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Creation of Recombinant Chaperone Vaccine Using Large Heat Shock Protein for Antigen-Targeted Cancer Immunotherapy.

Guo C, Subjeck JR, Wang XY.

Methods Mol Biol. 2018;1709:345-357. doi: 10.1007/978-1-4939-7477-1_25.


Scavenger Receptors: Emerging Roles in Cancer Biology and Immunology.

Yu X, Guo C, Fisher PB, Subjeck JR, Wang XY.

Adv Cancer Res. 2015;128:309-64. doi: 10.1016/bs.acr.2015.04.004. Epub 2015 Jun 17. Review.


The Endoplasmic Reticulum Chaperone GRP170: From Immunobiology to Cancer Therapeutics.

Wang H, Pezeshki AM, Yu X, Guo C, Subjeck JR, Wang XY.

Front Oncol. 2015 Jan 12;4:377. doi: 10.3389/fonc.2014.00377. eCollection 2014. Review.


Enhanced endoplasmic reticulum entry of tumor antigen is crucial for cross-presentation induced by dendritic cell-targeted vaccination.

Wang H, Yu X, Guo C, Zuo D, Fisher PB, Subjeck JR, Wang XY.

J Immunol. 2013 Dec 15;191(12):6010-21. doi: 10.4049/jimmunol.1302312. Epub 2013 Nov 11.


Therapeutic cancer vaccines: past, present, and future.

Guo C, Manjili MH, Subjeck JR, Sarkar D, Fisher PB, Wang XY.

Adv Cancer Res. 2013;119:421-75. doi: 10.1016/B978-0-12-407190-2.00007-1. Review.


High molecular weight stress proteins: Identification, cloning and utilisation in cancer immunotherapy.

Wang XY, Subjeck JR.

Int J Hyperthermia. 2013 Aug;29(5):364-75. doi: 10.3109/02656736.2013.803607. Epub 2013 Jul 5. Review.


Integrating a 'danger' signal into molecular chaperoning to improve vaccination against cancer.

Yu X, Subjeck JR, Wang XY.

Expert Rev Vaccines. 2013 Jun;12(6):581-3. doi: 10.1586/erv.13.47. No abstract available.


A multifunctional chimeric chaperone serves as a novel immune modulator inducing therapeutic antitumor immunity.

Yu X, Guo C, Yi H, Qian J, Fisher PB, Subjeck JR, Wang XY.

Cancer Res. 2013 Apr 1;73(7):2093-103. doi: 10.1158/0008-5472.CAN-12-1740. Epub 2013 Jan 18.


In situ vaccination with CD204 gene-silenced dendritic cell, not unmodified dendritic cell, enhances radiation therapy of prostate cancer.

Guo C, Yi H, Yu X, Zuo D, Qian J, Yang G, Foster BA, Subjeck JR, Sun X, Mikkelsen RB, Fisher PB, Wang XY.

Mol Cancer Ther. 2012 Nov;11(11):2331-41. doi: 10.1158/1535-7163.MCT-12-0164. Epub 2012 Aug 15.


Scavenger receptor A restrains T-cell activation and protects against concanavalin A-induced hepatic injury.

Zuo D, Yu X, Guo C, Wang H, Qian J, Yi H, Lu X, Lv ZP, Subjeck JR, Zhou H, Sanyal AJ, Chen Z, Wang XY.

Hepatology. 2013 Jan;57(1):228-38. doi: 10.1002/hep.25983.


Molecular chaperoning by glucose-regulated protein 170 in the extracellular milieu promotes macrophage-mediated pathogen sensing and innate immunity.

Zuo D, Yu X, Guo C, Yi H, Chen X, Conrad DH, Guo TL, Chen Z, Fisher PB, Subjeck JR, Wang XY.

FASEB J. 2012 Apr;26(4):1493-505. doi: 10.1096/fj.11-197707. Epub 2011 Dec 29.


Suppression of antigen-specific CD4+ T cell activation by SRA/CD204 through reducing the immunostimulatory capability of antigen-presenting cell.

Yi H, Zuo D, Yu X, Hu F, Manjili MH, Chen Z, Subjeck JR, Wang XY.

J Mol Med (Berl). 2012 Apr;90(4):413-26. doi: 10.1007/s00109-011-0828-1. Epub 2011 Nov 15.


Targeting the immunoregulator SRA/CD204 potentiates specific dendritic cell vaccine-induced T-cell response and antitumor immunity.

Yi H, Guo C, Yu X, Gao P, Qian J, Zuo D, Manjili MH, Fisher PB, Subjeck JR, Wang XY.

Cancer Res. 2011 Nov 1;71(21):6611-20. doi: 10.1158/0008-5472.CAN-11-1801. Epub 2011 Sep 13.


Enhancing antigen cross-presentation and T-cell priming by complexing protein antigen to recombinant large heat-shock protein.

Wang XY, Yi H, Yu X, Zuo D, Subjeck JR.

Methods Mol Biol. 2011;787:277-87. doi: 10.1007/978-1-61779-295-3_21.


CD204 suppresses large heat shock protein-facilitated priming of tumor antigen gp100-specific T cells and chaperone vaccine activity against mouse melanoma.

Qian J, Yi H, Guo C, Yu X, Zuo D, Chen X, Kane JM 3rd, Repasky EA, Subjeck JR, Wang XY.

J Immunol. 2011 Sep 15;187(6):2905-14. doi: 10.4049/jimmunol.1100703. Epub 2011 Aug 10.


Heat shock proteins and cancer therapy: the trail grows hotter!

Subjeck JR, Repasky EA.

Oncotarget. 2011 Jun;2(6):433-4. No abstract available.


Pattern recognition scavenger receptor CD204 attenuates Toll-like receptor 4-induced NF-kappaB activation by directly inhibiting ubiquitination of tumor necrosis factor (TNF) receptor-associated factor 6.

Yu X, Yi H, Guo C, Zuo D, Wang Y, Kim HL, Subjeck JR, Wang XY.

J Biol Chem. 2011 May 27;286(21):18795-806. doi: 10.1074/jbc.M111.224345. Epub 2011 Apr 1.


ER stress and its regulator X-box-binding protein-1 enhance polyIC-induced innate immune response in dendritic cells.

Hu F, Yu X, Wang H, Zuo D, Guo C, Yi H, Tirosh B, Subjeck JR, Qiu X, Wang XY.

Eur J Immunol. 2011 Apr;41(4):1086-97. doi: 10.1002/eji.201040831. Epub 2011 Mar 14.


Absence of scavenger receptor A promotes dendritic cell-mediated cross-presentation of cell-associated antigen and antitumor immune response.

Guo C, Yi H, Yu X, Hu F, Zuo D, Subjeck JR, Wang XY.

Immunol Cell Biol. 2012 Jan;90(1):101-8. doi: 10.1038/icb.2011.10. Epub 2011 Mar 8.


Temsirolimus, an mTOR inhibitor, enhances anti-tumour effects of heat shock protein cancer vaccines.

Wang Y, Wang XY, Subjeck JR, Shrikant PA, Kim HL.

Br J Cancer. 2011 Feb 15;104(4):643-52. doi: 10.1038/bjc.2011.15. Epub 2011 Feb 1.


Covalent crosslinking of tumor antigens stimulates an antitumor immune response.

Wang Y, Wang XY, Subjeck JR, Kim HL.

Vaccine. 2010 Sep 14;28(40):6613-20. doi: 10.1016/j.vaccine.2010.07.060. Epub 2010 Aug 2.


Superior antitumor response induced by large stress protein chaperoned protein antigen compared with peptide antigen.

Wang XY, Sun X, Chen X, Facciponte J, Repasky EA, Kane J, Subjeck JR.

J Immunol. 2010 Jun 1;184(11):6309-19. doi: 10.4049/jimmunol.0903891. Epub 2010 May 3.


Tumour secreted grp170 chaperones full-length protein substrates and induces an adaptive anti-tumour immune response in vivo.

Arnouk H, Zynda ER, Wang XY, Hylander BL, Manjili MH, Repasky EA, Subjeck JR, Latif Kazim A.

Int J Hyperthermia. 2010;26(4):366-75. doi: 10.3109/02656730903485910.


Pattern recognition scavenger receptor SRA/CD204 down-regulates Toll-like receptor 4 signaling-dependent CD8 T-cell activation.

Yi H, Yu X, Gao P, Wang Y, Baek SH, Chen X, Kim HL, Subjeck JR, Wang XY.

Blood. 2009 Jun 4;113(23):5819-28. doi: 10.1182/blood-2008-11-190033. Epub 2009 Apr 6.


Carbonic anhydrase IX has chaperone-like functions and is an immunoadjuvant.

Wang Y, Wang XY, Subjeck JR, Kim HL.

Mol Cancer Ther. 2008 Dec;7(12):3867-77. doi: 10.1158/1535-7163.MCT-08-0603.


Engineering secretable forms of chaperones for immune modulation and vaccine development.

Beachy SH, Kisailus AJ, Repasky EA, Subjeck JR, Wang XY, Kazim AL.

Methods. 2007 Nov;43(3):184-93. Review.


Scavenger receptor-A negatively regulates antitumor immunity.

Wang XY, Facciponte J, Chen X, Subjeck JR, Repasky EA.

Cancer Res. 2007 May 15;67(10):4996-5002.


Evaluation of renal cell carcinoma vaccines targeting carbonic anhydrase IX using heat shock protein 110.

Kim HL, Sun X, Subjeck JR, Wang XY.

Cancer Immunol Immunother. 2007 Jul;56(7):1097-105. Epub 2006 Dec 5.


Heat shock proteins as vaccine adjuvants in infections and cancer.

Segal BH, Wang XY, Dennis CG, Youn R, Repasky EA, Manjili MH, Subjeck JR.

Drug Discov Today. 2006 Jun;11(11-12):534-40. Review.


Molecular chaperones and cancer immunotherapy.

Wang XY, Facciponte JG, Subjeck JR.

Handb Exp Pharmacol. 2006;(172):305-29. Review.


Erratum to: Emergence of immune escape variant of mammary tumors that has distinct proteomic profile and a reduced ability to induce "danger signals".

Manjili MH, Arnouk H, Knutson KL, Kmieciak M, Disis ML, Subjeck JR, Kazim AL.

Breast Cancer Res Treat. 2006 Apr;96(3):243. doi: 10.1007/s10549-006-9163-6. Epub 2006 Mar 16. No abstract available.


Immunoadjuvant chaperone, GRP170, induces 'danger signals' upon interaction with dendritic cells.

Manjili MH, Park JE, Facciponte JG, Wang XY, Subjeck JR.

Immunol Cell Biol. 2006 Apr;84(2):203-8.


Chaperoning function of stress protein grp170, a member of the hsp70 superfamily, is responsible for its immunoadjuvant activity.

Park JE, Facciponte J, Chen X, MacDonald I, Repasky EA, Manjili MH, Wang XY, Subjeck JR.

Cancer Res. 2006 Jan 15;66(2):1161-8.


Current ideas about applications of heat shock proteins in vaccine design and immunotherapy.

Wang XY, Li Y, Yang G, Subjeck JR.

Int J Hyperthermia. 2005 Dec;21(8):717-22. Review.


Emergence of immune escape variant of mammary tumors that has distinct proteomic profile and a reduced ability to induce "danger signals".

Manjili MH, Arnouk H, Knutson KL, Kmieciak M, Disis ML, Subjeck JR, Kazim AL.

Breast Cancer Res Treat. 2006 Apr;96(3):233-41. Epub 2005 Oct 7. Erratum in: Breast Cancer Res Treat. 2006 Apr;96(3):243. Breast Cancer Res Treat. 2006 Apr;96(3):243.


HSP110 induces "danger signals" upon interaction with antigen presenting cells and mouse mammary carcinoma.

Manjili MH, Park J, Facciponte JG, Subjeck JR.

Immunobiology. 2005;210(5):295-303.


Heat shock proteins and scavenger receptors: role in adaptive immune responses.

Facciponte JG, MacDonald IJ, Wang XY, Kim H, Manjili MH, Subjeck JR.

Immunol Invest. 2005;34(3):325-42. Review.


Heat shock proteins HSP70 and GP96: structural insights.

Facciponte JG, Wang XY, MacDonald IJ, Park JE, Arnouk H, Grimm MJ, Li Y, Kim H, Manjili MH, Easton DP, Subjeck JR.

Cancer Immunol Immunother. 2006 Mar;55(3):339-46. Epub 2005 Jul 20. Review.


Cancer immunotherapy and heat-shock proteins: promises and challenges.

Manjili MH, Wang XY, MacDonald IJ, Arnouk H, Yang GY, Pritchard MT, Subjeck JR.

Expert Opin Biol Ther. 2004 Mar;4(3):363-73. Review.


Apg-2 has a chaperone-like activity similar to Hsp110 and is overexpressed in hepatocellular carcinomas.

Gotoh K, Nonoguchi K, Higashitsuji H, Kaneko Y, Sakurai T, Sumitomo Y, Itoh K, Subjeck JR, Fujita J.

FEBS Lett. 2004 Feb 27;560(1-3):19-24.


The chaperoning properties of mouse grp170, a member of the third family of hsp70 related proteins.

Park J, Easton DP, Chen X, MacDonald IJ, Wang XY, Subjeck JR.

Biochemistry. 2003 Dec 23;42(50):14893-902.


Development of cancer vaccines using autologous and recombinant high molecular weight stress proteins.

Wang XY, Manjili MH, Park J, Chen X, Repasky E, Subjeck JR.

Methods. 2004 Jan;32(1):13-20.


HSP110-HER2/neu chaperone complex vaccine induces protective immunity against spontaneous mammary tumors in HER-2/neu transgenic mice.

Manjili MH, Wang XY, Chen X, Martin T, Repasky EA, Henderson R, Subjeck JR.

J Immunol. 2003 Oct 15;171(8):4054-61.


Intestinal heat shock protein 110 regulates expression of CD1d on intestinal epithelial cells.

Colgan SP, Pitman RS, Nagaishi T, Mizoguchi A, Mizoguchi E, Mayer LF, Shao L, Sartor RB, Subjeck JR, Blumberg RS.

J Clin Invest. 2003 Sep;112(5):745-54.


Targeted immunotherapy using reconstituted chaperone complexes of heat shock protein 110 and melanoma-associated antigen gp100.

Wang XY, Chen X, Manjili MH, Repasky E, Henderson R, Subjeck JR.

Cancer Res. 2003 May 15;63(10):2553-60.


Cancer immunotherapy: stress proteins and hyperthermia.

Manjili MH, Wang XY, Park J, Macdonald IJ, Li Y, Van Schie RC, Subjeck JR.

Int J Hyperthermia. 2002 Nov-Dec;18(6):506-20. Review.


Hsp110 over-expression increases the immunogenicity of the murine CT26 colon tumor.

Wang XY, Li Y, Manjili MH, Repasky EA, Pardoll DM, Subjeck JR.

Cancer Immunol Immunother. 2002 Aug;51(6):311-9. Epub 2002 Jun 13.


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