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Botulinum toxin for the treatment of hypercontractile esophagus: Results of a double-blind randomized sham-controlled study.

Mion F, Marjoux S, Subtil F, Pioche M, Rivory J, Roman S, Zerbib F.

Neurogastroenterol Motil. 2019 May;31(5):e13587. doi: 10.1111/nmo.13587. Epub 2019 Apr 11.


Bench Assessment of the Effect of a Collapsible Tube on the Efficiency of a Mechanical Insufflation-Exsufflation Device.

Lachal R, Louis B, Subtil F, Guérin C.

Respir Care. 2019 Mar 12. pii: respcare.06478. doi: 10.4187/respcare.06478. [Epub ahead of print]


A Bayesian method to estimate the optimal threshold of a marker used to select patients' treatment.

Blangero Y, Rabilloud M, Ecochard R, Subtil F.

Stat Methods Med Res. 2019 Jan 2:962280218821394. doi: 10.1177/0962280218821394. [Epub ahead of print]


[Do scoliotic patients need increased orthodontic treatment? A comparative study on 104 cases].

Servant C, Garnier E, Subtil F, Gebeile-Chauty S.

Orthod Fr. 2018 Dec;89(4):355-363. doi: 10.1051/orthodfr/2018028. Epub 2018 Dec 19. French.


On-Demand Sildenafil as a Treatment for Raynaud Phenomenon: A Series of n-of-1 Trials.

Roustit M, Giai J, Gaget O, Khouri C, Mouhib M, Lotito A, Blaise S, Seinturier C, Subtil F, Paris A, Cracowski C, Imbert B, Carpentier P, Vohra S, Cracowski JL.

Ann Intern Med. 2018 Nov 20;169(10):694-703. doi: 10.7326/M18-0517. Epub 2018 Oct 30.


[Focal HIFU vs robot-assisted total prostatectomy: Functionnal and oncologic outcomes at one year].

Arnouil N, Gelet A, Matillon X, Rouviere O, Colombel M, Ruffion A, Mège-Lechevallier F, Subtil F, Badet L, Crouzet S.

Prog Urol. 2018 Oct;28(12):603-610. doi: 10.1016/j.purol.2018.07.285. Epub 2018 Sep 19. French.


Unequal intra-group variance in trajectory classification.

Klich A, Ecochard R, Subtil F.

Stat Med. 2018 Dec 10;37(28):4155-4166. doi: 10.1002/sim.7921. Epub 2018 Aug 2.


Targeting CREB-binding protein overrides LPS induced radioresistance in non-small cell lung cancer cell lines.

Gökyildirim MY, Grandel U, Hattar K, Dahlem G, Schuetz E, Leinberger FH, Eberle F, Sibelius U, Grimminger F, Seeger W, Engenhart-Cabillic R, Dikomey E, Subtil FSB.

Oncotarget. 2018 Jun 22;9(48):28976-28988. doi: 10.18632/oncotarget.25665. eCollection 2018 Jun 22.


Accuracy of Delivery and Effects on Absolute Humidity of Low Tidal Volume by ICU Ventilators.

Moro B, Baboi L, Yonis H, Subtil F, Louis B, Guérin C.

Respir Care. 2018 Oct;63(10):1253-1263. doi: 10.4187/respcare.06132. Epub 2018 Jun 26.


Peripherally inserted central catheter with intracavitary electrocardiogram guidance: Malposition risk factors and indications for post-procedural control.

Monard C, Lefèvre M, Subtil F, Piriou V, David JS.

J Vasc Access. 2019 Mar;20(2):128-133. doi: 10.1177/1129729818781266. Epub 2018 Jun 25.


Reliability of Tidal Volume in Average Volume Assured Pressure Support Mode.

Stagnara A, Baboi L, Nesme P, Subtil F, Louis B, Guérin C.

Respir Care. 2018 Sep;63(9):1139-1146. doi: 10.4187/respcare.05917. Epub 2018 Jun 19.


1H-Benzo[d]imidazoles and 3,4-dihydroquinazolin-4-ones: Design, synthesis and antitubercular activity.

Macchi FS, Pissinate K, Villela AD, Abbadi BL, Rodrigues-Junior V, Nabinger DD, Altenhofen S, Sperotto N, da Silva Dadda A, Subtil FT, de Freitas TF, Erhart Rauber AP, Borsoi AF, Bonan CD, Bizarro CV, Basso LA, Santos DS, Machado P.

Eur J Med Chem. 2018 Jul 15;155:153-164. doi: 10.1016/j.ejmech.2018.06.005. Epub 2018 Jun 2.


Validation of the prognostic value of the knowledge bank approach to determine AML prognosis in real life.

Huet S, Paubelle E, Lours C, Grange B, Courtois L, Chabane K, Charlot C, Mosnier I, Simonet T, Hayette S, Tigaud I, Thomas X, Salles G, Subtil F, Sujobert P.

Blood. 2018 Aug 23;132(8):865-867. doi: 10.1182/blood-2018-03-840348. Epub 2018 Jun 4. No abstract available.


A Quadriparametric Model to Describe the Diversity of Waves Applied to Hormonal Data.

Abdullah S, Bouchard T, Klich A, Leiva R, Pyper C, Genolini C, Subtil F, Iwaz J, Ecochard R.

Methods Inf Med. 2018 May;57(3):101-110. doi: 10.3414/ME17-01-0102. Epub 2018 May 2.


Anal sphincter function as assessed by 3D high definition anorectal manometry.

Mion F, Garros A, Subtil F, Damon H, Roman S.

Clin Res Hepatol Gastroenterol. 2018 Sep;42(4):378-381. doi: 10.1016/j.clinre.2017.12.004. Epub 2018 Mar 16.


Effect of Optimal Medical Therapy at Discharge in Patients With Reperfused ST-Segment Elevation Myocardial Infarction on 1-Year Mortality (from the Regional RESCUe Registry).

Tomasevic D, El Khoury C, Subtil F, Dubien PY, Bochaton T, Serre P, Gueugniaud PY, Bonnefoy-Cudraz E, Mewton N; Observatoire des Syndromes Coronaires Aigus dans RESCUe (OSCAR) Research Group.

Am J Cardiol. 2018 Feb 15;121(4):403-409. doi: 10.1016/j.amjcard.2017.11.002. Epub 2017 Nov 22.


Roscovitine strongly enhances the effect of olaparib on radiosensitivity for HPV neg. but not for HPV pos. HNSCC cell lines.

Ziemann F, Seltzsam S, Dreffke K, Preising S, Arenz A, Subtil FSB, Rieckmann T, Engenhart-Cabillic R, Dikomey E, Wittig A.

Oncotarget. 2017 Oct 24;8(62):105170-105183. doi: 10.18632/oncotarget.22005. eCollection 2017 Dec 1.


Hospital-acquired infections documented by repeated annual prevalence surveys over 15 years.

Spiga R, Subtil F, Grattard F, Fascia P, Mariat C, Auboyer C, Lucht F, Pozzetto B, Berthelot P.

Med Mal Infect. 2018 Mar;48(2):136-140. doi: 10.1016/j.medmal.2017.11.008. Epub 2017 Dec 21.


Short-Term Effects of the Prone Positioning Maneuver on Lung and Chest Wall Mechanics in Patients with Acute Respiratory Distress Syndrome.

Riad Z, Mezidi M, Subtil F, Louis B, Guérin C.

Am J Respir Crit Care Med. 2018 May 15;197(10):1355-1358. doi: 10.1164/rccm.201709-1853LE. No abstract available.


Revisiting Activation of and Mechanism of Resistance to Compound IQG-607 in Mycobacterium tuberculosis.

Abbadi BL, Villela AD, Rodrigues-Junior VS, Subtil FT, Dalberto PF, Pinheiro APS, Santos DS, Machado P, Basso LA, Bizarro CV.

Antimicrob Agents Chemother. 2018 Jan 25;62(2). pii: e02222-17. doi: 10.1128/AAC.02222-17. Print 2018 Feb.


Characteristics of chronic lymphocytic leukemia patients achieving 5+ years of remission after FC-based first-line treatment: Retrospective observations from the FILO group.

Guillermin Y, Herbaux C, Subtil F, Aurran-Schleinitz T, Cymbalista F, Letestu R, Leprêtre S, Vaudaux S, Laribi K, Leblond V, Defoi Y, Benchikh R, Salles G, Godmer P, Jardel H, Vallais F, Feugier P, Orsini F, Pegourié B, Lévy V, Michallet AS.

Am J Hematol. 2018 Jan;93(1):E24-E27. doi: 10.1002/ajh.24951. Epub 2017 Nov 17. No abstract available.


Activity of 2-(quinolin-4-yloxy)acetamides in Mycobacterium tuberculosis clinical isolates and identification of their molecular target by whole-genome sequencing.

Subtil FT, Villela AD, Abbadi BL, Rodrigues-Junior VS, Bizarro CV, Timmers LFSM, de Souza ON, Pissinate K, Machado P, López-Gavín A, Tudó G, González-Martín J, Basso LA, Santos DS.

Int J Antimicrob Agents. 2018 Mar;51(3):378-384. doi: 10.1016/j.ijantimicag.2017.08.023. Epub 2017 Aug 23.


A sudden death risk score specifically for hypertension: based on 25 648 individual patient data from six randomized controlled trials.

Le HH, Subtil F, Cerou M, Marchant I, Al-Gobari M, Fall M, Mimouni Y, Kassaï B, Lindholm L, Thijs L, Gueyffier F.

J Hypertens. 2017 Nov;35(11):2178-2184. doi: 10.1097/HJH.0000000000001451. Review.


Vancomycin treatment is a risk factor for vancomycin-nonsusceptible Staphylococcus capitis sepsis in preterm neonates.

Butin M, Rasigade JP, Subtil F, Martins-Simões P, Pralong C, Freydière AM, Vandenesch F, Tigaud S, Picaud JC, Laurent F.

Clin Microbiol Infect. 2017 Nov;23(11):839-844. doi: 10.1016/j.cmi.2017.03.022. Epub 2017 Apr 1.


Dynamics of Ebola RNA Persistence in Semen: A Report From the Postebogui Cohort in Guinea.

Subtil F, Delaunay C, Keita AK, Sow MS, Touré A, Leroy S, Msellati P, Magassouba N, Baize S, Raoul H, Ecochard R, Barry M, Delaporte E, Etard JF; Postebogui Study Group.

Clin Infect Dis. 2017 Jun 15;64(12):1788-1790. doi: 10.1093/cid/cix210.


Lipoteichoic acids from Staphylococcus aureus stimulate proliferation of human non-small-cell lung cancer cells in vitro.

Hattar K, Reinert CP, Sibelius U, Gökyildirim MY, Subtil FSB, Wilhelm J, Eul B, Dahlem G, Grimminger F, Seeger W, Grandel U.

Cancer Immunol Immunother. 2017 Jun;66(6):799-809. doi: 10.1007/s00262-017-1980-4. Epub 2017 Mar 17.


Ibrutinib in very elderly patients with relapsed/refractory chronic lymphocytic leukemia: A real-world experience of 71 patients treated in France: A study from the French Innovative Leukemia Organization (FILO) group.

Michallet AS, Campidelli A, Lequeu H, Dilhuydy MS, Tournilhac O, Fornecker LM, Dupuis J, Cymbalista F, De Guibert S, Delmer A, Vilque JP, Ghez D, Leblond V, Subtil F, Feugier P, Ysebaert L.

Am J Hematol. 2017 Jun;92(6):E105-E107. doi: 10.1002/ajh.24715. Epub 2017 Apr 29. No abstract available.


In cancer cell lines inhibition of SCF/c-Kit pathway leads to radiosensitization only when SCF is strongly over-expressed.

Eberle F, Leinberger FH, Saulich MF, Seeger W, Engenhart-Cabillic R, Hänze J, Hattar K, Dikomey E, Subtil FSB.

Clin Transl Radiat Oncol. 2017 Feb 28;2:69-75. doi: 10.1016/j.ctro.2017.02.001. eCollection 2017 Feb.


A bench evaluation of fraction of oxygen in air delivery and tidal volume accuracy in home care ventilators available for hospital use.

Baboi L, Subtil F, Guérin C.

J Thorac Dis. 2016 Dec;8(12):3639-3647. doi: 10.21037/jtd.2016.12.64.


Cementless lateralized stems in primary THA: Mid-term survival and risk factors for failure in 172 stems.

Courtin C, Viste A, Subtil F, Cantin O, Desmarchelier R, Fessy MH.

Orthop Traumatol Surg Res. 2017 Feb;103(1):15-19. doi: 10.1016/j.otsr.2016.10.011. Epub 2016 Nov 30.


New insights into the SAR and drug combination synergy of 2-(quinolin-4-yloxy)acetamides against Mycobacterium tuberculosis.

Giacobbo BC, Pissinate K, Rodrigues-Junior V, Villela AD, Grams ES, Abbadi BL, Subtil FT, Sperotto N, Trindade RV, Back DF, Campos MM, Basso LA, Machado P, Santos DS.

Eur J Med Chem. 2017 Jan 27;126:491-501. doi: 10.1016/j.ejmech.2016.11.048. Epub 2016 Nov 23.


CopyMean: A new method to predict monotone missing values in longitudinal studies.

Genolini C, Lacombe A, Écochard R, Subtil F.

Comput Methods Programs Biomed. 2016 Aug;132:29-44. doi: 10.1016/j.cmpb.2016.04.010. Epub 2016 Apr 19.


kmlShape: An Efficient Method to Cluster Longitudinal Data (Time-Series) According to Their Shapes.

Genolini C, Ecochard R, Benghezal M, Driss T, Andrieu S, Subtil F.

PLoS One. 2016 Jun 3;11(6):e0150738. doi: 10.1371/journal.pone.0150738. eCollection 2016.


Cancer cell motility is affected through 3D cell culturing and SCF/c-Kit pathway but not by X-irradiation.

Eberle F, Saulich MF, Leinberger FH, Seeger W, Engenhart-Cabillic R, Dikomey E, Hänze J, Hattar K, Subtil FS.

Radiother Oncol. 2016 Jun;119(3):537-43. doi: 10.1016/j.radonc.2016.04.036. Epub 2016 May 10.


Early diagnosis of gestational trophoblastic neoplasia based on trajectory classification with compartment modeling.

Burny C, Rabilloud M, Golfier F, Massardier J, Hajri T, Schott AM, Subtil F.

BMC Med Res Methodol. 2016 Jan 5;16:3. doi: 10.1186/s12874-015-0106-y.


[Intra-uterine growth restriction impact on maternal serum concentration of PlGF (placental growth factor): A case control study].

Margossian A, Boisson-Gaudin C, Subtil F, Rudigoz RC, Dubernard G, Allias F, Huissoud C.

Gynecol Obstet Fertil. 2016 Jan;44(1):23-8. doi: 10.1016/j.gyobfe.2015.11.005. Epub 2015 Dec 24. French.


Performance of the 4-mg intravenous dexamethasone suppression test in differentiating Cushing disease from pseudo-Cushing syndrome.

Nouvel M, Rabilloud M, Raverot V, Subtil F, Vouillarmet J, Thivolet C, Jouanneau E, Borson-Chazot F, Pugeat M, Raverot G.

Ann Endocrinol (Paris). 2016 Feb;77(1):30-6. doi: 10.1016/j.ando.2015.11.001. Epub 2015 Dec 3.


An 18F-FDG-PET maximum standardized uptake value > 10 represents a novel valid marker for discerning Richter's Syndrome.

Michallet AS, Sesques P, Rabe KG, Itti E, Tordot J, Tychyj-Pinel C, Baseggio L, Subtil F, Salles G, Dupuis JM, Conte MJ.

Leuk Lymphoma. 2016;57(6):1474-7. doi: 10.3109/10428194.2015.1099643. No abstract available.


The precision--recall curve overcame the optimism of the receiver operating characteristic curve in rare diseases.

Ozenne B, Subtil F, Maucort-Boulch D.

J Clin Epidemiol. 2015 Aug;68(8):855-9. doi: 10.1016/j.jclinepi.2015.02.010. Epub 2015 Feb 28.


Sequential combination of gemcitabine, vinorelbine, pegylated liposomal doxorubicin and brentuximab as a bridge regimen to transplant in relapsed or refractory Hodgkin lymphoma.

Michallet AS, Guillermin Y, Deau B, Lebras L, Harel S, Amorin S, Reynes C, Salles G, Subtil F, Brice P.

Haematologica. 2015 Jul;100(7):e269-71. doi: 10.3324/haematol.2015.124784. Epub 2015 Apr 3. No abstract available.


Spatially regularized mixture model for lesion segmentation with application to stroke patients.

Ozenne B, Subtil F, Østergaard L, Maucort-Boulch D.

Biostatistics. 2015 Jul;16(3):580-95. doi: 10.1093/biostatistics/kxv004. Epub 2015 Mar 6.


An enhancement of ROC curves made them clinically relevant for diagnostic-test comparison and optimal-threshold determination.

Subtil F, Rabilloud M.

J Clin Epidemiol. 2015 Jul;68(7):752-9. doi: 10.1016/j.jclinepi.2015.01.003. Epub 2015 Jan 12.


Impact of variability in adherence to HIV antiretroviral therapy on the immunovirological response and mortality.

Boussari O, Subtil F, Genolini C, Bastard M, Iwaz J, Fonton N, Etard JF, Ecochard R; ANRS 1215 study group.

BMC Med Res Methodol. 2015 Feb 5;15:10. doi: 10.1186/1471-2288-15-10.


TLR4- and TLR9-dependent effects on cytokines, cell viability, and invasion in human bladder cancer cells.

Olbert PJ, Kesch C, Henrici M, Subtil FS, Honacker A, Hegele A, Hofmann R, Hänze J.

Urol Oncol. 2015 Mar;33(3):110.e19-27. doi: 10.1016/j.urolonc.2014.09.016. Epub 2014 Dec 10.


Gemcitabine plus cisplatin versus chemoradiotherapy in locally advanced biliary tract cancer: Fédération Francophone de Cancérologie Digestive 9902 phase II randomised study.

Phelip JM, Vendrely V, Rostain F, Subtil F, Jouve JL, Gasmi M, Michel P, Le Malicot K, Smith D, Seitz JF, Fauchart JP, Martin P, Bennouna J, Morin T, Bonnet I, Maingon P, Lepage C, Chauffert B.

Eur J Cancer. 2014 Nov;50(17):2975-82. doi: 10.1016/j.ejca.2014.08.013. Epub 2014 Sep 17.


Interactions between neutrophils and non-small cell lung cancer cells: enhancement of tumor proliferation and inflammatory mediator synthesis.

Hattar K, Franz K, Ludwig M, Sibelius U, Wilhelm J, Lohmeyer J, Savai R, Subtil FS, Dahlem G, Eul B, Seeger W, Grimminger F, Grandel U.

Cancer Immunol Immunother. 2014 Dec;63(12):1297-306. doi: 10.1007/s00262-014-1606-z. Epub 2014 Sep 4.


An alternative classification to mixture modeling for longitudinal counts or binary measures.

Subtil F, Boussari O, Bastard M, Etard JF, Ecochard R, Génolini C.

Stat Methods Med Res. 2017 Feb;26(1):453-470. doi: 10.1177/0962280214549040. Epub 2016 Sep 30.


Oxaliplatin, fluorouracil, and leucovorin with or without cetuximab in patients with resected stage III colon cancer (PETACC-8): an open-label, randomised phase 3 trial.

Taieb J, Tabernero J, Mini E, Subtil F, Folprecht G, Van Laethem JL, Thaler J, Bridgewater J, Petersen LN, Blons H, Collette L, Van Cutsem E, Rougier P, Salazar R, Bedenne L, Emile JF, Laurent-Puig P, Lepage C; PETACC-8 Study Investigators.

Lancet Oncol. 2014 Jul;15(8):862-73. doi: 10.1016/S1470-2045(14)70227-X. Epub 2014 Jun 11.


Estimating the optimal threshold for a diagnostic biomarker in case of complex biomarker distributions.

Subtil F, Rabilloud M.

BMC Med Inform Decis Mak. 2014 Jun 14;14:53. doi: 10.1186/1472-6947-14-53.


Can we identify response markers to antihypertensive drugs? First results from the IDEAL Trial.

Gueyffier F, Subtil F, Bejan-Angoulvant T, Zerbib Y, Baguet JP, Boivin JM, Mercier A, Leftheriotis G, Gagnol JP, Fauvel JP, Giraud C, Bricca G, Maucort-Boulch D, Erpeldinger S; IDEAL Trial Group.

J Hum Hypertens. 2015 Jan;29(1):22-7. doi: 10.1038/jhh.2014.29. Epub 2014 Apr 17.


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