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PGC1α suppresses kidney cancer progression by inhibiting collagen-induced SNAIL expression.

Nam H, Kundu A, Brinkley GJ, Chandrashekar DS, Kirkman RL, Chakravarthi BVSK, Orlandella RM, Norian LA, Sonpavde G, Ghatalia P, Fei F, Wei S, Varambally S, Sudarshan S.

Matrix Biol. 2020 Jan 23. pii: S0945-053X(20)30001-9. doi: 10.1016/j.matbio.2020.01.001. [Epub ahead of print]


14-3-3 proteins protect AMPK-phosphorylated ten-eleven translocation-2 (TET2) from PP2A-mediated dephosphorylation.

Kundu A, Shelar S, Ghosh AP, Ballestas M, Kirkman R, Nam H, Brinkley GJ, Karki S, Mobley JA, Bae S, Varambally S, Sudarshan S.

J Biol Chem. 2020 Feb 7;295(6):1754-1766. doi: 10.1074/jbc.RA119.011089. Epub 2020 Jan 3.


Characterization of breast lesions using diffusion kurtosis model-based imaging: An initial experience.

Zhou WP, Zan XY, Liu X, Sudarshan SKP, Yang SD, Fang XM, Guo YJ, Hu XY.

J Xray Sci Technol. 2019 Dec 2. doi: 10.3233/XST-190590. [Epub ahead of print]


Decoding of novel missense TSC2 gene variants using in-silico methods.

Sudarshan S, Kumar M, Kaur P, Kumar A, G S, Sapra S, Gulati S, Gupta N, Kabra M, Roy Chowdhury M.

BMC Med Genet. 2019 Oct 26;20(1):164. doi: 10.1186/s12881-019-0891-y.


Can Liking, Commenting, and Sharing Enhance Persuasion? The Interaction Effect between Modality Interactivity and Agency Affordances on Smokers' Quitting Intentions.

Oh J, Kang H, Sudarshan S, Lee JA.

Health Commun. 2019 Aug 16:1-12. doi: 10.1080/10410236.2019.1654172. [Epub ahead of print]


Transcriptome profiling of longissimus thoracis muscles identifies highly connected differentially expressed genes in meat type sheep of India.

Arora R, S NK, S S, Fairoze MN, Kaur M, Sharma A, Girdhar Y, M SR, Devatkal SK, Ahlawat S, Vijh RK, S MS.

PLoS One. 2019 Jun 6;14(6):e0217461. doi: 10.1371/journal.pone.0217461. eCollection 2019.


Spina bifida screening in the first trimester using ultrasound biparietal diameter measurement adjusted for crown-rump length or abdominal circumference.

Suresh S, Sudarshan S, Rangaraj A, Indrani S, Cuckle H.

Prenat Diagn. 2019 Mar;39(4):314-318. doi: 10.1002/pd.5433. Epub 2019 Mar 13.


An SVM-based method for assessment of transcription factor-DNA complex models.

Corona RI, Sudarshan S, Aluru S, Guo JT.

BMC Bioinformatics. 2018 Dec 21;19(Suppl 20):506. doi: 10.1186/s12859-018-2538-y.


Integrative Epigenetic and Gene Expression Analysis of Renal Tumor Progression to Metastasis.

Nam HY, Chandrashekar DS, Kundu A, Shelar S, Kho EY, Sonpavde G, Naik G, Ghatalia P, Livi CB, Varambally S, Sudarshan S.

Mol Cancer Res. 2019 Jan;17(1):84-96. doi: 10.1158/1541-7786.MCR-17-0636. Epub 2018 Aug 21.


Biochemical and Epigenetic Insights into L-2-Hydroxyglutarate, a Potential Therapeutic Target in Renal Cancer.

Shelar S, Shim EH, Brinkley GJ, Kundu A, Carobbio F, Poston T, Tan J, Parekh V, Benson D, Crossman DK, Buckhaults PJ, Rakheja D, Kirkman R, Sato Y, Ogawa S, Dutta S, Velu SE, Emberley E, Pan A, Chen J, Huang T, Absher D, Becker A, Kunick C, Sudarshan S.

Clin Cancer Res. 2018 Dec 15;24(24):6433-6446. doi: 10.1158/1078-0432.CCR-18-1727. Epub 2018 Aug 14.


Wnt receptor Frizzled 8 is a target of ERG in prostate cancer.

Chakravarthi BVSK, Chandrashekar DS, Hodigere Balasubramanya SA, Robinson AD, Carskadon S, Rao U, Gordetsky J, Manne U, Netto GJ, Sudarshan S, Palanisamy N, Varambally S.

Prostate. 2018 Dec;78(16):1311-1320. doi: 10.1002/pros.23704. Epub 2018 Jul 26.


Preliminary clinical application of integrated 125I seeds stents in the therapy of malignant lower biliary tract obstruction.

Chen W, Fang XM, Wang X, Sudarshan SKP, Hu XY, Chen HW.

J Xray Sci Technol. 2018;26(5):865-875. doi: 10.3233/XST-180403.


Dual Antithrombotic Therapy with Dabigatran after PCI in Atrial Fibrillation.

Cannon CP, Bhatt DL, Oldgren J, Lip GYH, Ellis SG, Kimura T, Maeng M, Merkely B, Zeymer U, Gropper S, Nordaby M, Kleine E, Harper R, Manassie J, Januzzi JL, Ten Berg JM, Steg PG, Hohnloser SH; RE-DUAL PCI Steering Committee and Investigators.

N Engl J Med. 2017 Oct 19;377(16):1513-1524. doi: 10.1056/NEJMoa1708454. Epub 2017 Aug 27.


Kinomic profiling identifies focal adhesion kinase 1 as a therapeutic target in advanced clear cell renal cell carcinoma.

Ghosh AP, Willey CD, Anderson JC, Welaya K, Chen D, Mehta A, Ghatalia P, Madan A, Naik G, Sudarshan S, Sonpavde G.

Oncotarget. 2017 Apr 25;8(17):29220-29232. doi: 10.18632/oncotarget.16352.


Serological Evidence of Lyssavirus Infection among Bats in Nagaland, a North-Eastern State in India.

Mani RS, Dovih DP, Ashwini MA, Chattopadhyay B, Harsha PK, Garg KM, Sudarshan S, Puttaswamaiah R, Ramakrishnan U, Madhusudana SN.

Epidemiol Infect. 2017 Jun;145(8):1635-1641. doi: 10.1017/S0950268817000310. Epub 2017 Feb 23.


Acute chest pain after bench press exercise in a healthy young adult.

Smereck JA, Papafilippaki A, Sudarshan S.

Open Access Emerg Med. 2016 Sep 22;8:73-76. eCollection 2016.


Kinase Gene Expression Profiling of Metastatic Clear Cell Renal Cell Carcinoma Tissue Identifies Potential New Therapeutic Targets.

Ghatalia P, Yang ES, Lasseigne BN, Ramaker RC, Cooper SJ, Chen D, Sudarshan S, Wei S, Guru AS, Zhao A, Cooper T, Della Manna DL, Naik G, Myers RM, Sonpavde G.

PLoS One. 2016 Aug 30;11(8):e0160924. doi: 10.1371/journal.pone.0160924. eCollection 2016.


The standard aqueous stem bark extract of Mangifera indica L. inhibits toxic PLA2 - NN-XIb-PLA2 of Indian cobra venom.

Dhananjaya BL, Sudarshan S, Dongol Y, More SS.

Saudi Pharm J. 2016 May;24(3):371-8. doi: 10.1016/j.jsps.2016.04.026. Epub 2016 Apr 30.


"Question of the Day": Impact on learning and retention.

Satheesha NB, Mohandas Rao KG, Sudarshan S, Naveen K, Srinivasa Rao S, Ashwini Aithal P.

Kathmandu Univ Med J (KUMJ). 2015 Jul-Sep;13(51):204-11.


Genetics of renal cancer: focus on MTOR.

Ghosh AP, Sudarshan S.

Aging (Albany NY). 2016 Mar;8(3):421-2. No abstract available.


Genetic Studies in Autism.

Sudarshan S, Gupta N, Kabra M.

Indian J Pediatr. 2016 Oct;83(10):1133-40. doi: 10.1007/s12098-015-1989-7. Epub 2016 Mar 3.


Antibacterial activity of an acidic phospholipase A2 (NN-XIb-PLA2) from the venom of Naja naja (Indian cobra).

Sudarshan S, Dhananjaya BL.

Springerplus. 2016 Feb 3;5:112. doi: 10.1186/s40064-016-1690-y. eCollection 2016.


High Throughput Kinomic Profiling of Human Clear Cell Renal Cell Carcinoma Identifies Kinase Activity Dependent Molecular Subtypes.

Anderson JC, Willey CD, Mehta A, Welaya K, Chen D, Duarte CW, Ghatalia P, Arafat W, Madan A, Sudarshan S, Naik G, Grizzle WE, Choueiri TK, Sonpavde G.

PLoS One. 2015 Sep 25;10(9):e0139267. doi: 10.1371/journal.pone.0139267. eCollection 2015.


Point mutations of the mTOR-RHEB pathway in renal cell carcinoma.

Ghosh AP, Marshall CB, Coric T, Shim EH, Kirkman R, Ballestas ME, Ikura M, Bjornsti MA, Sudarshan S.

Oncotarget. 2015 Jul 20;6(20):17895-910.


The Antimicrobial Activity of an Acidic Phospholipase A₂ (NN-XIa-PLA₂) from the Venom of Naja naja naja (Indian Cobra).

Sudarshan S, Dhananjaya BL.

Appl Biochem Biotechnol. 2015 Aug;176(7):2027-38. doi: 10.1007/s12010-015-1698-8. Epub 2015 Jun 25.


Another small molecule in the oncometabolite mix: L-2-Hydroxyglutarate in kidney cancer.

Shim EH, Sudarshan S.

Oncoscience. 2015 May 15;2(5):483-6. eCollection 2015.


Unusual infra-clavicular venous circle - a case report.

Nayak B S, Sirasanagandla SR, Aithal P A, Guru A, S S.

J Clin Diagn Res. 2014 Nov;8(11):AD01-2. doi: 10.7860/JCDR/2014/9396.5113. Epub 2014 Nov 20.


Antibacterial potential of a basic phospholipase A2 (VRV-PL-V) of Daboia russellii pulchella (Russell's Viper) venom.

Sudarshan S, Dhananjaya BL.

Biochemistry (Mosc). 2014 Nov;79(11):1237-44. doi: 10.1134/S000629791411011X.


L-2-Hydroxyglutarate: an epigenetic modifier and putative oncometabolite in renal cancer.

Shim EH, Livi CB, Rakheja D, Tan J, Benson D, Parekh V, Kho EY, Ghosh AP, Kirkman R, Velu S, Dutta S, Chenna B, Rea SL, Mishur RJ, Li Q, Johnson-Pais TL, Guo L, Bae S, Wei S, Block K, Sudarshan S.

Cancer Discov. 2014 Nov;4(11):1290-8. doi: 10.1158/2159-8290.CD-13-0696. Epub 2014 Sep 2.


The oncometabolite fumarate promotes pseudohypoxia through noncanonical activation of NF-κB signaling.

Shanmugasundaram K, Nayak B, Shim EH, Livi CB, Block K, Sudarshan S.

J Biol Chem. 2014 Aug 29;289(35):24691-9. doi: 10.1074/jbc.M114.568162. Epub 2014 Jul 15.


Protein-protein interface detection using the energy centrality relationship (ECR) characteristic of proteins.

Sudarshan S, Kodathala SB, Mahadik AC, Mehta I, Beck BW.

PLoS One. 2014 May 15;9(5):e97115. doi: 10.1371/journal.pone.0097115. eCollection 2014.


Efficacy of kinesio taping on isokinetic quadriceps torque in knee osteoarthritis: a double blinded randomized controlled study.

Anandkumar S, Sudarshan S, Nagpal P.

Physiother Theory Pract. 2014 Aug;30(6):375-83. doi: 10.3109/09593985.2014.896963. Epub 2014 Mar 11.


Fibroblast growth factor receptors as therapeutic targets in clear-cell renal cell carcinoma.

Sonpavde G, Willey CD, Sudarshan S.

Expert Opin Investig Drugs. 2014 Mar;23(3):305-15. doi: 10.1517/13543784.2014.871259. Epub 2014 Jan 3. Review.


Do the sites of metastases provide additional information regarding prognosis and biology in renal cell carcinoma?

Sonpavde G, Sudarshan S, Escudier B.

Eur Urol. 2014 Mar;65(3):585-6. doi: 10.1016/j.eururo.2013.09.001. Epub 2013 Sep 9. No abstract available.


Feasibility of reducing rabies immunoglobulin dosage for passive immunization against rabies: results of In vitro and In vivo studies.

Madhusudana SN, Ashwin BY, Sudarshan S.

Hum Vaccin Immunother. 2013 Sep;9(9):1914-7. doi: 10.4161/hv.25431. Epub 2013 Jun 21.


The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling.

Sullivan LB, Martinez-Garcia E, Nguyen H, Mullen AR, Dufour E, Sudarshan S, Licht JD, Deberardinis RJ, Chandel NS.

Mol Cell. 2013 Jul 25;51(2):236-48. doi: 10.1016/j.molcel.2013.05.003. Epub 2013 Jun 6. Erratum in: Mol Cell. 2013 Jul 25;51(2):273.


Strangulated Richter's Umbilical Hernia - A Case Report.

Martis JJ, Rajeshwara KV, Shridhar MK, Janardhanan D, Sudarshan S.

Indian J Surg. 2011 Dec;73(6):455-7. doi: 10.1007/s12262-011-0272-z. Epub 2011 Apr 15.


Metabolism of kidney cancer: from the lab to clinical practice.

Sudarshan S, Karam JA, Brugarolas J, Thompson RH, Uzzo R, Rini B, Margulis V, Patard JJ, Escudier B, Linehan WM.

Eur Urol. 2013 Feb;63(2):244-51. doi: 10.1016/j.eururo.2012.09.054. Epub 2012 Sep 28. Review.


A case of post-vaccination optic neuritis: coincidence or causative?

Sudarshan S, Huang EH, Lim PL, Leo YS, Lim SA.

Eye (Lond). 2012 Nov;26(11):1498. doi: 10.1038/eye.2012.146. Epub 2012 Aug 10. No abstract available.


Stabilization of HIF-2α through redox regulation of mTORC2 activation and initiation of mRNA translation.

Nayak BK, Feliers D, Sudarshan S, Friedrichs WE, Day RT, New DD, Fitzgerald JP, Eid A, Denapoli T, Parekh DJ, Gorin Y, Block K.

Oncogene. 2013 Jun 27;32(26):3147-55. doi: 10.1038/onc.2012.333. Epub 2012 Aug 6.


Quantitative measurement of human papillomavirus type 16 e5 oncoprotein levels in epithelial cell lines by mass spectrometry.

Sahab Z, Sudarshan SR, Liu X, Zhang Y, Kirilyuk A, Kamonjoh CM, Simic V, Dai Y, Byers SW, Doorbar J, Suprynowicz FA, Schlegel R.

J Virol. 2012 Sep;86(17):9465-73. doi: 10.1128/JVI.01032-12. Epub 2012 Jun 27.


PI3K regulation of the SKP-2/p27 axis through mTORC2.

Shanmugasundaram K, Block K, Nayak BK, Livi CB, Venkatachalam MA, Sudarshan S.

Oncogene. 2013 Apr 18;32(16):2027-36. doi: 10.1038/onc.2012.226. Epub 2012 Jun 25.


Nox4 mediates renal cell carcinoma cell invasion through hypoxia-induced interleukin 6- and 8- production.

Fitzgerald JP, Nayak B, Shanmugasundaram K, Friedrichs W, Sudarshan S, Eid AA, DeNapoli T, Parekh DJ, Gorin Y, Block K.

PLoS One. 2012;7(1):e30712. doi: 10.1371/journal.pone.0030712. Epub 2012 Jan 27.


Reduced expression of fumarate hydratase in clear cell renal cancer mediates HIF-2α accumulation and promotes migration and invasion.

Sudarshan S, Shanmugasundaram K, Naylor SL, Lin S, Livi CB, O'Neill CF, Parekh DJ, Yeh IT, Sun LZ, Block K.

PLoS One. 2011;6(6):e21037. doi: 10.1371/journal.pone.0021037. Epub 2011 Jun 14.


Increasing reactive oxygen species as a therapeutic approach to treat hereditary leiomyomatosis and renal cell carcinoma.

Sourbier C, Valera-Romero V, Giubellino A, Yang Y, Sudarshan S, Neckers L, Linehan WM.

Cell Cycle. 2010 Oct 15;9(20):4183-9. Epub 2010 Oct 27.


The HPV-16 E5 protein represses expression of stress pathway genes XBP-1 and COX-2 in genital keratinocytes.

Sudarshan SR, Schlegel R, Liu X.

Biochem Biophys Res Commun. 2010 Sep 3;399(4):617-22. doi: 10.1016/j.bbrc.2010.07.125. Epub 2010 Aug 3.


The human papillomavirus type 16 E5 oncoprotein inhibits epidermal growth factor trafficking independently of endosome acidification.

Suprynowicz FA, Krawczyk E, Hebert JD, Sudarshan SR, Simic V, Kamonjoh CM, Schlegel R.

J Virol. 2010 Oct;84(20):10619-29. doi: 10.1128/JVI.00831-10. Epub 2010 Aug 4.


Repeat partial nephrectomy on the solitary kidney: surgical, functional and oncological outcomes.

Liu NW, Khurana K, Sudarshan S, Pinto PA, Linehan WM, Bratslavsky G.

J Urol. 2010 May;183(5):1719-24. doi: 10.1016/j.juro.2010.01.010. Epub 2010 Mar 17.

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