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Items: 14

1.

Structure-based design of potent and selective 3-phosphoinositide-dependent kinase-1 (PDK1) inhibitors.

Medina JR, Becker CJ, Blackledge CW, Duquenne C, Feng Y, Grant SW, Heerding D, Li WH, Miller WH, Romeril SP, Scherzer D, Shu A, Bobko MA, Chadderton AR, Dumble M, Gardiner CM, Gilbert S, Liu Q, Rabindran SK, Sudakin V, Xiang H, Brady PG, Campobasso N, Ward P, Axten JM.

J Med Chem. 2011 Mar 24;54(6):1871-95. doi: 10.1021/jm101527u. Epub 2011 Feb 22.

PMID:
21341675
2.

Purification of the mitotic checkpoint complex (MCC) and the anaphase promoting complex/cyclosome (APC/C) from HeLa cells.

Sudakin V.

Cold Spring Harb Protoc. 2010 Jun;2010(6):pdb.prot5449. doi: 10.1101/pdb.prot5449.

PMID:
20516187
3.

Conformation-dependent ligand regulation of ATP hydrolysis by human KSP: activation of basal hydrolysis and inhibition of microtubule-stimulated hydrolysis by a single, small molecule modulator.

Luo L, Carson JD, Molnar KS, Tuske SJ, Coales SJ, Hamuro Y, Sung CM, Sudakin V, Auger KR, Dhanak D, Jackson JR, Huang PS, Tummino PJ, Copeland RA.

J Am Chem Soc. 2008 Jun 18;130(24):7584-91. doi: 10.1021/ja710889h. Epub 2008 May 21.

PMID:
18491908
4.

ATP-competitive inhibitors of the mitotic kinesin KSP that function via an allosteric mechanism.

Luo L, Parrish CA, Nevins N, McNulty DE, Chaudhari AM, Carson JD, Sudakin V, Shaw AN, Lehr R, Zhao H, Sweitzer S, Lad L, Wood KW, Sakowicz R, Annan RS, Huang PS, Jackson JR, Dhanak D, Copeland RA, Auger KR.

Nat Chem Biol. 2007 Nov;3(11):722-6. Epub 2007 Oct 7.

PMID:
17922005
5.

Targeting mitosis for anti-cancer therapy.

Sudakin V, Yen TJ.

BioDrugs. 2007;21(4):225-33. Review.

PMID:
17628120
6.
7.

Chfr regulates a mitotic stress pathway through its RING-finger domain with ubiquitin ligase activity.

Chaturvedi P, Sudakin V, Bobiak ML, Fisher PW, Mattern MR, Jablonski SA, Hurle MR, Zhu Y, Yen TJ, Zhou BB.

Cancer Res. 2002 Mar 15;62(6):1797-801.

8.
9.

Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC.

Chan GK, Jablonski SA, Sudakin V, Hittle JC, Yen TJ.

J Cell Biol. 1999 Sep 6;146(5):941-54.

10.

Binding of activated cyclosome to p13(suc1). Use for affinity purification.

Sudakin V, Shteinberg M, Ganoth D, Hershko J, Hershko A.

J Biol Chem. 1997 Jul 18;272(29):18051-9.

11.

Preparation of clam oocyte extracts for cell cycle studies.

Ruderman JV, Sudakin V, Hershko A.

Methods Enzymol. 1997;283:614-22. No abstract available.

PMID:
9251052
12.

Reversible phosphorylation controls the activity of cyclosome-associated cyclin-ubiquitin ligase.

Lahav-Baratz S, Sudakin V, Ruderman JV, Hershko A.

Proc Natl Acad Sci U S A. 1995 Sep 26;92(20):9303-7.

13.

The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis.

Sudakin V, Ganoth D, Dahan A, Heller H, Hershko J, Luca FC, Ruderman JV, Hershko A.

Mol Biol Cell. 1995 Feb;6(2):185-97.

14.

Components of a system that ligates cyclin to ubiquitin and their regulation by the protein kinase cdc2.

Hershko A, Ganoth D, Sudakin V, Dahan A, Cohen LH, Luca FC, Ruderman JV, Eytan E.

J Biol Chem. 1994 Feb 18;269(7):4940-6.

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