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Int J Androl. 2001 Oct;24(5):278-83.

Sperm disposal system in spermatic granuloma: a link with superoxide radicals.

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School of Life Sciences, Devi Ahilya University, Indore, India.


Spermatic granulomas are believed to maintain "physiological harmony" in the male reproductive tract by maintaining a balance of hydrostatic pressure post-vasectomy. The mechanism for the disposal of deposited spermatozoa in the granuloma core is not clear. A fourfold rise in the production of superoxide along with ascorbyl and dienyl radicals and a 50% drop in the production of nitric oxide (NO) radicals by granuloma tissue hints that a reaction between NO and superoxide radicals could lead to the formation of peroxynitrite species which may contribute to the disposal of spermatozoa in the granuloma core. A higher protease activity and low hypoxanthine content in the granuloma indicates that a free radical driven sperm disposal system is active in granulomas.

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