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Items: 1 to 50 of 84

1.

Covalent Docking Identifies a Potent and Selective MKK7 Inhibitor.

Shraga A, Olshvang E, Davidzohn N, Khoshkenar P, Germain N, Shurrush K, Carvalho S, Avram L, Albeck S, Unger T, Lefker B, Subramanyam C, Hudkins RL, Mitchell A, Shulman Z, Kinoshita T, London N.

Cell Chem Biol. 2019 Jan 17;26(1):98-108.e5. doi: 10.1016/j.chembiol.2018.10.011. Epub 2018 Nov 15.

PMID:
30449673
2.

Increased building block access through collaboration.

Helal CJ, Bartolozzi A, Goble SD, Mani NS, Guzman-Perez A, Ohri AK, Shi ZC, Subramanyam C.

Drug Discov Today. 2018 Aug;23(8):1458-1462. doi: 10.1016/j.drudis.2018.03.001. Epub 2018 Mar 20. Review. No abstract available.

PMID:
29571837
3.

Novel 3-fluoro-6-methoxyquinoline derivatives as inhibitors of bacterial DNA gyrase and topoisomerase IV.

Mitton-Fry MJ, Brickner SJ, Hamel JC, Barham R, Brennan L, Casavant JM, Ding X, Finegan S, Hardink J, Hoang T, Huband MD, Maloney M, Marfat A, McCurdy SP, McLeod D, Subramanyam C, Plotkin M, Reilly U, Schafer J, Stone GG, Uccello DP, Wisialowski T, Yoon K, Zaniewski R, Zook C.

Bioorg Med Chem Lett. 2017 Aug 1;27(15):3353-3358. doi: 10.1016/j.bmcl.2017.06.009. Epub 2017 Jun 3.

PMID:
28610977
4.

Identification and Profiling of a Selective and Brain Penetrant Radioligand for in Vivo Target Occupancy Measurement of Casein Kinase 1 (CK1) Inhibitors.

Wager TT, Galatsis P, Chandrasekaran RY, Butler TW, Li J, Zhang L, Mente S, Subramanyam C, Liu S, Doran AC, Chang C, Fisher K, Grimwood S, Hedde JR, Marconi M, Schildknegt K.

ACS Chem Neurosci. 2017 Sep 20;8(9):1995-2004. doi: 10.1021/acschemneuro.7b00155. Epub 2017 Jun 30.

PMID:
28609096
5.

Multivalent peptidic linker enables identification of preferred sites of conjugation for a potent thialanstatin antibody drug conjugate.

Puthenveetil S, He H, Loganzo F, Musto S, Teske J, Green M, Tan X, Hosselet C, Lucas J, Tumey LN, Sapra P, Subramanyam C, O'Donnell CJ, Graziani EI.

PLoS One. 2017 May 30;12(5):e0178452. doi: 10.1371/journal.pone.0178452. eCollection 2017.

6.

Altered intestinal microbiota in patients with chronic pancreatitis: implications in diabetes and metabolic abnormalities.

Jandhyala SM, Madhulika A, Deepika G, Rao GV, Reddy DN, Subramanyam C, Sasikala M, Talukdar R.

Sci Rep. 2017 Mar 3;7:43640. doi: 10.1038/srep43640.

7.

Pancreatic stellate cell: Pandora's box for pancreatic disease biology.

Bynigeri RR, Jakkampudi A, Jangala R, Subramanyam C, Sasikala M, Rao GV, Reddy DN, Talukdar R.

World J Gastroenterol. 2017 Jan 21;23(3):382-405. doi: 10.3748/wjg.v23.i3.382. Review.

8.

Design, Synthesis, and Cytotoxic Evaluation of Novel Tubulysin Analogues as ADC Payloads.

Leverett CA, Sukuru SC, Vetelino BC, Musto S, Parris K, Pandit J, Loganzo F, Varghese AH, Bai G, Liu B, Liu D, Hudson S, Doppalapudi VR, Stock J, O'Donnell CJ, Subramanyam C.

ACS Med Chem Lett. 2016 Aug 26;7(11):999-1004. eCollection 2016 Nov 10.

9.

Optimization of Tubulysin Antibody-Drug Conjugates: A Case Study in Addressing ADC Metabolism.

Tumey LN, Leverett CA, Vetelino B, Li F, Rago B, Han X, Loganzo F, Musto S, Bai G, Sukuru SC, Graziani EI, Puthenveetil S, Casavant J, Ratnayake A, Marquette K, Hudson S, Doppalapudi VR, Stock J, Tchistiakova L, Bessire AJ, Clark T, Lucas J, Hosselet C, O'Donnell CJ, Subramanyam C.

ACS Med Chem Lett. 2016 Jun 22;7(11):977-982. eCollection 2016 Nov 10.

10.

Polymorphisms in UGT1A1 Gene Predispose South Indians to Pigmentous Gallstones.

Ravikanth VV, Rao GV, Govardhan B, Sasikala M, Subramanyam C, Vivekananda Murthy HV, Siva Prasad S, Deepika G, Pradeep R, Nageshwar Reddy D.

J Clin Exp Hepatol. 2016 Sep;6(3):216-223. Epub 2016 Aug 30.

11.

Natural Product Splicing Inhibitors: A New Class of Antibody-Drug Conjugate (ADC) Payloads.

Puthenveetil S, Loganzo F, He H, Dirico K, Green M, Teske J, Musto S, Clark T, Rago B, Koehn F, Veneziale R, Falahaptisheh H, Han X, Barletta F, Lucas J, Subramanyam C, O'Donnell CJ, Tumey LN, Sapra P, Gerber HP, Ma D, Graziani EI.

Bioconjug Chem. 2016 Aug 17;27(8):1880-8. doi: 10.1021/acs.bioconjchem.6b00291. Epub 2016 Jul 28.

PMID:
27412791
12.

Determination of Antibody-Drug Conjugate Released Payload Species Using Directed in Vitro Assays and Mass Spectrometric Interrogation.

Bessire AJ, Ballard TE, Charati M, Cohen J, Green M, Lam MH, Loganzo F, Nolting B, Pierce B, Puthenveetil S, Roberts L, Schildknegt K, Subramanyam C.

Bioconjug Chem. 2016 Jul 20;27(7):1645-54. doi: 10.1021/acs.bioconjchem.6b00192. Epub 2016 Jun 13.

PMID:
27206324
13.

Role of the normal gut microbiota.

Jandhyala SM, Talukdar R, Subramanyam C, Vuyyuru H, Sasikala M, Nageshwar Reddy D.

World J Gastroenterol. 2015 Aug 7;21(29):8787-803. doi: 10.3748/wjg.v21.i29.8787. Review.

14.

Design of Pyridopyrazine-1,6-dione γ-Secretase Modulators that Align Potency, MDR Efflux Ratio, and Metabolic Stability.

Pettersson M, Johnson DS, Humphrey JM, Butler TW, Am Ende CW, Fish BA, Green ME, Kauffman GW, Mullins PB, O'Donnell CJ, Stepan AF, Stiff CM, Subramanyam C, Tran TP, Vetelino BC, Yang E, Xie L, Bales KR, Pustilnik LR, Steyn SJ, Wood KM, Verhoest PR.

ACS Med Chem Lett. 2015 Apr 3;6(5):596-601. doi: 10.1021/acsmedchemlett.5b00070. eCollection 2015 May 14.

15.

Influence of probiotic administration on the fecal microbiota in diarrhea-predominant irritable bowel syndrome.

Subramanyam C, Pratap N, Gandham P, Talukdar R, Sasikala M, Murthy HV, Nageshwar Reddy D.

Indian J Gastroenterol. 2015 May;34(3):275-6. doi: 10.1007/s12664-015-0545-8. No abstract available.

PMID:
25913294
16.

Discovery of cytotoxic dolastatin 10 analogues with N-terminal modifications.

Maderna A, Doroski M, Subramanyam C, Porte A, Leverett CA, Vetelino BC, Chen Z, Risley H, Parris K, Pandit J, Varghese AH, Shanker S, Song C, Sukuru SC, Farley KA, Wagenaar MM, Shapiro MJ, Musto S, Lam MH, Loganzo F, O'Donnell CJ.

J Med Chem. 2014 Dec 26;57(24):10527-43. doi: 10.1021/jm501649k. Epub 2014 Dec 9.

PMID:
25431858
17.

Design, synthesis, and pharmacological evaluation of a novel series of pyridopyrazine-1,6-dione γ-secretase modulators.

Pettersson M, Johnson DS, Subramanyam C, Bales KR, am Ende CW, Fish BA, Green ME, Kauffman GW, Mullins PB, Navaratnam T, Sakya SM, Stiff CM, Tran TP, Xie L, Zhang L, Pustilnik LR, Vetelino BC, Wood KM, Pozdnyakov N, Verhoest PR, O'Donnell CJ.

J Med Chem. 2014 Feb 13;57(3):1046-62. doi: 10.1021/jm401782h. Epub 2014 Jan 28.

PMID:
24428186
18.

Extremely low frequency magnetic fields induce oxidative stress in rat brain.

Manikonda PK, Rajendra P, Devendranath D, Gunasekaran B, Channakeshava, Aradhya SR, Sashidhar RB, Subramanyam C.

Gen Physiol Biophys. 2014;33(1):81-90. doi: 10.4149/gpb_2013059. Epub 2013 Dec 13.

PMID:
24334533
19.

Long-term functions of encapsulated islets grafted in nonhuman primates without immunosuppression.

Sasikala M, Rao GV, Vijayalakshmi V, Pradeep R, Pothani S, Kumar PP, Gaddipati R, Sirisha G, Cheemalakonda R, Tandan M, Subramanyam C, Vasudevan S, Reddy DN.

Transplantation. 2013 Oct 15;96(7):624-32. doi: 10.1097/TP.0b013e31829e26cf.

PMID:
23883970
20.

Novel quinoline derivatives as inhibitors of bacterial DNA gyrase and topoisomerase IV.

Mitton-Fry MJ, Brickner SJ, Hamel JC, Brennan L, Casavant JM, Chen M, Chen T, Ding X, Driscoll J, Hardink J, Hoang T, Hua E, Huband MD, Maloney M, Marfat A, McCurdy SP, McLeod D, Plotkin M, Reilly U, Robinson S, Schafer J, Shepard RM, Smith JF, Stone GG, Subramanyam C, Yoon K, Yuan W, Zaniewski RP, Zook C.

Bioorg Med Chem Lett. 2013 May 15;23(10):2955-61. doi: 10.1016/j.bmcl.2013.03.047. Epub 2013 Mar 21.

PMID:
23566517
21.

Interferon γ and glycemic status in diabetes associated with chronic pancreatitis.

Pavan Kumar P, Radhika G, Rao GV, Pradeep R, Subramanyam C, Talukdar R, Reddy DN, Sasikala M.

Pancreatology. 2012 Jan-Feb;12(1):65-70. doi: 10.1016/j.pan.2011.12.005. Epub 2011 Dec 8.

PMID:
22487478
22.

Design and synthesis of dihydrobenzofuran amides as orally bioavailable, centrally active γ-secretase modulators.

Pettersson M, Johnson DS, Subramanyam C, Bales KR, am Ende CW, Fish BA, Green ME, Kauffman GW, Lira R, Mullins PB, Navaratnam T, Sakya SM, Stiff CM, Tran TP, Vetelino BC, Xie L, Zhang L, Pustilnik LR, Wood KM, O'Donnell CJ.

Bioorg Med Chem Lett. 2012 Apr 15;22(8):2906-11. doi: 10.1016/j.bmcl.2012.02.059. Epub 2012 Mar 1.

PMID:
22429469
23.

Application of the bicyclo[1.1.1]pentane motif as a nonclassical phenyl ring bioisostere in the design of a potent and orally active γ-secretase inhibitor.

Stepan AF, Subramanyam C, Efremov IV, Dutra JK, O'Sullivan TJ, DiRico KJ, McDonald WS, Won A, Dorff PH, Nolan CE, Becker SL, Pustilnik LR, Riddell DR, Kauffman GW, Kormos BL, Zhang L, Lu Y, Capetta SH, Green ME, Karki K, Sibley E, Atchison KP, Hallgren AJ, Oborski CE, Robshaw AE, Sneed B, O'Donnell CJ.

J Med Chem. 2012 Apr 12;55(7):3414-24. doi: 10.1021/jm300094u. Epub 2012 Mar 29.

PMID:
22420884
24.

β-Cell dysfunction in chronic pancreatitis.

Sasikala M, Talukdar R, Pavan kumar P, Radhika G, Rao GV, Pradeep R, Subramanyam C, Nageshwar Reddy D.

Dig Dis Sci. 2012 Jul;57(7):1764-72. doi: 10.1007/s10620-012-2086-7. Epub 2012 Mar 2. Review.

PMID:
22383081
25.

Metabolism-directed design of oxetane-containing arylsulfonamide derivatives as γ-secretase inhibitors.

Stepan AF, Karki K, McDonald WS, Dorff PH, Dutra JK, Dirico KJ, Won A, Subramanyam C, Efremov IV, O'Donnell CJ, Nolan CE, Becker SL, Pustilnik LR, Sneed B, Sun H, Lu Y, Robshaw AE, Riddell D, O'Sullivan TJ, Sibley E, Capetta S, Atchison K, Hallgren AJ, Miller E, Wood A, Obach RS.

J Med Chem. 2011 Nov 24;54(22):7772-83. doi: 10.1021/jm200893p. Epub 2011 Oct 26.

PMID:
21995460
26.

Sugar coated ceramic nanocarriers for the oral delivery of hydrophobic drugs: formulation, optimization and evaluation.

Kommineni S, Ahmad S, Vengala P, Subramanyam CV.

Drug Dev Ind Pharm. 2012 May;38(5):577-86. doi: 10.3109/03639045.2011.617884. Epub 2011 Sep 30.

PMID:
21961937
27.

Quantitative pharmacokinetic/pharmacodynamic analyses suggest that the 129/SVE mouse is a suitable preclinical pharmacology model for identifying small-molecule γ-secretase inhibitors.

Lu Y, Zhang L, Nolan CE, Becker SL, Atchison K, Robshaw AE, Pustilnik LR, Osgood SM, Miller EH, Stepan AF, Subramanyam C, Efremov I, Hallgren AJ, Riddell D.

J Pharmacol Exp Ther. 2011 Dec;339(3):922-34. doi: 10.1124/jpet.111.186791. Epub 2011 Sep 19.

PMID:
21930801
28.

Discovery, synthesis and SAR of azinyl- and azolylbenzamides antagonists of the P2X₇ receptor.

Subramanyam C, Duplantier AJ, Dombroski MA, Chang SP, Gabel CA, Whitney-Pickett C, Perregaux DG, Labasi JM, Yoon K, Shepard RM, Fisher M.

Bioorg Med Chem Lett. 2011 Sep 15;21(18):5475-9. doi: 10.1016/j.bmcl.2011.06.117. Epub 2011 Jul 2.

PMID:
21782426
29.

Optimization of the physicochemical and pharmacokinetic attributes in a 6-azauracil series of P2X7 receptor antagonists leading to the discovery of the clinical candidate CE-224,535.

Duplantier AJ, Dombroski MA, Subramanyam C, Beaulieu AM, Chang SP, Gabel CA, Jordan C, Kalgutkar AS, Kraus KG, Labasi JM, Mussari C, Perregaux DG, Shepard R, Taylor TJ, Trevena KA, Whitney-Pickett C, Yoon K.

Bioorg Med Chem Lett. 2011 Jun 15;21(12):3708-11. doi: 10.1016/j.bmcl.2011.04.077. Epub 2011 Apr 24.

PMID:
21565499
30.

Discovery of CP-690,550: a potent and selective Janus kinase (JAK) inhibitor for the treatment of autoimmune diseases and organ transplant rejection.

Flanagan ME, Blumenkopf TA, Brissette WH, Brown MF, Casavant JM, Shang-Poa C, Doty JL, Elliott EA, Fisher MB, Hines M, Kent C, Kudlacz EM, Lillie BM, Magnuson KS, McCurdy SP, Munchhof MJ, Perry BD, Sawyer PS, Strelevitz TJ, Subramanyam C, Sun J, Whipple DA, Changelian PS.

J Med Chem. 2010 Dec 23;53(24):8468-84. doi: 10.1021/jm1004286. Epub 2010 Nov 24.

PMID:
21105711
31.

Design of selective, ATP-competitive inhibitors of Akt.

Freeman-Cook KD, Autry C, Borzillo G, Gordon D, Barbacci-Tobin E, Bernardo V, Briere D, Clark T, Corbett M, Jakubczak J, Kakar S, Knauth E, Lippa B, Luzzio MJ, Mansour M, Martinelli G, Marx M, Nelson K, Pandit J, Rajamohan F, Robinson S, Subramanyam C, Wei L, Wythes M, Morris J.

J Med Chem. 2010 Jun 24;53(12):4615-22. doi: 10.1021/jm1003842. Erratum in: J Med Chem. 2010 Aug 12;53(15):5895.

PMID:
20481595
32.

Structural comparison of chromosomal and exogenous dihydrofolate reductase from Staphylococcus aureus in complex with the potent inhibitor trimethoprim.

Heaslet H, Harris M, Fahnoe K, Sarver R, Putz H, Chang J, Subramanyam C, Barreiro G, Miller JR.

Proteins. 2009 Aug 15;76(3):706-17. doi: 10.1002/prot.22383.

PMID:
19280600
33.

Predictors of mortality in rhinocerebral mycosis.

Jayalakshmi SS, Reddy RG, Borgohain R, Subramanyam C, Panigrahi M, Sundaram C, Meena AK, Mohandas S.

Neurol India. 2007 Jul-Sep;55(3):292-7.

34.

Pyrimidine benzamide-based thrombopoietin receptor agonists.

Reiter LA, Subramanyam C, Mangual EJ, Jones CS, Smeets MI, Brissette WH, McCurdy SP, Lira PD, Linde RG, Li Q, Zhang F, Antipas AS, Blumberg LC, Doty JL, Driscoll JP, Munchhof MJ, Ripp SL, Shavnya A, Shepard RM, Sperger D, Thomasco LM, Trevena KA, Wolf-Gouveia LA, Zhang L.

Bioorg Med Chem Lett. 2007 Oct 1;17(19):5447-54. Epub 2007 Jul 31.

PMID:
17707640
35.

Influence of extremely low frequency magnetic fields on Ca2+ signaling and NMDA receptor functions in rat hippocampus.

Manikonda PK, Rajendra P, Devendranath D, Gunasekaran B, Channakeshava, Aradhya RS, Sashidhar RB, Subramanyam C.

Neurosci Lett. 2007 Feb 14;413(2):145-9. Epub 2006 Dec 28.

PMID:
17196332
36.

Biochemical analysis of oxidative stress in the production of aflatoxin and its precursor intermediates.

Narasaiah KV, Sashidhar RB, Subramanyam C.

Mycopathologia. 2006 Sep;162(3):179-89.

PMID:
16944285
37.

Prevention of isoproterenol-induced cardiac hypertrophy by eugenol, an antioxidant.

Choudhary R, Mishra KP, Subramanyam C.

Indian J Clin Biochem. 2006 Sep;21(2):107-13. doi: 10.1007/BF02912923.

38.

Characterization of calcineurin-dependent response element binding protein and its involvement in copper-metallothionein gene expression in Neurospora.

Kumar KS, Ravi Kumar B, Siddavattam D, Subramanyam C.

Biochem Biophys Res Commun. 2006 Jul 7;345(3):1010-3. Epub 2006 May 11.

PMID:
16707100
39.

Interrelations between oxidative stress and calcineurin in the attenuation of cardiac apoptosis by eugenol.

Choudhary R, Mishra KP, Subramanyam C.

Mol Cell Biochem. 2006 Feb;283(1-2):115-22.

PMID:
16444593
40.

Positive correlations between serum calcineurin activity and left ventricular hypertrophy.

Choudhary R, Sastry BK, Subramanyam C.

Int J Cardiol. 2005 Dec 7;105(3):327-31.

PMID:
16274778
41.

Cryptococcal abscess--unusual presentation.

Rao TV, Subramanyam CS.

J Assoc Physicians India. 2005 May;53:448. No abstract available.

PMID:
16124354
42.

Potent pyrimidinetrione-based inhibitors of MMP-13 with enhanced selectivity over MMP-14.

Blagg JA, Noe MC, Wolf-Gouveia LA, Reiter LA, Laird ER, Chang SP, Danley DE, Downs JT, Elliott NC, Eskra JD, Griffiths RJ, Hardink JR, Haugeto AI, Jones CS, Liras JL, Lopresti-Morrow LL, Mitchell PG, Pandit J, Robinson RP, Subramanyam C, Vaughn-Bowser ML, Yocum SA.

Bioorg Med Chem Lett. 2005 Apr 1;15(7):1807-10.

PMID:
15780611
43.

Serum calcineurin activity in relation to oxidative stress and glycemic control in type II diabetes mellitus.

Sankaranarayanan TK, Sethi BK, Subramanyam C.

Clin Biochem. 2005 Mar;38(3):218-22.

PMID:
15708541
44.

Copper alone, but not oxidative stress, induces copper-metallothionein gene in Neurospora crassa.

Kumar KS, Dayananda S, Subramanyam C.

FEMS Microbiol Lett. 2005 Jan 1;242(1):45-50.

45.

Biological effects of power frequency magnetic fields: Neurochemical and toxicological changes in developing chick embryos.

Rajendra P, Sujatha H, Devendranath D, Gunasekaran B, Sashidhar R, Subramanyam C, Channakeshava.

Biomagn Res Technol. 2004 Jan 31;2(1):1.

46.

Prevention of organ allograft rejection by a specific Janus kinase 3 inhibitor.

Changelian PS, Flanagan ME, Ball DJ, Kent CR, Magnuson KS, Martin WH, Rizzuti BJ, Sawyer PS, Perry BD, Brissette WH, McCurdy SP, Kudlacz EM, Conklyn MJ, Elliott EA, Koslov ER, Fisher MB, Strelevitz TJ, Yoon K, Whipple DA, Sun J, Munchhof MJ, Doty JL, Casavant JM, Blumenkopf TA, Hines M, Brown MF, Lillie BM, Subramanyam C, Shang-Poa C, Milici AJ, Beckius GE, Moyer JD, Su C, Woodworth TG, Gaweco AS, Beals CR, Littman BH, Fisher DA, Smith JF, Zagouras P, Magna HA, Saltarelli MJ, Johnson KS, Nelms LF, Des Etages SG, Hayes LS, Kawabata TT, Finco-Kent D, Baker DL, Larson M, Si MS, Paniagua R, Higgins J, Holm B, Reitz B, Zhou YJ, Morris RE, O'Shea JJ, Borie DC.

Science. 2003 Oct 31;302(5646):875-8.

47.

Calcineurin activity as an indicator of oxidative stress in normal islet cells and insulinoma cells.

Sankaranarayanan TK, Subramanyam C.

Indian J Clin Biochem. 2003 Jan;18(1):1-4. doi: 10.1007/BF02867657.

48.

Clinical significance of serum calcineurin in acute leukemia.

Padma S, Subramanyam C.

Clin Chim Acta. 2002 Jul;321(1-2):17-21.

PMID:
12031587
49.

A putative role for calcineurin in lymphopenia associated with chronic renal failure.

Sasikala M, Sadasivudu B, Subramanyam C.

Clin Biochem. 2000 Nov;33(8):691-4. No abstract available.

PMID:
11166020
50.

Oxidative stress as a prerequisite for aflatoxin production by Aspergillus parasiticus.

Jayashree T, Subramanyam C.

Free Radic Biol Med. 2000 Nov 15;29(10):981-5.

PMID:
11084286

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