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[A Case of Pediatric Soft Tissue Sarcoma with LMNA-NTRK1 Gene Fusion Treated with Larotrectinib under Single Patient Expanded Access System].

Kato S, Fujimura J, Nozaki Y, Yamaguchi S, Takagi T, Hayashi T, Saito T, Henry D, Ku N, Suehara Y.

Gan To Kagaku Ryoho. 2019 Oct;46(10):1595-1597. Japanese.


Molecular and clinicopathological analyses of esophageal carcinosarcoma with special reference to morphological change.

Tsuyama S, Saito T, Akazawa Y, Yanai Y, Yatagai N, Akaike K, Hayashi T, Suehara Y, Takahashi F, Takamochi K, Hashimoto T, Kajiyama Y, Tsurumaru M, Fukunaga T, Yao T.

Virchows Arch. 2019 Oct;475(4):415-424. doi: 10.1007/s00428-019-02643-4. Epub 2019 Aug 23.


Mutations found in cell-free DNAs of patients with malignant lymphoma at remission can derive from clonal hematopoiesis.

Suehara Y, Sakata-Yanagimoto M, Hattori K, Kusakabe M, Nanmoku T, Sato T, Noguchi M, Chiba S.

Cancer Sci. 2019 Oct;110(10):3375-3381. doi: 10.1111/cas.14176. Epub 2019 Sep 12.


Protein Expression Profiles Corresponding to Histological Changes with Denosumab Treatment in Giant Cell Tumors of Bone.

Suehara Y, Okubo T, Kurihara T, Hayashi T, Kohsaka S, Kazuno S, Sano K, Hasegawa N, Miura Y, Akaike K, Kim Y, Takamochi K, Takahashi F, Ueno T, Kaneko K, Saito T.

Proteomics Clin Appl. 2019 Sep;13(5):e1800147. doi: 10.1002/prca.201800147. Epub 2019 Jul 22.


Role of FBXW7 in the quiescence of gefitinib-resistant lung cancer stem cells in EGFR-mutant non-small cell lung cancer.

Hidayat M, Mitsuishi Y, Takahashi F, Tajima K, Yae T, Miyahara K, Hayakawa D, Winardi W, Ihara H, Koinuma Y, Wirawan A, Nurwidya F, Kato M, Kobayashi I, Sasaki S, Takamochi K, Hayashi T, Suehara Y, Moriyama M, Moriyama H, Habu S, Takahashi K.

Bosn J Basic Med Sci. 2019 Nov 8;19(4):355-367. doi: 10.17305/bjbms.2019.4227.


Clinical Genomic Sequencing of Pediatric and Adult Osteosarcoma Reveals Distinct Molecular Subsets with Potentially Targetable Alterations.

Suehara Y, Alex D, Bowman A, Middha S, Zehir A, Chakravarty D, Wang L, Jour G, Nafa K, Hayashi T, Jungbluth AA, Frosina D, Slotkin E, Shukla N, Meyers P, Healey JH, Hameed M, Ladanyi M.

Clin Cancer Res. 2019 Nov 1;25(21):6346-6356. doi: 10.1158/1078-0432.CCR-18-4032. Epub 2019 Jun 7.


Massively parallel sequencing of tenosynovial giant cell tumors reveals novel CSF1 fusion transcripts and novel somatic CBL mutations.

Tsuda Y, Hirata M, Katayama K, Motoi T, Matsubara D, Oda Y, Fujita M, Kobayashi H, Kawano H, Nishida Y, Sakai T, Okuma T, Goto T, Ogura K, Kawai A, Ae K, Anazawa U, Suehara Y, Iwata S, Miyano S, Imoto S, Shibata T, Nakagawa H, Yamaguchi R, Tanaka S, Matsuda K.

Int J Cancer. 2019 Dec 15;145(12):3276-3284. doi: 10.1002/ijc.32421. Epub 2019 May 31.


Comprehensive assay for the molecular profiling of cancer by target enrichment from formalin-fixed paraffin-embedded specimens.

Kohsaka S, Tatsuno K, Ueno T, Nagano M, Shinozaki-Ushiku A, Ushiku T, Takai D, Ikegami M, Kobayashi H, Kage H, Ando M, Hata K, Ueda H, Yamamoto S, Kojima S, Oseto K, Akaike K, Suehara Y, Hayashi T, Saito T, Takahashi F, Takahashi K, Takamochi K, Suzuki K, Nagayama S, Oda Y, Mimori K, Ishihara S, Yatomi Y, Nagase T, Nakajima J, Tanaka S, Fukayama M, Oda K, Nangaku M, Miyazono K, Miyagawa K, Aburatani H, Mano H.

Cancer Sci. 2019 Apr;110(4):1464-1479. doi: 10.1111/cas.13968. Epub 2019 Mar 5.


Proteomic signatures corresponding to the SS18/SSX fusion gene in synovial sarcoma.

Ishii M, Suehara Y, Sano K, Kohsaka S, Hayashi T, Kazuno S, Akaike K, Mukaihara K, Kim Y, Okubo T, Takamochi K, Takahashi F, Kaneko K, Saito T.

Oncotarget. 2018 Dec 25;9(101):37509-37519. doi: 10.18632/oncotarget.26493. eCollection 2018 Dec 25.


Multicenter experience with large panel next-generation sequencing in patients with advanced solid cancers in Japan.

Kato S, Hayashi T, Suehara Y, Hamanoue H, Yamanaka S, Ichikawa Y, Higurashi T, Ohashi K, Yamaguchi S, Nozaki Y, Terao Y, Saito T.

Jpn J Clin Oncol. 2019 Feb 1;49(2):174-182. doi: 10.1093/jjco/hyy173.


Genetic evidence implies that primary and relapsed tumors arise from common precursor cells in primary central nervous system lymphoma.

Hattori K, Sakata-Yanagimoto M, Kusakabe M, Nanmoku T, Suehara Y, Matsuoka R, Noguchi M, Yokoyama Y, Kato T, Kurita N, Nishikii H, Obara N, Takano S, Ishikawa E, Matsumura A, Muratani M, Hasegawa Y, Chiba S.

Cancer Sci. 2019 Jan;110(1):401-407. doi: 10.1111/cas.13848. Epub 2018 Nov 18.


KCTD12 is negatively regulated by Kit in gastrointestinal stromal tumors.

Suehara Y, Akaike K, Mukaihara K, Kurisaki-Arakawa A, Kubota D, Okubo T, Mitomi H, Mitani K, Takahashi M, Toda-Ishii M, Kim Y, Tanabe Y, Takagi T, Hayashi T, Mogushi K, Kaneko K, Yao T, Saito T.

Oncotarget. 2018 Jun 5;9(43):27016-27026. doi: 10.18632/oncotarget.25469. eCollection 2018 Jun 5.


PPP2R1A regulated by PAX3/FOXO1 fusion contributes to the acquisition of aggressive behavior in PAX3/FOXO1-positive alveolar rhabdomyosarcoma.

Akaike K, Suehara Y, Kohsaka S, Hayashi T, Tanabe Y, Kazuno S, Mukaihara K, Toda-Ishii M, Kurihara T, Kim Y, Okubo T, Hayashi Y, Takamochi K, Takahashi F, Kaneko K, Ladanyi M, Saito T.

Oncotarget. 2018 May 18;9(38):25206-25215. doi: 10.18632/oncotarget.25392. eCollection 2018 May 18.


Next-generation sequencing analysis for gastric adenocarcinoma with enteroblastic differentiation: emphasis on the relationship with hepatoid adenocarcinoma.

Akazawa Y, Saito T, Hayashi T, Yanai Y, Tsuyama S, Akaike K, Suehara Y, Takahashi F, Takamochi K, Ueyama H, Murakami T, Watanabe S, Nagahara A, Yao T.

Hum Pathol. 2018 Aug;78:79-88. doi: 10.1016/j.humpath.2018.04.022. Epub 2018 May 8.


IRE1α-XBP1 inhibitors exerted anti-tumor activities in Ewing's sarcoma.

Tanabe Y, Suehara Y, Kohsaka S, Hayashi T, Akaike K, Mukaihara K, Kurihara T, Kim Y, Okubo T, Ishii M, Kazuno S, Kaneko K, Saito T.

Oncotarget. 2018 Feb 12;9(18):14428-14443. doi: 10.18632/oncotarget.24467. eCollection 2018 Mar 6.


Droplet digital polymerase chain reaction assay and peptide nucleic acid-locked nucleic acid clamp method for RHOA mutation detection in angioimmunoblastic T-cell lymphoma.

Tanzima Nuhat S, Sakata-Yanagimoto M, Komori D, Hattori K, Suehara Y, Fukumoto K, Fujisawa M, Kusakabe M, Matsue K, Wakamatsu H, Shimadzu M, Chiba S.

Cancer Sci. 2018 May;109(5):1682-1689. doi: 10.1111/cas.13557. Epub 2018 Mar 31.


Liquid biopsy for the identification of intravascular large B-cell lymphoma.

Suehara Y, Sakata-Yanagimoto M, Hattori K, Nanmoku T, Itoh T, Kaji D, Yamamoto G, Abe Y, Narita K, Takeuchi M, Matsue K, Sato T, Noguchi M, Baba N, Sakamoto T, Kusakabe M, Kurita N, Kato T, Yokoyama Y, Nishikii H, Obara N, Hasegawa Y, Chiba S.

Haematologica. 2018 Jun;103(6):e241-e244. doi: 10.3324/haematol.2017.178830. Epub 2018 Feb 22. No abstract available.


[Relationship between clinical features and somatic gene mutations in myelodysplastic syndrome].

Hirasawa N, Sakata-Yanagimoto M, Nannya Y, Hattori K, Suehara Y, Kato T, Yokoyama Y, Kurita N, Obara N, Ogawa S, Hasegawa Y, Chiba S.

Rinsho Ketsueki. 2018;59(1):80-83. doi: 10.11406/rinketsu.59.80. Japanese.


Non-small cell lung carcinoma with diffuse coexpression of thyroid transcription factor-1 and ΔNp63/p40.

Hayashi T, Takamochi K, Yanai Y, Mitani K, Tomita H, Mogushi K, Suehara Y, Takahashi F, Suzuki K, Saito T, Yao T.

Hum Pathol. 2018 Aug;78:177-181. doi: 10.1016/j.humpath.2018.01.023. Epub 2018 Feb 2.


Arterial Thoracic Outlet Syndrome and Cerebellar Infarction Following a Stress Fracture of the First Rib and Extensive Callus Formation: A Case Report.

Suehara Y, Imashimizu K, Miyamoto N, Uehara H, Tanabe Y, Hattori N, Suzuki K, Saito T, Kaneko K.

JBJS Case Connect. 2017 Jul-Sep;7(3):e64. doi: 10.2106/JBJS.CC.17.00001.


Clinical significance of disease-specific MYD88 mutations in circulating DNA in primary central nervous system lymphoma.

Hattori K, Sakata-Yanagimoto M, Suehara Y, Yokoyama Y, Kato T, Kurita N, Nishikii H, Obara N, Takano S, Ishikawa E, Matsumura A, Hasegawa Y, Chiba S.

Cancer Sci. 2018 Jan;109(1):225-230. doi: 10.1111/cas.13450. Epub 2017 Dec 23.


A method of high-throughput functional evaluation of EGFR gene variants of unknown significance in cancer.

Kohsaka S, Nagano M, Ueno T, Suehara Y, Hayashi T, Shimada N, Takahashi K, Suzuki K, Takamochi K, Takahashi F, Mano H.

Sci Transl Med. 2017 Nov 15;9(416). pii: eaan6566. doi: 10.1126/scitranslmed.aan6566.


Cabozantinib and dastinib exert anti-tumor activity in alveolar soft part sarcoma.

Mukaihara K, Tanabe Y, Kubota D, Akaike K, Hayashi T, Mogushi K, Hosoya M, Sato S, Kobayashi E, Okubo T, Kim Y, Kohsaka S, Saito T, Kaneko K, Suehara Y.

PLoS One. 2017 Sep 25;12(9):e0185321. doi: 10.1371/journal.pone.0185321. eCollection 2017.


Pediatric soft tissue tumor of the upper arm with LMNA-NTRK1 fusion.

Kohsaka S, Saito T, Akaike K, Suehara Y, Hayashi T, Takagi T, Kaneko K, Ueno T, Kojima S, Kohashi KI, Mano H, Oda Y, Yao T.

Hum Pathol. 2018 Feb;72:167-173. doi: 10.1016/j.humpath.2017.08.017. Epub 2017 Aug 26.


Whole-body computed tomography versus conventional skeletal survey in patients with multiple myeloma: a study of the International Myeloma Working Group.

Hillengass J, Moulopoulos LA, Delorme S, Koutoulidis V, Mosebach J, Hielscher T, Drake M, Rajkumar SV, Oestergaard B, Abildgaard N, Hinge M, Plesner T, Suehara Y, Matsue K, Withofs N, Caers J, Waage A, Goldschmidt H, Dimopoulos MA, Lentzsch S, Durie B, Terpos E.

Blood Cancer J. 2017 Aug 25;7(8):e599. doi: 10.1038/bcj.2017.78.


DNA mismatch repair deficiency in surgically resected lung adenocarcinoma: Microsatellite instability analysis using the Promega panel.

Takamochi K, Takahashi F, Suehara Y, Sato E, Kohsaka S, Hayashi T, Kitano S, Uneno T, Kojima S, Takeuchi K, Mano H, Suzuki K.

Lung Cancer. 2017 Aug;110:26-31. doi: 10.1016/j.lungcan.2017.05.016. Epub 2017 May 21.


Abnormal heavy/light chain ratio after treatment is associated with shorter survival in patients with IgA myeloma.

Suehara Y, Takamatsu H, Fukumoto K, Fujisawa M, Narita K, Usui Y, Takeuchi M, Endean K, Matsue K.

Cancer Sci. 2017 Feb;108(2):187-192. doi: 10.1111/cas.13125.


Clinicopathological effects of protein phosphatase 2, regulatory subunit A, alpha mutations in gastrointestinal stromal tumors.

Toda-Ishii M, Akaike K, Suehara Y, Mukaihara K, Kubota D, Kohsaka S, Okubo T, Mitani K, Mogushi K, Takagi T, Kaneko K, Yao T, Saito T.

Mod Pathol. 2016 Nov;29(11):1424-1432. doi: 10.1038/modpathol.2016.138. Epub 2016 Jul 29.


Reduced argininosuccinate synthetase expression in refractory sarcomas: Impacts on therapeutic potential and drug resistance.

Kim Y, Kobayashi E, Kubota D, Suehara Y, Mukaihara K, Akaike K, Ito A, Kaneko K, Chuman H, Kawai A, Kitano S.

Oncotarget. 2016 Oct 25;7(43):70832-70844. doi: 10.18632/oncotarget.12225.


A case report of using nivolumab for a malignant melanoma patient with rheumatoid arthritis.

Kageyama SI, Yamaguchi S, Ito S, Suehara Y, Saito T, Akaike K, Miura K, Kato S.

Int Cancer Conf J. 2016 Jul 23;5(4):192-196. doi: 10.1007/s13691-016-0256-8. eCollection 2016 Oct.


Large Skin Ulcer Due to a Subcutaneous Orthopaedic Implant After Bevacizumab Therapy: A Case Report.

Suehara Y, Osawa H, Kubota D, Kato S, Akaike K, Tanabe Y, Saito T, Kaneko K.

JBJS Case Connect. 2016 Jul-Sep;6(3):e70. doi: 10.2106/JBJS.CC.15.00281.


Quantification of bone marrow plasma cell infiltration in multiple myeloma: usefulness of bone marrow aspirate clot with CD138 immunohistochemistry.

Matsue K, Matsue Y, Kumata K, Usui Y, Suehara Y, Fukumoto K, Fujisawa M, Narita K, Takeuchi M.

Hematol Oncol. 2017 Sep;35(3):323-328. doi: 10.1002/hon.2300. Epub 2016 May 3.


Expression of F-actin-capping protein subunit beta, CAPZB, is associated with cell growth and motility in epithelioid sarcoma.

Mukaihara K, Suehara Y, Kohsaka S, Kubota D, Toda-Ishii M, Akaike K, Fujimura T, Kobayashi E, Yao T, Ladanyi M, Kaneko K, Saito T.

BMC Cancer. 2016 Mar 10;16:206. doi: 10.1186/s12885-016-2235-z.


TERT promoter mutations are rare in bone and soft tissue sarcomas of Japanese patients.

Saito T, Akaike K, Kurisaki-Arakawa A, Toda-Ishii M, Mukaihara K, Suehara Y, Takagi T, Kaneko K, Yao T.

Mol Clin Oncol. 2016 Jan;4(1):61-64. Epub 2015 Nov 9.


Protein Expression Profiling of Giant Cell Tumors of Bone Treated with Denosumab.

Mukaihara K, Suehara Y, Kohsaka S, Akaike K, Tanabe Y, Kubota D, Ishii M, Fujimura T, Kazuno S, Okubo T, Takagi T, Yao T, Kaneko K, Saito T.

PLoS One. 2016 Feb 10;11(2):e0148401. doi: 10.1371/journal.pone.0148401. eCollection 2016.


Prognostic impact of immunophenotypic complete response in patients with multiple myeloma achieving better than complete response.

Fukumoto K, Fujisawa M, Suehara Y, Narita KT, Usui Y, Takeuchi M, Matsue K.

Leuk Lymphoma. 2016 Aug;57(8):1786-92. doi: 10.3109/10428194.2015.1121262. Epub 2016 Jan 13.


TERT promoter mutations are a rare event in gastrointestinal stromal tumors.

Akaike K, Toda-Ishii M, Suehara Y, Mukaihara K, Kubota D, Mitani K, Takagi T, Kaneko K, Yao T, Saito T.

Springerplus. 2015 Dec 30;4:836. doi: 10.1186/s40064-015-1606-2. eCollection 2015.


Changes in survival rate of multiple myeloma after the introduction of bortezomib: a single institutional experience over 20 years.

Fujisawa M, Suehara Y, Fukumoto K, Takeuchi M, Matsue K.

Ann Hematol. 2016 Jan;95(1):63-72. doi: 10.1007/s00277-015-2522-9.


Clinical and prognostic significance of bone marrow abnormalities in the appendicular skeleton detected by low-dose whole-body multidetector computed tomography in patients with multiple myeloma.

Nishida Y, Matsue Y, Suehara Y, Fukumoto K, Fujisawa M, Takeuchi M, Ouchi E, Matsue K.

Blood Cancer J. 2015 Jul 31;5:e329. doi: 10.1038/bcj.2015.57.


Clinical features and treatment outcome of very elderly patients over 80 years old with multiple myeloma: comparison with patients in different age groups in the era of novel agents.

Matsue K, Matsue Y, Fujisawa M, Fukumoto K, Suehara Y, Sugihara H, Takeuchi M.

Leuk Lymphoma. 2016;57(1):110-5. doi: 10.3109/10428194.2015.1041386. Epub 2015 Jul 7.


Skeletal Metastasis of Unknown Primary Origin at the Initial Visit: A Retrospective Analysis of 286 Cases.

Takagi T, Katagiri H, Kim Y, Suehara Y, Kubota D, Akaike K, Ishii M, Mukaihara K, Okubo T, Murata H, Takahashi M, Kaneko K, Saito T.

PLoS One. 2015 Jun 26;10(6):e0129428. doi: 10.1371/journal.pone.0129428. eCollection 2015.


Spindle cell lipoma of the wrist, occurring in a distinctly rare location: a case report with review of literature.

Akaike K, Suehara Y, Takagi T, Kaneko K, Yamashita A, Yao T, Saito T.

Int J Clin Exp Pathol. 2015 Mar 1;8(3):3299-303. eCollection 2015.


Sarcomatous transformation of EGFR and TP53 mutation-positive metastatic adenocarcinoma of the lungs, masquerading as a primary pleomorphic sarcoma of the proximal femur.

Toda-Ishii M, Akaike K, Kurisaki-Arakawa A, Arakawa A, Mukaihara K, Suehara Y, Takagi T, Kaneko K, Yao T, Saito T.

Int J Clin Exp Pathol. 2015 Mar 1;8(3):3270-8. eCollection 2015.


[The role of therapeutic target tyrosine kinases and inhibitors and its current situation in bone and soft tissue tumor].

Mukaihara K, Suehara Y.

Gan To Kagaku Ryoho. 2015 Mar;42(3):296-300. Japanese. No abstract available.


Distinct clinicopathological features of NAB2-STAT6 fusion gene variants in solitary fibrous tumor with emphasis on the acquisition of highly malignant potential.

Akaike K, Kurisaki-Arakawa A, Hara K, Suehara Y, Takagi T, Mitani K, Kaneko K, Yao T, Saito T.

Hum Pathol. 2015 Mar;46(3):347-56. doi: 10.1016/j.humpath.2014.11.018. Epub 2014 Dec 10.


A case of low-grade fibromyxoid sarcoma with unusual central necrosis in a 77-year-old man confirmed by FUS-CREB3L2 gene fusion.

Kurisaki-Arakawa A, Akaike K, Tomomasa R, Arakawa A, Suehara Y, Takagi T, Kaneko K, Yao T, Saito T.

Int J Surg Case Rep. 2014;5(12):1123-7. doi: 10.1016/j.ijscr.2014.09.034. Epub 2014 Nov 13.


A case of primary spindle cell variant of embryonal rhabdomyosarcoma of the prostate.

Asahina M, Saito T, Arakawa A, Suehara Y, Takagi T, Hisasue S, Kaneko K, Horie S, Yao T.

Int J Clin Exp Pathol. 2014 Jul 15;7(8):5181-5. eCollection 2014.


Deeply located low-grade fibromyxoid sarcoma with FUS-CREB3L2 gene fusion in a 5-year-old boy with review of literature.

Kurisaki-Arakawa A, Suehara Y, Arakawa A, Takagi T, Takahashi M, Mitani K, Kaneko K, Yao T, Saito T.

Diagn Pathol. 2014 Sep 3;9:163. doi: 10.1186/s13000-014-0163-2. Review.


oligoclonal bands in patients with multiple myeloma: its emergence per se could not be translated to improved survival.

Fujisawa M, Seike K, Fukumoto K, Suehara Y, Fukaya M, Sugihara H, Takeuchi M, Matsue K.

Cancer Sci. 2014 Nov;105(11):1442-6. doi: 10.1111/cas.12527. Epub 2014 Oct 9.


Rationale for co-targeting IGF-1R and ALK in ALK fusion-positive lung cancer.

Lovly CM, McDonald NT, Chen H, Ortiz-Cuaran S, Heukamp LC, Yan Y, Florin A, Ozretić L, Lim D, Wang L, Chen Z, Chen X, Lu P, Paik PK, Shen R, Jin H, Buettner R, Ansén S, Perner S, Brockmann M, Bos M, Wolf J, Gardizi M, Wright GM, Solomon B, Russell PA, Rogers TM, Suehara Y, Red-Brewer M, Tieu R, de Stanchina E, Wang Q, Zhao Z, Johnson DH, Horn L, Wong KK, Thomas RK, Ladanyi M, Pao W.

Nat Med. 2014 Sep;20(9):1027-34. doi: 10.1038/nm.3667. Epub 2014 Aug 31.

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