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Guselkumab in patients with active psoriatic arthritis who were biologic-naive or had previously received TNFα inhibitor treatment (DISCOVER-1): a double-blind, randomised, placebo-controlled phase 3 trial.

Deodhar A, Helliwell PS, Boehncke WH, Kollmeier AP, Hsia EC, Subramanian RA, Xu XL, Sheng S, Agarwal P, Zhou B, Zhuang Y, Ritchlin CT; DISCOVER-1 Study Group.

Lancet. 2020 Mar 13. pii: S0140-6736(20)30265-8. doi: 10.1016/S0140-6736(20)30265-8. [Epub ahead of print] Erratum in: Lancet. 2020 Mar 20;:.


Underutilization of Hospice in Inpatients with Cirrhosis: The NACSELD Experience.

O'Leary JG, Tandon P, Reddy KR, Biggins SW, Wong F, Kamath PS, Garcia-Tsao G, Maliakkal B, Lai J, Fallon M, Vargas HE, Thuluvath P, Subramanian R, Thacker LR, Bajaj JS.

Dig Dis Sci. 2020 Mar 7. doi: 10.1007/s10620-020-06168-8. [Epub ahead of print]


Living donor liver transplantation in a patient with severe portopulmonary hypertension.

Singh SA, Ashraf H, Subramanian R, Krishnan GA, Pandey V, Gupta S.

Indian J Anaesth. 2020 Feb;64(2):153-155. doi: 10.4103/ija.IJA_512_19. Epub 2020 Feb 4. No abstract available.


A perspective on challenges and opportunities in characterizing oral cancer stem cells.

Sadasivam S, Subramanian R.

Front Biosci (Landmark Ed). 2020 Mar 1;25:1011-1021.


Guidelines for the Management of Adult Acute and Acute-on-Chronic Liver Failure in the ICU: Cardiovascular, Endocrine, Hematologic, Pulmonary, and Renal Considerations.

Nanchal R, Subramanian R, Karvellas CJ, Hollenberg SM, Peppard WJ, Singbartl K, Truwit J, Al-Khafaji AH, Killian AJ, Alquraini M, Alshammari K, Alshamsi F, Belley-Cote E, Cartin-Ceba R, Dionne JC, Galusca DM, Huang DT, Hyzy RC, Junek M, Kandiah P, Kumar G, Morgan RL, Morris PE, Olson JC, Sieracki R, Steadman R, Taylor B, Alhazzani W.

Crit Care Med. 2020 Mar;48(3):e173-e191. doi: 10.1097/CCM.0000000000004192.


Guidelines for the Management of Adult Acute and Acute-on-Chronic Liver Failure in the ICU: Cardiovascular, Endocrine, Hematologic, Pulmonary and Renal Considerations: Executive Summary.

Nanchal R, Subramanian R, Karvellas CJ, Hollenberg SM, Peppard WJ, Singbartl K, Truwit J, Al-Khafaji AH, Killian AJ, Alquraini M, Alshammari K, Alshamsi F, Belley-Cote E, Cartin-Ceba R, Dionne JC, Galusca DM, Huang DT, Hyzy RC, Junek M, Kandiah P, Kumar G, Morgan RL, Morris PE, Olson JC, Sieracki R, Steadman R, Taylor B, Alhazzani W.

Crit Care Med. 2020 Mar;48(3):415-419. doi: 10.1097/CCM.0000000000004193. No abstract available.


Discovery and Development of 3-(6-Chloropyridine-3-yloxymethyl)-2-azabicyclo[3.1.0]hexane Hydrochloride (SUVN-911): A Novel, Potent, Selective, and Orally Active Neuronal Nicotinic Acetylcholine α4β2 Receptor Antagonist for the Treatment of Depression.

Nirogi R, Mohammed AR, Shinde AK, Ravella SR, Bogaraju N, Subramanian R, Mekala VR, Palacharla RC, Muddana N, Thentu JB, Bhyrapuneni G, Abraham R, Jasti V.

J Med Chem. 2020 Mar 26;63(6):2833-2853. doi: 10.1021/acs.jmedchem.9b00790. Epub 2020 Feb 21.


Gastrointestinal and hepatic critical care: a domain of intensive care in evolution.

Subramanian RM.

Curr Opin Crit Care. 2020 Apr;26(2):162. doi: 10.1097/MCC.0000000000000711. No abstract available.


Constructing protein polyhedra via orthogonal chemical interactions.

Golub E, Subramanian RH, Esselborn J, Alberstein RG, Bailey JB, Chiong JA, Yan X, Booth T, Baker TS, Tezcan FA.

Nature. 2020 Feb;578(7793):172-176. doi: 10.1038/s41586-019-1928-2. Epub 2020 Jan 22.


The basis for non-canonical ROK family function in the N-acetylmannosamine kinase from the pathogen Staphylococcus aureus.

Coombes D, Davies JS, Newton-Vesty MC, Horne CR, Setty TG, Subramanian R, Moir JWB, Friemann R, Panjikar S, Griffin MDW, North RA, Dobson RCJ.

J Biol Chem. 2020 Mar 6;295(10):3301-3315. doi: 10.1074/jbc.RA119.010526. Epub 2020 Jan 15.


Time-Resolved sub-Ångström Metrology by Temporal Phase Interferometry near X-Ray Resonances of Nuclei.

Goerttler S, Heeg K, Kaldun A, Reiser P, Strohm C, Haber J, Ott C, Subramanian R, Röhlsberger R, Evers J, Pfeifer T.

Phys Rev Lett. 2019 Oct 11;123(15):153902. doi: 10.1103/PhysRevLett.123.153902.


Exploring the structural interaction of BSA with amine functionalized ruthenium(II) metal complex.

Anish Babu A, Karthick K, Subramanian R, Swarnalatha K.

J Biomol Struct Dyn. 2019 Nov 1:1-8. doi: 10.1080/07391102.2019.1683071. [Epub ahead of print]


Extracorporeal liver support in patients with liver failure: a systematic review and meta-analysis of randomized trials.

Alshamsi F, Alshammari K, Belley-Cote E, Dionne J, Albrahim T, Albudoor B, Ismail M, Al-Judaibi B, Baw B, Subramanian RM, Steadman R, Galusca D, Huang DT, Nanchal R, Al Quraini M, Yuan Y, Alhazzani W; GUIDE Group.

Intensive Care Med. 2020 Jan;46(1):1-16. doi: 10.1007/s00134-019-05783-y. Epub 2019 Oct 7. Review.


Organic Anion-Transporting Polypeptide Genes Are Not Induced by the Pregnane X Receptor Activator Rifampin: Studies in Hepatocytes In Vitro and in Monkeys In Vivo.

Niu C, Wang Y, Zhao X, Tep S, Murakami E, Subramanian R, Smith B, Lai Y.

Drug Metab Dispos. 2019 Dec;47(12):1433-1442. doi: 10.1124/dmd.119.088922. Epub 2019 Oct 3.


Perioperative anesthetic management of a combined right atrial thrombectomy with living donor liver transplantation.

Subramanian R, Singh SA, Gupta S, Majhi SK, Malhotra R.

J Anaesthesiol Clin Pharmacol. 2019 Jul-Sep;35(3):396-399. doi: 10.4103/joacp.JOACP_180_18.


Serotonin is essential for eye regeneration in planaria Schmidtea mediterranea.

Sarkar A, Mukundan N, Sowndarya S, Dubey VK, Babu R, Lakshmanan V, Rangiah K, Panicker MM, Palakodeti D, Subramanian SP, Subramanian R.

FEBS Lett. 2019 Nov;593(22):3198-3209. doi: 10.1002/1873-3468.13607. Epub 2019 Sep 27.


Meeting report - Mitotic spindle: from living and synthetic systems to theory.

Simunić J, Subramanian R.

J Cell Sci. 2019 Sep 2;132(17). pii: jcs237602. doi: 10.1242/jcs.237602. Review.


Impact of physicochemical properties on duration and head rice yield during abrasive and friction milling of rice.

Kalpanadevi C, Singh V, Subramanian R.

J Food Sci Technol. 2019 Aug;56(8):3900-3909. doi: 10.1007/s13197-019-03861-z. Epub 2019 Jun 7.


Hypotension in Cirrhosis.

Vora RS, Subramanian RM.

Clin Liver Dis (Hoboken). 2019 Jul 2;13(6):149-153. doi: 10.1002/cld.764. eCollection 2019 Jun. Review. No abstract available.


Demonstration of a Low-Cost Multi-Pollutant Network to Quantify Intra-Urban Spatial Variations in Air Pollutant Source Impacts and to Evaluate Environmental Justice.

Tanzer R, Malings C, Hauryliuk A, Subramanian R, Presto AA.

Int J Environ Res Public Health. 2019 Jul 15;16(14). pii: E2523. doi: 10.3390/ijerph16142523.


The resolution revolution reaches India.

Subramanian R, Mayor S, Vinothkumar KR.

Biophys Rev. 2019 Jul 2:513-514. doi: 10.1007/s12551-019-00558-7. [Epub ahead of print] No abstract available.


Structural and functional characterization of CMP-N-acetylneuraminate synthetase from Vibrio cholerae.

Bose S, Purkait D, Joseph D, Nayak V, Subramanian R.

Acta Crystallogr D Struct Biol. 2019 Jun 1;75(Pt 6):564-577. doi: 10.1107/S2059798319006831. Epub 2019 May 31.


Nosocomial Infections Are Frequent and Negatively Impact Outcomes in Hospitalized Patients With Cirrhosis.

Bajaj JS, OʼLeary JG, Tandon P, Wong F, Garcia-Tsao G, Kamath PS, Biggins SW, Lai JC, Vargas HE, Maliakkal B, Fallon MB, Thuluvath PJ, Subramanian RM, Thacker LR, Reddy KR.

Am J Gastroenterol. 2019 Jul;114(7):1091-1100. doi: 10.14309/ajg.0000000000000280.


Dosimetric analysis and clinical outcomes of brachial plexus as an organ-at-risk in head-and-neck cancer patients treated with intensity-modulated radiotherapy.

Prakash BB, Yathiraj PH, Sharan TK, Singh A, Reddy AS, Chandraguthi SG, Subramanian RB, Nagesh J, Nair SS, Fernandes DJ, Mamidipudi VS.

J Cancer Res Ther. 2019 Jul-Sep;15(3):522-527. doi: 10.4103/jcrt.JCRT_959_17.


Locally advanced high-risk HPV related oropharyngeal squamous cell carcinoma (OPSCC); have we forgotten it is a different disease?

Saba NF, Li S, Hussain ZA, Subramanian R, Califano JA, Chung CH.

Cancers Head Neck. 2018 Oct 3;3:8. doi: 10.1186/s41199-018-0035-7. eCollection 2018.


The Functional and Molecular Effects of Doxycycline Treatment on Borrelia burgdorferi Phenotype.

Caskey JR, Hasenkampf NR, Martin DS, Chouljenko VN, Subramanian R, Cheslock MA, Embers ME.

Front Microbiol. 2019 Apr 18;10:690. doi: 10.3389/fmicb.2019.00690. eCollection 2019.


Targets to improve quality of care for patients with hepatic encephalopathy: data from a multi-centre cohort.

Bajaj JS, O'Leary JG, Tandon P, Wong F, Kamath PS, Biggins SW, Garcia-Tsao G, Lai J, Fallon MB, Thuluvath PJ, Vargas HE, Maliakkal B, Subramanian RM, Thacker LR, Reddy KR.

Aliment Pharmacol Ther. 2019 Jun;49(12):1518-1527. doi: 10.1111/apt.15265. Epub 2019 Apr 29.


Interplay between the Kinesin and Tubulin Mechanochemical Cycles Underlies Microtubule Tip Tracking by the Non-motile Ciliary Kinesin Kif7.

Jiang S, Mani N, Wilson-Kubalek EM, Ku PI, Milligan RA, Subramanian R.

Dev Cell. 2019 Jun 3;49(5):711-730.e8. doi: 10.1016/j.devcel.2019.04.001. Epub 2019 Apr 25.


A rare cause of desaturation in an infant after anesthesia induction.

Seetharamaiah S, Subramanian R, Sharma A, Vyas V.

Saudi J Anaesth. 2019 Apr-Jun;13(2):164-165. doi: 10.4103/sja.SJA_841_18. No abstract available.


Preparation, characterization and functional properties of Moringa oleifera seed protein isolate.

Jain A, Subramanian R, Manohar B, Radha C.

J Food Sci Technol. 2019 Apr;56(4):2093-2104. doi: 10.1007/s13197-019-03690-0. Epub 2019 Mar 9.


Influence of disease duration and socioeconomic factors on the prevalence of infection and hospitalization in rheumatoid arthritis: KRAC study.

Chandrashekara S, Shobha V, Dharmanand BG, Jois R, Kumar S, Mahendranath KM, Haridas V, Prasad S, Singh Y, Daware MA, Swamy A, Subramanian R, Somashekar SA, Shanthappa AM, Anupama KR.

Int J Rheum Dis. 2019 Jul;22(7):1216-1225. doi: 10.1111/1756-185X.13562. Epub 2019 Apr 11.


Age-specific differences in the dynamics of protective immunity to influenza.

Ranjeva S, Subramanian R, Fang VJ, Leung GM, Ip DKM, Perera RAPM, Peiris JSM, Cowling BJ, Cobey S.

Nat Commun. 2019 Apr 10;10(1):1660. doi: 10.1038/s41467-019-09652-6.


Information-Theoretic Inference of an Optimal Dictionary of Protein Supersecondary Structures.

Konagurthu AS, Subramanian R, Allison L, Abramson D, de la Banda MG, Stuckey PJ, Lesk AM.

Methods Mol Biol. 2019;1958:123-131. doi: 10.1007/978-1-4939-9161-7_6.


Impact of Chronic Kidney Disease on Outcomes in Cirrhosis.

Wong F, Reddy KR, O'Leary JG, Tandon P, Biggins SW, Garcia-Tsao G, Maliakkal BJ, Lai JC, Fallon MB, Vargas HE, Subramanian R, Thuluvath PJ, Kamath PS, Thacker L, Bajaj JS.

Liver Transpl. 2019 Jun;25(6):870-880. doi: 10.1002/lt.25454. Epub 2019 Apr 25.


Theoretical studies of hydrogen abstraction from H2X and CH3XH (X = O, S) by trichloromethyl radicals.

Pal J, Subramanian R.

Phys Chem Chem Phys. 2019 Mar 28;21(12):6525-6534. doi: 10.1039/c8cp07677d. Epub 2019 Mar 7.


Renal Safety of Intravenous Gadolinium-enhanced MRI in Patients Following Liver Transplantation.

Flynn MM, Parekh AN, Parikh MR, Sood A, Shaffer KM, Runge TM, Lipowska AM, Perez SD, Sakaria SS, Subramanian RM.

Transplantation. 2019 Jun;103(6):e159-e163. doi: 10.1097/TP.0000000000002678.


Correlation of early ROTEM parameters with conventional coagulation tests in patients with chronic liver disease undergoing liver transplant.

Hashir A, Singh SA, Krishnan G, Subramanian R, Gupta S.

Indian J Anaesth. 2019 Jan;63(1):21-25. doi: 10.4103/ija.IJA_334_18.


Acetaminophen is Undetectable in Plasma From More Than Half of Patients Believed to Have Acute Liver Failure Due to Overdose.

Leventhal TM, Gottfried M, Olson JC, Subramanian RM, Hameed B, Lee WM; Acute Liver Failure Study Group.

Clin Gastroenterol Hepatol. 2019 Sep;17(10):2110-2116. doi: 10.1016/j.cgh.2019.01.040. Epub 2019 Feb 5.


Outcomes After Listing for Liver Transplant in Patients With Acute-on-Chronic Liver Failure: The Multicenter North American Consortium for the Study of End-Stage Liver Disease Experience.

O'Leary JG, Bajaj JS, Tandon P, Biggins SW, Wong F, Kamath PS, Garcia-Tsao G, Maliakkal B, Lai J, Fallon M, Vargas HE, Thuluvath P, Subramanian R, Thacker LR, Reddy KR.

Liver Transpl. 2019 Apr;25(4):571-579. doi: 10.1002/lt.25426. Epub 2019 Mar 24.


Outcomes in Patients With Cirrhosis on Primary Compared to Secondary Prophylaxis for Spontaneous Bacterial Peritonitis.

Bajaj JS, Tandon P, OʼLeary JG, Wong F, Biggins SW, Garcia-Tsao G, Kamath PS, Maliakkal B, Fallon MB, Lai JC, Thuluvath PJ, Vargas HE, Subramanian RM, Thacker LR, Reddy KR.

Am J Gastroenterol. 2019 Apr;114(4):599-606. doi: 10.14309/ajg.0000000000000044.


Systemic Alanine Glyoxylate Aminotransferase mRNA Improves Glyoxylate Metabolism in a Mouse Model of Primary Hyperoxaluria Type 1.

Kukreja A, Lasaro M, Cobaugh C, Forbes C, Tang JP, Gao X, Martin-Higueras C, Pey AL, Salido E, Sobolov S, Subramanian RR.

Nucleic Acid Ther. 2019 Apr;29(2):104-113. doi: 10.1089/nat.2018.0740. Epub 2019 Jan 24.


Probabilistic Assessment of Glass Forming Ability Rules for Metallic Glasses Aided by Automated Analysis of Phase Diagrams.

Dasgupta A, Broderick SR, Mack C, Kota BU, Subramanian R, Setlur S, Govindaraju V, Rajan K.

Sci Rep. 2019 Jan 23;9(1):357. doi: 10.1038/s41598-018-36224-3.


Discovery and Development of N-[4-(1-Cyclobutylpiperidin-4-yloxy)phenyl]-2-(morpholin-4-yl)acetamide Dihydrochloride (SUVN-G3031): A Novel, Potent, Selective, and Orally Active Histamine H3 Receptor Inverse Agonist with Robust Wake-Promoting Activity.

Nirogi R, Shinde A, Mohammed AR, Badange RK, Reballi V, Bandyala TR, Saraf SK, Bojja K, Manchineella S, Achanta PK, Kandukuri KK, Subramanian R, Benade V, Palacharla RC, Jayarajan P, Pandey S, Jasti V.

J Med Chem. 2019 Feb 14;62(3):1203-1217. doi: 10.1021/acs.jmedchem.8b01280. Epub 2019 Jan 25.


Value of VKORC1 (-1639G>A) rs9923231 genotyping in predicting warfarin dose: A replication study in South Indian population.

Harikrishnan S, Koshy L, Subramanian R, Sanjay G, Vineeth CP, Nair AJ, Nair GM, Sudhakaran PR.

Indian Heart J. 2018 Dec;70 Suppl 3:S110-S115. doi: 10.1016/j.ihj.2018.07.006. Epub 2018 Jul 19.


First reported case of Human Parechovirus encephalitis in an adult patient complicated by Refractory Status Epilepticus.

Chimunda T, Subramanian R, Smith J, Mahony A.

IDCases. 2018 Dec 3;15:e00475. doi: 10.1016/j.idcr.2018.e00475. eCollection 2019.


An integrated process for the production of 1,3-propanediol, lactate and 3-hydroxypropionic acid by an engineered Lactobacillus reuteri.

Suppuram P, Ramakrishnan GG, Subramanian R.

Biosci Biotechnol Biochem. 2019 Apr;83(4):755-762. doi: 10.1080/09168451.2018.1559720. Epub 2018 Dec 22.


Beating the Odds: A Full-Term Delivery After Liver Transplantation of a Pregnant Hyperthyroid Patient at 19 Weeks' Gestation for Propylthiouracil-Induced Acute Liver Failure.

Bartnik CM, Maheshwari RN, Subramanian RM.

Transplant Proc. 2018 Dec;50(10):3995-3999. doi: 10.1016/j.transproceed.2018.06.046. Epub 2018 Jun 30.


Factors Affecting Growth Kinetics and Spontaneous Metastasis in the B16F10 Syngeneic Murine Melanoma Model.

Fowlkes N, Clemons K, Rider PJ, Subramanian R, Wakamatsu N, Langohr I, Kousoulas KG.

Comp Med. 2019 Feb 1;69(1):48-54. doi: 10.30802/AALAS-CM-18-000036. Epub 2018 Dec 18.


Caring for the Critically Ill Alcoholic Liver Disease Patient: An Uphill Battle Worth Fighting.

Flynn MM, Subramanian RM.

Crit Care Med. 2019 Jan;47(1):123-124. doi: 10.1097/CCM.0000000000003488. No abstract available.


Self-Assembly of a Designed Nucleoprotein Architecture through Multimodal Interactions.

Subramanian RH, Smith SJ, Alberstein RG, Bailey JB, Zhang L, Cardone G, Suominen L, Chami M, Stahlberg H, Baker TS, Tezcan FA.

ACS Cent Sci. 2018 Nov 28;4(11):1578-1586. doi: 10.1021/acscentsci.8b00745. Epub 2018 Nov 15.

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