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Items: 37

1.

Rescue by 4-phenylbutyrate of several misfolded creatine transporter-1 variants linked to the creatine transporter deficiency syndrome.

El-Kasaby A, Kasture A, Koban F, Hotka M, Asjad HM, Kubista H, Freissmuth M, Sucic S.

Neuropharmacology. 2019 Mar 15. pii: S0028-3908(19)30100-5. doi: 10.1016/j.neuropharm.2019.03.015. [Epub ahead of print] Review.

2.

Distinct contribution of axonal and somatodendritic serotonin transporters in drosophila olfaction.

Kasture AS, Bartel D, Steinkellner T, Sucic S, Hummel T, Freissmuth M.

Neuropharmacology. 2019 Mar 6. pii: S0028-3908(19)30084-X. doi: 10.1016/j.neuropharm.2019.03.007. [Epub ahead of print]

3.

Trafficking of the amino acid transporter B0,+ (SLC6A14) to the plasma membrane involves an exclusive interaction with SEC24C for its exit from the endoplasmic reticulum.

Kovalchuk V, Samluk Ł, Juraszek B, Jurkiewicz-Trząska D, Sucic S, Freissmuth M, Nałęcz KA.

Biochim Biophys Acta Mol Cell Res. 2019 Feb;1866(2):252-263. doi: 10.1016/j.bbamcr.2018.11.005. Epub 2018 Nov 14.

4.

Standardized phytotherapic extracts rescue anomalous locomotion and electrophysiological responses of TDP-43 Drosophila melanogaster model of ALS.

Maccioni R, Setzu MD, Talani G, Solari P, Kasture A, Sucic S, Porru S, Muroni P, Sanna E, Kasture S, Acquas E, Liscia A.

Sci Rep. 2018 Oct 30;8(1):16002. doi: 10.1038/s41598-018-34452-1.

5.

Big Lessons from Tiny Flies: Drosophila melanogaster as a Model to Explore Dysfunction of Dopaminergic and Serotonergic Neurotransmitter Systems.

Kasture AS, Hummel T, Sucic S, Freissmuth M.

Int J Mol Sci. 2018 Jun 16;19(6). pii: E1788. doi: 10.3390/ijms19061788. Review.

6.

Efficacy and safety of repetitive transcranial magnetic stimulation using an H1-coil or figure-8-coil in the treatment of unipolar major depressive disorder: A study protocol for a randomized controlled trial.

Filipčić I, Šimunović Filipčić I, Gajšak T, Milovac Ž, Sučić S, Ivezić E, Zečević Penić S, Orgulan I, Šebo D, Jeleč V, Bajić Ž.

Psychiatr Danub. 2018 Mar;30(1):41-46. doi: 10.24869/psyd.2018.41.

7.

Relax, Cool Down and Scaffold: How to Restore Surface Expression of Folding-Deficient Mutant GPCRs and SLC6 Transporters.

Asjad HMM, Nasrollahi-Shirazi S, Sucic S, Freissmuth M, Nanoff C.

Int J Mol Sci. 2017 Nov 14;18(11). pii: E2416. doi: 10.3390/ijms18112416. Review.

8.

SLC6 Transporter Folding Diseases and Pharmacochaperoning.

Freissmuth M, Stockner T, Sucic S.

Handb Exp Pharmacol. 2018;245:249-270. doi: 10.1007/164_2017_71. Review.

PMID:
29086036
9.

Pharmacochaperoning in a Drosophila model system rescues human dopamine transporter variants associated with infantile/juvenile parkinsonism.

Asjad HMM, Kasture A, El-Kasaby A, Sackel M, Hummel T, Freissmuth M, Sucic S.

J Biol Chem. 2017 Nov 24;292(47):19250-19265. doi: 10.1074/jbc.M117.797092. Epub 2017 Sep 29.

10.

An unfolding story: Small molecules remedy misfolded monoamine transporters.

Kasture A, Stockner T, Freissmuth M, Sucic S.

Int J Biochem Cell Biol. 2017 Nov;92:1-5. doi: 10.1016/j.biocel.2017.09.004. Epub 2017 Sep 7. Review.

11.

Conformational state interactions provide clues to the pharmacochaperone potential of serotonin transporter partial substrates.

Bhat S, Hasenhuetl PS, Kasture A, El-Kasaby A, Baumann MH, Blough BE, Sucic S, Sandtner W, Freissmuth M.

J Biol Chem. 2017 Oct 6;292(40):16773-16786. doi: 10.1074/jbc.M117.794081. Epub 2017 Aug 23.

12.

When transporters fail to be transported: how to rescue folding-deficient SLC6 transporters.

Sucic S, Kasture A, Mazhar Asjad HM, Kern C, El-Kasaby A, Freissmuth M.

J Neurol Neuromedicine. 2016 Dec 30;1(9):34-40.

13.

Efficacy, Safety and Tolerability of Augmentative rTMS in Treatment of Major Depressive Disorder (MDD): A Prospective Cohort Study in Croatia.

Filipcic I, Milovac Z, Sucic S, Gajsak T, Filipcic IS, Ivezic E, Aljinovic V, Orgulan I, Penic SZ, Bajic Z.

Psychiatr Danub. 2017 Mar;29(1):31-38.

14.

The N Terminus Specifies the Switch between Transport Modes of the Human Serotonin Transporter.

Kern C, Erdem FA, El-Kasaby A, Sandtner W, Freissmuth M, Sucic S.

J Biol Chem. 2017 Mar 3;292(9):3603-3613. doi: 10.1074/jbc.M116.771360. Epub 2017 Jan 19.

15.

Several adaptor proteins promote intracellular localisation of the transporter MRP4/ABCC4 in platelets and haematopoietic cells.

Schaletzki Y, Kromrey ML, Bröderdorf S, Hammer E, Grube M, Hagen P, Sucic S, Freissmuth M, Völker U, Greinacher A, Rauch BH, Kroemer HK, Jedlitschky G.

Thromb Haemost. 2017 Jan 5;117(1):105-115. doi: 10.1160/TH16-01-0045. Epub 2016 Oct 20.

PMID:
27761583
16.

Functional Rescue of a Misfolded Drosophila melanogaster Dopamine Transporter Mutant Associated with a Sleepless Phenotype by Pharmacological Chaperones.

Kasture A, El-Kasaby A, Szöllősi D, Asjad HMM, Grimm A, Stockner T, Hummel T, Freissmuth M, Sucic S.

J Biol Chem. 2016 Sep 30;291(40):20876-20890. doi: 10.1074/jbc.M116.737551. Epub 2016 Aug 1.

17.

Comparison of the β-Adrenergic Receptor Antagonists Landiolol and Esmolol: Receptor Selectivity, Partial Agonism, and Pharmacochaperoning Actions.

Nasrollahi-Shirazi S, Sucic S, Yang Q, Freissmuth M, Nanoff C.

J Pharmacol Exp Ther. 2016 Oct;359(1):73-81. doi: 10.1124/jpet.116.232884. Epub 2016 Jul 22.

PMID:
27451411
18.

Nanopharmacological Force Sensing to Reveal Allosteric Coupling in Transporter Binding Sites.

Zhu R, Sinwel D, Hasenhuetl PS, Saha K, Kumar V, Zhang P, Rankl C, Holy M, Sucic S, Kudlacek O, Karner A, Sandtner W, Stockner T, Gruber HJ, Freissmuth M, Newman AH, Sitte HH, Hinterdorfer P.

Angew Chem Int Ed Engl. 2016 Jan 26;55(5):1719-22. doi: 10.1002/anie.201508755. Epub 2015 Dec 22.

19.

Corrigendum: STAT3 controls IL6-dependent regulation of serotonin transporter function and depression-like behaviour.

Kong E, Sucic S, Monje FJ, Reisinger SN, Savalli G, Diao W, Khan D, Ronovsky M, Cabatic M, Koban F, Freissmuth M, Pollak DD.

Sci Rep. 2015 Jul 15;5:11965. doi: 10.1038/srep11965. No abstract available.

20.

Ligand Selectivity among the Dopamine and Serotonin Transporters Specified by the Forward Binding Reaction.

Hasenhuetl PS, Schicker K, Koenig X, Li Y, Sarker S, Stockner T, Sucic S, Sitte HH, Freissmuth M, Sandtner W.

Mol Pharmacol. 2015 Jul;88(1):12-8. doi: 10.1124/mol.115.099036. Epub 2015 Apr 14.

PMID:
25873594
21.

A salt bridge linking the first intracellular loop with the C terminus facilitates the folding of the serotonin transporter.

Koban F, El-Kasaby A, Häusler C, Stockner T, Simbrunner BM, Sitte HH, Freissmuth M, Sucic S.

J Biol Chem. 2015 May 22;290(21):13263-78. doi: 10.1074/jbc.M115.641357. Epub 2015 Apr 13.

22.

STAT3 controls IL6-dependent regulation of serotonin transporter function and depression-like behavior.

Kong E, Sucic S, Monje FJ, Savalli G, Diao W, Khan D, Ronovsky M, Cabatic M, Koban F, Freissmuth M, Pollak DD.

Sci Rep. 2015 Mar 11;5:9009. doi: 10.1038/srep09009. Erratum in: Sci Rep. 2015;5:11965.

23.

A cytosolic relay of heat shock proteins HSP70-1A and HSP90β monitors the folding trajectory of the serotonin transporter.

El-Kasaby A, Koban F, Sitte HH, Freissmuth M, Sucic S.

J Biol Chem. 2014 Oct 17;289(42):28987-9000. doi: 10.1074/jbc.M114.595090. Epub 2014 Sep 8.

24.

Axonal targeting of the serotonin transporter in cultured rat dorsal raphe neurons is specified by SEC24C-dependent export from the endoplasmic reticulum.

Montgomery TR, Steinkellner T, Sucic S, Koban F, Schüchner S, Ogris E, Sitte HH, Freissmuth M.

J Neurosci. 2014 Apr 30;34(18):6344-6351. doi: 10.1523/JNEUROSCI.2991-13.2014.

25.

Switching the clientele: a lysine residing in the C terminus of the serotonin transporter specifies its preference for the coat protein complex II component SEC24C.

Sucic S, Koban F, El-Kasaby A, Kudlacek O, Stockner T, Sitte HH, Freissmuth M.

J Biol Chem. 2013 Feb 22;288(8):5330-41. doi: 10.1074/jbc.M112.408237. Epub 2013 Jan 3.

26.

Ca(2+)/calmodulin-dependent protein kinase IIα (αCaMKII) controls the activity of the dopamine transporter: implications for Angelman syndrome.

Steinkellner T, Yang JW, Montgomery TR, Chen WQ, Winkler MT, Sucic S, Lubec G, Freissmuth M, Elgersma Y, Sitte HH, Kudlacek O.

J Biol Chem. 2012 Aug 24;287(35):29627-35. doi: 10.1074/jbc.M112.367219. Epub 2012 Jul 9.

27.

The cysteines of the extracellular loop are crucial for trafficking of human organic cation transporter 2 to the plasma membrane and are involved in oligomerization.

Brast S, Grabner A, Sucic S, Sitte HH, Hermann E, Pavenstädt H, Schlatter E, Ciarimboli G.

FASEB J. 2012 Mar;26(3):976-86. doi: 10.1096/fj.11-180679. Epub 2011 Nov 15.

28.

Cell death mechanisms at the maternal-fetal interface: insights into the role of granulysin.

Veljkovic Vujaklija D, Sucic S, Gulic T, Dominovic M, Rukavina D.

Clin Dev Immunol. 2012;2012:180272. doi: 10.1155/2012/180272. Epub 2011 Sep 8. Review.

29.

First trimester pregnancy decidual natural killer cells contain and spontaneously release high quantities of granulysin.

Vujaklija DV, Gulic T, Sucic S, Nagata K, Ogawa K, Laskarin G, Saito S, Haller H, Rukavina D.

Am J Reprod Immunol. 2011 Nov;66(5):363-72. doi: 10.1111/j.1600-0897.2011.01015.x. Epub 2011 May 27.

PMID:
21623991
30.

LAPTM4A interacts with hOCT2 and regulates its endocytotic recruitment.

Grabner A, Brast S, Sucic S, Bierer S, Hirsch B, Pavenstädt H, Sitte HH, Schlatter E, Ciarimboli G.

Cell Mol Life Sci. 2011 Dec;68(24):4079-90. doi: 10.1007/s00018-011-0694-6. Epub 2011 May 8.

PMID:
21553234
31.

The serotonin transporter is an exclusive client of the coat protein complex II (COPII) component SEC24C.

Sucic S, El-Kasaby A, Kudlacek O, Sarker S, Sitte HH, Marin P, Freissmuth M.

J Biol Chem. 2011 May 6;286(18):16482-90. doi: 10.1074/jbc.M111.230037. Epub 2011 Mar 17.

32.

The high-affinity binding site for tricyclic antidepressants resides in the outer vestibule of the serotonin transporter.

Sarker S, Weissensteiner R, Steiner I, Sitte HH, Ecker GF, Freissmuth M, Sucic S.

Mol Pharmacol. 2010 Dec;78(6):1026-35. doi: 10.1124/mol.110.067538. Epub 2010 Sep 9.

33.

The N terminus of monoamine transporters is a lever required for the action of amphetamines.

Sucic S, Dallinger S, Zdrazil B, Weissensteiner R, Jørgensen TN, Holy M, Kudlacek O, Seidel S, Cha JH, Gether U, Newman AH, Ecker GF, Freissmuth M, Sitte HH.

J Biol Chem. 2010 Apr 2;285(14):10924-38. doi: 10.1074/jbc.M109.083154. Epub 2010 Jan 29.

34.

Investigation of the functional roles of the MELAL and GQXXRXG motifs of the human noradrenaline transporter using cysteine mutants.

Sucic S, Bryan-Lluka LJ.

Eur J Pharmacol. 2007 Feb 5;556(1-3):27-35. Epub 2006 Nov 3.

PMID:
17141753
35.
36.

The role of the conserved GXXXRXG motif in the expression and function of the human norepinephrine transporter.

Sucic S, Bryan-Lluka LJ.

Brain Res Mol Brain Res. 2002 Dec;108(1-2):40-50.

PMID:
12480177
37.

Functional significance of a highly conserved glutamate residue of the human noradrenaline transporter.

Sucic S, Paczkowski FA, Runkel F, Bönisch H, Bryan-Lluka LJ.

J Neurochem. 2002 Apr;81(2):344-54.

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