Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 32

1.

A general method for making peptide therapeutics resistant to serine protease degradation: application to dipeptidyl peptidase IV substrates.

Heard KR, Wu W, Li Y, Zhao P, Woznica I, Lai JH, Beinborn M, Sanford DG, Dimare MT, Chiluwal AK, Peters DE, Whicher D, Sudmeier JL, Bachovchin WW.

J Med Chem. 2013 Nov 14;56(21):8339-51. doi: 10.1021/jm400423p. Epub 2013 Oct 16.

PMID:
24044354
2.

Identification of selective and potent inhibitors of fibroblast activation protein and prolyl oligopeptidase.

Poplawski SE, Lai JH, Li Y, Jin Z, Liu Y, Wu W, Wu Y, Zhou Y, Sudmeier JL, Sanford DG, Bachovchin WW.

J Med Chem. 2013 May 9;56(9):3467-77. doi: 10.1021/jm400351a. Epub 2013 Apr 29.

3.

4-Substituted boro-proline dipeptides: synthesis, characterization, and dipeptidyl peptidase IV, 8, and 9 activities.

Wu W, Liu Y, Milo LJ Jr, Shu Y, Zhao P, Li Y, Woznica I, Yu G, Sanford DG, Zhou Y, Poplawski SE, Connolly BA, Sudmeier JL, Bachovchin WW, Lai JH.

Bioorg Med Chem Lett. 2012 Sep 1;22(17):5536-40. doi: 10.1016/j.bmcl.2012.07.033. Epub 2012 Jul 14.

PMID:
22853995
4.

Direct NMR observation and pKa determination of the Asp102 side chain in a serine protease.

Everill P, Sudmeier JL, Bachovchin WW.

J Am Chem Soc. 2012 Feb 1;134(4):2348-54. doi: 10.1021/ja210091q. Epub 2012 Jan 24.

PMID:
22229736
5.

Chemical and biological evaluation of dipeptidyl boronic acid proteasome inhibitors for use in prodrugs and pro-soft drugs targeting solid tumors.

Milo LJ Jr, Lai JH, Wu W, Liu Y, Maw H, Li Y, Jin Z, Shu Y, Poplawski SE, Wu Y, Sanford DG, Sudmeier JL, Bachovchin WW.

J Med Chem. 2011 Jul 14;54(13):4365-77. doi: 10.1021/jm200460q. Epub 2011 Jun 20.

PMID:
21634429
6.

Pro-soft Val-boroPro: a strategy for enhancing in vivo performance of boronic acid inhibitors of serine proteases.

Poplawski SE, Lai JH, Sanford DG, Sudmeier JL, Wu W, Bachovchin WW.

J Med Chem. 2011 Apr 14;54(7):2022-8. doi: 10.1021/jm100972f. Epub 2011 Mar 9.

PMID:
21388136
7.

Dipeptide boronic acid inhibitors of dipeptidyl peptidase IV: determinants of potency and in vivo efficacy and safety.

Connolly BA, Sanford DG, Chiluwal AK, Healey SE, Peters DE, Dimare MT, Wu W, Liu Y, Maw H, Zhou Y, Li Y, Jin Z, Sudmeier JL, Lai JH, Bachovchin WW.

J Med Chem. 2008 Oct 9;51(19):6005-13. doi: 10.1021/jm800390n. Epub 2008 Sep 11.

PMID:
18783201
8.

Synthesis and characterization of constrained peptidomimetic dipeptidyl peptidase IV inhibitors: amino-lactam boroalanines.

Lai JH, Wu W, Zhou Y, Maw HH, Liu Y, Milo LJ Jr, Poplawski SE, Henry GD, Sudmeier JL, Sanford DG, Bachovchin WW.

J Med Chem. 2007 May 17;50(10):2391-8. Epub 2007 Apr 26.

PMID:
17458948
9.

Analyses of the interaction between the origin binding domain from simian virus 40 T antigen and single-stranded DNA provide insights into DNA unwinding and initiation of DNA replication.

Reese DK, Meinke G, Kumar A, Moine S, Chen K, Sudmeier JL, Bachovchin W, Bohm A, Bullock PA.

J Virol. 2006 Dec;80(24):12248-59. Epub 2006 Sep 27.

10.

Autochelation in dipeptide boronic acids: pH-dependent structures and equilibria of Asp-boroPro and His-boroPro by NMR spectroscopy.

Sudmeier JL, Zhou Y, Lai JH, Maw HH, Wu W, Bachovchin WW.

J Am Chem Soc. 2005 Jun 8;127(22):8112-9.

PMID:
15926838
11.

alpha-lytic protease can exist in two separately stable conformations with different His57 mobilities and catalytic activities.

Haddad KC, Sudmeier JL, Bachovchin DA, Bachovchin WW.

Proc Natl Acad Sci U S A. 2005 Jan 25;102(4):1006-11. Epub 2005 Jan 18.

12.

T antigen origin-binding domain of simian virus 40: determinants of specific DNA binding.

Bradshaw EM, Sanford DG, Luo X, Sudmeier JL, Gurard-Levin ZA, Bullock PA, Bachovchin WW.

Biochemistry. 2004 Jun 8;43(22):6928-36.

PMID:
15170330
13.

Identification of histidine tautomers in proteins by 2D 1H/13C(delta2) one-bond correlated NMR.

Sudmeier JL, Bradshaw EM, Haddad KE, Day RM, Thalhauser CJ, Bullock PA, Bachovchin WW.

J Am Chem Soc. 2003 Jul 16;125(28):8430-1.

PMID:
12848537
14.

Microscopic acid-base equilibra of alanyl-boroAlanine.

Lai JH, Zhou Y, Sudmeier JL, Wu W, Sanford DG, Hliang M, Poplawski S, Bachovchin WW.

Adv Exp Med Biol. 2003;524:333-8. No abstract available.

PMID:
12675255
15.

Tautomerism, acid-base equilibria, and H-bonding of the six histidines in subtilisin BPN' by NMR.

Day RM, Thalhauser CJ, Sudmeier JL, Vincent MP, Torchilin EV, Sanford DG, Bachovchin CW, Bachovchin WW.

Protein Sci. 2003 Apr;12(4):794-810.

16.

Serotonin (5-hydroxytryptamine) glucuronidation in vitro: assay development, human liver microsome activities and species differences.

Krishnaswamy S, Duan SX, Von Moltke LL, Greenblatt DJ, Sudmeier JL, Bachovchin WW, Court MH.

Xenobiotica. 2003 Feb;33(2):169-80.

PMID:
12623759
17.

Measurement of NH bond lengths by fast magic-angle spinning solid-state NMR spectroscopy: a new method for the quantification of hydrogen bonds.

Zhao X, Sudmeier JL, Bachovchin WW, Levitt MH.

J Am Chem Soc. 2001 Nov 7;123(44):11097-8. No abstract available.

PMID:
11686729
18.

Unusual 1H NMR chemical shifts support (His) C(epsilon) 1...O==C H-bond: proposal for reaction-driven ring flip mechanism in serine protease catalysis.

Ash EL, Sudmeier JL, Day RM, Vincent M, Torchilin EV, Haddad KC, Bradshaw EM, Sanford DG, Bachovchin WW.

Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10371-6.

19.

A low-barrier hydrogen bond in the catalytic triad of serine proteases? Theory versus experiment.

Ash EL, Sudmeier JL, De Fabo EC, Bachovchin WW.

Science. 1997 Nov 7;278(5340):1128-32.

20.

HCN, a triple-resonance NMR technique for selective observation of histidine and tryptophan side chains in 13C/15N-labeled proteins.

Sudmeier JL, Ash EL, Günther UL, Luo X, Bullock PA, Bachovchin WW.

J Magn Reson B. 1996 Dec;113(3):236-47.

PMID:
8995843
21.

Solution structures of active and inactive forms of the DP IV (CD26) inhibitor Pro-boroPro determined by NMR spectroscopy.

Sudmeier JL, Günther UL, Gutheil WG, Coutts SJ, Snow RJ, Barton RW, Bachovchin WW.

Biochemistry. 1994 Oct 18;33(41):12427-38.

PMID:
7918465
22.

Structure of the propeptide of prothrombin containing the gamma-carboxylation recognition site determined by two-dimensional NMR spectroscopy.

Sanford DG, Kanagy C, Sudmeier JL, Furie BC, Furie B, Bachovchin WW.

Biochemistry. 1991 Oct 15;30(41):9835-41.

PMID:
1911775
23.

Continuous-flow 13C-filtered 1H NMR spectroscopy of ethanol metabolism in rat liver perfusate.

Albert K, Sudmeier JL, Anwer MS, Bachovchin WW.

Magn Reson Med. 1989 Sep;11(3):309-15.

PMID:
2779419
24.

Characterization of the internal calcium(II) binding sites in dissolved insulin hexamer using europium(III) fluorescence.

Alameda GK, Evelhoch JL, Sudmeier JL, Birge RR.

Biochemistry. 1985 Mar 26;24(7):1757-62.

PMID:
3890940
25.

Degradation of 3-phenylbutyric acid by Pseudomonas sp.

Sariaslani FS, Sudmeier JL, Focht DD.

J Bacteriol. 1982 Oct;152(1):411-21.

27.

Cadmium-113 nuclear magnetic resonance studies of bovine insulin: two-zinc insulin hexamer specifically binds calcium.

Sudmeier JL, Bell SJ, Storm MC, Dunn MF.

Science. 1981 May 1;212(4494):560-2.

PMID:
7010607
28.

Cadmium-113 NMR of carbonic anhydrases: effect of pH, bicarbonate, and cyanide.

Jonsson NB, Tibell LA, Evelhoch JL, Bell SJ, Sudmeier JL.

Proc Natl Acad Sci U S A. 1980 Jun;77(6):3269-72.

29.
30.

Cadmium-113 nuclear magnetic resonance studies of 113Cd(ii)-substituted human carbonic anhydrase B.

Sudmeier JL, Bell SJ.

J Am Chem Soc. 1977 Jun 22;99(13):4499-4500. No abstract available.

PMID:
405410
31.

35Cl nuclear magnetic resonance studies of metal binding to bovine serum albumin.

Sudmeier JL, Pesek JJ.

Anal Biochem. 1971 May;41(1):39-50. No abstract available.

PMID:
4996106
32.

DETERMINATION OF A PROTONATION SCHEME OF TETRACYCLINE USING NUCLEAR MAGNETIC RESONANCE.

RIGLER NE, BAG SP, LEYDEN DE, SUDMEIER JL, REILLEY CN.

Anal Chem. 1965 Jun;37:872-5. No abstract available.

PMID:
14330582

Supplemental Content

Loading ...
Support Center