Clin Transl Sci. 2018 Jan;11(1):21-27. doi: 10.1111/cts.12500. Epub 2017 Oct 23. Review. No abstract available.

24.

Japan's initiative on rare and undiagnosed diseases (IRUD): towards an end to the diagnostic odyssey.

Adachi T, Kawamura K, Furusawa Y, Nishizaki Y, Imanishi N, Umehara S, Izumi K, Suematsu M.

Eur J Hum Genet. 2017 Sep;25(9):1025-1028. doi: 10.1038/ejhg.2017.106. Epub 2017 Jul 5.

25.

Early-onset parkinsonism in a pedigree with phosphoglycerate kinase deficiency and a heterozygous carrier: do PGK-1 mutations contribute to vulnerability to parkinsonism?

Sakaue S, Kasai T, Mizuta I, Suematsu M, Osone S, Azuma Y, Imamura T, Tokuda T, Kanno H, El-Agnaf OMA, Morimoto M, Nakagawa M, Hosoi H, Mizuno T.

NPJ Parkinsons Dis. 2017 Mar 31;3:13. doi: 10.1038/s41531-017-0014-4. eCollection 2017.

26.

Targeting Oxygen-Sensing Prolyl Hydroxylase for Metformin-Associated Lactic Acidosis Treatment.

Oyaizu-Toramaru T, Suhara T, Hayakawa N, Nakamura T, Kubo A, Minamishima S, Yamaguchi K, Hishiki T, Morisaki H, Suematsu M, Minamishima YA.

Mol Cell Biol. 2017 Jul 28;37(16). pii: e00248-17. doi: 10.1128/MCB.00248-17. Print 2017 Aug 15.

27.

Placental labyrinth formation in mice requires endothelial FLRT2/UNC5B signaling.

Tai-Nagara I, Yoshikawa Y, Numata N, Ando T, Okabe K, Sugiura Y, Ieda M, Takakura N, Nakagawa O, Zhou B, Okabayashi K, Suematsu M, Kitagawa Y, Bastmeyer M, Sato K, Klein R, Navankasattusas S, Li DY, Yamagishi S, Kubota Y.

Development. 2017 Jul 1;144(13):2392-2401. doi: 10.1242/dev.149757. Epub 2017 Jun 2.

28.

Usefulness of Interprofessional Education (Tsurumai-Meijo IPE) in Program Collaborating with Simulated Patients.

Goto A, Hanya M, Yoshimi A, Uchida M, Takeuchi S, Aida N, Suematsu M, Abe K, Yasui H, Kamei H, Noda Y.

Yakugaku Zasshi. 2017;137(6):733-744. doi: 10.1248/yakushi.16-00215. Japanese.

29.

Quiescence of adult oligodendrocyte precursor cells requires thyroid hormone and hypoxia to activate Runx1.

Tokumoto Y, Tamaki S, Kabe Y, Takubo K, Suematsu M.

Sci Rep. 2017 Apr 21;7(1):1019. doi: 10.1038/s41598-017-01023-9.

30.

Plant hormone cytokinins control cell cycle progression and plastid replication in apicomplexan parasites.

Andrabi SBA, Tahara M, Matsubara R, Toyama T, Aonuma H, Sakakibara H, Suematsu M, Tanabe K, Nozaki T, Nagamune K.

Parasitol Int. 2018 Feb;67(1):47-58. doi: 10.1016/j.parint.2017.03.003. Epub 2017 Mar 23.

31.

The histone 3 lysine 9 methyltransferase inhibitor chaetocin improves prognosis in a rat model of high salt diet-induced heart failure.

Ono T, Kamimura N, Matsuhashi T, Nagai T, Nishiyama T, Endo J, Hishiki T, Nakanishi T, Shimizu N, Tanaka H, Ohta S, Suematsu M, Ieda M, Sano M, Fukuda K, Kaneda R.

Sci Rep. 2017 Jan 4;7:39752. doi: 10.1038/srep39752.

32.

Rewiring of embryonic glucose metabolism via suppression of PFK-1 and aldolase during mouse chorioallantoic branching.

Miyazawa H, Yamaguchi Y, Sugiura Y, Honda K, Kondo K, Matsuda F, Yamamoto T, Suematsu M, Miura M.

Development. 2017 Jan 1;144(1):63-73. doi: 10.1242/dev.138545.

33.

Sigma-2 receptor and progesterone receptor membrane component 1 (PGRMC1) are two different proteins: Proofs by fluorescent labeling and binding of sigma-2 receptor ligands to PGRMC1.

Pati ML, Groza D, Riganti C, Kopecka J, Niso M, Berardi F, Hager S, Heffeter P, Hirai M, Tsugawa H, Kabe Y, Suematsu M, Abate C.

Pharmacol Res. 2017 Mar;117:67-74. doi: 10.1016/j.phrs.2016.12.023. Epub 2016 Dec 19.

PMID:
28007569
34.

Epidermal cell turnover across tight junctions based on Kelvin's tetrakaidecahedron cell shape.

Yokouchi M, Atsugi T, Logtestijn MV, Tanaka RJ, Kajimura M, Suematsu M, Furuse M, Amagai M, Kubo A.

Elife. 2016 Nov 29;5. pii: e19593. doi: 10.7554/eLife.19593.

35.

Acquired platinum resistance involves epithelial to mesenchymal transition through ubiquitin ligase FBXO32 dysregulation.

Tanaka N, Kosaka T, Miyazaki Y, Mikami S, Niwa N, Otsuka Y, Minamishima YA, Mizuno R, Kikuchi E, Miyajima A, Sabe H, Okada Y, Uhlén P, Suematsu M, Oya M.

JCI Insight. 2016 Nov 3;1(18):e83654.

36.

Immunohistochemistry of aldosterone synthase leads the way to the pathogenesis of primary aldosteronism.

Nishimoto K, Koga M, Seki T, Oki K, Gomez-Sanchez EP, Gomez-Sanchez CE, Naruse M, Sakaguchi T, Morita S, Kosaka T, Oya M, Ogishima T, Yasuda M, Suematsu M, Kabe Y, Omura M, Nishikawa T, Mukai K.

Mol Cell Endocrinol. 2017 Feb 5;441:124-133. doi: 10.1016/j.mce.2016.10.014. Epub 2016 Oct 14. Review.

37.

Cystathionine β-synthase and PGRMC1 as CO sensors.

Kabe Y, Yamamoto T, Kajimura M, Sugiura Y, Koike I, Ohmura M, Nakamura T, Tokumoto Y, Tsugawa H, Handa H, Kobayashi T, Suematsu M.

Free Radic Biol Med. 2016 Oct;99:333-344. doi: 10.1016/j.freeradbiomed.2016.08.025. Epub 2016 Aug 24. Review.

PMID:
27565814
38.

Human Adrenocortical Remodeling Leading to Aldosterone-Producing Cell Cluster Generation.

Nishimoto K, Seki T, Hayashi Y, Mikami S, Al-Eyd G, Nakagawa K, Morita S, Kosaka T, Oya M, Mitani F, Suematsu M, Kabe Y, Mukai K.

Int J Endocrinol. 2016;2016:7834356. Epub 2016 Sep 18.

39.

Visualization of in vivo metabolic flows reveals accelerated utilization of glucose and lactate in penumbra of ischemic heart.

Sugiura Y, Katsumata Y, Sano M, Honda K, Kajimura M, Fukuda K, Suematsu M.

Sci Rep. 2016 Sep 1;6:32361. doi: 10.1038/srep32361.

40.

Cortical microcirculatory disturbance in the super acute phase of subarachnoid hemorrhage - In vivo analysis using two-photon laser scanning microscopy.

Ishikawa M, Kajimura M, Morikawa T, Tsukada K, Tsuji T, Kusaka G, Tanaka Y, Suematsu M.

J Neurol Sci. 2016 Sep 15;368:326-33. doi: 10.1016/j.jns.2016.06.067. Epub 2016 Jul 2.

PMID:
27538658
41.

[Methionine metabolism regulates biotransformation of glucose via protein arginine methylation in cancer cells].

Yamamoto T, Suematsu M.

Seikagaku. 2016 Jun;88(3):397-401. Review. Japanese. No abstract available.

PMID:
27483959
42.

Disorganized Steroidogenesis in Adrenocortical Carcinoma, a Case Study.

Uchida T, Nishimoto K, Fukumura Y, Asahina M, Goto H, Kawano Y, Shimizu F, Tsujimura A, Seki T, Mukai K, Kabe Y, Suematsu M, Gomez-Sanchez CE, Yao T, Horie S, Watada H.

Endocr Pathol. 2017 Mar;28(1):27-35. doi: 10.1007/s12022-016-9441-8.

43.

[AMED: Missions and Challenges].

Suematsu M.

Hokkaido Igaku Zasshi. 2016 May;91(1):7-9. Japanese. No abstract available.

PMID:
27416707
44.

p38α Activates Purine Metabolism to Initiate Hematopoietic Stem/Progenitor Cell Cycling in Response to Stress.

Karigane D, Kobayashi H, Morikawa T, Ootomo Y, Sakai M, Nagamatsu G, Kubota Y, Goda N, Matsumoto M, Nishimura EK, Soga T, Otsu K, Suematsu M, Okamoto S, Suda T, Takubo K.

Cell Stem Cell. 2016 Aug 4;19(2):192-204. doi: 10.1016/j.stem.2016.05.013. Epub 2016 Jun 23.

45.

Alteration of matrix metalloproteinase-3 O-glycan structure as a biomarker for disease activity of rheumatoid arthritis.

Takeshita M, Kuno A, Suzuki K, Matsuda A, Shimazaki H, Nakagawa T, Otomo Y, Kabe Y, Suematsu M, Narimatsu H, Takeuchi T.

Arthritis Res Ther. 2016 May 21;18(1):112. doi: 10.1186/s13075-016-1013-2.

46.

A possible role of microglia-derived nitric oxide by lipopolysaccharide in activation of astroglial pentose-phosphate pathway via the Keap1/Nrf2 system.

Iizumi T, Takahashi S, Mashima K, Minami K, Izawa Y, Abe T, Hishiki T, Suematsu M, Kajimura M, Suzuki N.

J Neuroinflammation. 2016 May 4;13(1):99. doi: 10.1186/s12974-016-0564-0.

47.

Glutamine Oxidation Is Indispensable for Survival of Human Pluripotent Stem Cells.

Tohyama S, Fujita J, Hishiki T, Matsuura T, Hattori F, Ohno R, Kanazawa H, Seki T, Nakajima K, Kishino Y, Okada M, Hirano A, Kuroda T, Yasuda S, Sato Y, Yuasa S, Sano M, Suematsu M, Fukuda K.

Cell Metab. 2016 Apr 12;23(4):663-74. doi: 10.1016/j.cmet.2016.03.001. Epub 2016 Mar 31.

48.

Leukocyte plugging and cortical capillary flow after subarachnoid hemorrhage.

Ishikawa M, Kajimura M, Morikawa T, Tsukada K, Tsuji T, Kusaka G, Tanaka Y, Suematsu M.

Acta Neurochir (Wien). 2016 Jun;158(6):1057-67. doi: 10.1007/s00701-016-2792-6. Epub 2016 Apr 4.

PMID:
27040552
49.

Haem-dependent dimerization of PGRMC1/Sigma-2 receptor facilitates cancer proliferation and chemoresistance.

Kabe Y, Nakane T, Koike I, Yamamoto T, Sugiura Y, Harada E, Sugase K, Shimamura T, Ohmura M, Muraoka K, Yamamoto A, Uchida T, Iwata S, Yamaguchi Y, Krayukhina E, Noda M, Handa H, Ishimori K, Uchiyama S, Kobayashi T, Suematsu M.

Nat Commun. 2016 Mar 18;7:11030. doi: 10.1038/ncomms11030.

50.

The EGF Receptor Promotes the Malignant Potential of Glioma by Regulating Amino Acid Transport System xc(-).

Tsuchihashi K, Okazaki S, Ohmura M, Ishikawa M, Sampetrean O, Onishi N, Wakimoto H, Yoshikawa M, Seishima R, Iwasaki Y, Morikawa T, Abe S, Takao A, Shimizu M, Masuko T, Nagane M, Furnari FB, Akiyama T, Suematsu M, Baba E, Akashi K, Saya H, Nagano O.

Cancer Res. 2016 May 15;76(10):2954-63. doi: 10.1158/0008-5472.CAN-15-2121. Epub 2016 Mar 15.

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